CD40 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description CD40 molecule, TNF receptor superfamily member 5|This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 958)
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Genes

348 genes differentially expressed following the CD40 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LAPTM5 lysosomal protein transmembrane 5 3.70579
PDYN prodynorphin 3.70579
GPR151 G protein-coupled receptor 151 3.70579
GJA10 gap junction protein, alpha 10, 62kDa 3.70579
PDE7B phosphodiesterase 7B 3.70579
CSMD3 CUB and Sushi multiple domains 3 3.70579
RSPO1 R-spondin 1 3.70579
MUSK muscle, skeletal, receptor tyrosine kinase 3.70579
TLX2 T-cell leukemia homeobox 2 3.70579
CIITA class II, major histocompatibility complex, transactivator 3.70579
GYPB glycophorin B (MNS blood group) 3.70579
CELA3A chymotrypsin-like elastase family, member 3A 3.70579
CD163 CD163 molecule 3.70579
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 3.70579
DNAJC5B DnaJ (Hsp40) homolog, subfamily C, member 5 beta 3.70579
MAP3K7CL MAP3K7 C-terminal like 3.70579
CDH5 cadherin 5, type 2 (vascular endothelium) 3.70579
KNG1 kininogen 1 3.70579
IGFL2 IGF-like family member 2 3.70579
ANKRD22 ankyrin repeat domain 22 3.70579
CYP2A13 cytochrome P450, family 2, subfamily A, polypeptide 13 3.70579
TMEM176B transmembrane protein 176B 3.70579
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 3.70579
GPR26 G protein-coupled receptor 26 3.70579
HCRTR2 hypocretin (orexin) receptor 2 3.70579
SPACA5 sperm acrosome associated 5 3.70579
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.70579
SPAG6 sperm associated antigen 6 3.70579
LEP leptin 3.70579
CCDC83 coiled-coil domain containing 83 3.70579
IL23R interleukin 23 receptor 3.70579
BTBD16 BTB (POZ) domain containing 16 3.70579
SOST sclerostin 3.70579
OR4E2 olfactory receptor, family 4, subfamily E, member 2 3.70579
PITX3 paired-like homeodomain 3 3.70579
HMX1 H6 family homeobox 1 3.70579
GALR2 galanin receptor 2 3.70579
NRROS negative regulator of reactive oxygen species 3.70579
TPSD1 tryptase delta 1 3.70579
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 3.70579
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.70579
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 3.70579
CD68 CD68 molecule 3.70579
F2 coagulation factor II (thrombin) 3.70579
ADAT3 adenosine deaminase, tRNA-specific 3 3.70579
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 3.70579
TAS2R10 taste receptor, type 2, member 10 3.70579
MNX1 motor neuron and pancreas homeobox 1 3.70579
HLX H2.0-like homeobox 3.70579
DRC5 dynein regulatory complex subunit 5 3.70579
GBP3 guanylate binding protein 3 3.70579
BGN biglycan 3.70579
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 3.70579
LTB4R2 leukotriene B4 receptor 2 3.70579
TCERG1L transcription elongation regulator 1-like 3.70579
ASB11 ankyrin repeat and SOCS box containing 11, E3 ubiquitin protein ligase 3.70579
SMLR1 small leucine-rich protein 1 3.70579
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 3.70579
RTL1 retrotransposon-like 1 3.70579
SPATA25 spermatogenesis associated 25 3.70579
GBP4 guanylate binding protein 4 3.70579
CFAP65 cilia and flagella associated protein 65 3.70579
OR56B2 olfactory receptor family 56 subfamily B member 2 3.70579
IHO1 interactor of HORMAD1 1 3.70579
CLEC20A C-type lectin domain containing 20A 3.70579
NFILZ NFIL3 like basic leucine zipper 3.70579
DNAAF8 dynein axonemal assembly factor 8 3.70579
