CCNT1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cyclin T1|This gene encodes a member of the highly conserved cyclin C subfamily. The encoded protein tightly associates with cyclin-dependent kinase 9, and is a major subunit of positive transcription elongation factor b (p-TEFb). In humans, there are multiple forms of positive transcription elongation factor b, which may include one of several different cyclins along with cyclin-dependent kinase 9. The complex containing the encoded cyclin and cyclin-dependent kinase 9 acts as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and is both necessary and sufficient for full activation of viral transcription. This cyclin and its kinase partner are also involved in triggering transcript elongation through phosphorylation of the carboxy-terminal domain of the largest RNA polymerase II subunit. Overexpression of this gene is implicated in tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013] (NCBI Entrez Gene Database, 904)
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Genes

308 genes differentially expressed following the CCNT1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PRSS41 protease, serine, 41 2.7535
CCDC38 coiled-coil domain containing 38 2.7535
UBA7 ubiquitin-like modifier activating enzyme 7 2.7535
LCN12 lipocalin 12 2.7535
TMEM71 transmembrane protein 71 2.7535
C1ORF141 chromosome 1 open reading frame 141 2.7535
ANGPTL8 angiopoietin like 8 2.7535
VSIR V-set immunoregulatory receptor 2.7535
ZNF181 zinc finger protein 181 2.7535
MYCT1 myc target 1 2.7535
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.7535
CIITA class II, major histocompatibility complex, transactivator 2.7535
ROPN1L rhophilin associated tail protein 1-like 2.7535
PLCH2 phospholipase C, eta 2 2.7535
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.7535
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4 2.7535
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.7535
LRRC52 leucine rich repeat containing 52 2.7535
SOWAHB sosondowah ankyrin repeat domain family member B 2.7535
DEPP1 DEPP autophagy regulator 1 2.7535
TREML1 triggering receptor expressed on myeloid cells-like 1 2.7535
RAB7B RAB7B, member RAS oncogene family 2.7535
MYOZ2 myozenin 2 2.7535
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) 2.7535
DCST1 DC-STAMP domain containing 1 2.7535
ABRA actin binding Rho activating protein 2.7535
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.7535
KRTAP4-1 keratin associated protein 4-1 2.7535
CCDC83 coiled-coil domain containing 83 2.7535
ERAP2 endoplasmic reticulum aminopeptidase 2 2.7535
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 2.7535
CALHM5 calcium homeostasis modulator family member 5 2.7535
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.7535
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.7535
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.7535
RSPH1 radial spoke head 1 homolog (Chlamydomonas) 2.7535
CDK16 cyclin-dependent kinase 16 2.7535
CCN4 cellular communication network factor 4 2.7535
EPB42 erythrocyte membrane protein band 4.2 2.7535
UMOD uromodulin 2.7535
ALX4 ALX homeobox 4 2.7535
PTTG2 pituitary tumor-transforming 2 2.7535
LIPK lipase, family member K 2.7535
RAB44 RAB44, member RAS oncogene family 2.7535
PCDHA2 protocadherin alpha 2 2.7535
PRB2 proline-rich protein BstNI subfamily 2 2.7535
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.7535
GATA2 GATA binding protein 2 2.7535
CBLN3 cerebellin 3 precursor 2.7535
NPIPB9 nuclear pore complex interacting protein family, member B9 2.7535
TEKTL1 tektin like 1 2.7535
MYH13 myosin, heavy chain 13, skeletal muscle 2.7535
TBX3 T-box 3 2.7535
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.7535
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 2.7535
CNTN6 contactin 6 2.7535
RBM44 RNA binding motif protein 44 2.7535
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.7535
SLC22A10 solute carrier family 22, member 10 2.7535
DYNLRB2 dynein, light chain, roadblock-type 2 2.7535
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.7535
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 2.7535
SOX18 SRY (sex determining region Y)-box 18 2.7535
HES7 hes family bHLH transcription factor 7 2.7535
CAPNS2 calpain, small subunit 2 2.7535
C16ORF90 chromosome 16 open reading frame 90 2.7535
DNASE1L2 deoxyribonuclease I-like 2 2.7535
MAGEA8 melanoma antigen family A8 2.7535
CD1C CD1c molecule 2.7535
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.7535
NPPB natriuretic peptide B 2.7535
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.7535
ASB5 ankyrin repeat and SOCS box containing 5 2.7535
ASB15 ankyrin repeat and SOCS box containing 15 2.7535
RDH8 retinol dehydrogenase 8 (all-trans) 2.7535
MIOX myo-inositol oxygenase 2.7535
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.7535
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.7535
ASIC3 acid sensing (proton gated) ion channel 3 2.7535
ANGPTL6 angiopoietin-like 6 2.7535
GOLGA8M golgin A8 family, member M 2.7535
C16ORF78 chromosome 16 open reading frame 78 2.7535
CPA3 carboxypeptidase A3 (mast cell) 2.7535
MRPS12 mitochondrial ribosomal protein S12 2.7535
DRD2 dopamine receptor D2 2.7535
EBF3 early B-cell factor 3 2.7535
CCDC180 coiled-coil domain containing 180 2.7535
ISLR immunoglobulin superfamily containing leucine-rich repeat 2.7535
REELD1 reeler domain containing 1 2.7535
AKNAD1 AKNA domain containing 1 2.7535
C11ORF16 chromosome 11 open reading frame 16 2.7535
ANKRD65 ankyrin repeat domain 65 2.7535
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.7535
CYSLTR1 cysteinyl leukotriene receptor 1 2.7535
RNASE10 ribonuclease, RNase A family, 10 (non-active) 2.7535
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 2.7535
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.7535
SLC6A17 solute carrier family 6 (neutral amino acid transporter), member 17 2.7535
HAVCR1 hepatitis A virus cellular receptor 1 2.7535
THBD thrombomodulin 2.7535
GTF2A1L general transcription factor IIA, 1-like 2.7535
TRIM7 tripartite motif containing 7 2.7535
EFCC1 EF-hand and coiled-coil domain containing 1 2.7535
MYADML2 myeloid-associated differentiation marker-like 2 2.7535
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.7535
CLEC18B C-type lectin domain family 18, member B 2.7535
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.7535
ADRA2A adrenoceptor alpha 2A 2.7535
ZNF831 zinc finger protein 831 2.7535
IBSP integrin-binding sialoprotein 2.7535
ATP10B ATPase, class V, type 10B 2.7535
ZNF596 zinc finger protein 596 2.7535
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 2.7535
HK3 hexokinase 3 (white cell) 2.7535
ZC3H11D zinc finger CCCH-type containing 11D 2.7535
LY96 lymphocyte antigen 96 2.7535
DMRT2 doublesex and mab-3 related transcription factor 2 2.7535
OTOP1 otopetrin 1 2.7535
NT5C1B 5'-nucleotidase, cytosolic IB 2.7535
LOC124903372 uncharacterized LOC124903372 2.7535
ADGRA1 adhesion G protein-coupled receptor A1 2.7535
ANXA1 annexin A1 2.7535
FGF17 fibroblast growth factor 17 2.7535
STPG3 sperm-tail PG-rich repeat containing 3 2.7535
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.7535
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.7535
LHFPL7 LHFPL tetraspan subfamily member 7 2.7535
SPNS3 spinster homolog 3 (Drosophila) 2.7535
LPAR5 lysophosphatidic acid receptor 5 2.7535
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.7535
GLT6D1 glycosyltransferase 6 domain containing 1 2.7535
RTN4RL1 reticulon 4 receptor-like 1 2.7535
ADAM20 ADAM metallopeptidase domain 20 2.7535
CCDC187 coiled-coil domain containing 187 2.7535
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.7535
AMDHD1 amidohydrolase domain containing 1 2.7535
CIROP ciliated left-right organizer metallopeptidase 2.7535
CLCNKB chloride channel, voltage-sensitive Kb 2.7535
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.7535
GARIN1A golgi associated RAB2 interactor 1A 2.7535
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.7535
NPPA natriuretic peptide A 2.7535
ERICH3 glutamate-rich 3 2.7535
SMIM35 small integral membrane protein 35 2.7535
CIMAP1D CIMAP1 family member D 2.7535
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.7535
MYF6 myogenic factor 6 (herculin) 2.7535
MINDY4B MINDY family member 4B 2.7535
NOG noggin 2.7535
NXNL1 nucleoredoxin-like 1 2.7535
H2AC19 H2A clustered histone 19 2.7535
CHRFAM7A CHRNA7 (cholinergic receptor, nicotinic, alpha 7, exons 5-10) and FAM7A (family with sequence similarity 7A, exons A-E) fusion 2.7535
FIGLA folliculogenesis specific basic helix-loop-helix 2.7535
KLHDC10 kelch domain containing 10 2.66676
PET100 PET100 homolog (S. cerevisiae) 2.66676
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit 2.65179
TMIGD2 transmembrane and immunoglobulin domain containing 2 2.65179
FCRL5 Fc receptor-like 5 2.65179
BCCIP BRCA2 and CDKN1A interacting protein 2.61965
TPO thyroid peroxidase 2.59661
DTD1 D-tyrosyl-tRNA deacylase 1 2.3793
HID1 HID1 domain containing 2.3793
METTL25B methyltransferase like 25B 2.36666
GARNL3 GTPase activating Rap/RanGAP domain-like 3 2.35913
ROMO1 reactive oxygen species modulator 1 2.35913
VPS26C VPS26 endosomal protein sorting factor C 2.34136
HS6ST3 heparan sulfate 6-O-sulfotransferase 3 2.32349
STK11 serine/threonine kinase 11 2.32138
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 2.28076
GZMM granzyme M (lymphocyte met-ase 1) 2.27661
FMNL3 formin-like 3 2.26649
IQCE IQ motif containing E 2.25409
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.21708
RBKS ribokinase 2.21548
VGLL4 vestigial-like family member 4 2.21548
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2.19979
FABP7 fatty acid binding protein 7, brain 2.19195
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 2.18208
IL15 interleukin 15 2.18197
CLC Charcot-Leyden crystal galectin 2.17927
ROR2 receptor tyrosine kinase-like orphan receptor 2 2.16331
SEZ6L2 seizure related 6 homolog (mouse)-like 2 2.16316
RB1 retinoblastoma 1 2.16107
NMRK2 nicotinamide riboside kinase 2 2.15964
ARMS2 age-related maculopathy susceptibility 2 2.15675
PLVAP plasmalemma vesicle associated protein 2.15675
PRDM7 PR domain containing 7 2.15675
C19ORF25 chromosome 19 open reading frame 25 2.15197
PYROXD2 pyridine nucleotide-disulphide oxidoreductase domain 2 2.13384
TWNK twinkle mtDNA helicase 2.13101
FBLIM1 filamin binding LIM protein 1 2.09245
CWF19L1 CWF19-like 1, cell cycle control (S. pombe) 2.07751
BCL2L1 BCL2-like 1 2.07492
REX1BD required for excision 1-B domain containing 2.0739
COA6 cytochrome c oxidase assembly factor 6 2.07255
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 2.06909
NCKAP5 NCK-associated protein 5 2.05831
CEP104 centrosomal protein 104kDa 2.05652
TJP3 tight junction protein 3 2.05363
MYB v-myb avian myeloblastosis viral oncogene homolog 2.05282
MRPL2 mitochondrial ribosomal protein L2 2.05139
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6 2.04813
STEAP3 STEAP family member 3, metalloreductase 2.04813
RNF7 ring finger protein 7 2.04779
NSG1 neuron specific gene family member 1 2.04779
RFESD Rieske (Fe-S) domain containing 2.0391
ISOC1 isochorismatase domain containing 1 2.03687
PWWP2B PWWP domain containing 2B 2.03635
LRRC57 leucine rich repeat containing 57 2.03318
CYB5D1 cytochrome b5 domain containing 1 2.03037
SPART spartin 2.02554
SBNO1 strawberry notch homolog 1 (Drosophila) 2.00676

decreased expression

Symbol Name Standardized Value
CRYZL2P-SEC16B CRYZL2P-SEC16B readthrough -2.7535
FAM86B2 family with sequence similarity 86, member B2 -2.7535
ADGB androglobin -2.7535
PLK2 polo-like kinase 2 -2.7535
LGI1 leucine-rich, glioma inactivated 1 -2.7535
ACOT12 acyl-CoA thioesterase 12 -2.7535
AVP arginine vasopressin -2.7535
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -2.7535
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 -2.7535
PRSS22 protease, serine, 22 -2.7535
APCDD1 adenomatosis polyposis coli down-regulated 1 -2.7535
