CD59 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description CD59 molecule, complement regulatory protein|This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 966)
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Genes

336 genes differentially expressed following the CD59 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
PTPRQ protein tyrosine phosphatase, receptor type, Q 2.94
GP1BA glycoprotein Ib (platelet), alpha polypeptide 2.94
HTR6 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled 2.94
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 2.94
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.94
NPIPB7 nuclear pore complex interacting protein family, member B7 2.94
NBPF8 neuroblastoma breakpoint family, member 8 2.94
CPSF4L cleavage and polyadenylation specific factor 4-like 2.94
C7ORF57 chromosome 7 open reading frame 57 2.94
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 2.94
ARR3 arrestin 3, retinal (X-arrestin) 2.94
ALOX15B arachidonate 15-lipoxygenase, type B 2.94
REC114 REC114 meiotic recombination protein 2.94
HES7 hes family bHLH transcription factor 7 2.94
GFAP glial fibrillary acidic protein 2.94
NIM1K NIM1 serine/threonine protein kinase 2.94
TRPV3 transient receptor potential cation channel, subfamily V, member 3 2.94
TSPAN19 tetraspanin 19 2.94
ETV7 ets variant 7 2.94
MOG myelin oligodendrocyte glycoprotein 2.94
SMIM36 small integral membrane protein 36 2.94
EFCC1 EF-hand and coiled-coil domain containing 1 2.94
TYW1 tRNA-yW synthesizing protein 1 homolog (S. cerevisiae) 2.92753
SLC9C2 solute carrier family 9, member C2 (putative) 2.88499
HLX H2.0-like homeobox 2.88499
GCKR glucokinase (hexokinase 4) regulator 2.88499
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.88499
TMPRSS11F transmembrane protease, serine 11F 2.88499
WDR38 WD repeat domain 38 2.88499
GDA guanine deaminase 2.88499
INIP INTS3 and NABP interacting protein 2.88499
DTHD1 death domain containing 1 2.88499
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 2.88499
NSMCE1 non-SMC element 1 homolog (S. cerevisiae) 2.88499
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.88499
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.88499
GPR26 G protein-coupled receptor 26 2.88499
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.88499
PAX8 paired box 8 2.88499
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.88499
FFAR4 free fatty acid receptor 4 2.88499
GJB4 gap junction protein, beta 4, 30.3kDa 2.88499
XCL1 chemokine (C motif) ligand 1 2.88499
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 2.88499
SCGB3A1 secretoglobin, family 3A, member 1 2.88499
TMEM176B transmembrane protein 176B 2.88499
NANOS2 nanos homolog 2 (Drosophila) 2.88499
DUXB double homeobox B 2.88499
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.88499
UCN urocortin 2.88499
ARID3C AT rich interactive domain 3C (BRIGHT-like) 2.88499
LRRD1 leucine-rich repeats and death domain containing 1 2.88499
ASB10 ankyrin repeat and SOCS box containing 10 2.88499
LY86 lymphocyte antigen 86 2.88499
LRRC72 leucine rich repeat containing 72 2.88499
MAGEB3 melanoma antigen family B3 2.88499
SMIM31 small integral membrane protein 31 2.88499
VGLL2 vestigial-like family member 2 2.88499
RSU1 Ras suppressor protein 1 2.88499
MLN motilin 2.88499
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.88499
TBC1D3L TBC1 domain family, member 3L 2.88499
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 2.88499
LOC124901449 uncharacterized LOC124901449 2.88499
LMNTD1 lamin tail domain containing 1 2.88499
CLDN16 claudin 16 2.88499
AVPR1A arginine vasopressin receptor 1A 2.88499
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 2.88499
SERTM2 serine rich and transmembrane domain containing 2 2.88499
LHFPL7 LHFPL tetraspan subfamily member 7 2.88499
H2AC1 H2A clustered histone 1 2.88499
TEX46 testis expressed 46 2.88499
ODAPH odontogenesis associated phosphoprotein 2.88499
CCN6 cellular communication network factor 6 2.88499
CPHXL2 cytoplasmic polyadenylated homeobox like 2 2.88499
H2BC1 H2B clustered histone 1 2.88499
TMPRSS6 transmembrane protease, serine 6 2.88499
ADRB1 adrenoceptor beta 1 2.88499
