CCR10 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description chemokine (C-C motif) receptor 10|Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008] (NCBI Entrez Gene Database, 2826)
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Genes

347 genes differentially expressed following the CCR10 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
ETV2 ets variant 2 2.60875
POTEF POTE ankyrin domain family, member F 2.60875
GJA9 gap junction protein, alpha 9, 59kDa 2.60875
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 2.60875
PTGDS prostaglandin D2 synthase 21kDa (brain) 2.60875
FNDC1 fibronectin type III domain containing 1 2.60875
ARHGAP15 Rho GTPase activating protein 15 2.60875
WNT9B wingless-type MMTV integration site family, member 9B 2.60875
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 2.60875
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled 2.60875
KLHL31 kelch-like family member 31 2.60875
AGBL4 ATP/GTP binding protein-like 4 2.60875
TMPRSS11D transmembrane protease, serine 11D 2.60875
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.60875
TRIM73 tripartite motif containing 73 2.60875
GPR20 G protein-coupled receptor 20 2.60875
WLS wntless Wnt ligand secretion mediator 2.60875
TMEM121 transmembrane protein 121 2.60875
WT1 Wilms tumor 1 2.60875
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.60875
PCDHB4 protocadherin beta 4 2.60875
AOC1 amine oxidase, copper containing 1 2.60875
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.60875
CD248 CD248 molecule, endosialin 2.60875
SPATA16 spermatogenesis associated 16 2.60875
CXORF58 chromosome X open reading frame 58 2.60875
PPA2 pyrophosphatase (inorganic) 2 2.60875
ACP4 acid phosphatase 4 2.60875
ADAM11 ADAM metallopeptidase domain 11 2.60875
MEX3D mex-3 RNA binding family member D 2.50731
MAGEA6 melanoma antigen family A6 2.4579
THAP11 THAP domain containing 11 2.4579
OLIG3 oligodendrocyte transcription factor 3 2.4579
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.4579
DEFB131B defensin beta 131B 2.4579
TNNI1 troponin I type 1 (skeletal, slow) 2.4579
BBIP1 BBSome interacting protein 1 2.4579
KLRK1 killer cell lectin-like receptor subfamily K, member 1 2.4579
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.4579
SIX2 SIX homeobox 2 2.4579
SIX1 SIX homeobox 1 2.4579
DUSP29 dual specificity phosphatase 29 2.4579
IL4I1 interleukin 4 induced 1 2.4579
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 2.4579
FGF21 fibroblast growth factor 21 2.4579
NPAP1 nuclear pore associated protein 1 2.4579
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.4579
HGD homogentisate 1,2-dioxygenase 2.4579
HES7 hes family bHLH transcription factor 7 2.4579
H2BW2 H2B.W histone 2 2.4579
DNAAF19 dynein axonemal assembly factor 19 2.4579
SMIM5 small integral membrane protein 5 2.4579
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 2.4579
TTLL8 tubulin tyrosine ligase-like family member 8 2.4579
CLEC5A C-type lectin domain family 5, member A 2.4579
PHYHIPL phytanoyl-CoA 2-hydroxylase interacting protein-like 2.4579
LONRF3 LON peptidase N-terminal domain and ring finger 3 2.4579
S100A5 S100 calcium binding protein A5 2.4579
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 2.4579
LY6S-AS1 LY6S antisense RNA 1 2.4579
FABP12 fatty acid binding protein 12 2.4579
PAX2 paired box 2 2.4579
PAX5 paired box 5 2.4579
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.4579
LRG1 leucine-rich alpha-2-glycoprotein 1 2.4579
OLFM4 olfactomedin 4 2.4579
SFXN3 sideroflexin 3 2.4579
H4C15 H4 clustered histone 15 2.4579
MFAP4 microfibrillar-associated protein 4 2.4579
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.4579
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.4579
LRRN4CL LRRN4 C-terminal like 2.4579
DLK1 delta-like 1 homolog (Drosophila) 2.4579
OPRM1 opioid receptor, mu 1 2.4579
ARMC12 armadillo repeat containing 12 2.4579
PROP1 PROP paired-like homeobox 1 2.4579
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 2.4579
SAA2 serum amyloid A2 2.4579
CLDN23 claudin 23 2.4579
SAPCD1 suppressor APC domain containing 1 2.4579
