CDC25C Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cell division cycle 25C|This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 995)
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Genes

320 genes differentially expressed following the CDC25C gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 3.19913
SPINK4 serine peptidase inhibitor, Kazal type 4 3.19913
CABP4 calcium binding protein 4 3.19913
TMEM176B transmembrane protein 176B 3.19913
AKR1C2 aldo-keto reductase family 1, member C2 3.19913
OR1A1 olfactory receptor, family 1, subfamily A, member 1 3.19913
PCDHB1 protocadherin beta 1 3.19913
APLN apelin 3.19913
CCL5 chemokine (C-C motif) ligand 5 3.19913
LRRC56 leucine rich repeat containing 56 3.19913
FFAR4 free fatty acid receptor 4 3.19913
LRRTM2 leucine rich repeat transmembrane neuronal 2 3.19913
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 3.19913
HRH1 histamine receptor H1 3.19913
ZNF285 zinc finger protein 285 3.19913
CD5 CD5 molecule 3.19913
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 3.19913
ALB albumin 3.19913
RASL10A RAS-like, family 10, member A 3.19913
AKR7L aldo-keto reductase family 7-like (gene/pseudogene) 3.19913
MS4A4E membrane-spanning 4-domains, subfamily A, member 4E 3.19913
SACK1A scaffolding CK1 anchoring protein A 3.19913
LIPH lipase, member H 3.19913
DSG3 desmoglein 3 3.19913
SLC15A5 solute carrier family 15, member 5 3.19913
BMP8B bone morphogenetic protein 8b 3.19913
IDUA iduronidase, alpha-L- 3.19913
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 3.19913
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 3.19913
ATG4A autophagy related 4A, cysteine peptidase 3.19913
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 3.19913
OIT3 oncoprotein induced transcript 3 3.19913
CFAP53 cilia and flagella associated protein 53 3.19913
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 3.19913
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 3.19913
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 3.19913
NPIPA5 nuclear pore complex interacting protein family, member A5 3.19913
HIPK4 homeodomain interacting protein kinase 4 3.19913
MEI1 meiosis inhibitor 1 3.19913
MSC musculin 3.19913
CIITA class II, major histocompatibility complex, transactivator 3.19913
LYZL6 lysozyme-like 6 3.19913
TRPV6 transient receptor potential cation channel, subfamily V, member 6 3.19913
NLRP10 NLR family, pyrin domain containing 10 3.19913
GMFG glia maturation factor, gamma 3.19913
RGPD4 RANBP2-like and GRIP domain containing 4 3.19913
CRIP1 cysteine-rich protein 1 (intestinal) 3.19913
DLX4 distal-less homeobox 4 3.19913
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 3.19913
GNG14 G protein subunit gamma 14 3.19913
LMNTD1 lamin tail domain containing 1 3.19913
IFIT1B interferon-induced protein with tetratricopeptide repeats 1B 3.19913
ACSL5 acyl-CoA synthetase long-chain family member 5 3.19913
SPATA25 spermatogenesis associated 25 3.19913
KL klotho 3.19913
OSTC oligosaccharyltransferase complex subunit (non-catalytic) 3.19913
STAC2 SH3 and cysteine rich domain 2 3.19913
CATSPERT catsper channel auxiliary subunit tau 3.19913
FAM107A family with sequence similarity 107, member A 3.19913
MOV10L1 Mov10 RISC complex RNA helicase like 1 3.19913
PKD2L1 polycystic kidney disease 2-like 1 3.19913
SRGN serglycin 3.19913
SRARP steroid receptor associated and regulated protein 3.19913
GREP1 glycine rich extracellular protein 1 3.19913
HJV hemojuvelin BMP co-receptor 3.19913
CBLIF cobalamin binding intrinsic factor 3.19913
EOLA1 endothelium and lymphocyte associated ASCH domain 1 3.19913
TMEM275 transmembrane protein 275 3.19913
CES4A carboxylesterase 4A 3.19913
KY kyphoscoliosis peptidase 3.19913
PANK4 pantothenate kinase 4 3.19913
HTRA4 HtrA serine peptidase 4 3.19913
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 3.19913
FGFBP1 fibroblast growth factor binding protein 1 3.19913
PTH parathyroid hormone 3.19913