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.88499
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.88499
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.88499
RNF113B ring finger protein 113B 2.88499
TEX53 testis expressed 53 2.88499
ULBP1 UL16 binding protein 1 2.88499
CD79A CD79a molecule, immunoglobulin-associated alpha 2.88499
MAL mal, T-cell differentiation protein 2.88499
PRR18 proline rich 18 2.88499
EXOC3L1 exocyst complex component 3-like 1 2.88499
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 2.88499
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.88499
GPR37L1 G protein-coupled receptor 37 like 1 2.88499
GCSAM germinal center-associated, signaling and motility 2.88499
DYNLRB2 dynein, light chain, roadblock-type 2 2.88499
CLEC6A C-type lectin domain family 6, member A 2.88499
MSGN1 mesogenin 1 2.88499
SOAT2 sterol O-acyltransferase 2 2.88499
OR10AG1 olfactory receptor, family 10, subfamily AG, member 1 2.88499
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.88499
VNN1 vanin 1 2.88499
TNR tenascin R 2.88499
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.88499
KLHL1 kelch-like family member 1 2.88499
FAM163A family with sequence similarity 163, member A 2.88499
KLHL41 kelch-like family member 41 2.88499
TBC1D10C TBC1 domain family, member 10C 2.88499
TDRD10 tudor domain containing 10 2.88499
PKDREJ polycystin (PKD) family receptor for egg jelly 2.88499
POF1B premature ovarian failure, 1B 2.88499
TCEA3 transcription elongation factor A (SII), 3 2.88499
DNAJB13 DnaJ (Hsp40) homolog, subfamily B, member 13 2.88499
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.88499
HSF4 heat shock transcription factor 4 2.88499
TBPL2 TATA box binding protein like 2 2.88499
PHOSPHO1 phosphatase, orphan 1 2.88499
DYTN dystrotelin 2.88499
NGB neuroglobin 2.88499
VAX2 ventral anterior homeobox 2 2.88499
AMH anti-Mullerian hormone 2.88499
CPA3 carboxypeptidase A3 (mast cell) 2.88499
CPA2 carboxypeptidase A2 (pancreatic) 2.88499
PTPN20 protein tyrosine phosphatase, non-receptor type 20 2.88499
TF transferrin 2.88499
ZC3H12D zinc finger CCCH-type containing 12D 2.88499
GSTA4 glutathione S-transferase alpha 4 2.88499
TMPPE transmembrane protein with metallophosphoesterase domain 2.88499
GCGR glucagon receptor 2.88499
CCNI2 cyclin I family, member 2 2.88499
OTP orthopedia homeobox 2.88499
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.88499
ZC3H11D zinc finger CCCH-type containing 11D 2.88499
SIRPG signal-regulatory protein gamma 2.88499
PSKH2 protein serine kinase H2 2.88499
POU2AF1 POU class 2 associating factor 1 2.88499
TM2D3 TM2 domain containing 3 2.88499
MUC15 mucin 15, cell surface associated 2.88499
C17ORF99 chromosome 17 open reading frame 99 2.88499
ANKRD20A1 ankyrin repeat domain 20 family, member A1 2.88499
KLK15 kallikrein-related peptidase 15 2.88499
TEX12 testis expressed 12 2.88499
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 2.88499
SLC7A4 solute carrier family 7, member 4 2.88499
BTBD16 BTB (POZ) domain containing 16 2.88499
TMEM156 transmembrane protein 156 2.88499
F2 coagulation factor II (thrombin) 2.88499
BOLA2 bolA family member 2 2.88499
CCNO cyclin O 2.88499
NPIPA3 nuclear pore complex interacting protein family, member A3 2.88499
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.88499
CPLX1 complexin 1 2.88499
GUCA2A guanylate cyclase activator 2A (guanylin) 2.88499
ALLC allantoicase 2.88499
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.88499
PASD1 PAS domain containing 1 2.88499
MNX1 motor neuron and pancreas homeobox 1 2.88499
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.88499
CRX cone-rod homeobox 2.88499
C5ORF46 chromosome 5 open reading frame 46 2.88499
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.88499
GRAPL GRB2-related adaptor protein-like 2.88499
RNF222 ring finger protein 222 2.88499
CELA1 chymotrypsin-like elastase family, member 1 2.88499
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.88499
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 2.88499
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.85718
FOXP2 forkhead box P2 2.84623
TNS1-AS1 TNS1 antisense RNA 1 2.84623
