CDC25C Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cell division cycle 25C|This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 995)
External Link http://www.ncbi.nlm.nih.gov/gene/995
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259 interacting proteins for CDC25C from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AAR2 AAR2 splicing factor homolog (S. cerevisiae)
ABLIM1 actin binding LIM protein 1
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
AGAP3 ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
AKAP2 A kinase (PRKA) anchor protein 2
AKT1S1 AKT1 substrate 1 (proline-rich)
AMPD2 adenosine monophosphate deaminase 2
ANAPC1 anaphase promoting complex subunit 1
ANAPC11 anaphase promoting complex subunit 11
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC7 anaphase promoting complex subunit 7
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A
ANXA4 annexin A4
ANXA8 annexin A8
ANXA8L1 annexin A8-like 1
ARAF A-Raf proto-oncogene, serine/threonine kinase
ARF4 ADP-ribosylation factor 4
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
BAD BCL2-associated agonist of cell death
BAIAP2 BAI1-associated protein 2
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRSK1 BR serine/threonine kinase 1
BRSK2 BR serine/threonine kinase 2
BSG basigin (Ok blood group)
CA2 carbonic anhydrase II
CAMKK1 calcium/calmodulin-dependent protein kinase kinase 1, alpha
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CCDC6 coiled-coil domain containing 6
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCNO cyclin O
CDC23 cell division cycle 23
CDC27 cell division cycle 27
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK1 cyclin-dependent kinase 1
CDK16 cyclin-dependent kinase 16
CDK17 cyclin-dependent kinase 17
CDK18 cyclin-dependent kinase 18
CDK2 cyclin-dependent kinase 2
CDK5 cyclin-dependent kinase 5
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
CEP170 centrosomal protein 170kDa
CEP170B centrosomal protein 170B
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLASP1 cytoplasmic linker associated protein 1
CLASP2 cytoplasmic linker associated protein 2
CORO1C coronin, actin binding protein, 1C
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRTC2 CREB regulated transcription coactivator 2
CRTC3 CREB regulated transcription coactivator 3
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYLD cylindromatosis (turban tumor syndrome)
DCAF7 DDB1 and CUL4 associated factor 7
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DENND1A DENN/MADD domain containing 1A
DENND4A DENN/MADD domain containing 4A
DENND4C DENN/MADD domain containing 4C
DMTN dematin actin binding protein
DOCK11 dedicator of cytokinesis 11
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
E2F4 E2F transcription factor 4, p107/p130-binding
EDC3 enhancer of mRNA decapping 3
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF4A1 eukaryotic translation initiation factor 4A1
EIF4E2 eukaryotic translation initiation factor 4E family member 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZR ezrin
FAM83B family with sequence similarity 83, member B
FOLR1 folate receptor 1 (adult)
FOXO3 forkhead box O3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GAPVD1 GTPase activating protein and VPS9 domains 1
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GDI2 GDP dissociation inhibitor 2
GIGYF1 GRB10 interacting GYF protein 1
GIGYF2 GRB10 interacting GYF protein 2
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB4 guanine nucleotide binding protein (G protein), beta polypeptide 4
GRIP1 glutamate receptor interacting protein 1
GTSE1 G-2 and S-phase expressed 1
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HRAS Harvey rat sarcoma viral oncogene homolog
IDE insulin-degrading enzyme
INPP5F inositol polyphosphate-5-phosphatase F
IQGAP1 IQ motif containing GTPase activating protein 1
IRS2 insulin receptor substrate 2
IRS4 insulin receptor substrate 4
KIAA0355 KIAA0355
KIAA0930 KIAA0930
KIAA1671 KIAA1671
KIF1B kinesin family member 1B
KIF1C kinesin family member 1C
KIF24 kinesin family member 24
KLC2 kinesin light chain 2
KLC4 kinesin light chain 4
KSR1 kinase suppressor of ras 1
LARP1 La ribonucleoprotein domain family, member 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LIMA1 LIM domain and actin binding 1
