CD3D Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description CD3d molecule, delta (CD3-TCR complex)|The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009] (NCBI Entrez Gene Database, 915)
External Link http://www.ncbi.nlm.nih.gov/gene/915
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Genes

89 interacting proteins for CD3D from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
AP2M1 adaptor-related protein complex 2, mu 1 subunit
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CANX calnexin
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD247 CD247 molecule
CD274 CD274 molecule
CD28 CD28 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD80 CD80 molecule
CD86 CD86 molecule
CD8A CD8a molecule
CD8B CD8b molecule
CSK c-src tyrosine kinase
CSNK1A1 casein kinase 1, alpha 1
DBNL drebrin-like
DERL1 derlin 1
ERLIN2 ER lipid raft associated 2
FKBP1A FK506 binding protein 1A, 12kDa
FYB FYN binding protein
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNG2 guanine nucleotide binding protein (G protein), gamma 2
GRAP2 GRB2-related adaptor protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2
HLA-DRA major histocompatibility complex, class II, DR alpha
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-DRB3 major histocompatibility complex, class II, DR beta 3
HLA-DRB4 major histocompatibility complex, class II, DR beta 4
HLA-DRB5 major histocompatibility complex, class II, DR beta 5
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
ITK IL2-inducible T-cell kinase
JUN jun proto-oncogene
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NOS3 nitric oxide synthase 3 (endothelial cell)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PDCD1 programmed cell death 1
PDCD1LG2 programmed cell death 1 ligand 2
PDIA2 protein disulfide isomerase family A, member 2
PLCG1 phospholipase C, gamma 1
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PRKCD protein kinase C, delta
PRKCG protein kinase C, gamma
PRKCQ protein kinase C, theta
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RGS1 regulator of G-protein signaling 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SPHK1 sphingosine kinase 1
TRA T cell receptor alpha locus
TRAC T cell receptor alpha constant
TRB T cell receptor beta locus
TRBC1 T cell receptor beta constant 1
TRBV12-3 T cell receptor beta variable 12-3
UBC ubiquitin C
VAV1 vav 1 guanine nucleotide exchange factor
VCP valosin containing protein
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa