CCND3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cyclin D3|The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 896)
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Genes

290 genes differentially expressed following the CCND3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SPAG8 sperm associated antigen 8 2.87272
NXPH3 neurexophilin 3 2.87272
MGAM2 maltase-glucoamylase 2 (putative) 2.87272
UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8 2.87272
RAX retina and anterior neural fold homeobox 2.87272
INSM2 insulinoma-associated 2 2.87272
CNTNAP4 contactin associated protein-like 4 2.87272
IL5RA interleukin 5 receptor, alpha 2.87272
ZNF560 zinc finger protein 560 2.87272
ALOX15 arachidonate 15-lipoxygenase 2.87272
SCN2B sodium channel, voltage gated, type II beta subunit 2.87272
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.87272
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.87272
SRL sarcalumenin 2.87272
FOLR1 folate receptor 1 (adult) 2.87272
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 2.87272
CD6 CD6 molecule 2.87272
NAPSA napsin A aspartic peptidase 2.87272
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.87272
PAX6 paired box 6 2.87272
PAX7 paired box 7 2.87272
SPHK1 sphingosine kinase 1 2.87272
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.87272
PODNL1 podocan-like 1 2.87272
SPACA3 sperm acrosome associated 3 2.87272
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.87272
INTS5 integrator complex subunit 5 2.87272
ITIH6 inter-alpha-trypsin inhibitor heavy chain family, member 6 2.87272
NMUR2 neuromedin U receptor 2 2.87272
B3GNT8 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8 2.87272
TMEM121 transmembrane protein 121 2.87272
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.87272
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 2.87272
GDNF glial cell derived neurotrophic factor 2.87272
NEU4 sialidase 4 2.87272
MFAP4 microfibrillar-associated protein 4 2.87272
C19ORF67 chromosome 19 open reading frame 67 2.87272
POSTN periostin, osteoblast specific factor 2.87272
LCN12 lipocalin 12 2.87272
KLHL33 kelch-like family member 33 2.87272
MTNR1B melatonin receptor 1B 2.87272
CCDC9B coiled-coil domain containing 9B 2.87272
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.87272
PCDHGA9 protocadherin gamma subfamily A, 9 2.87272
VN1R2 vomeronasal 1 receptor 2 2.87272
FRG2C FSHD region gene 2 family, member C 2.87272
TBC1D3B TBC1 domain family, member 3B 2.87272
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 2.87272
SPATA22 spermatogenesis associated 22 2.87272
FYB1 FYN binding protein 1 2.87272
MYOCOS myocilin opposite strand 2.87272
CIMIP2B ciliary microtubule inner protein 2B 2.87272
FAM240A family with sequence similarity 240 member A 2.87272
H2BW1 H2B.W histone 1 2.87272
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.87272
RNF227 ring finger protein 227 2.87272
CALHM5 calcium homeostasis modulator family member 5 2.87272
CLXN calaxin 2.87272
CBLIF cobalamin binding intrinsic factor 2.87272
SAMD9L sterile alpha motif domain containing 9-like 2.87272
ZNF705G zinc finger protein 705G 2.87272
CREB3L3 cAMP responsive element binding protein 3-like 3 2.87272
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 2.87272
NPNT nephronectin 2.87272
TMCO2 transmembrane and coiled-coil domains 2 2.87272
CALCA calcitonin-related polypeptide alpha 2.87272
LRTM3 leucine rich repeat transmembrane protein 3 2.87272
CCR6 chemokine (C-C motif) receptor 6 2.87272
VIT vitrin 2.87272
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.87272
PGLYRP2 peptidoglycan recognition protein 2 2.87272
