| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | CD40 molecule, TNF receptor superfamily member 5|This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] (NCBI Entrez Gene Database, 958) |
| External Link | https://ncbi.nlm.nih.gov/gene/958 |
| Similar Terms | |
| Downloads & Tools |
499 genes differentially expressed following the CD40 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ADIRF | adipogenesis regulatory factor | 0.0123307 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | 0.0105948 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00912472 |
| TFF3 | trefoil factor 3 (intestinal) | 0.00901168 |
| FABP1 | fatty acid binding protein 1, liver | 0.00899747 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.00865088 |
| IFI44L | interferon-induced protein 44-like | 0.00816645 |
| OLFM4 | olfactomedin 4 | 0.00801147 |
| CXCL12 | chemokine (C-X-C motif) ligand 12 | 0.00798484 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.00775099 |
| S100P | S100 calcium binding protein P | 0.00748524 |
| SNX11 | sorting nexin 11 | 0.00739172 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | 0.00707812 |
| TSPAN8 | tetraspanin 8 | 0.00705735 |
| HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | 0.00687758 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00679673 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00676837 |
| ABCA8 | ATP-binding cassette, sub-family A (ABC1), member 8 | 0.00671227 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.00665064 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.00664796 |
| MT1E | metallothionein 1E | 0.00658621 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00651057 |
| ADAMDEC1 | ADAM-like, decysin 1 | 0.00650706 |
| STEAP1 | six transmembrane epithelial antigen of the prostate 1 | 0.00649254 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.00645958 |
| CXCL13 | chemokine (C-X-C motif) ligand 13 | 0.00643589 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.00638577 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.00632693 |
| ANPEP | alanyl (membrane) aminopeptidase | 0.00630883 |
| SLC26A3 | solute carrier family 26 (anion exchanger), member 3 | 0.00628095 |
| CCL5 | chemokine (C-C motif) ligand 5 | 0.0062156 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.00619019 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.00618298 |
| CD320 | CD320 molecule | 0.00615219 |
| AOC1 | amine oxidase, copper containing 1 | 0.00609126 |
| MDFIC | MyoD family inhibitor domain containing | 0.00604884 |
| GIMAP6 | GTPase, IMAP family member 6 | 0.0060193 |
| TSPAN7 | tetraspanin 7 | 0.00599304 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.00580699 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | 0.00576056 |
| SYBU | syntabulin (syntaxin-interacting) | 0.00575501 |
| GREM1 | gremlin 1, DAN family BMP antagonist | 0.00572493 |
| IGFBP2 | insulin-like growth factor binding protein 2, 36kDa | 0.00568253 |
| PDZD8 | PDZ domain containing 8 | 0.00563721 |
| GPM6B | glycoprotein M6B | 0.0055998 |
| PLN | phospholamban | 0.00559818 |
| WIPF1 | WAS/WASL interacting protein family, member 1 | 0.00559032 |
| FIS1 | fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) | 0.00558208 |
| SLC26A2 | solute carrier family 26 (anion exchanger), member 2 | 0.00555827 |
| MT1G | metallothionein 1G | 0.00551677 |
| IFI44 | interferon-induced protein 44 | 0.00549353 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.00547244 |
| DHRS9 | dehydrogenase/reductase (SDR family) member 9 | 0.00546784 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | 0.0054552 |
| GZMA | granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) | 0.00544931 |
| CCL4 | chemokine (C-C motif) ligand 4 | 0.0054459 |
| ADD3 | adducin 3 (gamma) | 0.00544426 |
| TMEM14A | transmembrane protein 14A | 0.00544397 |
| OGN | osteoglycin | 0.00539259 |
| TRIM22 | tripartite motif containing 22 | 0.0053913 |
| ICAM2 | intercellular adhesion molecule 2 | 0.00538164 |
| ASPN | asporin | 0.00525085 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.00522569 |
| KCNJ2 | potassium channel, inwardly rectifying subfamily J, member 2 | 0.00519612 |
| PTGER4 | prostaglandin E receptor 4 (subtype EP4) | 0.00515234 |
| TMC5 | transmembrane channel-like 5 | 0.00513797 |
| NKG7 | natural killer cell granule protein 7 | 0.00510701 |
| CTBP2 | C-terminal binding protein 2 | 0.00507361 |
| AXL | AXL receptor tyrosine kinase | 0.0050364 |
| GRK5 | G protein-coupled receptor kinase 5 | 0.00503256 |
| MT1H | metallothionein 1H | 0.00503105 |
| HDAC4 | histone deacetylase 4 | 0.00498741 |
| CYP4F3 | cytochrome P450, family 4, subfamily F, polypeptide 3 | 0.00495438 |
| MNDA | myeloid cell nuclear differentiation antigen | 0.00495384 |
| CD8A | CD8a molecule | 0.0049434 |
| HEPH | hephaestin | 0.00491988 |
| JCHAIN | joining chain of multimeric IgA and IgM | 0.00490252 |
| CDCP1 | CUB domain containing protein 1 | 0.00488592 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.00487527 |
| TAC1 | tachykinin, precursor 1 | 0.00483428 |
| RGS4 | regulator of G-protein signaling 4 | 0.00479456 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00478825 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.00477703 |
| PLS3 | plastin 3 | 0.00476524 |
| EVI2A | ecotropic viral integration site 2A | 0.00476451 |
| GZMK | granzyme K (granzyme 3; tryptase II) | 0.00475493 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 0.00475111 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.00474342 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.00473951 |
| GSTA4 | glutathione S-transferase alpha 4 | 0.00472934 |
| STK10 | serine/threonine kinase 10 | 0.00472442 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | 0.00472383 |
| SPARCL1 | SPARC-like 1 (hevin) | 0.00471981 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.00471385 |
| TEK | TEK tyrosine kinase, endothelial | 0.00471067 |
| CDH17 | cadherin 17, LI cadherin (liver-intestine) | 0.00470518 |
| MOXD1 | monooxygenase, DBH-like 1 | 0.00469776 |
| DEFA5 | defensin, alpha 5, Paneth cell-specific | 0.00468699 |
| AKAP7 | A kinase (PRKA) anchor protein 7 | 0.00465485 |
| KRT20 | keratin 20, type I | 0.00464162 |
| WBP1L | WW domain binding protein 1-like | 0.00461352 |
| TP53I3 | tumor protein p53 inducible protein 3 | 0.00460989 |
| PPARG | peroxisome proliferator-activated receptor gamma | 0.00460423 |
| SPRY2 | sprouty homolog 2 (Drosophila) | 0.00458966 |
| PRF1 | perforin 1 (pore forming protein) | 0.00458845 |
| CEACAM7 | carcinoembryonic antigen-related cell adhesion molecule 7 | 0.0045779 |
| PIR | pirin (iron-binding nuclear protein) | 0.00455169 |
| LDB2 | LIM domain binding 2 | 0.0045429 |
| MANSC1 | MANSC domain containing 1 | 0.00453332 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.00452645 |
| MXRA7 | matrix-remodelling associated 7 | 0.00451951 |
| KCNE4 | potassium channel, voltage gated subfamily E regulatory beta subunit 4 | 0.00451529 |
| GCA | grancalcin, EF-hand calcium binding protein | 0.00451111 |
| EDNRB | endothelin receptor type B | 0.00450634 |
| APOBEC3G | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G | 0.00450164 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0045013 |
| CST7 | cystatin F (leukocystatin) | 0.00446979 |
| CLEC7A | C-type lectin domain family 7, member A | 0.00446963 |
| CCL19 | chemokine (C-C motif) ligand 19 | 0.00446919 |
