CD59 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description CD59 molecule, complement regulatory protein|This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 966)
External Link http://www.ncbi.nlm.nih.gov/gene/966
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387 interacting proteins for CD59 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ABLIM1 actin binding LIM protein 1
ABLIM3 actin binding LIM protein family, member 3
ACTC1 actin, alpha, cardiac muscle 1
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ACTN4 actinin, alpha 4
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADGRL4 adhesion G protein-coupled receptor L4
ALDOC aldolase C, fructose-bisphosphate
ANXA2 annexin A2
ANXA6 annexin A6
AP1B1 adaptor-related protein complex 1, beta 1 subunit
AP2A1 adaptor-related protein complex 2, alpha 1 subunit
AP2B1 adaptor-related protein complex 2, beta 1 subunit
AP2M1 adaptor-related protein complex 2, mu 1 subunit
AP2S1 adaptor-related protein complex 2, sigma 1 subunit
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ATAD3A ATPase family, AAA domain containing 3A
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2A3 ATPase, Ca++ transporting, ubiquitous
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BASP1 brain abundant, membrane attached signal protein 1
BCLAF1 BCL2-associated transcription factor 1
BSG basigin (Ok blood group)
C8A complement component 8, alpha polypeptide
C9 complement component 9
CA4 carbonic anhydrase IV
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAPZB capping protein (actin filament) muscle Z-line, beta
CAV1 caveolin 1, caveolae protein, 22kDa
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBR1 carbonyl reductase 1
CCM2L cerebral cavernous malformation 2-like
CD109 CD109 molecule
CD2 CD2 molecule
CD276 CD276 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD44 CD44 molecule (Indian blood group)
CD47 CD47 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD63 CD63 molecule
CD8A CD8a molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CEP170 centrosomal protein 170kDa
CFL1 cofilin 1 (non-muscle)
CFL2 cofilin 2 (muscle)
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
CLDND1 claudin domain containing 1
CLINT1 clathrin interactor 1
CLTA clathrin, light chain A
CLTC clathrin, heavy chain (Hc)
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CNTN1 contactin 1
CORO1B coronin, actin binding protein, 1B
CORO1C coronin, actin binding protein, 1C
COX5A cytochrome c oxidase subunit Va
COX5B cytochrome c oxidase subunit Vb
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1
COX6B1 cytochrome c oxidase subunit VIb polypeptide 1 (ubiquitous)
COX6C cytochrome c oxidase subunit VIc
CPM carboxypeptidase M
CSPG4 chondroitin sulfate proteoglycan 4
CTTN cortactin
CYC1 cytochrome c-1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAPK3 death-associated protein kinase 3
DBN1 drebrin 1
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DIRAS2 DIRAS family, GTP-binding RAS-like 2
DLD dihydrolipoamide dehydrogenase
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DPYSL2 dihydropyrimidinase-like 2
DSG2 desmoglein 2
DST dystonin
DUT deoxyuridine triphosphatase
DYNLL1 dynein, light chain, LC8-type 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1G eukaryotic translation elongation factor 1 gamma
EEF2 eukaryotic translation elongation factor 2
EGFR epidermal growth factor receptor
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4A3 eukaryotic translation initiation factor 4A3
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
ENG endoglin
EPB41L3 erythrocyte membrane protein band 4.1-like 3
EPCAM epithelial cell adhesion molecule
EPPK1 epiplakin 1
EPS8 epidermal growth factor receptor pathway substrate 8
FAP fibroblast activation protein, alpha
FBN2 fibrillin 2
FLII flightless I homolog (Drosophila)
FLNA filamin A, alpha
FLNB filamin B, beta
FLOT2 flotillin 2
FOLR1 folate receptor 1 (adult)
FSCN1 fascin actin-bundling protein 1
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GFAP glial fibrillary acidic protein
GLMP glycosylated lysosomal membrane protein
GMFB glia maturation factor, beta
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GPM6A glycoprotein M6A
GRB2 growth factor receptor-bound protein 2
GRWD1 glutamate-rich WD repeat containing 1
GSN gelsolin
GSTM1 glutathione S-transferase mu 1
GSTM3 glutathione S-transferase mu 3 (brain)
GSTP1 glutathione S-transferase pi 1
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HCLS1 hematopoietic cell-specific Lyn substrate 1
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H2BH histone cluster 1, H2bh
HIST1H3B histone cluster 1, H3b
HIST1H4F histone cluster 1, H4f
HIST2H2AA4 histone cluster 2, H2aa4
HLA-A major histocompatibility complex, class I, A
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1L heat shock 70kDa protein 1-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HTRA1 HtrA serine peptidase 1
HTT huntingtin
ICAM2 intercellular adhesion molecule 2
IL13RA2 interleukin 13 receptor, alpha 2
IL1RAPL1 interleukin 1 receptor accessory protein-like 1
ILF3 interleukin enhancer binding factor 3, 90kDa
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IPO7 importin 7
IQGAP1 IQ motif containing GTPase activating protein 1
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
JCHAIN joining chain of multimeric IgA and IgM
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT7 keratin 7, type II
KRT8 keratin 8, type II
L1CAM L1 cell adhesion molecule
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS4 lectin, galactoside-binding, soluble, 4
LIMA1 LIM domain and actin binding 1
LMNA lamin A/C
LMO7 LIM domain 7
LNPEP leucyl/cystinyl aminopeptidase
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2
LUC7L2 LUC7-like 2 (S. cerevisiae)
LUZP1 leucine zipper protein 1
MATR3 matrin 3
MPRIP myosin phosphatase Rho interacting protein
MPZL1 myelin protein zero-like 1
MPZL2 myelin protein zero-like 2
MS4A5 membrane-spanning 4-domains, subfamily A, member 5
MUC13 mucin 13, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MYH10 myosin, heavy chain 10, non-muscle
MYH14 myosin, heavy chain 14, non-muscle
MYH9 myosin, heavy chain 9, non-muscle
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
MYO1A myosin IA
MYO1B myosin IB
MYO1C myosin IC
MYO3B myosin IIIB
MYO6 myosin VI
NCR1 natural cytotoxicity triggering receptor 1
NCR3 natural cytotoxicity triggering receptor 3
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase)
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
NEGR1 neuronal growth regulator 1
NEXN nexilin (F actin binding protein)
NONO non-POU domain containing, octamer-binding
NPC1 Niemann-Pick disease, type C1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPTN neuroplastin
NRF1 nuclear respiratory factor 1
NTM neurotrimin
NUCLEOLIN nucleolin multifunctional protein
OBFC1 oligonucleotide/oligosaccharide-binding fold containing 1
OPCML opioid binding protein/cell adhesion molecule-like
P4HB prolyl 4-hydroxylase, beta polypeptide
PABPC1 poly(A) binding protein, cytoplasmic 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAWR PRKC, apoptosis, WT1, regulator
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDCD6 programmed cell death 6
PDIA6 protein disulfide isomerase family A, member 6
PDLIM7 PDZ and LIM domain 7 (enigma)
PHGDH phosphoglycerate dehydrogenase
PKM pyruvate kinase, muscle
PLD2 phospholipase D2
PLEC plectin
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLP1 proteolipid protein 1
PLS3 plastin 3
PLXNB2 plexin B2
PPAP2C phosphatidic acid phosphatase type 2C
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRDX1 peroxiredoxin 1
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PRMT5 protein arginine methyltransferase 5
PRNP prion protein
PROCR protein C receptor, endothelial
PTBP1 polypyrimidine tract binding protein 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRJ protein tyrosine phosphatase, receptor type, J
RAB10 RAB10, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RACGAP1 Rac GTPase activating protein 1
