CCND3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cyclin D3|The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activtiy is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The CDK4 activity associated with this cyclin was reported to be necessary for cell cycle progression through G2 phase into mitosis after UV radiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] (NCBI Entrez Gene Database, 896)
External Link http://www.ncbi.nlm.nih.gov/gene/896
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98 interacting proteins for CCND3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKAP8 A kinase (PRKA) anchor protein 8
AMY2A amylase, alpha 2A (pancreatic)
APP amyloid beta (A4) precursor protein
AREG amphiregulin
ATF5 activating transcription factor 5
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
C2CD5 C2 calcium-dependent domain containing 5
CABLES1 Cdk5 and Abl enzyme substrate 1
CABLES2 Cdk5 and Abl enzyme substrate 2
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND1 cyclin D1
CCND2 cyclin D2
CCNH cyclin H
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDK11B cyclin-dependent kinase 11B
CDK14 cyclin-dependent kinase 14
CDK18 cyclin-dependent kinase 18
CDK2 cyclin-dependent kinase 2
CDK3 cyclin-dependent kinase 3
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CDKL3 cyclin-dependent kinase-like 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CRABP2 cellular retinoic acid binding protein 2
DCLK3 doublecortin-like kinase 3
DMBT1 deleted in malignant brain tumors 1
DMTF1 cyclin D binding myb-like transcription factor 1
DTNBP1 dystrobrevin binding protein 1
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EIF3K eukaryotic translation initiation factor 3, subunit K
ETV1 ets variant 1
FAS Fas cell surface death receptor
FBXO7 F-box protein 7
FIBP fibroblast growth factor (acidic) intracellular binding protein
FOXM1 forkhead box M1
GC group-specific component (vitamin D binding protein)
GLUD1 glutamate dehydrogenase 1
GSK3B glycogen synthase kinase 3 beta
HDAC1 histone deacetylase 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
KIAA0195 KIAA0195
MAF1 MAF1 homolog (S. cerevisiae)
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK4 mitogen-activated protein kinase 4
MAPK6 mitogen-activated protein kinase 6
MCM10 minichromosome maintenance complex component 10
MNAT1 MNAT CDK-activating kinase assembly factor 1
MYB v-myb avian myeloblastosis viral oncogene homolog
NCOA2 nuclear receptor coactivator 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NPDC1 neural proliferation, differentiation and control, 1
PCNA proliferating cell nuclear antigen
PIGR polymeric immunoglobulin receptor
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RBX1 ring-box 1, E3 ubiquitin protein ligase
RUNX1 runt-related transcription factor 1
SIL1 SIL1 nucleotide exchange factor
STIP1 stress-induced phosphoprotein 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCP1 t-complex 1
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TRAP1 TNF receptor-associated protein 1
TSC2 tuberous sclerosis 2
UBC ubiquitin C
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
WDR33 WD repeat domain 33