CBLIF cobalamin binding intrinsic factor 3.70579
TBXT T-box transcription factor T 3.70579
TASL TLR adaptor interacting with endolysosomal SLC15A4 3.70579
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 3.70579
GK3 glycerol kinase 3 3.70579
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 3.70579
NDP Norrie disease (pseudoglioma) 3.70579
TLR8 toll-like receptor 8 3.70579
F8A2 coagulation factor VIII-associated 2 3.70579
AMHR2 anti-Mullerian hormone receptor, type II 3.70579
IL31RA interleukin 31 receptor A 3.70579
WNT11 wingless-type MMTV integration site family, member 11 3.70579
NKX2-5 NK2 homeobox 5 3.70579
TAS2R5 taste receptor, type 2, member 5 3.70579
WEE2 WEE1 homolog 2 (S. pombe) 3.70579
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 3.70579
HNF4A hepatocyte nuclear factor 4, alpha 3.70579
MIP major intrinsic protein of lens fiber 3.70579
ARHGEF33 Rho guanine nucleotide exchange factor (GEF) 33 3.70579
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 3.70579
CCDC42 coiled-coil domain containing 42 3.70579
ASIC4 acid sensing (proton gated) ion channel family member 4 3.70579
GPR83 G protein-coupled receptor 83 3.70579
STARD6 StAR-related lipid transfer (START) domain containing 6 3.70579
PGA4 pepsinogen 4, group I (pepsinogen A) 3.70579
C7 complement component 7 3.70579
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.70579
CCR8 chemokine (C-C motif) receptor 8 3.70579
PRR4 proline rich 4 (lacrimal) 3.70579
CFHR3 complement factor H-related 3 3.70579
RORC RAR-related orphan receptor C 3.70579
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.70579
KLHL6 kelch-like family member 6 3.70579
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 3.70579
GPR150 G protein-coupled receptor 150 3.70579
BTNL3 butyrophilin-like 3 3.70579
ERVV-1 endogenous retrovirus group V, member 1 3.70579
CRYBB3 crystallin, beta B3 3.70579
CYSLTR1 cysteinyl leukotriene receptor 1 3.70579
CERKL ceramide kinase-like 3.70579
CST7 cystatin F (leukocystatin) 3.70579
CLDN34 claudin 34 3.70579
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 3.70579
LMX1B LIM homeobox transcription factor 1, beta 3.70579
WNT10B wingless-type MMTV integration site family, member 10B 3.70579
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.70579
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.70579
BRDT bromodomain, testis-specific 3.70579
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 3.70579
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 3.70579
ADAMDEC1 ADAM-like, decysin 1 3.70579
MAB21L3 mab-21-like 3 (C. elegans) 3.70579
FAIM2 Fas apoptotic inhibitory molecule 2 3.70579
EPHA3 EPH receptor A3 3.70579
MORN5 MORN repeat containing 5 3.70579
SIGLEC11 sialic acid binding Ig-like lectin 11 3.70579
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.70579
PRSS33 protease, serine, 33 3.70579
PRH2 proline-rich protein HaeIII subfamily 2 3.70579
GPR61 G protein-coupled receptor 61 3.70579
CA5A carbonic anhydrase VA, mitochondrial 3.70579
ZC3H12D zinc finger CCCH-type containing 12D 3.70579
C8ORF89 chromosome 8 open reading frame 89 3.70579
HOPX HOP homeobox 3.70579
C2CD4A C2 calcium-dependent domain containing 4A 3.70579
HMGB4 high mobility group box 4 3.70579
IBSP integrin-binding sialoprotein 3.70579
MUC13 mucin 13, cell surface associated 3.70579
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 3.70579
COMP cartilage oligomeric matrix protein 3.70579
DHH desert hedgehog 3.70579
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 3.70579
