CDC25B Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cell division cycle 25B|CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 994)
External Link http://www.ncbi.nlm.nih.gov/gene/994
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67 interacting proteins for CDC25B from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AR androgen receptor
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
AURKA aurora kinase A
BRSK1 BR serine/threonine kinase 1
BRSK2 BR serine/threonine kinase 2
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CDC14A cell division cycle 14A
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CHEK1 checkpoint kinase 1
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CREBBP CREB binding protein
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CUL1 cullin 1
DOCK2 dedicator of cytokinesis 2
E2F1 E2F transcription factor 1
ESR1 estrogen receptor 1
FBXW11 F-box and WD repeat domain containing 11
FHL3 four and a half LIM domains 3
FOXM1 forkhead box M1
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2
HRAS Harvey rat sarcoma viral oncogene homolog
KAT2B K(lysine) acetyltransferase 2B
KRT31 keratin 31, type I
KRT35 keratin 35, type I
KRT85 keratin 85, type II
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAX MYC associated factor X
MELK maternal embryonic leucine zipper kinase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO10 myosin X
NRD1 nardilysin (N-arginine dibasic convertase)
NUDC nudC nuclear distribution protein
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PGR progesterone receptor
PHB2 prohibitin 2
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SFN stratifin
SKP1 S-phase kinase-associated protein 1
SUN2 Sad1 and UNC84 domain containing 2
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TUBGCP3 tubulin, gamma complex associated protein 3
UBC ubiquitin C
UBD ubiquitin D
USP37 ubiquitin specific peptidase 37
USP47 ubiquitin specific peptidase 47
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZRANB1 zinc finger, RAN-binding domain containing 1