CCNE1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cyclin E1|The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 898)
External Link http://www.ncbi.nlm.nih.gov/gene/898
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162 interacting proteins for CCNE1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AKAP9 A kinase (PRKA) anchor protein 9
AR androgen receptor
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARID4A AT rich interactive domain 4A (RBP1-like)
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
BARD1 BRCA1 associated RING domain 1
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CABLES1 Cdk5 and Abl enzyme substrate 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CCNE2 cyclin E2
CCNH cyclin H
CCNJ cyclin J
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC34 cell division cycle 34
CDC5L cell division cycle 5-like
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CDK13 cyclin-dependent kinase 13
CDK2 cyclin-dependent kinase 2
CDK3 cyclin-dependent kinase 3
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDT1 chromatin licensing and DNA replication factor 1
CETN1 centrin, EF-hand protein, 1
CISH cytokine inducible SH2-containing protein
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
COIL coilin
CREBBP CREB binding protein
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CUL1 cullin 1
CUL3 cullin 3
CUL4A cullin 4A
CUL4B cullin 4B
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EP300 E1A binding protein p300
ESR1 estrogen receptor 1
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FOXM1 forkhead box M1
GMNN geminin, DNA replication inhibitor
GOLGA2 golgin A2
GSK3A glycogen synthase kinase 3 alpha
GSK3B glycogen synthase kinase 3 beta
H1F0 H1 histone family, member 0
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1A histone cluster 1, H1a
HIST1H1B histone cluster 1, H1b
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
MAPK15 mitogen-activated protein kinase 15
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM3 minichromosome maintenance complex component 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MNAT1 MNAT CDK-activating kinase assembly factor 1
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NBN nibrin
NFYB nuclear transcription factor Y, beta
NPAT nuclear protein, ataxia-telangiectasia locus
NRF1 nuclear respiratory factor 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PRC1 protein regulator of cytokinesis 1
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRKCH protein kinase C, eta
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PSMA6 proteasome (prosome, macropain) subunit, alpha type, 6
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3
PSMB4 proteasome (prosome, macropain) subunit, beta type, 4
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PSMB6 proteasome (prosome, macropain) subunit, beta type, 6
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PSMC1 proteasome (prosome, macropain) 26S subunit, ATPase, 1
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RBX1 ring-box 1, E3 ubiquitin protein ligase
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RHOBTB3 Rho-related BTB domain containing 3
RPA3 replication protein A3, 14kDa
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
SF3B1 splicing factor 3b, subunit 1, 155kDa
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
STIP1 stress-induced phosphoprotein 1
TCOF1 Treacher Collins-Franceschetti syndrome 1
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TP53 tumor protein p53
TP73 tumor protein p73
TUBG1 tubulin, gamma 1
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBTF upstream binding transcription factor, RNA polymerase I
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
WEE1 WEE1 G2 checkpoint kinase