GATA3 GATA binding protein 3 2.87272
CLEC6A C-type lectin domain family 6, member A 2.87272
MROH5 maestro heat-like repeat family member 5 2.87272
GPR85 G protein-coupled receptor 85 2.87272
FGFBP2 fibroblast growth factor binding protein 2 2.87272
FMR1NB fragile X mental retardation 1 neighbor 2.87272
PGA5 pepsinogen 5, group I (pepsinogen A) 2.87272
SAA1 serum amyloid A1 2.87272
COXFA4L3 cytochrome c oxidase associated subunit FA4L3 2.87272
A3GALT2 alpha 1,3-galactosyltransferase 2 2.87272
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 2.87272
ZBED6 zinc finger, BED-type containing 6 2.87272
TTC9B tetratricopeptide repeat domain 9B 2.87272
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 2.87272
WNT7A wingless-type MMTV integration site family, member 7A 2.87272
VWA3B von Willebrand factor A domain containing 3B 2.87272
DHH desert hedgehog 2.87272
TEX36 testis expressed 36 2.87272
HRCT1 histidine rich carboxyl terminus 1 2.87272
EIF3I eukaryotic translation initiation factor 3, subunit I 2.87272
AMDHD1 amidohydrolase domain containing 1 2.87272
LRRC15 leucine rich repeat containing 15 2.87272
VCAM1 vascular cell adhesion molecule 1 2.87272
DEFB134 defensin, beta 134 2.87272
NPPA natriuretic peptide A 2.87272
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 2.87272
GAGE10 G antigen 10 2.87272
S100A14 S100 calcium binding protein A14 2.87272
C11ORF91 chromosome 11 open reading frame 91 2.87272
KRT16 keratin 16, type I 2.87272
CTAGE4 CTAGE family, member 4 2.87272
IL21R interleukin 21 receptor 2.87272
ERICH6B glutamate-rich 6B 2.87272
CLEC4D C-type lectin domain family 4, member D 2.87272
PRR15L proline rich 15-like 2.87272
MAEL maelstrom spermatogenic transposon silencer 2.87272
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.87272
PRR35 proline rich 35 2.87272
LMX1B LIM homeobox transcription factor 1, beta 2.87272
CNGB1 cyclic nucleotide gated channel beta 1 2.87272
NR2F2 nuclear receptor subfamily 2, group F, member 2 2.87272
SFTA2 surfactant associated 2 2.87272
ADRA2A adrenoceptor alpha 2A 2.87272
HRG histidine-rich glycoprotein 2.87272
GPR78 G protein-coupled receptor 78 2.87272
STH saitohin 2.87272
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.87272
RNASE9 ribonuclease, RNase A family, 9 (non-active) 2.87272
FGF9 fibroblast growth factor 9 2.87272
GSDMA gasdermin A 2.87272
APOC4 apolipoprotein C-IV 2.87272
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.87272
FGR FGR proto-oncogene, Src family tyrosine kinase 2.87272
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.87272
NTN5 netrin 5 2.87272
GPR61 G protein-coupled receptor 61 2.87272
OR4D2 olfactory receptor, family 4, subfamily D, member 2 2.87272
DND1 DND microRNA-mediated repression inhibitor 1 2.87272
GGN gametogenetin 2.87272
CAPSL calcyphosine-like 2.87272
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.87272
ADCY10 adenylate cyclase 10 (soluble) 2.87272
GBX2 gastrulation brain homeobox 2 2.87272
AOC1 amine oxidase, copper containing 1 2.87272
NKPD1 NTPase, KAP family P-loop domain containing 1 2.87272
SESTD1 SEC14 and spectrin domains 1 2.82483
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.81917
TENT4B terminal nucleotidyltransferase 4B 2.77403
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 2.76416
CAMK1G calcium/calmodulin-dependent protein kinase IG 2.76416
C2ORF80 chromosome 2 open reading frame 80 2.76416
EBPL emopamil binding protein-like 2.69898
LIMK2 LIM domain kinase 2 2.61889
ZSWIM1 zinc finger, SWIM-type containing 1 2.58532
RCL1 RNA terminal phosphate cyclase-like 1 2.57214
TAFA2 TAFA chemokine like family member 2 2.57196