| LPAR6 | lysophosphatidic acid receptor 6 | 0.0044678 |
| GZMB | granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) | 0.00446642 |
| MALL | mal, T-cell differentiation protein-like | 0.00445955 |
| SRGN | serglycin | 0.00445902 |
| XCL1 | chemokine (C motif) ligand 1 | 0.0044385 |
| COQ2 | coenzyme Q2 4-hydroxybenzoate polyprenyltransferase | 0.00443814 |
| RCAN1 | regulator of calcineurin 1 | 0.00440205 |
| LYZ | lysozyme | 0.00439188 |
| HOPX | HOP homeobox | 0.00438401 |
| FRZB | frizzled-related protein | 0.00435784 |
| LYN | LYN proto-oncogene, Src family tyrosine kinase | 0.00435473 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.00434121 |
| SLC4A4 | solute carrier family 4 (sodium bicarbonate cotransporter), member 4 | 0.00432647 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.00431662 |
| COL5A2 | collagen, type V, alpha 2 | 0.00431386 |
| ANKRD46 | ankyrin repeat domain 46 | 0.004299 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.00429357 |
| ADH1C | alcohol dehydrogenase 1C (class I), gamma polypeptide | 0.00429118 |
| PBLD | phenazine biosynthesis-like protein domain containing | 0.0042904 |
| CD302 | CD302 molecule | 0.00427598 |
| ENPP4 | ectonucleotide pyrophosphatase/phosphodiesterase 4 (putative) | 0.00425388 |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | 0.00424622 |
| CALML4 | calmodulin-like 4 | 0.00424495 |
| TGFA | transforming growth factor, alpha | 0.00424405 |
| ANK2 | ankyrin 2, neuronal | 0.00423859 |
| GIPC2 | GIPC PDZ domain containing family, member 2 | 0.00423058 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00422778 |
| FOXG1 | forkhead box G1 | 0.00420707 |
| TMEM47 | transmembrane protein 47 | 0.00417282 |
| PSMB9 | proteasome (prosome, macropain) subunit, beta type, 9 | 0.00416628 |
| ADGRL4 | adhesion G protein-coupled receptor L4 | 0.00416171 |
| CD93 | CD93 molecule | 0.00416112 |
| CLIC5 | chloride intracellular channel 5 | 0.00416081 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.00415985 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | 0.00415756 |
| RRAGA | Ras-related GTP binding A | 0.00415556 |
| KLRB1 | killer cell lectin-like receptor subfamily B, member 1 | 0.00415508 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.00415028 |
| MT1F | metallothionein 1F | 0.00414598 |
| FBN2 | fibrillin 2 | 0.00413429 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | 0.00413407 |
| WBP5 | WW domain binding protein 5 | 0.00413401 |
| PTCH1 | patched 1 | 0.00412495 |
| TXNDC9 | thioredoxin domain containing 9 | 0.00412423 |
| PRKACB | protein kinase, cAMP-dependent, catalytic, beta | 0.00412279 |
| PPAP2A | phosphatidic acid phosphatase type 2A | 0.00412157 |
| ENTPD1 | ectonucleoside triphosphate diphosphohydrolase 1 | 0.00411299 |
| ZG16 | zymogen granule protein 16 | 0.0041125 |
| ZNF423 | zinc finger protein 423 | 0.00409816 |
| CXCL14 | chemokine (C-X-C motif) ligand 14 | 0.00409299 |
| AP1S2 | adaptor-related protein complex 1, sigma 2 subunit | 0.00409176 |
| MGAM | maltase-glucoamylase | 0.00407653 |
| GSTA1 | glutathione S-transferase alpha 1 | 0.00407445 |
| DPYD | dihydropyrimidine dehydrogenase | 0.00404622 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00404559 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | 0.00404001 |
| DNAJB4 | DnaJ (Hsp40) homolog, subfamily B, member 4 | 0.00403831 |
| PLSCR4 | phospholipid scramblase 4 | 0.00403826 |
| PPP1R3C | protein phosphatase 1, regulatory subunit 3C | 0.00403282 |
| TPBG | trophoblast glycoprotein | 0.00403114 |
| SORD | sorbitol dehydrogenase | 0.0040282 |
| SRPX | sushi-repeat containing protein, X-linked | 0.00402643 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0040246 |
| STAT4 | signal transducer and activator of transcription 4 | 0.00401776 |
| COL3A1 | collagen, type III, alpha 1 | 0.00401614 |
| CPA3 | carboxypeptidase A3 (mast cell) | 0.00400289 |
| OLFM1 | olfactomedin 1 | 0.0039964 |
| MSANTD2 | Myb/SANT-like DNA-binding domain containing 2 | 0.00399556 |
| CCL8 | chemokine (C-C motif) ligand 8 | 0.0039919 |
| RAP2A | RAP2A, member of RAS oncogene family | 0.00398499 |
| PENK | proenkephalin | 0.00398353 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.00397983 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | 0.00397688 |
| MS4A1 | membrane-spanning 4-domains, subfamily A, member 1 | 0.00397603 |
| C1ORF115 | chromosome 1 open reading frame 115 | 0.00395611 |
| AGL | amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase | 0.00395197 |
| DIXDC1 | DIX domain containing 1 | 0.00394806 |
| COX7B | cytochrome c oxidase subunit VIIb | 0.00394787 |
| PAK1IP1 | PAK1 interacting protein 1 | 0.00394677 |
| C12ORF29 | chromosome 12 open reading frame 29 | 0.00394159 |
| SI | sucrase-isomaltase (alpha-glucosidase) | 0.00393187 |
| CPB1 | carboxypeptidase B1 (tissue) | 0.00392923 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | 0.00392097 |
| CADPS2 | Ca++-dependent secretion activator 2 | 0.00391865 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | 0.00391852 |
| TSPAN6 | tetraspanin 6 | 0.00391528 |
| CCP110 | centriolar coiled coil protein 110kDa | 0.00390059 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.00389733 |
| TOB1 | transducer of ERBB2, 1 | 0.00388784 |
| SFRP1 | secreted frizzled-related protein 1 | 0.00387987 |
| COL21A1 | collagen, type XXI, alpha 1 | 0.00387886 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.00387268 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00386913 |
| SIGIRR | single immunoglobulin and toll-interleukin 1 receptor (TIR) domain | 0.00386792 |
| EAF2 | ELL associated factor 2 | 0.00386074 |
| ALDH3A1 | aldehyde dehydrogenase 3 family, member A1 | 0.00385017 |
| CLCA1 | chloride channel accessory 1 | 0.00384858 |
| GGH | gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) | 0.00384414 |
| KCNAB1 | potassium channel, voltage gated subfamily A regulatory beta subunit 1 | 0.00384019 |
| ANO3 | anoctamin 3 | 0.00383638 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.00383627 |
| FAS | Fas cell surface death receptor | 0.00382102 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 | 0.00381457 |
| CAV2 | caveolin 2 | 0.00380864 |
| BCL2A1 | BCL2-related protein A1 | 0.00380826 |
| GNAO1 | guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O | 0.00380763 |
| PRR5L | proline rich 5 like | 0.00380726 |
| CLU | clusterin | 0.00379494 |
| S100A4 | S100 calcium binding protein A4 | 0.00377835 |
| SLC15A2 | solute carrier family 15 (oligopeptide transporter), member 2 | 0.00377404 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.00377349 |
| GCNT3 | glucosaminyl (N-acetyl) transferase 3, mucin type | 0.00377333 |
| MERTK | MER proto-oncogene, tyrosine kinase | 0.00376738 |
| TYROBP | TYRO protein tyrosine kinase binding protein | 0.00376074 |
| IFITM2 | interferon induced transmembrane protein 2 | 0.00375689 |
| MYBL1 | v-myb avian myeloblastosis viral oncogene homolog-like 1 | 0.00375192 |
| SAR1B | secretion associated, Ras related GTPase 1B | 0.00375013 |
| ADH1B | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.00375009 |
| SLC16A5 | solute carrier family 16 (monocarboxylate transporter), member 5 | 0.00373458 |
| ZNF395 | zinc finger protein 395 | 0.00373224 |
| IL33 | interleukin 33 | 0.00371833 |
| FGL2 | fibrinogen-like 2 | 0.00371431 |
| ADORA2B | adenosine A2b receptor | 0.00371313 |
| GOLM1 | golgi membrane protein 1 | 0.00370912 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | 0.00370434 |
| HNMT | histamine N-methyltransferase | 0.00370238 |
| NTS | neurotensin | 0.00369945 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | 0.00369745 |
| GNG11 | guanine nucleotide binding protein (G protein), gamma 11 | 0.00369544 |
| BANK1 | B-cell scaffold protein with ankyrin repeats 1 | 0.00369182 |
| FCER1G | Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide | 0.00368511 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA1A | heat shock 70kDa protein 1A | -0.0114415 |
| KRT7 | keratin 7, type II | -0.00868737 |
| MAP7 | microtubule-associated protein 7 | -0.00857154 |
| S100A7 | S100 calcium binding protein A7 | -0.00806707 |
| GRB7 | growth factor receptor-bound protein 7 | -0.00688567 |
| NEAT1 | nuclear paraspeckle assembly transcript 1 (non-protein coding) | -0.00670307 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.00668478 |
| GAL | galanin/GMAP prepropeptide | -0.00638805 |
| MBOAT7 | membrane bound O-acyltransferase domain containing 7 | -0.00635007 |
| KRT8 | keratin 8, type II | -0.0062208 |
| HSPB1 | heat shock 27kDa protein 1 | -0.00620661 |
| KRT14 | keratin 14, type I | -0.00613771 |
| NCOA3 | nuclear receptor coactivator 3 | -0.00609687 |
| NBPF10 | neuroblastoma breakpoint family, member 10 | -0.00608895 |
| CST6 | cystatin E/M | -0.00593927 |
| PDZK1IP1 | PDZK1 interacting protein 1 | -0.00574538 |
| DUSP10 | dual specificity phosphatase 10 | -0.00566693 |
| G6PD | glucose-6-phosphate dehydrogenase | -0.00564076 |
| NVL | nuclear VCP-like | -0.00563013 |
| CA2 | carbonic anhydrase II | -0.00552784 |
| FGG | fibrinogen gamma chain | -0.00536187 |
| KRT19 | keratin 19, type I | -0.00524901 |
| GNAS | GNAS complex locus | -0.00521159 |
| DLK1 | delta-like 1 homolog (Drosophila) | -0.00517027 |
| DNM1L | dynamin 1-like | -0.00506795 |
| ATF3 | activating transcription factor 3 | -0.00505544 |
| YBX3 | Y box binding protein 3 | -0.00492854 |
| CTSH | cathepsin H | -0.00492742 |
| TAGLN2 | transgelin 2 | -0.00492701 |
| TUFT1 | tuftelin 1 | -0.00487959 |
| LPIN1 | lipin 1 | -0.00486551 |
| NRCAM | neuronal cell adhesion molecule | -0.00483922 |
| KLF6 | Kruppel-like factor 6 | -0.00482727 |
| FN1 | fibronectin 1 | -0.004805 |
| ACTB | actin, beta | -0.00479346 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.00477914 |
| UCP2 | uncoupling protein 2 (mitochondrial, proton carrier) | -0.00469445 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.00469272 |
| KRAS | Kirsten rat sarcoma viral oncogene homolog | -0.00466605 |
| MFGE8 | milk fat globule-EGF factor 8 protein | -0.00466135 |
| PEG10 | paternally expressed 10 | -0.004647 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | -0.00461212 |
| TP53BP2 | tumor protein p53 binding protein 2 | -0.00459694 |
| SOX9 | SRY (sex determining region Y)-box 9 | -0.00459223 |
| SPINK2 | serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) | -0.00457569 |
| PROM1 | prominin 1 | -0.0045687 |
| TFRC | transferrin receptor | -0.00455416 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.00449723 |
| RNPS1 | RNA binding protein S1, serine-rich domain | -0.00449364 |
| KRT23 | keratin 23, type I | -0.00448939 |
| ERP29 | endoplasmic reticulum protein 29 | -0.00447303 |
| SEPTIN9 | septin 9 | -0.00439812 |
| ZC3H12A | zinc finger CCCH-type containing 12A | -0.00439269 |
| VPS72 | vacuolar protein sorting 72 homolog (S. cerevisiae) | -0.00437574 |
| FLRT3 | fibronectin leucine rich transmembrane protein 3 | -0.00428028 |
| IGSF3 | immunoglobulin superfamily, member 3 | -0.00427255 |
| PDE4DIP | phosphodiesterase 4D interacting protein | -0.00424412 |
| TPM4 | tropomyosin 4 | -0.0042396 |
| L1CAM | L1 cell adhesion molecule | -0.00422759 |
| KHDRBS3 | KH domain containing, RNA binding, signal transduction associated 3 | -0.00422459 |
| SLPI | secretory leukocyte peptidase inhibitor | -0.00421845 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.00416463 |
| ERBB3 | erb-b2 receptor tyrosine kinase 3 | -0.00415137 |
| CALML5 | calmodulin-like 5 | -0.00414767 |
| INAVA | innate immunity activator | -0.00408659 |
| CEBPB | CCAAT/enhancer binding protein (C/EBP), beta | -0.00406757 |
| PKP1 | plakophilin 1 | -0.00406467 |
| INHBA | inhibin, beta A | -0.00405615 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.00405192 |
| GSPT1 | G1 to S phase transition 1 | -0.00403654 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00402448 |
| SDC4 | syndecan 4 | -0.00398841 |
| GSTM3 | glutathione S-transferase mu 3 (brain) | -0.00395389 |
| U2AF1 | U2 small nuclear RNA auxiliary factor 1 | -0.00394702 |
| SPON2 | spondin 2, extracellular matrix protein | -0.00394323 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.00392439 |
| ARHGEF2 | Rho/Rac guanine nucleotide exchange factor (GEF) 2 | -0.00391616 |
| MAGEA3 | melanoma antigen family A3 | -0.00391597 |
| ZYX | zyxin | -0.00390638 |
| MYH10 | myosin, heavy chain 10, non-muscle | -0.00389647 |
| UBAP2L | ubiquitin associated protein 2-like | -0.00388834 |
| QPRT | quinolinate phosphoribosyltransferase | -0.00388726 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | -0.00386709 |
| RBM47 | RNA binding motif protein 47 | -0.00386009 |
| TMEM132A | transmembrane protein 132A | -0.00383797 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.00382762 |
| PKD1P1 | polycystic kidney disease 1 (autosomal dominant) pseudogene 1 | -0.00380776 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.00380761 |
| BEX4 | brain expressed, X-linked 4 | -0.00380657 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -0.00379611 |
| PERP | PERP, TP53 apoptosis effector | -0.00379441 |
| KRT18 | keratin 18, type I | -0.00379126 |
| NELFCD | negative elongation factor complex member C/D | -0.00375089 |
| GDF15 | growth differentiation factor 15 | -0.00374867 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.00374125 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.003692 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.00368377 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -0.00366231 |
| THBS2 | thrombospondin 2 | -0.00363774 |
| TMOD1 | tropomodulin 1 | -0.00363742 |
| FPGS | folylpolyglutamate synthase | -0.00363539 |
| S100A8 | S100 calcium binding protein A8 | -0.00361822 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.00361112 |
| DNAJC2 | DnaJ (Hsp40) homolog, subfamily C, member 2 | -0.00360412 |
| KLK5 | kallikrein-related peptidase 5 | -0.00360079 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0035921 |
| POLR2D | polymerase (RNA) II (DNA directed) polypeptide D | -0.00358269 |
| LAD1 | ladinin 1 | -0.00358155 |
| PNMT | phenylethanolamine N-methyltransferase | -0.00358025 |
| WDR61 | WD repeat domain 61 | -0.00357622 |
| TRAF3IP2 | TRAF3 interacting protein 2 | -0.00357605 |
| CD1E | CD1e molecule | -0.00357054 |
| TCAF1 | TRPM8 channel-associated factor 1 | -0.00355257 |
| RAB25 | RAB25, member RAS oncogene family | -0.00354846 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.00354238 |
| CLTB | clathrin, light chain B | -0.00354092 |
| EIF5B | eukaryotic translation initiation factor 5B | -0.0035389 |
| COG7 | component of oligomeric golgi complex 7 | -0.00353867 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | -0.00353453 |
| AK2 | adenylate kinase 2 | -0.00352321 |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) | -0.00351544 |
| DEFB1 | defensin, beta 1 | -0.00350261 |
| PAEP | progestagen-associated endometrial protein | -0.00349736 |
| RAD23A | RAD23 homolog A (S. cerevisiae) | -0.00349492 |
| WWC1 | WW and C2 domain containing 1 | -0.00348579 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -0.0034829 |
| CALR | calreticulin | -0.00348062 |
| STX16 | syntaxin 16 | -0.00347448 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | -0.00347047 |
| ACIN1 | apoptotic chromatin condensation inducer 1 | -0.00344826 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -0.00343763 |
| NUP205 | nucleoporin 205kDa | -0.00342617 |
| FUS | FUS RNA binding protein | -0.00342268 |
| PSMD6 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 | -0.00341171 |
| OLFML2A | olfactomedin-like 2A | -0.00340376 |
| SIK1 | salt-inducible kinase 1 | -0.00339019 |
| ORM1 | orosomucoid 1 | -0.00338378 |
| DNAJB2 | DnaJ (Hsp40) homolog, subfamily B, member 2 | -0.00337189 |
| ENAH | enabled homolog (Drosophila) | -0.00337103 |
| TES | testin LIM domain protein | -0.00336942 |
| ACSS3 | acyl-CoA synthetase short-chain family member 3 | -0.00336644 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.00336436 |
| WBP11 | WW domain binding protein 11 | -0.00336432 |
| KPNA6 | karyopherin alpha 6 (importin alpha 7) | -0.00336329 |
| IFNAR1 | interferon (alpha, beta and omega) receptor 1 | -0.00335659 |
| CTSV | cathepsin V | -0.0033544 |
| SCAMP2 | secretory carrier membrane protein 2 | -0.00335175 |
| NEU1 | sialidase 1 (lysosomal sialidase) | -0.00334458 |
| CCNB1IP1 | cyclin B1 interacting protein 1, E3 ubiquitin protein ligase | -0.00334297 |
| SF3B4 | splicing factor 3b, subunit 4, 49kDa | -0.00333294 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | -0.00331578 |
| SCARB2 | scavenger receptor class B, member 2 | -0.00331331 |
| CDH18 | cadherin 18, type 2 | -0.00331078 |
| DDX11 | DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 | -0.00329952 |
| PACSIN2 | protein kinase C and casein kinase substrate in neurons 2 | -0.0032983 |
| CD1B | CD1b molecule | -0.00329759 |
| ARF1 | ADP-ribosylation factor 1 | -0.00329199 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | -0.00328673 |
| MRPL9 | mitochondrial ribosomal protein L9 | -0.00326833 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.00326197 |
| MCL1 | myeloid cell leukemia 1 | -0.00326132 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.00325826 |
| CTTN | cortactin | -0.00323625 |
| NMD3 | NMD3 ribosome export adaptor | -0.00323208 |
| CDC42EP1 | CDC42 effector protein (Rho GTPase binding) 1 | -0.00322929 |
| CTSB | cathepsin B | -0.00322639 |
| FRS2 | fibroblast growth factor receptor substrate 2 | -0.00322566 |
| BUD23 | BUD23 rRNA methyltransferase and ribosome maturation factor | -0.00322246 |
| GNA13 | guanine nucleotide binding protein (G protein), alpha 13 | -0.00321274 |
| E2F2 | E2F transcription factor 2 | -0.00321243 |
| EPHB6 | EPH receptor B6 | -0.00321239 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.00321197 |
| CXCR4 | chemokine (C-X-C motif) receptor 4 | -0.00320768 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | -0.00320269 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | -0.00320111 |
| KRT17 | keratin 17, type I | -0.00319782 |
| LOXL1 | lysyl oxidase-like 1 | -0.00319616 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.00319612 |
| NNAT | neuronatin | -0.00318885 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | -0.00317296 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -0.00316089 |
| FGB | fibrinogen beta chain | -0.00315548 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.00315052 |
| CD82 | CD82 molecule | -0.00314413 |
| DDX27 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 | -0.00314108 |
