CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant) Gene Set

Dataset CORUM Protein Complexes
Category structural or functional annotations
Type protein complex
Description A protein complex that has aspartic-type endopeptidase activity, and contains a catalytic subunit, presenilin (PS), that is a prototypical member of the GxGD-type aspartyl peptidases. The complex also contains additional subunits, including nicastrin, APH-1, PEN-2, and a regulatory subunit, CD147. Gamma-secretase cleaves several transmembrane proteins including the cell surface receptor Notch and the beta-amyloid precursor protein. (Gene Ontology, GO_0070765)
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5 proteins in the CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant) protein complex from the CORUM Protein Complexes dataset.

Symbol Name
APH1A APH1A gamma secretase subunit
BSG basigin (Ok blood group)
NCSTN nicastrin
PSEN1 presenilin 1
PSENEN presenilin enhancer gamma secretase subunit