CCR5 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description chemokine (C-C motif) receptor 5 (gene/pseudogene)|This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1234)
External Link http://www.ncbi.nlm.nih.gov/gene/1234
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Genes

47 interacting proteins for CCR5 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADRBK1 adrenergic, beta, receptor kinase 1
ADRBK2 adrenergic, beta, receptor kinase 2
AFP alpha-fetoprotein
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
CCL11 chemokine (C-C motif) ligand 11
CCL13 chemokine (C-C motif) ligand 13
CCL14 chemokine (C-C motif) ligand 14
CCL16 chemokine (C-C motif) ligand 16
CCL2 chemokine (C-C motif) ligand 2
CCL3 chemokine (C-C motif) ligand 3
CCL3L1 chemokine (C-C motif) ligand 3-like 1
CCL4 chemokine (C-C motif) ligand 4
CCL5 chemokine (C-C motif) ligand 5
CCL7 chemokine (C-C motif) ligand 7
CCL8 chemokine (C-C motif) ligand 8
CCR2 chemokine (C-C motif) receptor 2
CD4 CD4 molecule
CREB3 cAMP responsive element binding protein 3
CST9L cystatin 9-like
CTBP2 C-terminal binding protein 2
CXCR4 chemokine (C-X-C motif) receptor 4
DNM2 dynamin 2
ETV5 ets variant 5
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GRK6 G protein-coupled receptor kinase 6
IL24 interleukin 24
JAK1 Janus kinase 1
JAK2 Janus kinase 2
LCK LCK proto-oncogene, Src family tyrosine kinase
MYH9 myosin, heavy chain 9, non-muscle
ORM1 orosomucoid 1
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PRAF2 PRA1 domain family, member 2
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
TXK TXK tyrosine kinase