DNAL1 dynein, axonemal, light chain 1 2.48279
MBTPS1 membrane-bound transcription factor peptidase, site 1 2.48279
MCAM melanoma cell adhesion molecule 2.47465
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 2.45351
ADM adrenomedullin 2.40896
FANCM Fanconi anemia, complementation group M 2.40068
PARP12 poly (ADP-ribose) polymerase family, member 12 2.40068
WDR74 WD repeat domain 74 2.37939
WNK4 WNK lysine deficient protein kinase 4 2.37939
ETV3 ets variant 3 2.37619
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 2.36802
OAT ornithine aminotransferase 2.33857
KCTD4 potassium channel tetramerization domain containing 4 2.32325
ACOT12 acyl-CoA thioesterase 12 2.32325
SAXO4 stabilizer of axonemal microtubules 4 2.32325
F11 coagulation factor XI 2.31862
DCAKD dephospho-CoA kinase domain containing 2.31862
BSN bassoon presynaptic cytomatrix protein 2.31862
EFCAB9 EF-hand calcium binding domain 9 2.31862
TJAP1 tight junction associated protein 1 (peripheral) 2.31569
FRMPD2 FERM and PDZ domain containing 2 2.29096
DPPA3 developmental pluripotency associated 3 2.29096
TRPV2 transient receptor potential cation channel, subfamily V, member 2 2.28172
IKZF3 IKAROS family zinc finger 3 (Aiolos) 2.28172
ZMYM3 zinc finger, MYM-type 3 2.26881
UBE2M ubiquitin-conjugating enzyme E2M 2.15682
ACTR1A ARP1 actin-related protein 1 homolog A, centractin alpha (yeast) 2.15682
MRPS6 mitochondrial ribosomal protein S6 2.15682
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1 2.15436
ZNF652 zinc finger protein 652 2.12569
SETD7 SET domain containing (lysine methyltransferase) 7 2.11822
BID BH3 interacting domain death agonist 2.11047
MBNL2 muscleblind-like splicing regulator 2 2.10381
TTBK2 tau tubulin kinase 2 2.10015
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.08821
MTA1 metastasis associated 1 2.08429
XPR1 xenotropic and polytropic retrovirus receptor 1 2.08429
APEH acylaminoacyl-peptide hydrolase 2.06683
KIF25 kinesin family member 25 2.06683
RHBDD1 rhomboid domain containing 1 2.05121
KAT5 K(lysine) acetyltransferase 5 2.05121
TMEM74B transmembrane protein 74B 2.04137
H2AZ1 H2A.Z variant histone 1 2.03647
TLN1 talin 1 2.02549

decreased expression

Symbol Name Standardized Value
IL22RA1 interleukin 22 receptor, alpha 1 -2.87272
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma -2.87272
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.87272
CYSRT1 cysteine-rich tail protein 1 -2.87272
CCDC13 coiled-coil domain containing 13 -2.87272
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) -2.87272
FAM186B family with sequence similarity 186, member B -2.87272
OVOL1 ovo-like zinc finger 1 -2.87272
SPDYE2B speedy/RINGO cell cycle regulator family member E2B -2.87272
JUN jun proto-oncogene -2.87272
PRAM1 PML-RARA regulated adaptor molecule 1 -2.87272
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 -2.87272
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.87272
PRB2 proline-rich protein BstNI subfamily 2 -2.87272
PNMA5 paraneoplastic Ma antigen family member 5 -2.87272
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.87272
CMYA5 cardiomyopathy associated 5 -2.87272
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase -2.87272
SCARA5 scavenger receptor class A, member 5 -2.87272
PTGER3 prostaglandin E receptor 3 (subtype EP3) -2.87272
WDR5B WD repeat domain 5B -2.87272
USH1G Usher syndrome 1G (autosomal recessive) -2.87272
CORO6 coronin 6 -2.87272
RXRB retinoid X receptor, beta -2.87272
FGF8 fibroblast growth factor 8 (androgen-induced) -2.87272
C11ORF96 chromosome 11 open reading frame 96 -2.87272
CXCR5 chemokine (C-X-C motif) receptor 5 -2.87272
