CD8A Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description CD8a molecule|The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] (NCBI Entrez Gene Database, 925)
External Link http://www.ncbi.nlm.nih.gov/gene/925
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Genes

50 interacting proteins for CD8A from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
B2M beta-2-microglobulin
CACYBP calcyclin binding protein
CD1A CD1a molecule
CD1B CD1b molecule
CD1C CD1c molecule
CD28 CD28 molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD59 CD59 molecule, complement regulatory protein
CD80 CD80 molecule
CD86 CD86 molecule
CD8B CD8b molecule
CDK1 cyclin-dependent kinase 1
CHD4 chromodomain helicase DNA binding protein 4
CSK c-src tyrosine kinase
EIF3A eukaryotic translation initiation factor 3, subunit A
GRAP2 GRB2-related adaptor protein 2
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
IL2 interleukin 2
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL2RG interleukin 2 receptor, gamma
JUN jun proto-oncogene
LAT linker for activation of T cells
LCK LCK proto-oncogene, Src family tyrosine kinase
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS1 lectin, galactoside-binding, soluble, 1
LNX1 ligand of numb-protein X 1, E3 ubiquitin protein ligase
LNX2 ligand of numb-protein X 2
MBD2 methyl-CpG binding domain protein 2
MBD3 methyl-CpG binding domain protein 3
MTA2 metastasis associated 1 family, member 2
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PRKCQ protein kinase C, theta
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PTPRC protein tyrosine phosphatase, receptor type, C
RBBP4 retinoblastoma binding protein 4
RBBP7 retinoblastoma binding protein 7
SAP30 Sin3A-associated protein, 30kDa
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIN3A SIN3 transcription regulator family member A
SREK1 splicing regulatory glutamine/lysine-rich protein 1
SRSF1 serine/arginine-rich splicing factor 1
UBC ubiquitin C
VAV1 vav 1 guanine nucleotide exchange factor