C5ORF47 chromosome 5 open reading frame 47 -2.7535
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor -2.7535
RIMBP2 RIMS binding protein 2 -2.7535
FILIP1L filamin A interacting protein 1-like -2.7535
SPATS1 spermatogenesis associated, serine-rich 1 -2.7535
MYPN myopalladin -2.7535
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 -2.7535
FAM186A family with sequence similarity 186, member A -2.7535
RSPH14 radial spoke head 14 homolog (Chlamydomonas) -2.7535
MSX1 msh homeobox 1 -2.7535
HRH1 histamine receptor H1 -2.7535
CD5 CD5 molecule -2.7535
RENBP renin binding protein -2.7535
SLC26A4 solute carrier family 26 (anion exchanger), member 4 -2.7535
TRIM33 tripartite motif containing 33 -2.7535
ADAM29 ADAM metallopeptidase domain 29 -2.7535
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 -2.7535
WFDC8 WAP four-disulfide core domain 8 -2.7535
ARL2BP ADP-ribosylation factor-like 2 binding protein -2.7535
C11ORF96 chromosome 11 open reading frame 96 -2.7535
SYNPO synaptopodin -2.7535
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 -2.7535
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) -2.7535
ASIP agouti signaling protein -2.7535
IL1A interleukin 1, alpha -2.7535
SLC51B solute carrier family 51, beta subunit -2.7535
LRMDA leucine rich melanocyte differentiation associated -2.72903
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 -2.68523
HIGD1B HIG1 hypoxia inducible domain family, member 1B -2.66676
LINC02798 long intergenic non-protein coding RNA 2798 -2.66676
NBPF9 neuroblastoma breakpoint family, member 9 -2.66676
CCDC163 CCDC163 homolog -2.66676
ZNF714 zinc finger protein 714 -2.63305
IL4R interleukin 4 receptor -2.5933
DRC2 dynein regulatory complex subunit 2 -2.54279
OPTC opticin -2.54279
BDKRB2 bradykinin receptor B2 -2.54279
ANKRD7 ankyrin repeat domain 7 -2.53547
MFN2 mitofusin 2 -2.53404
MEGF9 multiple EGF-like-domains 9 -2.48958
LAMA1 laminin, alpha 1 -2.46757
SF3B4 splicing factor 3b, subunit 4, 49kDa -2.38122
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 -2.3793
RCAN1 regulator of calcineurin 1 -2.35913
SFXN5 sideroflexin 5 -2.33314
TCEAL9 transcription elongation factor A like 9 -2.31764
BAIAP2L1 BAI1-associated protein 2-like 1 -2.31748
ATE1 arginyltransferase 1 -2.31748
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -2.30097
MFF mitochondrial fission factor -2.2807
DPF2 D4, zinc and double PHD fingers family 2 -2.27757
STYXL1 serine/threonine/tyrosine interacting-like 1 -2.26649
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3 -2.22692
LDHB lactate dehydrogenase B -2.20674
PACRG PARK2 co-regulated -2.2026
MYLK4 myosin light chain kinase family, member 4 -2.19979
ACAN aggrecan -2.19979
NUAK2 NUAK family, SNF1-like kinase, 2 -2.18755
DUOX1 dual oxidase 1 -2.18208
PALM2AKAP2 PALM2 and AKAP2 fusion -2.17927
TIPE3 TNF alpha induced protein 8 like 3 -2.17708
MYOCD myocardin -2.17708
C1ORF21 chromosome 1 open reading frame 21 -2.16316
CCDC63 coiled-coil domain containing 63 -2.16267
FGR FGR proto-oncogene, Src family tyrosine kinase -2.16267
PGBD4 piggyBac transposable element derived 4 -2.16108
DCP1B decapping mRNA 1B -2.16107
FXR1 fragile X mental retardation, autosomal homolog 1 -2.15652
KCNIP2 Kv channel interacting protein 2 -2.14104
PHACTR1 phosphatase and actin regulator 1 -2.13212
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.13101
FBXO15 F-box protein 15 -2.13101
MRM2 mitochondrial rRNA methyltransferase 2 -2.1243
HK2 hexokinase 2 -2.08686
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.07441
SEPTIN10 septin 10 -2.07255
TIGD1 tigger transposable element derived 1 -2.05652
MYEF2 myelin expression factor 2 -2.05652
ZNF638 zinc finger protein 638 -2.04813
PLAGL1 pleiomorphic adenoma gene-like 1 -2.03929
LRP11 low density lipoprotein receptor-related protein 11 -2.03116
ERCC6L excision repair cross-complementation group 6-like -2.02692
ADPGK ADP-dependent glucokinase -2.02554
TMEM276 transmembrane protein 276 -2.01335
ELN elastin -2.01144