ZG16B zymogen granule protein 16B 2.4579
GATA3 GATA binding protein 3 2.4579
DUSP2 dual specificity phosphatase 2 2.4579
PAPOLB poly(A) polymerase beta (testis specific) 2.4579
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.4579
DOK2 docking protein 2, 56kDa 2.4579
SQOR sulfide quinone oxidoreductase 2.4579
ALX4 ALX homeobox 4 2.4579
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.4579
AANAT aralkylamine N-acetyltransferase 2.4579
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.4579
CCR3 chemokine (C-C motif) receptor 3 2.4579
PIWIL1 piwi-like RNA-mediated gene silencing 1 2.4579
OLAH oleoyl-ACP hydrolase 2.4579
OR2J1 olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene) 2.4579
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 2.4579
H4C1 H4 clustered histone 1 2.4579
TRIM60 tripartite motif containing 60 2.4579
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.4579
LCMT1 leucine carboxyl methyltransferase 1 2.4579
RS1 retinoschisin 1 2.4579
RGS9BP regulator of G protein signaling 9 binding protein 2.4579
UROC1 urocanate hydratase 1 2.4579
GIPC3 GIPC PDZ domain containing family, member 3 2.4579
FAM186A family with sequence similarity 186, member A 2.4579
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.4579
PRRT4 proline-rich transmembrane protein 4 2.4579
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.4579
RNF113B ring finger protein 113B 2.4579
BHLHA9 basic helix-loop-helix family, member a9 2.4579
TLR7 toll-like receptor 7 2.4579
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.4579
NHLRC4 NHL repeat containing 4 2.4579
KLHL35 kelch-like family member 35 2.4579
GDE1 glycerophosphodiester phosphodiesterase 1 2.4579
DMRTC1 DMRT-like family C1 2.4579
BARHL2 BarH-like homeobox 2 2.4579
DES desmin 2.4579
LRRC32 leucine rich repeat containing 32 2.4579
STAB1 stabilin 1 2.4579
DUSP26 dual specificity phosphatase 26 (putative) 2.4579
FRZB frizzled-related protein 2.4579
PALMD palmdelphin 2.4579
ZSCAN4 zinc finger and SCAN domain containing 4 2.4579
UBQLNL ubiquilin-like 2.4579
C11ORF91 chromosome 11 open reading frame 91 2.4579
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.4579
WDFY4 WDFY family member 4 2.4579
DUOXA1 dual oxidase maturation factor 1 2.4579
SLC51B solute carrier family 51, beta subunit 2.4579
CD8A CD8a molecule 2.4579
TMEM86A transmembrane protein 86A 2.4579
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.4579
AMER2 APC membrane recruitment protein 2 2.4579
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.4579
NUTM2B NUT family member 2B 2.4579
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 2.4579
SUN3 Sad1 and UNC84 domain containing 3 2.4579
CXCR6 chemokine (C-X-C motif) receptor 6 2.4579
GCOM1 GRINL1A complex locus 1 2.4579
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.4579
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 2.4579
NLGN1 neuroligin 1 2.4579
CA5A carbonic anhydrase VA, mitochondrial 2.4579
LHX5 LIM homeobox 5 2.4579
CD27 CD27 molecule 2.4579
MOG myelin oligodendrocyte glycoprotein 2.4579
GPR150 G protein-coupled receptor 150 2.4579
RIN1 Ras and Rab interactor 1 2.4579
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.4579
ARHGAP40 Rho GTPase activating protein 40 2.4579
UTS2R urotensin 2 receptor 2.4579
KLK3 kallikrein-related peptidase 3 2.4579
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1 2.4579
NIPAL4 NIPA-like domain containing 4 2.4579
CPA4 carboxypeptidase A4 2.4579
PCDHGA3 protocadherin gamma subfamily A, 3 2.4579
PCDHGA2 protocadherin gamma subfamily A, 2 2.4579
DSC1 desmocollin 1 2.4579
PCDH12 protocadherin 12 2.4579
KLK11 kallikrein-related peptidase 11 2.4579
KLK12 kallikrein-related peptidase 12 2.4579
EGR2 early growth response 2 2.4579
C10ORF105 chromosome 10 open reading frame 105 2.4579
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.4579
SDSL serine dehydratase-like 2.4579
LVRN laeverin 2.4579
MNX1 motor neuron and pancreas homeobox 1 2.4579
ACAD8 acyl-CoA dehydrogenase family, member 8 2.4579
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.4579
STEAP4 STEAP family member 4 2.4579
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.4579
