CD81 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description CD81 molecule|The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014] (NCBI Entrez Gene Database, 975)
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Genes

352 genes differentially expressed following the CD81 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TPPP tubulin polymerization promoting protein 3.29255
ANXA1 annexin A1 3.29255
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.29255
ZC3H12D zinc finger CCCH-type containing 12D 3.29255
PTGDR2 prostaglandin D2 receptor 2 3.29255
PTGER3 prostaglandin E receptor 3 (subtype EP3) 3.29255
TTLL2 tubulin tyrosine ligase-like family member 2 3.29255
DAO D-amino-acid oxidase 3.29255
ZSCAN4 zinc finger and SCAN domain containing 4 3.29255
CLCNKB chloride channel, voltage-sensitive Kb 3.29255
OVOL3 ovo-like zinc finger 3 3.29255
ADAMTSL2 ADAMTS-like 2 3.29255
MKRN3 makorin ring finger protein 3 3.29255
FLI1 Fli-1 proto-oncogene, ETS transcription factor 3.29255
PAGE4 P antigen family, member 4 (prostate associated) 3.29255
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.29255
MAMDC4 MAM domain containing 4 3.29255
CARMIL3 capping protein regulator and myosin 1 linker 3 3.29255
H2BK1 H2B.K variant histone 1 3.29255
GPR150 G protein-coupled receptor 150 3.29255
NLRP7 NLR family, pyrin domain containing 7 3.29255
GLYATL1B glycine-N-acyltransferase like 1B 3.29255
INHBC inhibin, beta C 3.29255
C8ORF90 chromosome 8 open reading frame 90 3.29255
NLRP14 NLR family, pyrin domain containing 14 3.29255
PERM1 PPARGC1 and ESRR induced regulator, muscle 1 3.2023
AZGP1 alpha-2-glycoprotein 1, zinc-binding 3.2023
OR2B6 olfactory receptor, family 2, subfamily B, member 6 3.2023
PGBDF plakoglobin binding and degradation factor 3.2023
FAM90A26 family with sequence similarity 90, member A26, pseudogene 3.2023
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 3.2023
PKP1 plakophilin 1 3.2023
CD2 CD2 molecule 3.2023
LRRD1 leucine-rich repeats and death domain containing 1 3.2023
OR5K1 olfactory receptor, family 5, subfamily K, member 1 3.2023
GDF10 growth differentiation factor 10 3.2023
PCDHB6 protocadherin beta 6 3.2023
PRODH2 proline dehydrogenase (oxidase) 2 3.2023
PAX8 paired box 8 3.2023
OLFM4 olfactomedin 4 3.2023
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 3.2023
NRGN neurogranin (protein kinase C substrate, RC3) 3.2023
OIT3 oncoprotein induced transcript 3 3.2023
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 3.2023
TMEM132C transmembrane protein 132C 3.2023
KIAA1755 KIAA1755 3.2023
RNASE9 ribonuclease, RNase A family, 9 (non-active) 3.2023
PCDHGA12 protocadherin gamma subfamily A, 12 3.2023
OR2B11 olfactory receptor, family 2, subfamily B, member 11 3.2023
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.2023
MRC1 mannose receptor, C type 1 3.2023
TRPV5 transient receptor potential cation channel, subfamily V, member 5 3.2023
RAPSN receptor-associated protein of the synapse 3.2023
TPSD1 tryptase delta 1 3.2023
MYO16 myosin XVI 3.2023
NLRP10 NLR family, pyrin domain containing 10 3.2023
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 3.2023
EDDM3A epididymal protein 3A 3.2023
CPB1 carboxypeptidase B1 (tissue) 3.2023
TPH1 tryptophan hydroxylase 1 3.2023
SMIM39 small integral membrane protein 39 3.2023
PHF24 PHD finger protein 24 3.2023
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 3.2023
GNGT2 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2 3.2023
ERVW-1 endogenous retrovirus group W, member 1 3.2023
