CDC42 Gene Set

Dataset Hub Proteins Protein-Protein Interactions
Category physical interactions
Type hub protein
Description cell division cycle 42|The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013] (NCBI Entrez Gene Database, 998)
External Link http://www.ncbi.nlm.nih.gov/gene/998
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Genes

187 interacting proteins for hub protein CDC42 from the curated Hub Proteins Protein-Protein Interactions dataset.

Symbol Name
A2M alpha-2-macroglobulin
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA2 annexin A2
APOH apolipoprotein H (beta-2-glycoprotein I)
ARHGAP1 Rho GTPase activating protein 1
ARHGAP10 Rho GTPase activating protein 10
ARHGAP17 Rho GTPase activating protein 17
ARHGAP26 Rho GTPase activating protein 26
ARHGAP27 Rho GTPase activating protein 27
ARHGAP29 Rho GTPase activating protein 29
ARHGAP32 Rho GTPase activating protein 32
ARHGAP35 Rho GTPase activating protein 35
ARHGAP44 Rho GTPase activating protein 44
ARHGAP5 Rho GTPase activating protein 5
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11
ARHGEF25 Rho guanine nucleotide exchange factor (GEF) 25
ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6
ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7
ARRB1 arrestin, beta 1
ARRB2 arrestin, beta 2
BAIAP2 BAI1-associated protein 2
BCR breakpoint cluster region
BIN1 bridging integrator 1
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
BNIPL BCL2/adenovirus E1B 19kD interacting protein like
C14ORF1 chromosome 14 open reading frame 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CDC42 cell division cycle 42
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDC42BPB CDC42 binding protein kinase beta (DMPK-like)
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like)
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC42EP5 CDC42 effector protein (Rho GTPase binding) 5
CDC42SE1 CDC42 small effector 1
CDC42SE2 CDC42 small effector 2
CFHR4 complement factor H-related 4
CHN1 chimerin 1
CLIP1 CAP-GLY domain containing linker protein 1
CNTNAP1 contactin associated protein 1
COX1
CPN1 carboxypeptidase N, polypeptide 1
CSN2 casein beta
CSPG4 chondroitin sulfate proteoglycan 4
CTNND1 catenin (cadherin-associated protein), delta 1
DEF6 differentially expressed in FDCP 6 homolog (mouse)
DIAPH2 diaphanous-related formin 2
DIAPH3 diaphanous-related formin 3
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DOCK7 dedicator of cytokinesis 7
DOCK8 dedicator of cytokinesis 8
DOCK9 dedicator of cytokinesis 9
ECT2 epithelial cell transforming 2
EEF1G eukaryotic translation elongation factor 1 gamma
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERRFI1 ERBB receptor feedback inhibitor 1
ETFA electron-transfer-flavoprotein, alpha polypeptide
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FGD3 FYVE, RhoGEF and PH domain containing 3
FGD4 FYVE, RhoGEF and PH domain containing 4
FLNA filamin A, alpha
FMNL2 formin-like 2
FNBP1 formin binding protein 1
FNBP1L formin binding protein 1-like
FNTA farnesyltransferase, CAAX box, alpha
GDI1 GDP dissociation inhibitor 1
GOPC golgi-associated PDZ and coiled-coil motif containing
GRM1 glutamate receptor, metabotropic 1
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
IQGAP3 IQ motif containing GTPase activating protein 3
ITGB1BP1 integrin beta 1 binding protein 1
ITSN1 intersectin 1 (SH3 domain protein)
KAT5 K(lysine) acetyltransferase 5
KDR kinase insert domain receptor
KIAA2026 KIAA2026
KIN Kin17 DNA and RNA binding protein
KTN1 kinectin 1 (kinesin receptor)
LCK LCK proto-oncogene, Src family tyrosine kinase
LGALS1 lectin, galactoside-binding, soluble, 1
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K10 mitogen-activated protein kinase kinase kinase 10
MAP3K11 mitogen-activated protein kinase kinase kinase 11
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK11 mitogen-activated protein kinase 11
MAPK12 mitogen-activated protein kinase 12
MAPK13 mitogen-activated protein kinase 13
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MARK4 MAP/microtubule affinity-regulating kinase 4
MCF2 MCF.2 cell line derived transforming sequence
MCF2L MCF.2 cell line derived transforming sequence-like
MCM3AP minichromosome maintenance complex component 3 associated protein
METAP2 methionyl aminopeptidase 2
MUC12 mucin 12, cell surface associated
MYO6 myosin VI
MYO9A myosin IXA
NCF2 neutrophil cytosolic factor 2
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NET1 neuroepithelial cell transforming 1
NGEF neuronal guanine nucleotide exchange factor
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NUF2 NUF2, NDC80 kinetochore complex component
OCRL oculocerebrorenal syndrome of Lowe
OPHN1 oligophrenin 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PAK6 p21 protein (Cdc42/Rac)-activated kinase 6
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PARD3 par-3 family cell polarity regulator
PARD6A par-6 family cell polarity regulator alpha
PARD6B par-6 family cell polarity regulator beta
PARD6G par-6 family cell polarity regulator gamma
PDE6D phosphodiesterase 6D, cGMP-specific, rod, delta
PGGT1B protein geranylgeranyltransferase type I, beta subunit
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLD1 phospholipase D1, phosphatidylcholine-specific
PLEKHG2 pleckstrin homology domain containing, family G (with RhoGef domain) member 2
PRKCA protein kinase C, alpha
PRKCG protein kinase C, gamma
PRKCI protein kinase C, iota
PRKCZ protein kinase C, zeta
PRTN3 proteinase 3
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RACGAP1 Rac GTPase activating protein 1
RALBP1 ralA binding protein 1
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RHOJ ras homolog family member J
RIF1 replication timing regulatory factor 1
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPL22 ribosomal protein L22
RPL23 ribosomal protein L23
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
S100A9 S100 calcium binding protein A9
SCRIB scribbled planar cell polarity protein
SH2D1A SH2 domain containing 1A
SH3D19 SH3 domain containing 19
SPI1 Spi-1 proto-oncogene
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1
SRGAP2 SLIT-ROBO Rho GTPase activating protein 2
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAU1 staufen double-stranded RNA binding protein 1
STK24 serine/threonine kinase 24
SYNE1 spectrin repeat containing, nuclear envelope 1
TBC1D3 TBC1 domain family, member 3
TBC1D3F TBC1 domain family, member 3F
TNF tumor necrosis factor
TNK2 tyrosine kinase, non-receptor, 2
TP53 tumor protein p53
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRIM21 tripartite motif containing 21
TRIP10 thyroid hormone receptor interactor 10
UBC ubiquitin C
UBR1 ubiquitin protein ligase E3 component n-recognin 1
UNC119 unc-119 homolog (C. elegans)
VAMP2 vesicle-associated membrane protein 2 (synaptobrevin 2)
VAV1 vav 1 guanine nucleotide exchange factor
VAV2 vav 2 guanine nucleotide exchange factor
VAV3 vav 3 guanine nucleotide exchange factor
VRK2 vaccinia related kinase 2
WAS Wiskott-Aldrich syndrome
WASF1 WAS protein family, member 1
WASF2 WAS protein family, member 2
WASL Wiskott-Aldrich syndrome-like
ZNF175 zinc finger protein 175
ZNF234 zinc finger protein 234