EMCN endomucin 2.4579
EXOC7 exocyst complex component 7 2.4579
FXYD3 FXYD domain containing ion transport regulator 3 2.4579
NPR3 natriuretic peptide receptor 3 2.4579
SPDEF SAM pointed domain containing ETS transcription factor 2.4579
TPH1 tryptophan hydroxylase 1 2.4579
DEAF1 DEAF1 transcription factor 2.4579
PROM2 prominin 2 2.4579
CCDC83 coiled-coil domain containing 83 2.4579
DCST2 DC-STAMP domain containing 2 2.4579
NRGN neurogranin (protein kinase C substrate, RC3) 2.4579
PRR22 proline rich 22 2.4579
ANXA1 annexin A1 2.4579
ATOH8 atonal homolog 8 (Drosophila) 2.4579
LGALS2 lectin, galactoside-binding, soluble, 2 2.4579
CPLX1 complexin 1 2.4579
GREM1 gremlin 1, DAN family BMP antagonist 2.4579
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.4579
HMG20B high mobility group 20B 2.4579
AHSG alpha-2-HS-glycoprotein 2.4579
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.4579
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 2.4579
SP6 Sp6 transcription factor 2.4579
KRT72 keratin 72, type II 2.4579
GGN gametogenetin 2.4579
CSNK2A2 casein kinase 2, alpha prime polypeptide 2.4579
PADI4 peptidyl arginine deiminase, type IV 2.4579
TM7SF2 transmembrane 7 superfamily member 2 2.42845
CFAP52 cilia and flagella associated protein 52 2.41279
WNK1 WNK lysine deficient protein kinase 1 2.41279
CYB561D1 cytochrome b561 family, member D1 2.41279
NPY neuropeptide Y 2.41279
RPP38 ribonuclease P/MRP 38kDa subunit 2.37989
NTNG2 netrin G2 2.37557
WBP1 WW domain binding protein 1 2.3682
HGH1 HGH1 homolog (S. cerevisiae) 2.3489
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome 2.30187
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.29532
BABAM1 BRISC and BRCA1 A complex member 1 2.29198
ADGRG3 adhesion G protein-coupled receptor G3 2.28936
RPL37A ribosomal protein L37a 2.287
CUEDC2 CUE domain containing 2 2.287
ACVR1B activin A receptor, type IB 2.27032
MYO16 myosin XVI 2.25341
AHSP alpha hemoglobin stabilizing protein 2.23836
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 2.22364
LYPD6 LY6/PLAUR domain containing 6 2.16377
CSKMT citrate synthase lysine methyltransferase 2.15682
ICE2 interactor of little elongation complex ELL subunit 2 2.14878
H2AJ H2A.J histone 2.14404
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 2.14063
RSL24D1 ribosomal L24 domain containing 1 2.10027
C19ORF44 chromosome 19 open reading frame 44 2.08501
ERVMER34-1 endogenous retrovirus group MER34, member 1 2.08285
ZNF283 zinc finger protein 283 2.06119
SEC61B Sec61 beta subunit 2.05531
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.04033
ZNF646 zinc finger protein 646 2.03419
FLAD1 flavin adenine dinucleotide synthetase 1 2.03373
MSANTD7 Myb/SANT DNA binding domain containing 7 2.02626
PDLIM7 PDZ and LIM domain 7 (enigma) 2.00779
SREK1IP1 SREK1-interacting protein 1 2.00139

decreased expression

Symbol Name Standardized Value
RNF25 ring finger protein 25 -2.60875
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 -2.60875
KIRREL2 kin of IRRE like 2 (Drosophila) -2.60875
TLR2 toll-like receptor 2 -2.60875
KCNK10 potassium channel, two pore domain subfamily K, member 10 -2.60875
SLC35F4 solute carrier family 35, member F4 -2.60875
VAMP5 vesicle-associated membrane protein 5 -2.60875
ANKRD7 ankyrin repeat domain 7 -2.60875
KIAA2012 KIAA2012 -2.4579
NRSN1 neurensin 1 -2.4579
SMCO2 single-pass membrane protein with coiled-coil domains 2 -2.4579
ADAM33 ADAM metallopeptidase domain 33 -2.4579
POPDC3 popeye domain containing 3 -2.4579
CAPN11 calpain 11 -2.4579
PCDHA6 protocadherin alpha 6 -2.4579
PTPRQ protein tyrosine phosphatase, receptor type, Q -2.4579
CBR3 carbonyl reductase 3 -2.4579
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 -2.4579
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 -2.4579
TECTA tectorin alpha -2.4579
PDE7B phosphodiesterase 7B -2.4579
SNX4 sorting nexin 4 -2.4579
CIITA class II, major histocompatibility complex, transactivator -2.4579
LRRC56 leucine rich repeat containing 56 -2.4579
TBX15 T-box 15 -2.4579
CTRL chymotrypsin-like -2.4579
CPB2 carboxypeptidase B2 (plasma) -2.4579
AKAP13 A kinase (PRKA) anchor protein 13 -2.4579
NUDCD1 NudC domain containing 1 -2.4579
NMB neuromedin B -2.4579
LURAP1L leucine rich adaptor protein 1-like -2.4579
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 -2.4579
TGM2 transglutaminase 2 -2.4579
CCDC169 coiled-coil domain containing 169 -2.4579
GJD3 gap junction protein, delta 3, 31.9kDa -2.4579
PKNOX1 PBX/knotted 1 homeobox 1 -2.4579
SFRP5 secreted frizzled-related protein 5 -2.4579
TMEM196 transmembrane protein 196 -2.4579
ANO9 anoctamin 9 -2.4579
CALY calcyon neuron-specific vesicular protein -2.4579
STAT4 signal transducer and activator of transcription 4 -2.4579
GPC3 glypican 3 -2.4579
SLC25A34 solute carrier family 25, member 34 -2.4579
FAIM2 Fas apoptotic inhibitory molecule 2 -2.4579
GALNT17 polypeptide N-acetylgalactosaminyltransferase 17 -2.4579
C13ORF42 chromosome 13 open reading frame 42 -2.4579
ADGRB2 adhesion G protein-coupled receptor B2 -2.4579
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) -2.4579
ADM5 adrenomedullin 5 (putative) -2.4579
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) -2.4579
TTBK1 tau tubulin kinase 1 -2.4579
DKK2 dickkopf WNT signaling pathway inhibitor 2 -2.4579
ZNF24 zinc finger protein 24 -2.4579
RAP1A RAP1A, member of RAS oncogene family -2.4579
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.4579
DAPK2 death-associated protein kinase 2 -2.4579
ISOC2 isochorismatase domain containing 2 -2.38438
POU6F2 POU class 6 homeobox 2 -2.35625
DGCR2 DiGeorge syndrome critical region gene 2 -2.3505
POGLUT2 protein O-glucosyltransferase 2 -2.33434
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.32022
EDNRA endothelin receptor type A -2.31233
RAB24 RAB24, member RAS oncogene family -2.28843
SH3BGR SH3 domain binding glutamate-rich protein -2.28843
FAM167B family with sequence similarity 167, member B -2.28843
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) -2.28356
HLA-F major histocompatibility complex, class I, F -2.28356
PHC2 polyhomeotic homolog 2 (Drosophila) -2.27032
ZRANB3 zinc finger, RAN-binding domain containing 3 -2.27032
DGKD diacylglycerol kinase, delta 130kDa -2.27032
TTLL4 tubulin tyrosine ligase-like family member 4 -2.25271
SPTAN1 spectrin, alpha, non-erythrocytic 1 -2.24943
RNF43 ring finger protein 43 -2.24943
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.23836
PRR3 proline rich 3 -2.2348
PARP8 poly (ADP-ribose) polymerase family, member 8 -2.22364
CNTNAP3B contactin associated protein-like 3B -2.22364
PGBD4 piggyBac transposable element derived 4 -2.1975
SPATS2 spermatogenesis associated, serine-rich 2 -2.19409
GLIPR2 GLI pathogenesis-related 2 -2.16835
TMEM8B transmembrane protein 8B -2.16835
OTUD7B OTU deubiquitinase 7B -2.16545
NSFL1C NSFL1 (p97) cofactor (p47) -2.16204
FASTKD2 FAST kinase domains 2 -2.15513
MUC4 mucin 4, cell surface associated -2.15457
ZNF395 zinc finger protein 395 -2.1486
GRIA1 glutamate receptor, ionotropic, AMPA 1 -2.14718
ANXA3 annexin A3 -2.13633
ESRRG estrogen-related receptor gamma -2.10027
EDC4 enhancer of mRNA decapping 4 -2.10027
ZNF296 zinc finger protein 296 -2.08792
GANAB glucosidase, alpha; neutral AB -2.08792
SGK2 serum/glucocorticoid regulated kinase 2 -2.08792
ELP3 elongator acetyltransferase complex subunit 3 -2.06548
GAPVD1 GTPase activating protein and VPS9 domains 1 -2.06119
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -2.05876
DMGDH dimethylglycine dehydrogenase -2.05569
MAP7D3 MAP7 domain containing 3 -2.0556
TNS3 tensin 3 -2.05211
ZBTB45 zinc finger and BTB domain containing 45 -2.04749
PICK1 protein interacting with PRKCA 1 -2.04595
MZF1 myeloid zinc finger 1 -2.0454
KLF11 Kruppel-like factor 11 -2.04385
C4ORF51 chromosome 4 open reading frame 51 -2.04385
AGFG2 ArfGAP with FG repeats 2 -2.04124
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -2.02472
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -2.01602
COG5 component of oligomeric golgi complex 5 -2.01302
AKAP6 A kinase (PRKA) anchor protein 6 -2.01302
CLYBL citrate lyase beta like -2.00848
MBTD1 mbt domain containing 1 -2.00754
ABRACL ABRA C-terminal like -2.00085
SLC60A2 solute carrier family 60 member 2 -2.00085