CDC25A Gene Set

Dataset DEPOD Substrates of Phosphatases
Category physical interactions
Type phosphatase
Description cell division cycle 25A|CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 993)
External Link http://www.koehn.embl.de/depod/showp.php?gene=CDC25A
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Genes

8 substrates of the phosphatase CDC25A from the curated DEPOD Substrates of Phosphatases dataset.

Symbol Name
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CUX1 cut-like homeobox 1
EGFR epidermal growth factor receptor
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
RAF1 Raf-1 proto-oncogene, serine/threonine kinase