CDC27 Gene Set

Dataset NURSA Protein-Protein Interactions
Category proteomics
Type interacting protein
Description cell division cycle 27|The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014] (NCBI Entrez Gene Database, 996)
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9 interacting proteins for CDC27 from the NURSA Protein-Protein Interactions dataset.

Symbol Name Standardized Value
ANAPC7 anaphase promoting complex subunit 7 2.39646
CDC23 cell division cycle 23 2.14801
ANAPC5 anaphase promoting complex subunit 5 1.64214
CDC16 cell division cycle 16 1.61788
ANAPC1 anaphase promoting complex subunit 1 1.43534
ANAPC2 anaphase promoting complex subunit 2 1.36168
ANAPC4 anaphase promoting complex subunit 4 0.790311
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila) 0.249338
RBBP5 retinoblastoma binding protein 5 0.077484