CDC27 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description cell division cycle 27|The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 996)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GNF2_CDC27
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Genes

60 co-expressed genes for CDC27 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
AHSP alpha hemoglobin stabilizing protein
ALAD aminolevulinate dehydratase
ALAS2 5'-aminolevulinate synthase 2
ANK1 ankyrin 1, erythrocytic
BLVRB biliverdin reductase B
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CA2 carbonic anhydrase II
CDC27 cell division cycle 27
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CTSE cathepsin E
DCAF11 DDB1 and CUL4 associated factor 11
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EPB42 erythrocyte membrane protein band 4.2
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FBXO7 F-box protein 7
FECH ferrochelatase
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLRX5 glutaredoxin 5
GYPA glycophorin A (MNS blood group)
GYPB glycophorin B (MNS blood group)
GYPC glycophorin C (Gerbich blood group)
GYPE glycophorin E (MNS blood group)
HBQ1 hemoglobin, theta 1
HDGF hepatoma-derived growth factor
HMBS hydroxymethylbilane synthase
HTRA2 HtrA serine peptidase 2
KLF1 Kruppel-like factor 1 (erythroid)
MAP2K3 mitogen-activated protein kinase kinase 3
MARK3 MAP/microtubule affinity-regulating kinase 3
MINPP1 multiple inositol-polyphosphate phosphatase 1
NARF nuclear prelamin A recognition factor
NUDT4 nudix (nucleoside diphosphate linked moiety X)-type motif 4
PPOX protoporphyrinogen oxidase
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
RAD23A RAD23 homolog A (S. cerevisiae)
RBM38 RNA binding motif protein 38
RBX1 ring-box 1, E3 ubiquitin protein ligase
RCL1 RNA terminal phosphate cyclase-like 1
RHAG Rh-associated glycoprotein
RHCE Rh blood group, CcEe antigens
RPIA ribose 5-phosphate isomerase A
SELENBP1 selenium binding protein 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group)
SPTA1 spectrin, alpha, erythrocytic 1
SPTB spectrin, beta, erythrocytic
TAL1 T-cell acute lymphocytic leukemia 1
TFDP1 transcription factor Dp-1
TFRC transferrin receptor
TOP1 topoisomerase (DNA) I
TRAK2 trafficking protein, kinesin binding 2
TRIM10 tripartite motif containing 10
UBAC1 UBA domain containing 1
UROD uroporphyrinogen decarboxylase
XK X-linked Kx blood group
XPO7 exportin 7