DAW1 dynein assembly factor with WDR repeat domains 1 3.70579
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 3.70579
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 3.70579
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 3.70579
ITGAD integrin, alpha D 3.70579
OR11G2 olfactory receptor, family 11, subfamily G, member 2 3.70579
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.70579
NAT16 N-acetyltransferase 16 (GCN5-related, putative) 3.70579
ANGPTL3 angiopoietin-like 3 3.70579
TRPM2 transient receptor potential cation channel, subfamily M, member 2 3.70579
SSX3 synovial sarcoma, X breakpoint 3 3.70579
SLC51B solute carrier family 51, beta subunit 3.70579
IFNE interferon, epsilon 3.70579
OR9A4 olfactory receptor, family 9, subfamily A, member 4 3.70579
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.70579
PATE1 prostate and testis expressed 1 3.70579
TMPRSS15 transmembrane protease, serine 15 3.70579
LPAR5 lysophosphatidic acid receptor 5 3.70579
STMND1 stathmin domain containing 1 3.70579
LY6G6C lymphocyte antigen 6 complex, locus G6C 3.70579
TBC1D28 TBC1 domain family, member 28 3.70579
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 3.70579
POU3F3 POU class 3 homeobox 3 3.70579
USP17L2 ubiquitin specific peptidase 17-like family member 2 3.70579
LHB luteinizing hormone beta polypeptide 3.70579
OR52N5 olfactory receptor, family 52, subfamily N, member 5 3.70579
NRGN neurogranin (protein kinase C substrate, RC3) 3.70579
SLC46A1 solute carrier family 46 (folate transporter), member 1 3.66405
OR56A1 olfactory receptor, family 56, subfamily A, member 1 3.66405
KPNA7 karyopherin alpha 7 (importin alpha 8) 3.66405
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase 3.60305
H2AC7 H2A clustered histone 7 3.39691
PM20D2 peptidase M20 domain containing 2 3.3354
RPL36A ribosomal protein L36a 3.18535
RAB10 RAB10, member RAS oncogene family 3.02564
ADAM8 ADAM metallopeptidase domain 8 2.97822
MBNL1 muscleblind-like splicing regulator 1 2.95304
ZNF503 zinc finger protein 503 2.95304
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.9076
TMEM128 transmembrane protein 128 2.87995
WDR47 WD repeat domain 47 2.87403
TBC1D22A TBC1 domain family, member 22A 2.86306
SLC39A14 solute carrier family 39 (zinc transporter), member 14 2.7935
LAMP5 lysosomal-associated membrane protein family, member 5 2.74154
NBPF10 neuroblastoma breakpoint family, member 10 2.74154
MPL MPL proto-oncogene, thrombopoietin receptor 2.74154
KLHL24 kelch-like family member 24 2.70807
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 2.69797
PPP1R35 protein phosphatase 1, regulatory subunit 35 2.68284
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase 2.67285
BET1 Bet1 golgi vesicular membrane trafficking protein 2.57214
KCTD5 potassium channel tetramerization domain containing 5 2.5603
TECTA tectorin alpha 2.544
RPS5 ribosomal protein S5 2.51113
CACFD1 calcium channel flower domain containing 1 2.47162
PPP6R1 protein phosphatase 6, regulatory subunit 1 2.47099
UNC93A unc-93 homolog A (C. elegans) 2.43652
MVP major vault protein 2.42715
MAP2K2 mitogen-activated protein kinase kinase 2 2.42322
EFR3B EFR3 homolog B (S. cerevisiae) 2.4052
CDT1 chromatin licensing and DNA replication factor 1 2.40099
MKRN2 makorin ring finger protein 2 2.38779
FMOD fibromodulin 2.35892
PNMA5 paraneoplastic Ma antigen family member 5 2.35892
PFN4 profilin family, member 4 2.35325
APOOL apolipoprotein O-like 2.31908
FAM156A family with sequence similarity 156, member A 2.28963