CBLN3 cerebellin 3 precursor 3.19913
CD79A CD79a molecule, immunoglobulin-associated alpha 3.19913
GOLGA6L2 golgin A6 family-like 2 3.19913
THPO thrombopoietin 3.19913
VSX2 visual system homeobox 2 3.19913
CHRD chordin 3.19913
TEX101 testis expressed 101 3.19913
CAPN14 calpain 14 3.19913
TMEM229A transmembrane protein 229A 3.19913
FPR2 formyl peptide receptor 2 3.19913
IDO2 indoleamine 2,3-dioxygenase 2 3.19913
SLC22A25 solute carrier family 22, member 25 3.19913
PGA5 pepsinogen 5, group I (pepsinogen A) 3.19913
CLDN22 claudin 22 3.19913
EXOC3L4 exocyst complex component 3-like 4 3.19913
PRR4 proline rich 4 (lacrimal) 3.19913
TBX3 T-box 3 3.19913
ZNF26 zinc finger protein 26 3.19913
AWAT1 acyl-CoA wax alcohol acyltransferase 1 3.19913
OR2A14 olfactory receptor, family 2, subfamily A, member 14 3.19913
MSX2 msh homeobox 2 3.19913
C10ORF67 chromosome 10 open reading frame 67 3.19913
SLC22A16 solute carrier family 22 (organic cation/carnitine transporter), member 16 3.19913
SOST sclerostin 3.19913
COL17A1 collagen, type XVII, alpha 1 3.19913
B4GALNT2 beta-1,4-N-acetyl-galactosaminyl transferase 2 3.19913
SYNE3 spectrin repeat containing, nuclear envelope family member 3 3.19913
FATE1 fetal and adult testis expressed 1 3.19913
KLHL1 kelch-like family member 1 3.19913
BTNL2 butyrophilin-like 2 3.19913
DPRX divergent-paired related homeobox 3.19913
CXCR5 chemokine (C-X-C motif) receptor 5 3.19913
CTAGE4 CTAGE family, member 4 3.19913
ZNF703 zinc finger protein 703 3.19913
CA5A carbonic anhydrase VA, mitochondrial 3.19913
KRT17 keratin 17, type I 3.19913
DOC2B double C2-like domains, beta 3.19913
STAB1 stabilin 1 3.19913
TMPPE transmembrane protein with metallophosphoesterase domain 3.19913
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 3.19913
NACA2 nascent polypeptide-associated complex alpha subunit 2 3.19913
TMEM132D transmembrane protein 132D 3.19913
GAGE10 G antigen 10 3.19913
ZNF750 zinc finger protein 750 3.19913
CTAGE9 CTAGE family, member 9 3.19913
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 3.19913
HUS1B HUS1 checkpoint homolog b (S. pombe) 3.19913
RANBP3L RAN binding protein 3-like 3.19913
SAMD5 sterile alpha motif domain containing 5 3.19913
DRD2 dopamine receptor D2 3.19913
PCDHGA7 protocadherin gamma subfamily A, 7 3.19913
FBXO40 F-box protein 40 3.19913
MCCD1 mitochondrial coiled-coil domain 1 3.19913
CD53 CD53 molecule 3.19913
CALB2 calbindin 2 3.19913
ITGB7 integrin, beta 7 3.19913
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 3.19913
LY96 lymphocyte antigen 96 3.19913
CTXN2 cortexin 2 3.19913
CALR3 calreticulin 3 3.19913
UTS2B urotensin 2B 3.19913
MAP3K19 mitogen-activated protein kinase kinase kinase 19 3.19913
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 3.19913
CCNI2 cyclin I family, member 2 3.19913
RBBP8NL RBBP8 N-terminal like 3.19913
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 3.19913
TEX38 testis expressed 38 3.19913
CCNO cyclin O 3.19913
CFB complement factor B 3.19913
TMEM156 transmembrane protein 156 3.19913
IL10RA interleukin 10 receptor, alpha 3.19913
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 3.19913
TRPM5 transient receptor potential cation channel, subfamily M, member 5 3.19913
APOL4 apolipoprotein L, 4 3.19913
ADRA1B adrenoceptor alpha 1B 3.19913
TGM7 transglutaminase 7 3.19913
ANXA1 annexin A1 3.19913
RDH16 retinol dehydrogenase 16 (all-trans) 3.19913
TRHR thyrotropin-releasing hormone receptor 3.19913
SLC36A3 solute carrier family 36, member 3 3.19913
IRX5 iroquois homeobox 5 3.19913
ART1 ADP-ribosyltransferase 1 3.19913
SGK2 serum/glucocorticoid regulated kinase 2 3.19913
NLRP1 NLR family, pyrin domain containing 1 3.19913
LPA lipoprotein, Lp(a) 3.19913
FGF17 fibroblast growth factor 17 3.19913
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.19913
ALOX15B arachidonate 15-lipoxygenase, type B 3.19913
EPX eosinophil peroxidase 3.19913
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.19913
TM4SF19 transmembrane 4 L six family member 19 3.19913
ADGRF5 adhesion G protein-coupled receptor F5 3.19913
ESPNL espin-like 3.19913
FITM1 fat storage-inducing transmembrane protein 1 3.19913
CSPG4 chondroitin sulfate proteoglycan 4 3.19913
SLC25A34 solute carrier family 25, member 34 3.19913
DEFB134 defensin, beta 134 3.19913
SP140L SP140 nuclear body protein-like 3.19913
PATE2 prostate and testis expressed 2 3.19913
ZMYND15 zinc finger, MYND-type containing 15 3.19913
C10ORF105 chromosome 10 open reading frame 105 3.19913
ABI3 ABI family, member 3 3.19913
C3ORF49 chromosome 3 open reading frame 49 3.04067
TP73 tumor protein p73 2.86024
MCM10 minichromosome maintenance complex component 10 2.84539
CBS cystathionine-beta-synthase 2.74579
CEMIP cell migration inducing protein, hyaluronan binding 2.745
PCDHGC3 protocadherin gamma subfamily C, 3 2.59177
TAFA1 TAFA chemokine like family member 1 2.5628
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.54601
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 2.49532
WWTR1 WW domain containing transcription regulator 1 2.48115
NXPH2 neurexophilin 2 2.42861
EMP1 epithelial membrane protein 1 2.41122
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) 2.39053
EDEM3 ER degradation enhancer, mannosidase alpha-like 3 2.34884
HSPA12B heat shock 70kD protein 12B 2.34884
GAL galanin/GMAP prepropeptide 2.32013
ZNF684 zinc finger protein 684 2.30602
EIF5A2 eukaryotic translation initiation factor 5A2 2.27982
ZNF221 zinc finger protein 221 2.25713
GLOD4 glyoxalase domain containing 4 2.25713
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1 2.24537
ZMYM4 zinc finger, MYM-type 4 2.24331
CNN3 calponin 3, acidic 2.22718
TERF2IP telomeric repeat binding factor 2, interacting protein 2.20837
MORC4 MORC family CW-type zinc finger 4 2.19517
FGF11 fibroblast growth factor 11 2.18097
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 2.17981
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.17551
HDHD5 haloacid dehalogenase like hydrolase domain containing 5 2.16714
PLEKHA7 pleckstrin homology domain containing, family A member 7 2.16286
NELFB negative elongation factor complex member B 2.13921
TMEM164 transmembrane protein 164 2.13851
RCCD1 RCC1 domain containing 1 2.13851
UBE2L3 ubiquitin-conjugating enzyme E2L 3 2.13851
PFDN5 prefoldin subunit 5 2.13467
NBPF3 neuroblastoma breakpoint family, member 3 2.12242
THAP12 THAP domain containing 12 2.1191
MTMR6 myotubularin related protein 6 2.11265
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 2.06914
THBS1 thrombospondin 1 2.05905
TMF1 TATA element modulatory factor 1 2.05028
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52 2.04027
CHIC1 cysteine-rich hydrophobic domain 1 2.0373
MAP4 microtubule-associated protein 4 2.03266
CYYR1 cysteine/tyrosine-rich 1 2.03212
UPP2 uridine phosphorylase 2 2.02887
CNR1 cannabinoid receptor 1 (brain) 2.02887
SCRG1 stimulator of chondrogenesis 1 2.02887
DET1 de-etiolated homolog 1 (Arabidopsis) 2.02887
IGFBP7 insulin-like growth factor binding protein 7 2.02887
TLE4 transducin-like enhancer of split 4 2.02198
ZNF586 zinc finger protein 586 2.02198
FXR2 fragile X mental retardation, autosomal homolog 2 2.01669
GASK1A golgi associated kinase 1A 2.00484
RARB retinoic acid receptor, beta 2.00114

decreased expression

Symbol Name Standardized Value
SYBU syntabulin (syntaxin-interacting) -3.19913
HHEX hematopoietically expressed homeobox -3.19913
DNAI1 dynein, axonemal, intermediate chain 1 -3.19913
SHD Src homology 2 domain containing transforming protein D -3.19913
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa -3.19913
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -3.19913
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -3.19913
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -3.19913
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 -3.19913
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 -3.19913
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 -3.19913
ANGPT4 angiopoietin 4 -3.19913
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) -3.19913
HORMAD2 HORMA domain containing 2 -3.19913
NPPC natriuretic peptide C -3.19913
A4GALT alpha 1,4-galactosyltransferase -3.19913
ZNF492 zinc finger protein 492 -3.19913
STKLD1 serine/threonine kinase-like domain containing 1 -3.19913
WLS wntless Wnt ligand secretion mediator -3.19913
GPR20 G protein-coupled receptor 20 -3.19913
ALPK2 alpha-kinase 2 -3.19913
MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase -3.19913
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -3.19913
XNDC1N XRCC1 N-terminal domain containing 1, N-terminal like -3.19913
ZNF222 zinc finger protein 222 -3.19913
PHF7 PHD finger protein 7 -3.19913
KLK14 kallikrein-related peptidase 14 -3.19913
DCDC2B doublecortin domain containing 2B -3.19913
TRPC7 transient receptor potential cation channel, subfamily C, member 7 -3.19913
AVIL advillin -3.19913
NIBAN3 niban apoptosis regulator 3 -3.19913
NOTCH2NLA notch 2 N-terminal like A -3.19913
HLA-DMB major histocompatibility complex, class II, DM beta -3.19913
LOC124906010 uncharacterized LOC124906010 -3.19913
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 -3.19913
KPNA7 karyopherin alpha 7 (importin alpha 8) -3.19913
ZNF671 zinc finger protein 671 -3.19913
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -3.19913
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F -3.19913
ETNPPL ethanolamine-phosphate phospho-lyase -3.19913
ACKR3 atypical chemokine receptor 3 -3.19913
NRXN3 neurexin 3 -3.15977
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 -3.01371
KLRG2 killer cell lectin-like receptor subfamily G, member 2 -2.99946
BCAM basal cell adhesion molecule (Lutheran blood group) -2.96332
PRICKLE1 prickle homolog 1 (Drosophila) -2.95838
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 -2.92621
FBLL1 fibrillarin-like 1 -2.87252
PTGIS prostaglandin I2 (prostacyclin) synthase -2.76457
TMOD1 tropomodulin 1 -2.66974
ZNF837 zinc finger protein 837 -2.66974
BMPER BMP binding endothelial regulator -2.66175
FRMD1 FERM domain containing 1 -2.61415
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19 -2.56739
MATCAP1 microtubule associated tyrosine carboxypeptidase 1 -2.55414
RPP25 ribonuclease P/MRP 25kDa subunit -2.55414
LAMC1 laminin, gamma 1 (formerly LAMB2) -2.55165
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.5239
LMAN2L lectin, mannose-binding 2-like -2.45033
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16 -2.43424
KRABD5 KRAB domain containing 5 -2.42451
AMOTL1 angiomotin like 1 -2.30602
MAP3K3 mitogen-activated protein kinase kinase kinase 3 -2.27948
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 -2.26929
PTPRR protein tyrosine phosphatase, receptor type, R -2.26187
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -2.24519
SH2D2A SH2 domain containing 2A -2.24331
EFNA3 ephrin-A3 -2.24331
DCTN1 dynactin 1 -2.22775
MRPL52 mitochondrial ribosomal protein L52 -2.21329
AKR1E2 aldo-keto reductase family 1, member E2 -2.17911
ADCK1 aarF domain containing kinase 1 -2.16286
GPAT4 glycerol-3-phosphate acyltransferase 4 -2.1468
CDC25C cell division cycle 25C -2.11638
GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 -2.11076
SH3RF1 SH3 domain containing ring finger 1 -2.08422
GPR180 G protein-coupled receptor 180 -2.0593
AMIGO2 adhesion molecule with Ig-like domain 2 -2.04289
PYY peptide YY -2.04289
PHETA2 PH domain containing endocytic trafficking adaptor 2 -2.04289
TSPOAP1 TSPO associated protein 1 -2.04289
CD163L1 CD163 molecule-like 1 -2.04289
CCDC160 coiled-coil domain containing 160 -2.03266
EPOR erythropoietin receptor -2.02856
MAPRE3 microtubule-associated protein, RP/EB family, member 3 -2.02658
KRTCAP2 keratinocyte associated protein 2 -2.02198
MIGA2 mitoguardin 2 -2.01092
LRRC47 leucine rich repeat containing 47 -2.00484