ZBTB16 zinc finger and BTB domain containing 16 2.84623
RIC8A RIC8 guanine nucleotide exchange factor A 2.7831
BRD7 bromodomain containing 7 2.74464
NLRP12 NLR family, pyrin domain containing 12 2.74302
CFAP96 cilia and flagella associated protein 96 2.72682
GFPT1 glutamine--fructose-6-phosphate transaminase 1 2.68937
LYG2 lysozyme G-like 2 2.67482
TTC17 tetratricopeptide repeat domain 17 2.62879
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 2.62879
NCOR1 nuclear receptor corepressor 1 2.60867
DMGDH dimethylglycine dehydrogenase 2.57908
CCPG1 cell cycle progression 1 2.54835
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 2.52472
SOBP sine oculis binding protein homolog (Drosophila) 2.49863
FAM161B family with sequence similarity 161, member B 2.487
ELAVL3 ELAV like neuron-specific RNA binding protein 3 2.47312
GIPR gastric inhibitory polypeptide receptor 2.47312
PRMT2 protein arginine methyltransferase 2 2.44067
FLYWCH1 FLYWCH-type zinc finger 1 2.4291
CCDC171 coiled-coil domain containing 171 2.41159
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) 2.38503
PKLR pyruvate kinase, liver and RBC 2.38503
MXD3 MAX dimerization protein 3 2.37994
ZRANB2 zinc finger, RAN-binding domain containing 2 2.37827
PRRX1 paired related homeobox 1 2.37827
SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 2.37128
SPDYE18 speedy/RINGO cell cycle regulator family member E18 2.35589
CHTF18 CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae) 2.35589
KIZ kizuna centrosomal protein 2.35589
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.34862
COL5A2 collagen, type V, alpha 2 2.30318
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4 2.13523
MGMT O-6-methylguanine-DNA methyltransferase 2.12419
KIAA1671 KIAA1671 2.12017
WASHC1 WASH complex subunit 1 2.11876
DYNC2LI1 dynein, cytoplasmic 2, light intermediate chain 1 2.1132
NXT2 nuclear transport factor 2-like export factor 2 2.06054
ABT1 activator of basal transcription 1 2.04483
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.04483
CYB5A cytochrome b5 type A (microsomal) 2.02971
KLHL12 kelch-like family member 12 2.02773
RCL1 RNA terminal phosphate cyclase-like 1 2.02773
MLH3 mutL homolog 3 2.01179
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 2.01094
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 2.01094
RND2 Rho family GTPase 2 2.01

decreased expression

Symbol Name Standardized Value
SH3RF3 SH3 domain containing ring finger 3 -2.94
RELL1 RELT-like 1 -2.94
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa -2.94
MYO3B myosin IIIB -2.94
RAI2 retinoic acid induced 2 -2.91693
CSMD3 CUB and Sushi multiple domains 3 -2.91693
MST1 macrophage stimulating 1 -2.91693
CLEC4A C-type lectin domain family 4, member A -2.91693
OR2B6 olfactory receptor, family 2, subfamily B, member 6 -2.91693
DOK3 docking protein 3 -2.88499
WIZ widely interspaced zinc finger motifs -2.88499
FIGNL1 fidgetin-like 1 -2.88499
TRAF1 TNF receptor-associated factor 1 -2.88499
IL18 interleukin 18 -2.88499
ARHGEF37 Rho guanine nucleotide exchange factor (GEF) 37 -2.88499
BTN1A1 butyrophilin, subfamily 1, member A1 -2.84623
REEP1 receptor accessory protein 1 -2.84623
NUTM2G NUT family member 2G -2.84623
PLGLB1 plasminogen-like B1 -2.84623
ZNF492 zinc finger protein 492 -2.84623
PARP3 poly (ADP-ribose) polymerase family, member 3 -2.84623
TMEM45B transmembrane protein 45B -2.84623
TMPRSS13 transmembrane protease, serine 13 -2.84623
LRRIQ4 leucine-rich repeats and IQ motif containing 4 -2.84623
LRRC10B leucine rich repeat containing 10B -2.84623
ARSI arylsulfatase family, member I -2.84623
SERF1A small EDRK-rich factor 1A (telomeric) -2.84623
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 -2.84623
PRDM6 PR domain containing 6 -2.84623
IRX4 iroquois homeobox 4 -2.84623
EPHX4 epoxide hydrolase 4 -2.84623
SHISA3 shisa family member 3 -2.84623
ANXA1 annexin A1 -2.84623
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) -2.84623
ISM2 isthmin 2 -2.84623
ACTL8 actin-like 8 -2.84623
LRRC73 leucine rich repeat containing 73 -2.84623
VSIG10 V-set and immunoglobulin domain containing 10 -2.84623
SMIM17 small integral membrane protein 17 -2.84623
CNTN3 contactin 3 (plasmacytoma associated) -2.84623
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -2.84623
DMRT1 doublesex and mab-3 related transcription factor 1 -2.84623
FLRT3 fibronectin leucine rich transmembrane protein 3 -2.84623
ARHGAP40 Rho GTPase activating protein 40 -2.84623
CNR2 cannabinoid receptor 2 (macrophage) -2.84623
TTC22 tetratricopeptide repeat domain 22 -2.84623
TTC29 tetratricopeptide repeat domain 29 -2.84623
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.84623
ADPRH ADP-ribosylarginine hydrolase -2.84623
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C -2.84623
FAM209A family with sequence similarity 209, member A -2.84623
LRRC32 leucine rich repeat containing 32 -2.84623
TTBK1 tau tubulin kinase 1 -2.84623
NPIPB9 nuclear pore complex interacting protein family, member B9 -2.84623
RGS11 regulator of G-protein signaling 11 -2.84623
OR56A3 olfactory receptor, family 56, subfamily A, member 3 -2.84623
LCT lactase -2.84623
OVOL3 ovo-like zinc finger 3 -2.84623
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 -2.84623
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 -2.84623
POLB polymerase (DNA directed), beta -2.84486
PXDNL peroxidasin-like -2.84258
JUP junction plakoglobin -2.83995
PLEKHA3 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 3 -2.79516
OLFM3 olfactomedin 3 -2.77127
SOAT1 sterol O-acyltransferase 1 -2.71997
LENG9 leukocyte receptor cluster (LRC) member 9 -2.71997
NR1D1 nuclear receptor subfamily 1, group D, member 1 -2.71997
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.71997
ASPG asparaginase -2.71997
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.68937
NEK9 NIMA-related kinase 9 -2.63066
CKMT1B creatine kinase, mitochondrial 1B -2.62879
TBCA tubulin folding cofactor A -2.60867
KCND1 potassium channel, voltage gated Shal related subfamily D, member 1 -2.60867
PRAM1 PML-RARA regulated adaptor molecule 1 -2.60867
TMEM154 transmembrane protein 154 -2.5846
ZKSCAN3 zinc finger with KRAB and SCAN domains 3 -2.57908
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.55005
H4C11 H4 clustered histone 11 -2.55005
CFAP161 cilia and flagella associated protein 161 -2.54475
WNK1 WNK lysine deficient protein kinase 1 -2.52004
TMEM190 transmembrane protein 190 -2.47312
CRELD1 cysteine-rich with EGF-like domains 1 -2.45484
LGALS3 lectin, galactoside-binding, soluble, 3 -2.45251
ZNF646 zinc finger protein 646 -2.45251
CFAP91 cilia and flagella associated protein 91 -2.45251
INHBE inhibin, beta E -2.444
BOLA3 bolA family member 3 -2.37827
GORAB golgin, RAB6-interacting -2.34862
EIF4H eukaryotic translation initiation factor 4H -2.29349
CD1D CD1d molecule -2.28136
BMP8A bone morphogenetic protein 8a -2.28136
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 -2.28136
MRPS12 mitochondrial ribosomal protein S12 -2.26603
ZBTB38 zinc finger and BTB domain containing 38 -2.22625
SLCO1B1 solute carrier organic anion transporter family, member 1B1 -2.19601
PPP2R5B protein phosphatase 2, regulatory subunit B', beta -2.19258
SLC35B1 solute carrier family 35, member B1 -2.18135
MAP7 microtubule-associated protein 7 -2.18135
KIAA1191 KIAA1191 -2.1738
CDK10 cyclin-dependent kinase 10 -2.15292
CD300A CD300a molecule -2.15207
ATL3 atlastin GTPase 3 -2.15168
NEURL1B neuralized E3 ubiquitin protein ligase 1B -2.15121
ZNHIT1 zinc finger, HIT-type containing 1 -2.11876
IL17RA interleukin 17 receptor A -2.1132
RGL3 ral guanine nucleotide dissociation stimulator-like 3 -2.1132
HNRNPL heterogeneous nuclear ribonucleoprotein L -2.10686
MED18 mediator complex subunit 18 -2.08698
ADCY2 adenylate cyclase 2 (brain) -2.08247
ZNF277 zinc finger protein 277 -2.07573
MAGED1 melanoma antigen family D1 -2.07568
NKTR natural killer cell triggering receptor -2.06577
SHLD2 shieldin complex subunit 2 -2.06341
TAC1 tachykinin, precursor 1 -2.06341
ABHD4 abhydrolase domain containing 4 -2.05305
EMX1 empty spiracles homeobox 1 -2.04877
TMEM179B transmembrane protein 179B -2.04823
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.04558
CBR1 carbonyl reductase 1 -2.04483
MEF2B myocyte enhancer factor 2B -2.04483
SGSM3 small G protein signaling modulator 3 -2.02171
XRN2 5'-3' exoribonuclease 2 -2.01752