LMO7 LIM domain 7
LUZP1 leucine zipper protein 1
LZTS1 leucine zipper, putative tumor suppressor 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MARK1 MAP/microtubule affinity-regulating kinase 1
MARK2 MAP/microtubule affinity-regulating kinase 2
MARK3 MAP/microtubule affinity-regulating kinase 3
MAST2 microtubule associated serine/threonine kinase 2
MISP mitotic spindle positioning
MTMR12 myotubularin related protein 12
NADK NAD kinase
NAV1 neuron navigator 1
NCKAP1 NCK-associated protein 1
NCKIPSD NCK interacting protein with SH3 domain
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NELFA negative elongation factor complex member A
NELFB negative elongation factor complex member B
NEXN nexilin (F actin binding protein)
NF1 neurofibromin 1
NSUN2 NOP2/Sun RNA methyltransferase family, member 2
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARD3 par-3 family cell polarity regulator
PARP8 poly (ADP-ribose) polymerase family, member 8
PCNA proliferating cell nuclear antigen
PDLIM7 PDZ and LIM domain 7 (enigma)
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PGK1 phosphoglycerate kinase 1
PHGDH phosphoglycerate dehydrogenase
PHLDB2 pleckstrin homology-like domain, family B, member 2
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKM pyruvate kinase, muscle
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PKN1 protein kinase N1
PKP2 plakophilin 2
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLEKHA7 pleckstrin homology domain containing, family A member 7
PLK1 polo-like kinase 1
PLK3 polo-like kinase 3
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPL periplakin
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP2R5D protein phosphatase 2, regulatory subunit B', delta
PRPF8 pre-mRNA processing factor 8
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PTPN14 protein tyrosine phosphatase, non-receptor type 14
PUM1 pumilio RNA-binding family member 1
R3HDM1 R3H domain containing 1
R3HDM2 R3H domain containing 2
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RASAL2 RAS protein activator like 2
REEP4 receptor accessory protein 4
RICTOR RPTOR independent companion of MTOR, complex 2
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RTKN rhotekin
SAMD4A sterile alpha motif domain containing 4A
SAMD4B sterile alpha motif domain containing 4B
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SH3PXD2A SH3 and PX domains 2A
SH3RF1 SH3 domain containing ring finger 1
SH3RF3 SH3 domain containing ring finger 3
SHKBP1 SH3KBP1 binding protein 1
SHROOM3 shroom family member 3
SIPA1L2 signal-induced proliferation-associated 1 like 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5)
SORBS1 sorbin and SH3 domain containing 1
SORBS2 sorbin and SH3 domain containing 2
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1
SPRR2A small proline-rich protein 2A
SPRR2B small proline-rich protein 2B
SPRR2E small proline-rich protein 2E
SPTBN2 spectrin, beta, non-erythrocytic 2
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SSBP1 single-stranded DNA binding protein 1, mitochondrial
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STK3 serine/threonine kinase 3
SVIL supervillin
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TBC1D22A TBC1 domain family, member 22A
TBC1D22B TBC1 domain family, member 22B
TBC1D4 TBC1 domain family, member 4
TBC1D5 TBC1 domain family, member 5
TJP1 tight junction protein 1
TMOD3 tropomodulin 3 (ubiquitous)
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TPD52L1 tumor protein D52-like 1
TRIM29 tripartite motif containing 29
TRIM32 tripartite motif containing 32
TSC2 tuberous sclerosis 2
TTC28 tetratricopeptide repeat domain 28
TYMP thymidine phosphorylase
UBC ubiquitin C
UHRF1BP1L UHRF1 binding protein 1-like
USP17L2 ubiquitin specific peptidase 17-like family member 2
USP54 ubiquitin specific peptidase 54
USP8 ubiquitin specific peptidase 8
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
VPS33B vacuolar protein sorting 33 homolog B (yeast)
WDR62 WD repeat domain 62
WEE1 WEE1 G2 checkpoint kinase
WNK1 WNK lysine deficient protein kinase 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZCCHC8 zinc finger, CCHC domain containing 8
ZFP36L2 ZFP36 ring finger protein-like 2