PARVG parvin, gamma -2.87272
GPR137 G protein-coupled receptor 137 -2.87272
CLDN34 claudin 34 -2.87272
IMPG2 interphotoreceptor matrix proteoglycan 2 -2.87272
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -2.87272
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -2.87272
SEL1L2 sel-1 suppressor of lin-12-like 2 (C. elegans) -2.87272
INSL6 insulin-like 6 -2.87272
FOXN4 forkhead box N4 -2.87272
GRID2IP glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein -2.87272
LY6K lymphocyte antigen 6 complex, locus K -2.87272
GBX1 gastrulation brain homeobox 1 -2.87272
BMX BMX non-receptor tyrosine kinase -2.87272
VMAC vimentin-type intermediate filament associated coiled-coil protein -2.78385
ZSCAN1 zinc finger and SCAN domain containing 1 -2.77875
RNF130 ring finger protein 130 -2.7733
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 -2.7543
PIN4 peptidylprolyl cis/trans isomerase, NIMA-interacting 4 -2.74057
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -2.74057
ZCCHC17 zinc finger, CCHC domain containing 17 -2.73274
ACAN aggrecan -2.57919
RUBCN rubicon autophagy regulator -2.56455
SPOPL speckle-type POZ protein-like -2.53549
IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog (S. cerevisiae) -2.52949
DACT3 dishevelled-binding antagonist of beta-catenin 3 -2.48279
REEP1 receptor accessory protein 1 -2.48279
SLA2 Src-like-adaptor 2 -2.48279
F10 coagulation factor X -2.48279
CYB561A3 cytochrome b561 family, member A3 -2.4652
METTL23 methyltransferase like 23 -2.41646
CETN3 centrin, EF-hand protein, 3 -2.40068
SLC25A25 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25 -2.40068
TOP6BL TOP6B like initiator of meiotic double strand breaks -2.39916
CD163L1 CD163 molecule-like 1 -2.37939
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 -2.36561
MGST2 microsomal glutathione S-transferase 2 -2.35207
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -2.3265
CASTOR1 cytosolic arginine sensor for mTORC1 subunit 1 -2.31862
SCCPDH saccharopine dehydrogenase (putative) -2.31862
HPSE heparanase -2.30543
NOAZFP nucleolar atypical zinc finger -2.26881
CLASP2 cytoplasmic linker associated protein 2 -2.26881
CAPN15 calpain 15 -2.24545
OSER1 oxidative stress responsive serine-rich 1 -2.22593
MRC2 mannose receptor, C type 2 -2.21131
CYREN cell cycle regulator of NHEJ -2.21036
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -2.20656
TMEM184C transmembrane protein 184C -2.17384
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -2.16079
REP15 RAB15 effector protein -2.15682
GALNT9 polypeptide N-acetylgalactosaminyltransferase 9 -2.15682
HIST1H2BF histone cluster 1, H2bf -2.15682
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) -2.13682
SLC35E4 solute carrier family 35, member E4 -2.13682
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 -2.13682
BOP1 block of proliferation 1 -2.11862
ABHD12B abhydrolase domain containing 12B -2.11862
C12ORF42 chromosome 12 open reading frame 42 -2.10381
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 -2.09263
HAS2 hyaluronan synthase 2 -2.08429
CMC1 C-x(9)-C motif containing 1 -2.06683
SMC1B structural maintenance of chromosomes 1B -2.05342
CFAP46 cilia and flagella associated protein 46 -2.04137
EMC3 ER membrane protein complex subunit 3 -2.03425
SNW1 SNW domain containing 1 -2.02582
CDX4 caudal type homeobox 4 -2.02549
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.02549
PAK5 p21 (RAC1) activated kinase 5 -2.02293
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type -2.00622
TTI2 TELO2 interacting protein 2 -2.00622
GMPS guanine monphosphate synthase -2.00451
CENPH centromere protein H -2.00451