CD46 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description CD46 molecule, complement regulatory protein|The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010] (NCBI Entrez Gene Database, 4179)
External Link http://www.ncbi.nlm.nih.gov/gene/4179
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Genes

208 interacting proteins for CD46 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase)
ACTB actin, beta
ACTG1 actin gamma 1
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
AHNAK AHNAK nucleoprotein
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
ANXA11 annexin A11
ANXA2 annexin A2
ANXA6 annexin A6
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
ARF1 ADP-ribosylation factor 1
ARF5 ADP-ribosylation factor 5
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARL2 ADP-ribosylation factor-like 2
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1
AXIN1 axin 1
C11ORF48
C3 complement component 3
C4A complement component 4A (Rodgers blood group)
C4B complement component 4B (Chido blood group)
CAND1 cullin-associated and neddylation-dissociated 1
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCDC53 coiled-coil domain containing 53
CD151 CD151 molecule (Raph blood group)
CD44 CD44 molecule (Indian blood group)
CD81 CD81 molecule
CD82 CD82 molecule
CD9 CD9 molecule
CDC42 cell division cycle 42
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDK1 cyclin-dependent kinase 1
CFL1 cofilin 1 (non-muscle)
CHMP2A charged multivesicular body protein 2A
CHMP4B charged multivesicular body protein 4B
CLDN3 claudin 3
CLTC clathrin, heavy chain (Hc)
CNN2 calponin 2
COMMD5 COMM domain containing 5
COPB1 coatomer protein complex, subunit beta 1
COPZ1 coatomer protein complex, subunit zeta 1
CPNE1 copine I
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSK c-src tyrosine kinase
CYFIP1 cytoplasmic FMR1 interacting protein 1
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DLG4 discs, large homolog 4 (Drosophila)
DNM1L dynamin 1-like
DNM2 dynamin 2
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EHD1 EH-domain containing 1
EHD4 EH-domain containing 4
EML4 echinoderm microtubule associated protein like 4
ENO1 enolase 1, (alpha)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EZR ezrin
FAM21C family with sequence similarity 21, member C
FEN1 flap structure-specific endonuclease 1
FLNA filamin A, alpha
FLNB filamin B, beta
FLNC filamin C, gamma
FNTA farnesyltransferase, CAAX box, alpha
FUK fucokinase
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae)
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GPA33 glycoprotein A33 (transmembrane)
GSK3B glycogen synthase kinase 3 beta
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HNF4A hepatocyte nuclear factor 4, alpha
IFIT5 interferon-induced protein with tetratricopeptide repeats 5
IFRD1 interferon-related developmental regulator 1
IPO5 importin 5
IPO7 importin 7
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA6 integrin, alpha 6
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB4 integrin, beta 4
JAG1 jagged 1
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KIAA1033 KIAA1033
KIF5B kinesin family member 5B
KLC1 kinesin light chain 1
KPNB1 karyopherin (importin) beta 1
LASP1 LIM and SH3 protein 1
LDHA lactate dehydrogenase A
LDHB lactate dehydrogenase B
LGALS4 lectin, galactoside-binding, soluble, 4
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LRRC57 leucine rich repeat containing 57
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAGED2 melanoma antigen family D2
MAP4 microtubule-associated protein 4
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MARCKSL1 MARCKS-like 1
MSN moesin
MX1 MX dynamin-like GTPase 1
MYH14 myosin, heavy chain 14, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
MYO1D myosin ID
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NACA nascent polypeptide-associated complex alpha subunit
NCAPG non-SMC condensin I complex, subunit G
PCNA proliferating cell nuclear antigen
PDCD10 programmed cell death 10
PHGDH phosphoglycerate dehydrogenase
PKM pyruvate kinase, muscle
PLAA phospholipase A2-activating protein
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEC plectin
PLXNB2 plexin B2
PPL periplakin
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PPP5C protein phosphatase 5, catalytic subunit
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRRC1 proline-rich coiled-coil 1
PTGFRN prostaglandin F2 receptor inhibitor
RAB11A RAB11A, member RAS oncogene family
RAB15 RAB15, member RAS oncogene family
RAB1A RAB1A, member RAS oncogene family
RAB21 RAB21, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAB8A RAB8A, member RAS oncogene family
RABL6 RAB, member RAS oncogene family-like 6
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RALB v-ral simian leukemia viral oncogene homolog B
RAN RAN, member RAS oncogene family
RANGAP1 Ran GTPase activating protein 1
RCC2 regulator of chromosome condensation 2
RDX radixin
RHOC ras homolog family member C
RHOG ras homolog family member G
RPRD1B regulation of nuclear pre-mRNA domain containing 1B
SAMHD1 SAM domain and HD domain 1
SARNP SAP domain containing ribonucleoprotein
SART3 squamous cell carcinoma antigen recognized by T cells 3
SEC31A SEC31 homolog A (S. cerevisiae)
SELENBP1 selenium binding protein 1
SEPT11 septin 11
SEPT2 septin 2
SEPT7 septin 7
SEPT9 septin 9
SET SET nuclear proto-oncogene
SETD3 SET domain containing 3
SH3GL2 SH3-domain GRB2-like 2
SLK STE20-like kinase
SNX1 sorting nexin 1
SNX2 sorting nexin 2
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
SRP54 signal recognition particle 54kDa
SRP68 signal recognition particle 68kDa
SRP72 signal recognition particle 72kDa
SSRP1 structure specific recognition protein 1
STIP1 stress-induced phosphoprotein 1
STK39 serine threonine kinase 39
STX3 syntaxin 3
TFRC transferrin receptor
TKFC triokinase/FMN cyclase
TLN1 talin 1
TNPO1 transportin 1
TPD52 tumor protein D52
TPM3 tropomyosin 3
TRAPPC3 trafficking protein particle complex 3
TRIM28 tripartite motif containing 28
TSPAN4 tetraspanin 4
UBC ubiquitin C
UBE2O ubiquitin-conjugating enzyme E2O
UBQLN1 ubiquilin 1
UBQLN2 ubiquilin 2
UBXN1 UBX domain protein 1
USO1 USO1 vesicle transport factor
VPS4B vacuolar protein sorting 4 homolog B (S. cerevisiae)
VSNL1 visinin-like 1
WNK1 WNK lysine deficient protein kinase 1
XPO1 exportin 1
XPO4 exportin 4
XPO5 exportin 5
XPO7 exportin 7
XPOT exportin, tRNA
YES1 YES proto-oncogene 1, Src family tyrosine kinase
ZWILCH zwilch kinetochore protein