CDC42 GTPase cycle Gene Set

Dataset Reactome Pathways 2024
Category structural or functional annotations
Type pathway
External Link https://reactome.org/PathwayBrowser/#/R-HSA-9013148
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Genes

155 proteins participating in the CDC42 GTPase cycle pathway from the Reactome Pathways 2024 dataset.

Symbol Name
ABR active BCR-related
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARAP3 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGAP1 Rho GTPase activating protein 1
ARHGAP10 Rho GTPase activating protein 10
ARHGAP11B Rho GTPase activating protein 11B
ARHGAP17 Rho GTPase activating protein 17
ARHGAP20 Rho GTPase activating protein 20
ARHGAP21 Rho GTPase activating protein 21
ARHGAP22 Rho GTPase activating protein 22
ARHGAP24 Rho GTPase activating protein 24
ARHGAP26 Rho GTPase activating protein 26
ARHGAP27 Rho GTPase activating protein 27
ARHGAP29 Rho GTPase activating protein 29
ARHGAP30 Rho GTPase activating protein 30
ARHGAP31 Rho GTPase activating protein 31
ARHGAP32 Rho GTPase activating protein 32
ARHGAP33 Rho GTPase activating protein 33
ARHGAP35 Rho GTPase activating protein 35
ARHGAP39 Rho GTPase activating protein 39
ARHGAP4 Rho GTPase activating protein 4
ARHGAP40 Rho GTPase activating protein 40
ARHGAP42 Rho GTPase activating protein 42
ARHGAP44 Rho GTPase activating protein 44
ARHGAP45 Rho GTPase activating protein 45
ARHGAP5 Rho GTPase activating protein 5
ARHGAP9 Rho GTPase activating protein 9
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF19 Rho guanine nucleotide exchange factor (GEF) 19
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9
BAIAP2 BAI1-associated protein 2
BCR breakpoint cluster region
CAV1 caveolin 1, caveolae protein, 22kDa
CDC42 cell division cycle 42
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5
CDC42SE2 CDC42 small effector 2
CHN1 chimerin 1
CPNE8 copine VIII
DAAM1 dishevelled associated activator of morphogenesis 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DEPDC1B DEP domain containing 1B
DIAPH3 diaphanous-related formin 3
DLC1 DLC1 Rho GTPase activating protein
DNMBP dynamin binding protein
DOCK10 dedicator of cytokinesis 10
DOCK11 dedicator of cytokinesis 11
DOCK6 dedicator of cytokinesis 6
DOCK7 dedicator of cytokinesis 7
DOCK8 dedicator of cytokinesis 8
DOCK9 dedicator of cytokinesis 9
ECT2 epithelial cell transforming 2
FAM13B family with sequence similarity 13, member B
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGD1 FYVE, RhoGEF and PH domain containing 1
FGD2 FYVE, RhoGEF and PH domain containing 2
FGD3 FYVE, RhoGEF and PH domain containing 3
FGD4 FYVE, RhoGEF and PH domain containing 4
FMNL1 formin-like 1
FMNL2 formin-like 2
FMNL3 formin-like 3
FNBP1 formin binding protein 1
FNBP1L formin binding protein 1-like
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GMIP GEM interacting protein
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GOLGA8R golgin A8 family, member R
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
IQGAP3 IQ motif containing GTPase activating protein 3
ITSN1 intersectin 1 (SH3 domain protein)
JUP junction plakoglobin
KCTD3 potassium channel tetramerization domain containing 3
KTN1 kinectin 1 (kinesin receptor)
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
LBR lamin B receptor
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MCF2 MCF.2 cell line derived transforming sequence
MCF2L MCF.2 cell line derived transforming sequence-like
MYO9B myosin IXB
NGEF neuronal guanine nucleotide exchange factor
OPHN1 oligophrenin 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAK5 p21 (RAC1) activated kinase 5
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PARD6A par-6 family cell polarity regulator alpha
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLD1 phospholipase D1, phosphatidylcholine-specific
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4
PLEKHG4B pleckstrin homology domain containing, family G (with RhoGef domain) member 4B
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
RAB7A RAB7A, member RAS oncogene family
RACGAP1 Rac GTPase activating protein 1
RALBP1 ralA binding protein 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
SCRIB scribbled planar cell polarity protein
SH3PXD2A SH3 and PX domains 2A
SHKBP1 SH3KBP1 binding protein 1
SNAP23 synaptosomal-associated protein, 23kDa
SPATA13 spermatogenesis associated 13
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
STARD13 StAR-related lipid transfer (START) domain containing 13
STARD8 StAR-related lipid transfer (START) domain containing 8
STEAP3 STEAP family member 3, metalloreductase
STOM stomatin
SYDE1 synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
TAGAP T-cell activation RhoGTPase activating protein
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TMPO thymopoietin
TRIO trio Rho guanine nucleotide exchange factor
VAMP3 vesicle-associated membrane protein 3
VANGL1 VANGL planar cell polarity protein 1
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
WAS Wiskott-Aldrich syndrome
WASL Wiskott-Aldrich syndrome-like
WDR81 WD repeat domain 81
WDR91 WD repeat domain 91
WIPF1 WAS/WASL interacting protein family, member 1
WIPF2 WAS/WASL interacting protein family, member 2
WIPF3 WAS/WASL interacting protein family, member 3
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)