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 2.28189
PCDHGB7 protocadherin gamma subfamily B, 7 2.28189
HPCA hippocalcin 2.28189
RPSA ribosomal protein SA 2.27723
COXFA4 cytochrome c oxidase associated subunit FA4 2.24343
IL18BP interleukin 18 binding protein 2.16743
ACTN2 actinin, alpha 2 2.15509
LOC728743 zinc finger protein pseudogene 2.14668
SUGCT succinyl-CoA:glutarate-CoA transferase 2.14668
YTHDC1 YTH domain containing 1 2.14226
NUMB numb homolog (Drosophila) 2.12242
DCXR dicarbonyl/L-xylulose reductase 2.11827
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G 2.1161
HCLS1 hematopoietic cell-specific Lyn substrate 1 2.1091
MARK4 MAP/microtubule affinity-regulating kinase 4 2.10891
ATN1 atrophin 1 2.0857
NT5C3A 5'-nucleotidase, cytosolic IIIA 2.06997
RBM17 RNA binding motif protein 17 2.06643
ARMCX4 armadillo repeat containing, X-linked 4 2.0582
SNIP1 Smad nuclear interacting protein 1 2.05613
MAP3K15 mitogen-activated protein kinase kinase kinase 15 2.0455
BTG3 BTG family, member 3 2.04261
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa 2.03767
HMGA2 high mobility group AT-hook 2 2.03588
LSM1 LSM1, U6 small nuclear RNA associated 2.03228
CEP162 centrosomal protein 162kDa 2.02079
C1QTNF2 C1q and tumor necrosis factor related protein 2 2.01875
ARMC3 armadillo repeat containing 3 2.01139
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha 2.01139
BATF3 basic leucine zipper transcription factor, ATF-like 3 2.01083
DEPDC1 DEP domain containing 1 2.00873

decreased expression

Symbol Name Standardized Value
PDCD1LG2 programmed cell death 1 ligand 2 -3.70579
ERMARD ER membrane-associated RNA degradation -3.70579
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 -3.70579
ADAMTSL4-AS2 ADAMTSL4 antisense RNA 2 -3.6468
PCDHGA11 protocadherin gamma subfamily A, 11 -3.6468
ADAM20 ADAM metallopeptidase domain 20 -3.6468
TRPM1 transient receptor potential cation channel, subfamily M, member 1 -3.6468
PSORS1C1 psoriasis susceptibility 1 candidate 1 -3.6468
GABRD gamma-aminobutyric acid (GABA) A receptor, delta -3.6468
TSNAXIP1 translin-associated factor X interacting protein 1 -3.6468
NIM1K NIM1 serine/threonine protein kinase -3.6468
EFCAB3 EF-hand calcium binding domain 3 -3.6468
LVRN laeverin -3.6468
TSHZ1 teashirt zinc finger homeobox 1 -3.6468
MYO16 myosin XVI -3.6468
CIMAP1B ciliary microtubule associated protein 1B -3.6468
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 -3.6468
SPATA22 spermatogenesis associated 22 -3.6468
PGA5 pepsinogen 5, group I (pepsinogen A) -3.6468
SPMAP2L sperm microtubule associated protein 2 like -3.6468
AMBP alpha-1-microglobulin/bikunin precursor -3.6468
TMEM100 transmembrane protein 100 -3.6468
NPIPA8 nuclear pore complex interacting protein family, member A8 -3.6468
LRRC63 leucine rich repeat containing 63 -3.6468
C11ORF96 chromosome 11 open reading frame 96 -3.6468
SLC45A1 solute carrier family 45, member 1 -3.6468
LYPD5 LY6/PLAUR domain containing 5 -3.6468
TEX19 testis expressed 19 -3.6468
PLCZ1 phospholipase C, zeta 1 -3.6468
PDZRN4 PDZ domain containing ring finger 4 -3.6468
NT5C1B 5'-nucleotidase, cytosolic IB -3.6468
RASA4 RAS p21 protein activator 4 -3.6468
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 -3.6468
ZNF835 zinc finger protein 835 -3.6468
ITGB7 integrin, beta 7 -3.6468
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 -3.6468
RGS8 regulator of G-protein signaling 8 -3.6468
PAN3 PAN3 poly(A) specific ribonuclease subunit -3.56401
ARMC12 armadillo repeat containing 12 -3.55526
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -3.53416
SHROOM1 shroom family member 1 -3.3383
ANKDD1B ankyrin repeat and death domain containing 1B -3.28376
OOEP oocyte expressed protein -3.12958
IFNAR1 interferon (alpha, beta and omega) receptor 1 -3.09273
OSBPL9 oxysterol binding protein-like 9 -3.04664
FEM1C fem-1 homolog c (C. elegans) -3.03579
B9D2 B9 protein domain 2 -3.02935
RDH5 retinol dehydrogenase 5 (11-cis/9-cis) -3.02935
MOSPD3 motile sperm domain containing 3 -2.99098
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.85316
PTRH2 peptidyl-tRNA hydrolase 2 -2.82403
DBNL drebrin-like -2.79786
JMJD6 jumonji domain containing 6 -2.78601
CHODL chondrolectin -2.72567
ZNF101 zinc finger protein 101 -2.70612
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -2.65424
JAM3 junctional adhesion molecule 3 -2.58994
CLC Charcot-Leyden crystal galectin -2.56386
ACSM6 acyl-CoA synthetase medium-chain family member 6 -2.51991
QKI QKI, KH domain containing, RNA binding -2.51113
SERTAD4 SERTA domain containing 4 -2.49788
GIPR gastric inhibitory polypeptide receptor -2.49655
STRIT1 small transmembrane regulator of ion transport 1 -2.49655
VSTM2B V-set and transmembrane domain containing 2B -2.49655
MBLAC1 metallo-beta-lactamase domain containing 1 -2.49655
ZNF843 zinc finger protein 843 -2.49655
NPIPB7 nuclear pore complex interacting protein family, member B7 -2.49655
MCOLN3 mucolipin 3 -2.49655
PRAM1 PML-RARA regulated adaptor molecule 1 -2.49655
APOL2 apolipoprotein L, 2 -2.47863
ZDHHC23 zinc finger, DHHC-type containing 23 -2.4783
PAGR1 PAXIP1 associated glutamate-rich protein 1 -2.47099
PRSS50 protease, serine, 50 -2.46603
PHACTR1 phosphatase and actin regulator 1 -2.44938
MIMS1 mitochondrial inner membrane scaffold 1 -2.41104
STOM stomatin -2.40524
MLF1 myeloid leukemia factor 1 -2.35892
CCNC cyclin C -2.34206
NSD3 nuclear receptor binding SET domain protein 3 -2.32816
LDLRAD2 low density lipoprotein receptor class A domain containing 2 -2.3181
CFAP126 cilia and flagella associated protein 126 -2.3181
CXCL14 chemokine (C-X-C motif) ligand 14 -2.31328
CCDC170 coiled-coil domain containing 170 -2.31328
TLR2 toll-like receptor 2 -2.31328
PRKD2 protein kinase D2 -2.29985
CRACD capping protein inhibiting regulator of actin dynamics -2.27953
TKFC triokinase/FMN cyclase -2.27723
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.27723
CLTCL1 clathrin, heavy chain-like 1 -2.2731
RBBP6 retinoblastoma binding protein 6 -2.24648
MOB3B MOB kinase activator 3B -2.24187
PCDHA12 protocadherin alpha 12 -2.21295
POLM polymerase (DNA directed), mu -2.20627
PANK4 pantothenate kinase 4 -2.15509
SCX scleraxis basic helix-loop-helix transcription factor -2.14668
CNTN5 contactin 5 -2.14668
SOX7 SRY (sex determining region Y)-box 7 -2.14668
ADCY10 adenylate cyclase 10 (soluble) -2.14668
ZNF730 zinc finger protein 730 -2.12658
POU6F1 POU class 6 homeobox 1 -2.12396
C2ORF72 chromosome 2 open reading frame 72 -2.1161
MBD1 methyl-CpG binding domain protein 1 -2.10769
PJA1 praja ring finger 1, E3 ubiquitin protein ligase -2.10471
WDR43 WD repeat domain 43 -2.09675
ZNF318 zinc finger protein 318 -2.09675
CACNG6 calcium channel, voltage-dependent, gamma subunit 6 -2.06573
ICAM4 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) -2.0455
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -2.03588
SEPTIN7 septin 7 -2.03228
FYCO1 FYVE and coiled-coil domain containing 1 -2.03228
CIRSR corepressor of RBPJ and splicing regulator -2.02128