RAI14 retinoic acid induced 14
RBBP7 retinoblastoma binding protein 7
RCC2 regulator of chromosome condensation 2
REPS1 RALBP1 associated Eps domain containing 1
RPL10 ribosomal protein L10
RPL12 ribosomal protein L12
RPL18 ribosomal protein L18
RPL18A ribosomal protein L18a
RPL21 ribosomal protein L21
RPL23 ribosomal protein L23
RPL23A ribosomal protein L23a
RPL24 ribosomal protein L24
RPL26 ribosomal protein L26
RPL27 ribosomal protein L27
RPL27A ribosomal protein L27a
RPL3 ribosomal protein L3
RPL30 ribosomal protein L30
RPL31 ribosomal protein L31
RPL35A ribosomal protein L35a
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RPL7 ribosomal protein L7
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RPS13 ribosomal protein S13
RPS14 ribosomal protein S14
RPS15A ribosomal protein S15a
RPS16 ribosomal protein S16
RPS18 ribosomal protein S18
RPS20 ribosomal protein S20
RPS23 ribosomal protein S23
RPS25 ribosomal protein S25
RPS26 ribosomal protein S26
RPS28 ribosomal protein S28
RPS3 ribosomal protein S3
RPS3A ribosomal protein S3A
RPS5 ribosomal protein S5
RPS8 ribosomal protein S8
RPS9 ribosomal protein S9
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
S100A6 S100 calcium binding protein A6
SAFB2 scaffold attachment factor B2
SCARB2 scavenger receptor class B, member 2
SCIN scinderin
SEPT7 septin 7
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGRL2 SH3 domain binding glutamate-rich protein like 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SIRPA signal-regulatory protein alpha
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC15A4 solute carrier family 15 (oligopeptide transporter), member 4
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC43A3 solute carrier family 43, member 3
SLC46A1 solute carrier family 46 (folate transporter), member 1
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC9A7 solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
SLCO3A1 solute carrier organic anion transporter family, member 3A1
SMAD4 SMAD family member 4
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
SMU1 smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans)
SNAP25 synaptosomal-associated protein, 25kDa
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SNX9 sorting nexin 9
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOS1 son of sevenless homolog 1 (Drosophila)
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like
SPPL2A signal peptide peptidase like 2A
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTBN1 spectrin, beta, non-erythrocytic 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein)
SRP9 signal recognition particle 9kDa
SRSF10 serine/arginine-rich splicing factor 10
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STX1A syntaxin 1A (brain)
STX1B syntaxin 1B
STXBP1 syntaxin binding protein 1
SVIL supervillin
SYNPO synaptopodin
SYP synaptophysin
SYPL1 synaptophysin-like 1
SYT2 synaptotagmin II
TAOK2 TAO kinase 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFRC transferrin receptor
THRAP3 thyroid hormone receptor associated protein 3
THY1 Thy-1 cell surface antigen
TIAF1 TGFB1-induced anti-apoptotic factor 1
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM181 transmembrane protein 181
TMEM206 transmembrane protein 206
TMEM87A transmembrane protein 87A
TMOD3 tropomodulin 3 (ubiquitous)
TPM1 tropomyosin 1 (alpha)
TPM2 tropomyosin 2 (beta)
TPM3 tropomyosin 3
TPP1 tripeptidyl peptidase I
TSPAN3 tetraspanin 3
TUBA1B tubulin, alpha 1b
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
TUFM Tu translation elongation factor, mitochondrial
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats
UBB ubiquitin B
UBC ubiquitin C
UGDH UDP-glucose 6-dehydrogenase
UQCRC1 ubiquinol-cytochrome c reductase core protein I
UQCRC2 ubiquinol-cytochrome c reductase core protein II
UQCRH ubiquinol-cytochrome c reductase hinge protein
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VDAC3 voltage-dependent anion channel 3
VTN vitronectin
WDR1 WD repeat domain 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma