CDC25A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cell division cycle 25A|CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 993)
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Genes

345 genes differentially expressed following the CDC25A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SRMS src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites 2.3536
MITF microphthalmia-associated transcription factor 2.3536
NOD2 nucleotide-binding oligomerization domain containing 2 2.3536
FCGBP Fc fragment of IgG binding protein 2.3536
CCDC149 coiled-coil domain containing 149 2.3536
PAX9 paired box 9 2.3536
DPYD dihydropyrimidine dehydrogenase 2.3536
MSC musculin 2.3536
XCL1 chemokine (C motif) ligand 1 2.3536
ASB17 ankyrin repeat and SOCS box containing 17 2.3536
NEU4 sialidase 4 2.3536
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.3536
FAM86B2 family with sequence similarity 86, member B2 2.3536
ZNF467 zinc finger protein 467 2.3536
UGT1A7 UDP glucuronosyltransferase 1 family, polypeptide A7 2.3536
NXPH4 neurexophilin 4 2.3536
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 2.3536
C7ORF25 chromosome 7 open reading frame 25 2.3536
FGF23 fibroblast growth factor 23 2.3536
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 2.3536
CILP2 cartilage intermediate layer protein 2 2.3536
C1ORF53 chromosome 1 open reading frame 53 2.3536
RXFP1 relaxin/insulin-like family peptide receptor 1 2.3536
CTRC chymotrypsin C (caldecrin) 2.3536
ADGRE2 adhesion G protein-coupled receptor E2 2.3536
NPPC natriuretic peptide C 2.3536
IGFL4 IGF-like family member 4 2.3536
PLIN1 perilipin 1 2.3536
C19ORF38 chromosome 19 open reading frame 38 2.3536
FBLN5 fibulin 5 2.3536
TRIM72 tripartite motif containing 72, E3 ubiquitin protein ligase 2.3536
MAGED4 melanoma antigen family D4 2.3536
PLK5 polo-like kinase 5 2.3536
NPIPA5 nuclear pore complex interacting protein family, member A5 2.3536
HYPK huntingtin interacting protein K 2.3536
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 2.3536
MMP21 matrix metallopeptidase 21 2.3536
BHMT2 betaine--homocysteine S-methyltransferase 2 2.3536
ATOH8 atonal homolog 8 (Drosophila) 2.3536
EIF1AX eukaryotic translation initiation factor 1A, X-linked 2.3536
CPLX3 complexin 3 2.3536
KISS1R KISS1 receptor 2.3536
OVCH1 ovochymase 1 2.3536
NEB nebulin 2.3536
MEIKIN meiotic kinetochore factor 2.3536
OR7A17 olfactory receptor, family 7, subfamily A, member 17 2.3536
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 2.3536
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.3536
ZNF791 zinc finger protein 791 2.3536
RAPSN receptor-associated protein of the synapse 2.3536
HAS1 hyaluronan synthase 1 2.3536
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 2.3536
KIF20B kinesin family member 20B 2.3536
EDDM3A epididymal protein 3A 2.3536
ARRDC5 arrestin domain containing 5 2.3536
KIAA2012 KIAA2012 2.3536
ZNF324B zinc finger protein 324B 2.3536
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.3536
PRR22 proline rich 22 2.3536
SOX7 SRY (sex determining region Y)-box 7 2.3536
LOC114841035 uncharacterized LOC114841035 2.3536
ROPN1B rhophilin associated tail protein 1B 2.3536
ZNF221 zinc finger protein 221 2.3536
IQUB IQ motif and ubiquitin domain containing 2.3536
LMNTD2 lamin tail domain containing 2 2.3536
TMPRSS5 transmembrane protease, serine 5 2.3536
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 2.3536
NHLH1 nescient helix loop helix 1 2.3536
MYEOV myeloma overexpressed 2.3536
RASD1 RAS, dexamethasone-induced 1 2.3536
BST1 bone marrow stromal cell antigen 1 2.3536
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae) 2.3536
F3 coagulation factor III (thromboplastin, tissue factor) 2.3536
ALDOB aldolase B, fructose-bisphosphate 2.3536
PSPN persephin 2.3536
CCDC9B coiled-coil domain containing 9B 2.3536
OR56B2 olfactory receptor family 56 subfamily B member 2 2.3536
SPMIP8 sperm microtubule inner protein 8 2.3536
NPIPA6 nuclear pore complex interacting protein family, member A6 2.3536
LOC124902694 uncharacterized LOC124902694 2.3536
CTXND1 cortexin domain containing 1 2.3536
CFAP90 cilia and flagella associated protein 90 2.3536
H4C13 H4 clustered histone 13 2.3536
DEFB131B defensin beta 131B 2.3536
ETFBKMT electron transfer flavoprotein subunit beta lysine methyltransferase 2.3536
EEF1AKMT3 EEF1A lysine methyltransferase 3 2.3536
STUM stum, mechanosensory transduction mediator homolog 2.3536
CARD19 caspase recruitment domain family member 19 2.3536
ABCA9 ATP-binding cassette, sub-family A (ABC1), member 9 2.3536
OSTN osteocrin 2.3536
DYNAP dynactin associated protein 2.3536
CDC6 cell division cycle 6 2.3536
PCDHA5 protocadherin alpha 5 2.3536
HINT3 histidine triad nucleotide binding protein 3 2.3536
ISM2 isthmin 2 2.3536
CPNE5 copine V 2.3536
SPDYE6 speedy/RINGO cell cycle regulator family member E6 2.3536
TAS2R30 taste receptor, type 2, member 30 2.3536
FPR1 formyl peptide receptor 1 2.3536
SBK2 SH3 domain binding kinase family, member 2 2.3536
GPR75 G protein-coupled receptor 75 2.3536
TMPRSS11E transmembrane protease, serine 11E 2.3536
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.3536
PCDHB10 protocadherin beta 10 2.3536
PCDHB16 protocadherin beta 16 2.3536
IRF5 interferon regulatory factor 5 2.3536
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.3536
ASIC4 acid sensing (proton gated) ion channel family member 4 2.3536
NPIPB8 nuclear pore complex interacting protein family, member B8 2.3536
SAMD10 sterile alpha motif domain containing 10 2.3536
PGA3 pepsinogen 3, group I (pepsinogen A) 2.3536
MTMR11 myotubularin related protein 11 2.3536
SPDYE16 speedy/RINGO cell cycle regulator family member E16 2.3536
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.3536
SLAMF6 SLAM family member 6 2.3536
MIA melanoma inhibitory activity 2.3536
CIDEB cell death-inducing DFFA-like effector b 2.3536
ARHGAP1 Rho GTPase activating protein 1 2.3536
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 2.3536
LVRN laeverin 2.3536
CCDC152 coiled-coil domain containing 152 2.3536
NPFFR1 neuropeptide FF receptor 1 2.3536
CD53 CD53 molecule 2.3536
TMED6 transmembrane emp24 protein transport domain containing 6 2.3536
ARG1 arginase 1 2.3536
ITSN2 intersectin 2 2.3536
CBX4 chromobox homolog 4 2.3536
MAMLD1 mastermind-like domain containing 1 2.3536
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 2.3536
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 2.3536
ZCCHC18 zinc finger, CCHC domain containing 18 2.3536
EMILIN1 elastin microfibril interfacer 1 2.3536
RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2.3536
FBP2 fructose-1,6-bisphosphatase 2 2.3536
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 2.3536
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.3536
SRRM5 serine/arginine repetitive matrix 5 2.3536
SOWAHD sosondowah ankyrin repeat domain family member D 2.3536
IGFBP3 insulin-like growth factor binding protein 3 2.3536
ERICH5 glutamate-rich 5 2.3536
SMAD9 SMAD family member 9 2.3536
UPK1B uroplakin 1B 2.3536
GPR18 G protein-coupled receptor 18 2.3536
GCOM1 GRINL1A complex locus 1 2.3536
HSPA1L heat shock 70kDa protein 1-like 2.3536
DCLK3 doublecortin-like kinase 3 2.3536
FHDC1 FH2 domain containing 1 2.3536
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.3536
FBXO47 F-box protein 47 2.3536
SLC31A2 solute carrier family 31 (copper transporter), member 2 2.3536
RGS8 regulator of G-protein signaling 8 2.3536
ANAPC2 anaphase promoting complex subunit 2 2.3536
ORM2 orosomucoid 2 2.3536
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 2.3536
NMBR neuromedin B receptor 2.3536
INSL3 insulin-like 3 (Leydig cell) 2.3536
MMAA methylmalonic aciduria (cobalamin deficiency) cblA type 2.3536
RIN1 Ras and Rab interactor 1 2.3536
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.3536
GBX1 gastrulation brain homeobox 1 2.3536
C10ORF105 chromosome 10 open reading frame 105 2.3536
CEND1 cell cycle exit and neuronal differentiation 1 2.3536
PSG8 pregnancy specific beta-1-glycoprotein 8 2.3536
CTRB1 chymotrypsinogen B1 2.3536
LHX2 LIM homeobox 2 2.3536
ZSCAN4 zinc finger and SCAN domain containing 4 2.3536
ZNF843 zinc finger protein 843 2.3536
PTH2R parathyroid hormone 2 receptor 2.3536
RELT RELT tumor necrosis factor receptor 2.3536
AP5Z1 adaptor-related protein complex 5, zeta 1 subunit 2.3536
SPATA9 spermatogenesis associated 9 2.3536
TH tyrosine hydroxylase 2.3536
RBM20 RNA binding motif protein 20 2.3536
DMRT1 doublesex and mab-3 related transcription factor 1 2.3536
VWF von Willebrand factor 2.3536
DAPL1 death associated protein-like 1 2.3536
TYMP thymidine phosphorylase 2.3536
MZB1 marginal zone B and B1 cell-specific protein 2.3536
NACA2 nascent polypeptide-associated complex alpha subunit 2 2.3536
AREG amphiregulin 2.3536
SETD2 SET domain containing 2 2.3536
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent) 2.3536
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.3536
MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2.3536
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6 2.3536
EPN3 epsin 3 2.3536
TRPM2 transient receptor potential cation channel, subfamily M, member 2 2.3536
BIN2 bridging integrator 2 2.3536
LAMP3 lysosomal-associated membrane protein 3 2.3536
FGF8 fibroblast growth factor 8 (androgen-induced) 2.3536
ADRA1A adrenoceptor alpha 1A 2.3536
PADI1 peptidyl arginine deiminase, type I 2.3536
NATD1 N-acetyltransferase domain containing 1 2.3536
DCST1 DC-STAMP domain containing 1 2.3536
CLASP2 cytoplasmic linker associated protein 2 2.3536
SPINT4 serine peptidase inhibitor, Kunitz type 4 2.3536
GLB1L galactosidase, beta 1-like 2.3536
SGMS2 sphingomyelin synthase 2 2.3536
RAB7B RAB7B, member RAS oncogene family 2.3536
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 2.3536
ZC2HC1B zinc finger, C2HC-type containing 1B 2.3536
DNAH1 dynein, axonemal, heavy chain 1 2.3536
ANGPTL7 angiopoietin-like 7 2.3536
APOL1 apolipoprotein L, 1 2.3536
FGF6 fibroblast growth factor 6 2.3536
IFI16 interferon, gamma-inducible protein 16 2.3536
TULP1 tubby like protein 1 2.3536
AK8 adenylate kinase 8 2.3536
RTP1 receptor (chemosensory) transporter protein 1 2.3536