| APOD | apolipoprotein D | -0.00313943 |
| JUP | junction plakoglobin | -0.00313381 |
| RIT1 | Ras-like without CAAX 1 | -0.00313214 |
| EMC3 | ER membrane protein complex subunit 3 | -0.0031185 |
| RXYLT1 | ribitol xylosyltransferase 1 | -0.00311024 |
| REEP1 | receptor accessory protein 1 | -0.00310652 |
| ANGPT1 | angiopoietin 1 | -0.00310604 |
| ITGB6 | integrin, beta 6 | -0.00309296 |
| BTF3P11 | basic transcription factor 3 pseudogene 11 | -0.00308933 |
| PPL | periplakin | -0.00308599 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | -0.00308552 |
| RFTN1 | raftlin, lipid raft linker 1 | -0.00308508 |
| NISCH | nischarin | -0.00307793 |
| COMMD4 | COMM domain containing 4 | -0.00307676 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | -0.00306679 |
| RGCC | regulator of cell cycle | -0.00306512 |
| NAPA | N-ethylmaleimide-sensitive factor attachment protein, alpha | -0.00305975 |
| RHCG | Rh family, C glycoprotein | -0.00305726 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.00305207 |
| DHDDS | dehydrodolichyl diphosphate synthase | -0.00303516 |
| CA8 | carbonic anhydrase VIII | -0.00302406 |
| SPINT1 | serine peptidase inhibitor, Kunitz type 1 | -0.00302362 |
| LOC105375355 | uroplakin-3b | -0.00302297 |
| EXOSC7 | exosome component 7 | -0.00302197 |
| OXA1L | oxidase (cytochrome c) assembly 1-like | -0.00302174 |
| IGF2R | insulin-like growth factor 2 receptor | -0.00300849 |
| NCSTN | nicastrin | -0.0030082 |
| HSPA6 | heat shock 70kDa protein 6 (HSP70B') | -0.00300441 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.00299889 |
| ZIC1 | Zic family member 1 | -0.00299526 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.00299129 |
| ZNF281 | zinc finger protein 281 | -0.00299026 |
| CGGBP1 | CGG triplet repeat binding protein 1 | -0.00298715 |
| MAP3K1 | mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase | -0.00298608 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.00298382 |
| SLC4A1 | solute carrier family 4 (anion exchanger), member 1 (Diego blood group) | -0.00298271 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.00297787 |
| C10ORF10 | chromosome 10 open reading frame 10 | -0.00297299 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0029668 |
| ZWILCH | zwilch kinetochore protein | -0.00296427 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.00296398 |
| GBP2 | guanylate binding protein 2, interferon-inducible | -0.00296266 |
| LIF | leukemia inhibitory factor | -0.00296079 |
| SLC4A2 | solute carrier family 4 (anion exchanger), member 2 | -0.00295619 |
| DDR2 | discoidin domain receptor tyrosine kinase 2 | -0.00295567 |
| MVP | major vault protein | -0.0029539 |
| CDC25B | cell division cycle 25B | -0.00295138 |
| MYO1B | myosin IB | -0.0029502 |
| BCAP31 | B-cell receptor-associated protein 31 | -0.00294844 |
| ELAVL1 | ELAV like RNA binding protein 1 | -0.00294792 |
| CPEB1 | cytoplasmic polyadenylation element binding protein 1 | -0.00294731 |
| PLXNB2 | plexin B2 | -0.00294671 |
| JUNB | jun B proto-oncogene | -0.00294628 |
| PXDN | peroxidasin | -0.00294091 |
| LYPD3 | LY6/PLAUR domain containing 3 | -0.00294034 |
| YTHDF1 | YTH N(6)-methyladenosine RNA binding protein 1 | -0.00293808 |
| AP5Z1 | adaptor-related protein complex 5, zeta 1 subunit | -0.00293804 |
| GSTZ1 | glutathione S-transferase zeta 1 | -0.00293724 |
| GOLGA2 | golgin A2 | -0.00293651 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.00293519 |
| PER1 | period circadian clock 1 | -0.00292517 |
| AREG | amphiregulin | -0.00291792 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.00291648 |
| ATP6AP1 | ATPase, H+ transporting, lysosomal accessory protein 1 | -0.00291473 |