PTH1R parathyroid hormone 1 receptor 3.2023
GPX6 glutathione peroxidase 6 3.2023
TRPC7 transient receptor potential cation channel, subfamily C, member 7 3.2023
ZNF705B zinc finger protein 705B 3.2023
LTF lactotransferrin 3.2023
ANGPTL8 angiopoietin like 8 3.2023
CCN3 cellular communication network factor 3 3.2023
EXOC1L exocyst complex component 1 like 3.2023
PRRT1B proline rich transmembrane protein 1B 3.2023
MDFIC2 MyoD family inhibitor domain containing 2 3.2023
SMIM45 small integral membrane protein 45 3.2023
GNG5B G protein subunit gamma 5B 3.2023
CCDC197 coiled-coil domain containing 197 3.2023
MEIOSIN meiosis initiator 3.2023
GSTT4 glutathione S-transferase theta 4 3.2023
H2BC3 H2B clustered histone 3 3.2023
ASZ1 ankyrin repeat, SAM and basic leucine zipper domain containing 1 3.2023
BEST3 bestrophin 3 3.2023
CHRD chordin 3.2023
PANX3 pannexin 3 3.2023
CFAP99 cilia and flagella associated protein 99 3.2023
PTPRH protein tyrosine phosphatase, receptor type, H 3.2023
GGT6 gamma-glutamyltransferase 6 3.2023
EEF2 eukaryotic translation elongation factor 2 3.2023
ACTRT1 actin-related protein T1 3.2023
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.2023
TAS2R5 taste receptor, type 2, member 5 3.2023
CATSPERH catsper channel auxiliary subunit eta 3.2023
ANXA13 annexin A13 3.2023
LRRC70 leucine rich repeat containing 70 3.2023
PGA5 pepsinogen 5, group I (pepsinogen A) 3.2023
CELA2A chymotrypsin-like elastase family, member 2A 3.2023
C1QTNF9 C1q and tumor necrosis factor related protein 9 3.2023
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.2023
KLRF1 killer cell lectin-like receptor subfamily F, member 1 3.2023
SLC45A2 solute carrier family 45, member 2 3.2023
BHLHA9 basic helix-loop-helix family, member a9 3.2023
TLR9 toll-like receptor 9 3.2023
TMEM212 transmembrane protein 212 3.2023
CYBB cytochrome b-245, beta polypeptide 3.2023
AQP9 aquaporin 9 3.2023
CPSF4L cleavage and polyadenylation specific factor 4-like 3.2023
KLHL41 kelch-like family member 41 3.2023
IL21R interleukin 21 receptor 3.2023
SLC7A9 solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 3.2023
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.2023
WFDC6 WAP four-disulfide core domain 6 3.2023
CPA2 carboxypeptidase A2 (pancreatic) 3.2023
C11ORF91 chromosome 11 open reading frame 91 3.2023
WFDC9 WAP four-disulfide core domain 9 3.2023
TIGIT T cell immunoreceptor with Ig and ITIM domains 3.2023
APOD apolipoprotein D 3.2023
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.2023
FNDC9 fibronectin type III domain containing 9 3.2023
FNDC8 fibronectin type III domain containing 8 3.2023
LRRC46 leucine rich repeat containing 46 3.2023
HAMP hepcidin antimicrobial peptide 3.2023
KCNA6 potassium channel, voltage gated shaker related subfamily A, member 6 3.2023
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.2023
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2 3.2023
CCDC182 coiled-coil domain containing 182 3.2023
NOBOX NOBOX oogenesis homeobox 3.2023
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 3.2023
RGS8 regulator of G-protein signaling 8 3.2023
MYLK2 myosin light chain kinase 2 3.2023
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 3.2023
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 3.2023
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 3.2023
GOLGA8R golgin A8 family, member R 3.2023
DMRT1 doublesex and mab-3 related transcription factor 1 3.2023
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 3.2023
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 3.2023
ISLR immunoglobulin superfamily containing leucine-rich repeat 3.2023
ISL1 ISL LIM homeobox 1 3.2023
SAMD7 sterile alpha motif domain containing 7 3.2023
PRR35 proline rich 35 3.2023
BSPH1 binder of sperm protein homolog 1 3.2023
AMN amnion associated transmembrane protein 3.2023
NT5DC4 5'-nucleotidase domain containing 4 3.2023
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5 3.2023
EPX eosinophil peroxidase 3.2023
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 3.2023
MMEL1 membrane metallo-endopeptidase-like 1 3.2023
TMPRSS15 transmembrane protease, serine 15 3.2023
PLA2G1B phospholipase A2, group IB (pancreas) 3.2023
IL17F interleukin 17F 3.2023
FOXG1 forkhead box G1 3.2023
TRPM8 transient receptor potential cation channel, subfamily M, member 8 3.2023
LAMP5 lysosomal-associated membrane protein family, member 5 3.2023
CLCA4 chloride channel accessory 4 3.2023
VTCN1 V-set domain containing T cell activation inhibitor 1 3.2023
TEX36 testis expressed 36 3.2023
POPDC2 popeye domain containing 2 3.2023
CSH2 chorionic somatomammotropin hormone 2 3.2023
NEUROD4 neuronal differentiation 4 3.2023
NLRP6 NLR family, pyrin domain containing 6 3.2023
FRMPD1 FERM and PDZ domain containing 1 3.2023
PADI1 peptidyl arginine deiminase, type I 3.2023
NUTM2D NUT family member 2D 3.2023
GREM1 gremlin 1, DAN family BMP antagonist 3.2023
TTN titin 3.12596
MEIS2 Meis homeobox 2 3.09869
ZNF682 zinc finger protein 682 3.09869
ETV7 ets variant 7 3.09869
CCDC57 coiled-coil domain containing 57 3.04783
TRAPPC2B trafficking protein particle complex 2B 2.9983
RFLNB refilin B 2.98432
H4C4 H4 clustered histone 4 2.94569
BRD4 bromodomain containing 4 2.90416
ZNF214 zinc finger protein 214 2.88918
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 2.86627
HINT3 histidine triad nucleotide binding protein 3 2.82042
CIP2A cellular inhibitor of PP2A 2.78681
KCTD12 potassium channel tetramerization domain containing 12 2.73354
NBPF9 neuroblastoma breakpoint family, member 9 2.70472
ZNRF3 zinc and ring finger 3 2.64259
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 2.60067
SLC25A51 solute carrier family 25, member 51 2.57136
COL1A1 collagen, type I, alpha 1 2.55431
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) 2.53175
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12 2.50006
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 2.48116
UTP11 UTP11 small subunit processome component 2.43316
ARHGAP24 Rho GTPase activating protein 24 2.42495
POT1 protection of telomeres 1 2.41209
ZMYM3 zinc finger, MYM-type 3 2.39333
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.36807
CBY3 chibby homolog 3 (Drosophila) 2.36386
SIRPA signal-regulatory protein alpha 2.31395
EPOP elongin BC and polycomb repressive complex 2 associated protein 2.3026
SYCP3 synaptonemal complex protein 3 2.27488
HABP4 hyaluronan binding protein 4 2.26734
IL34 interleukin 34 2.26678
PLAT plasminogen activator, tissue 2.26221
CCNA2 cyclin A2 2.26124
ZNF511 zinc finger protein 511 2.22844
MXRA7 matrix-remodelling associated 7 2.22844
EIF5 eukaryotic translation initiation factor 5 2.22194
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 2.1639
PUF60 poly-U binding splicing factor 60KDa 2.1486
ZC3H7B zinc finger CCCH-type containing 7B 2.1457
CNOT7 CCR4-NOT transcription complex, subunit 7 2.14265
PEA15 phosphoprotein enriched in astrocytes 15 2.13431
ZNF493 zinc finger protein 493 2.12475
ERI3 ERI1 exoribonuclease family member 3 2.12417
STK31 serine/threonine kinase 31 2.11387
MISP3 MISP family member 3 2.11387
CC2D2B coiled-coil and C2 domain containing 2B 2.11387
MSC musculin 2.11387
PROZ protein Z, vitamin K-dependent plasma glycoprotein 2.11387
VSTM2A V-set and transmembrane domain containing 2A 2.11387
TNS2 tensin 2 2.11387
FAM117B family with sequence similarity 117, member B 2.09949
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 2.09813
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B 2.09014
MCTP2 multiple C2 domains, transmembrane 2 2.08771
DLEU7 deleted in lymphocytic leukemia, 7 2.08645
SFXN1 sideroflexin 1 2.07497
PRMT2 protein arginine methyltransferase 2 2.05838
SMAD3 SMAD family member 3 2.05838
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 2.05838
COPS7A COP9 signalosome subunit 7A 2.04041
FAR2 fatty acyl CoA reductase 2 2.04041
SLC38A10 solute carrier family 38, member 10 2.04011
NRBF2 nuclear receptor binding factor 2 2.03231
SLF2 SMC5-SMC6 complex localization factor 2 2.02397
ESYT3 extended synaptotagmin-like protein 3 2.02158
USP49 ubiquitin specific peptidase 49 2.01399
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2) 2.00489
RFPL2 ret finger protein-like 2 2.00265
KLRB1 killer cell lectin-like receptor subfamily B, member 1 2.00265
PGCKA1 PDCD10 and GCKIII kinases associated 1 2.00265
MSR1 macrophage scavenger receptor 1 2.00265

decreased expression

Symbol Name Standardized Value
CALR3 calreticulin 3 -3.29255
SRRM5 serine/arginine repetitive matrix 5 -3.29255
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -3.29255
RASA4B RAS p21 protein activator 4B -3.29255
UBXN10 UBX domain protein 10 -3.29255
ANGPT1 angiopoietin 1 -3.29255
ISM2 isthmin 2 -3.2023
DIO1 deiodinase, iodothyronine, type I -3.2023
LHX6 LIM homeobox 6 -3.2023
CLNK cytokine-dependent hematopoietic cell linker -3.2023
CD81 CD81 molecule -3.2023
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 -3.2023
ROM1 retinal outer segment membrane protein 1 -3.2023
TBC1D26 TBC1 domain family, member 26 -3.2023
ARHGAP15 Rho GTPase activating protein 15 -3.2023
BMX BMX non-receptor tyrosine kinase -3.2023
ACOX2 acyl-CoA oxidase 2, branched chain -3.2023
C9ORF43 chromosome 9 open reading frame 43 -3.2023
PLK5 polo-like kinase 5 -3.2023
F7 coagulation factor VII (serum prothrombin conversion accelerator) -3.2023
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) -3.2023
AMBP alpha-1-microglobulin/bikunin precursor -3.2023
LINC02798 long intergenic non-protein coding RNA 2798 -3.2023
UCN urocortin -3.2023
COLEC10 collectin sub-family member 10 (C-type lectin) -3.2023
PRICKLE4 prickle homolog 4 (Drosophila) -3.2023
NANOS3 nanos homolog 3 (Drosophila) -3.2023
TRIM17 tripartite motif containing 17 -3.2023
C1ORF116 chromosome 1 open reading frame 116 -3.2023
S1PR1 sphingosine-1-phosphate receptor 1 -3.2023
TMEM100 transmembrane protein 100 -3.2023
GFI1B growth factor independent 1B transcription repressor -3.2023
MORN5 MORN repeat containing 5 -3.2023
VMO1 vitelline membrane outer layer 1 homolog (chicken) -3.2023
TMEM255A transmembrane protein 255A -3.2023
FBXL22 F-box and leucine-rich repeat protein 22 -3.2023
ADCY4 adenylate cyclase 4 -3.2023
ART1 ADP-ribosyltransferase 1 -3.2023
SCNN1D sodium channel, non voltage gated 1 delta subunit -3.2023
RSAD2 radical S-adenosyl methionine domain containing 2 -3.2023
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 -3.18329
SRCAP Snf2-related CREBBP activator protein -3.17983
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -3.17777
ZBTB18 zinc finger and BTB domain containing 18 -3.09462
SLCO4C1 solute carrier organic anion transporter family, member 4C1 -2.99073
DDB2 damage-specific DNA binding protein 2, 48kDa -2.9215
MTX2 metaxin 2 -2.83426
ELMOD3 ELMO/CED-12 domain containing 3 -2.83261
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -2.81932
ZNF860 zinc finger protein 860 -2.79829
HMGN5 high mobility group nucleosome binding domain 5 -2.7822
SSH2 slingshot protein phosphatase 2 -2.7485
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -2.61761
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 -2.60867
PIERCE2 piercer of microtubule wall 2 -2.60867
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) -2.59299
ABHD12 abhydrolase domain containing 12 -2.56684
WNK1 WNK lysine deficient protein kinase 1 -2.52865
DNM2 dynamin 2 -2.5116
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -2.48116
SOS1 son of sevenless homolog 1 (Drosophila) -2.46587
RABL2A RAB, member of RAS oncogene family-like 2A -2.45987
ADAP1 ArfGAP with dual PH domains 1 -2.45201
TAFA1 TAFA chemokine like family member 1 -2.45201
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.45201
MAX MYC associated factor X -2.44965
TSLIG3B tRNA splicing ligase complex subunit 3B -2.39658
CALHM2 calcium homeostasis modulator 2 -2.3874
ZNF180 zinc finger protein 180 -2.3795
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4 -2.36964
DDX19A DEAD (Asp-Glu-Ala-Asp) box polypeptide 19A -2.36807
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -2.35992
TAF1C TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa -2.3458
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) -2.3458
DCAF1 DDB1 and CUL4 associated factor 1 -2.3457
GTF2H5 general transcription factor IIH, polypeptide 5 -2.34398
EDA2R ectodysplasin A2 receptor -2.34229
SSBP2 single-stranded DNA binding protein 2 -2.31371
CEP350 centrosomal protein 350kDa -2.31216
ALMS1 Alstrom syndrome protein 1 -2.3098
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 -2.30061
ZCCHC2 zinc finger, CCHC domain containing 2 -2.29368
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 -2.27885
FBLN7 fibulin 7 -2.24118
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 -2.24118
GSG1 germ cell associated 1 -2.24118
KCNIP4 Kv channel interacting protein 4 -2.22844
CCDC30 coiled-coil domain containing 30 -2.22677
MICU2 mitochondrial calcium uptake 2 -2.20361
SIRT6 sirtuin 6 -2.20361
FRMPD2 FERM and PDZ domain containing 2 -2.19902
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 -2.19371
PTPN21 protein tyrosine phosphatase, non-receptor type 21 -2.19342
TRAM2 translocation associated membrane protein 2 -2.19342
UBL7 ubiquitin-like 7 -2.19067
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase -2.19067
ZNF785 zinc finger protein 785 -2.1639
RBM18 RNA binding motif protein 18 -2.1486
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 -2.14265
CFAP73 cilia and flagella associated protein 73 -2.13137
DCAF10 DDB1 and CUL4 associated factor 10 -2.13137
BRD7 bromodomain containing 7 -2.12271
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog -2.11033
TMEM243 transmembrane protein 243, mitochondrial -2.1069
CTBS chitobiase, di-N-acetyl- -2.07785
GATD1 glutamine amidotransferase class 1 domain containing 1 -2.06895
C2ORF72 chromosome 2 open reading frame 72 -2.06895
CDHR2 cadherin-related family member 2 -2.06895
RNF130 ring finger protein 130 -2.00671
CNGA1 cyclic nucleotide gated channel alpha 1 -2.00645
AIF1L allograft inflammatory factor 1-like -2.00489
MYO1H myosin IH -2.00265
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) -2.00265
SZT2 seizure threshold 2 homolog (mouse) -2.00219