CLPS colipase, pancreatic 2.3536
ZNF703 zinc finger protein 703 2.3536
TP53INP2 tumor protein p53 inducible nuclear protein 2 2.3536
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.3536
LIG3 ligase III, DNA, ATP-dependent 2.3536
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 2.3536
LIMS2 LIM and senescent cell antigen-like domains 2 2.3536
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 2.3536
RERGL RERG/RAS-like 2.3536
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.3536
AZIN2 antizyme inhibitor 2 2.3536
DEFB134 defensin, beta 134 2.3536
CERCAM cerebral endothelial cell adhesion molecule 2.3536
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.3536
PANO1 proapoptotic nucleolar protein 1 2.3536
CARD6 caspase recruitment domain family, member 6 2.3536
EEFSEC eukaryotic elongation factor, selenocysteine-tRNA-specific 2.34557
SNX4 sorting nexin 4 2.33248
MKRN1 makorin ring finger protein 1 2.33248
VCAN versican 2.30953
MMRN2 multimerin 2 2.29102
BTF3 basic transcription factor 3 2.28461
EXOSC9 exosome component 9 2.28295
COL26A1 collagen, type XXVI, alpha 1 2.26994
TANGO2 transport and golgi organization 2 homolog (Drosophila) 2.26994
PIR pirin (iron-binding nuclear protein) 2.17961
DUT deoxyuridine triphosphatase 2.17961
CTR9 CTR9, Paf1/RNA polymerase II complex component 2.16112
XKR5 XK, Kell blood group complex subunit-related family, member 5 2.13122
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.13087
ARHGAP25 Rho GTPase activating protein 25 2.13087
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2.13087
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 2.12921
PDPK1 3-phosphoinositide dependent protein kinase 1 2.12921
YPEL5 yippee-like 5 (Drosophila) 2.11481
TMEM263 transmembrane protein 263 2.11481
TM6SF1 transmembrane 6 superfamily member 1 2.11481
RRAS2 related RAS viral (r-ras) oncogene homolog 2 2.0778
SP1 Sp1 transcription factor 2.05433
AFAP1L2 actin filament associated protein 1-like 2 2.04124
CLBA1 clathrin binding box of aftiphilin containing 1 2.02494
ZNF33A zinc finger protein 33A 2.0223
CDK4 cyclin-dependent kinase 4 2.014
MRNIP MRN complex interacting protein 2.0125
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.0125

decreased expression

Symbol Name Standardized Value
INKA1 inka box actin regulator 1 -2.3536
MYRF myelin regulatory factor -2.3536
USP27X ubiquitin specific peptidase 27, X-linked -2.3536
RCSD1 RCSD domain containing 1 -2.3536
NINJ2 ninjurin 2 -2.3536
OGN osteoglycin -2.3536
FGFR3 fibroblast growth factor receptor 3 -2.3536
CNFN cornifelin -2.3536
WDR54 WD repeat domain 54 -2.3536
KCNIP2 Kv channel interacting protein 2 -2.3536
HACL2 2-hydroxyacyl-CoA lyase 2 -2.3536
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1 -2.3536
STOML1 stomatin (EPB72)-like 1 -2.3536
FNDC3A fibronectin type III domain containing 3A -2.3536
BOLA1 bolA family member 1 -2.3536
HRK harakiri, BCL2 interacting protein -2.3536
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -2.3536
C1ORF116 chromosome 1 open reading frame 116 -2.3536
SLC26A8 solute carrier family 26 (anion exchanger), member 8 -2.3536
EOLA1 endothelium and lymphocyte associated ASCH domain 1 -2.3536
FCSK fucose kinase -2.3536
RUSF1 RUS family member 1 -2.3536
HTATSF1 HIV-1 Tat specific factor 1 -2.3536
COMMD9 COMM domain containing 9 -2.3536
RAB3D RAB3D, member RAS oncogene family -2.3536
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 -2.3536
EID3 EP300 interacting inhibitor of differentiation 3 -2.3536
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -2.3536
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B -2.3536
SNX21 sorting nexin family member 21 -2.3536
PRB3 proline-rich protein BstNI subfamily 3 -2.3536
E2F2 E2F transcription factor 2 -2.3536
PDE6G phosphodiesterase 6G, cGMP-specific, rod, gamma -2.3536
SLC5A4 solute carrier family 5 (glucose activated ion channel), member 4 -2.3536
LRRC8E leucine rich repeat containing 8 family, member E -2.3536
LOXL4 lysyl oxidase-like 4 -2.3536
C5ORF47 chromosome 5 open reading frame 47 -2.3536
DNAH10 dynein, axonemal, heavy chain 10 -2.3536
CCDC27 coiled-coil domain containing 27 -2.3536
CKMT1A creatine kinase, mitochondrial 1A -2.3536
RNASEH2A ribonuclease H2, subunit A -2.3536
NEIL1 nei endonuclease VIII-like 1 (E. coli) -2.3536
RIMS4 regulating synaptic membrane exocytosis 4 -2.3536
MIEF2 mitochondrial elongation factor 2 -2.3536
MAP6 microtubule-associated protein 6 -2.3536
MUC4 mucin 4, cell surface associated -2.3536
HTR1A 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled -2.3536
CITED4 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 4 -2.3536
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 -2.3536
DLEC1 deleted in lung and esophageal cancer 1 -2.3536
GALNT16 polypeptide N-acetylgalactosaminyltransferase 16 -2.3536
DNAH6 dynein, axonemal, heavy chain 6 -2.3536
SULT1C4 sulfotransferase family, cytosolic, 1C, member 4 -2.3536
POU3F4 POU class 3 homeobox 4 -2.3536
PRSS35 protease, serine, 35 -2.3536
SETMAR SET domain and mariner transposase fusion gene -2.3536
CPM carboxypeptidase M -2.3536
DLL1 delta-like 1 (Drosophila) -2.3536
PCSK2 proprotein convertase subtilisin/kexin type 2 -2.3536
ERN1 endoplasmic reticulum to nucleus signaling 1 -2.32323
DCUN1D3 DCN1, defective in cullin neddylation 1, domain containing 3 -2.32323
FN3K fructosamine 3 kinase -2.32323
HHLA1 HERV-H LTR-associating 1 -2.29102
NPIPB6 nuclear pore complex interacting protein family, member B6 -2.29102
ADGRL1 adhesion G protein-coupled receptor L1 -2.28625
SLC25A43 solute carrier family 25, member 43 -2.24157
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -2.21242
CCDC125 coiled-coil domain containing 125 -2.20765
KIF1A kinesin family member 1A -2.20765
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -2.19442
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -2.18371
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 -2.18371
THAP8 THAP domain containing 8 -2.18371
OGFR opioid growth factor receptor -2.17961
SPTBN4 spectrin, beta, non-erythrocytic 4 -2.15824
TFF3 trefoil factor 3 (intestinal) -2.15824
GLRA1 glycine receptor, alpha 1 -2.15824
DOCK10 dedicator of cytokinesis 10 -2.15824
ZNF688 zinc finger protein 688 -2.15824
ADGRG5 adhesion G protein-coupled receptor G5 -2.15824
RHOBTB2 Rho-related BTB domain containing 2 -2.15824
TCTA T-cell leukemia translocation altered -2.15824
ZNF43 zinc finger protein 43 -2.13732
FBLN1 fibulin 1 -2.13087
ADCY10 adenylate cyclase 10 (soluble) -2.12551
RREB1 ras responsive element binding protein 1 -2.08994
TET1 tet methylcytosine dioxygenase 1 -2.08994
MED17 mediator complex subunit 17 -2.06229
DCTN3 dynactin 3 (p22) -2.04992
PCOLCE procollagen C-endopeptidase enhancer -2.0137
OLFML3 olfactomedin-like 3 -2.00264