CDC25A Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cell division cycle 25A|CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 993)
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90 interacting proteins for CDC25A from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
APC adenomatous polyposis coli
APP amyloid beta (A4) precursor protein
AR androgen receptor
BORA bora, aurora kinase A activator
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CAMK1D calcium/calmodulin-dependent protein kinase ID
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNE1 cyclin E1
CCNE2 cyclin E2
CCNI cyclin I
CDC34 cell division cycle 34
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN3 cyclin-dependent kinase inhibitor 3
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
COPS4 COP9 signalosome subunit 4
CSNK1A1 casein kinase 1, alpha 1
CUL1 cullin 1
CUL3 cullin 3
DMD dystrophin
DUSP8 dual specificity phosphatase 8
E2F1 E2F transcription factor 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGFR epidermal growth factor receptor
FAM193B family with sequence similarity 193, member B
FBXW11 F-box and WD repeat domain containing 11
FGF21 fibroblast growth factor 21
FTH1 ferritin, heavy polypeptide 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GPRASP2 G protein-coupled receptor associated sorting protein 2
GSK3B glycogen synthase kinase 3 beta
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HLA-C major histocompatibility complex, class I, C
HNF4A hepatocyte nuclear factor 4, alpha
HRAS Harvey rat sarcoma viral oncogene homolog
IL3RA interleukin 3 receptor, alpha (low affinity)
KEAP1 kelch-like ECH-associated protein 1
KRT79 keratin 79, type II
LMO2 LIM domain only 2 (rhombotin-like 1)
LRRK2 leucine-rich repeat kinase 2
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK14 mitogen-activated protein kinase 14
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAX MYC associated factor X
MCM3AP minichromosome maintenance complex component 3 associated protein
MTAP methylthioadenosine phosphorylase
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit
NEK11 NIMA-related kinase 11
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NFYA nuclear transcription factor Y, alpha
NPLOC4 nuclear protein localization 4 homolog (S. cerevisiae)
NRD1 nardilysin (N-arginine dibasic convertase)
NUDC nudC nuclear distribution protein
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
ONECUT1 one cut homeobox 1
PEX19 peroxisomal biogenesis factor 19
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PKM pyruvate kinase, muscle
PLK3 polo-like kinase 3
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SCYL1 SCY1-like 1 (S. cerevisiae)
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SKP1 S-phase kinase-associated protein 1
SMAD3 SMAD family member 3
SOX5 SRY (sex determining region Y)-box 5
SUN2 Sad1 and UNC84 domain containing 2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TRIB3 tribbles pseudokinase 3
TUBGCP2 tubulin, gamma complex associated protein 2
TUBGCP3 tubulin, gamma complex associated protein 3
UBB ubiquitin B
UBC ubiquitin C
USP47 ubiquitin specific peptidase 47
VAMP8 vesicle-associated membrane protein 8
VCP valosin containing protein
XPO1 exportin 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta