CDC45 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cell division cycle 45|The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] (NCBI Entrez Gene Database, 8318)
External Link http://www.ncbi.nlm.nih.gov/gene/8318
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Genes

232 interacting proteins for CDC45 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABHD10 abhydrolase domain containing 10
ADRA1B adrenoceptor alpha 1B
AGA aspartylglucosaminidase
AHSG alpha-2-HS-glycoprotein
ALB albumin
AMPD3 adenosine monophosphate deaminase 3
ANXA1 annexin A1
AP1M1 adaptor-related protein complex 1, mu 1 subunit
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOC1 apolipoprotein C-I
APOC2 apolipoprotein C-II
APOC3 apolipoprotein C-III
APOE apolipoprotein E
ASPH aspartate beta-hydroxylase
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
BLOC1S5 biogenesis of lysosomal organelles complex-1, subunit 5, muted
BRCA2 breast cancer 2, early onset
C10ORF2 chromosome 10 open reading frame 2
CABLES1 Cdk5 and Abl enzyme substrate 1
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CAMK1G calcium/calmodulin-dependent protein kinase IG
CAMTA1 calmodulin binding transcription activator 1
CCL2 chemokine (C-C motif) ligand 2
CDC37 cell division cycle 37
CDCP1 CUB domain containing protein 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEP44 centrosomal protein 44kDa
CEP78 centrosomal protein 78kDa
CFB complement factor B
CFD complement factor D (adipsin)
CFH complement factor H
CHEK1 checkpoint kinase 1
CHKB choline kinase beta
CIAO1 cytosolic iron-sulfur assembly component 1
CLCA2 chloride channel accessory 2
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLSPN claspin
CNOT1 CCR4-NOT transcription complex, subunit 1
COX11 COX11 cytochrome c oxidase copper chaperone
CRB1 crumbs family member 1, photoreceptor morphogenesis associated
CRNN cornulin
CROT carnitine O-octanoyltransferase
CST3 cystatin C
CTAGE5 CTAGE family, member 5
CTNND1 catenin (cadherin-associated protein), delta 1
CUL3 cullin 3
DCD dermcidin
DDB1 damage-specific DNA binding protein 1, 127kDa
DERL1 derlin 1
DGKG diacylglycerol kinase, gamma 90kDa
DICER1 dicer 1, ribonuclease type III
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila)
DMD dystrophin
DTD1 D-tyrosyl-tRNA deacylase 1
EMILIN3 elastin microfibril interfacer 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
EPDR1 ependymin related 1
EPPK1 epiplakin 1
EXOC6 exocyst complex component 6
F2 coagulation factor II (thrombin)
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAM71E2 family with sequence similarity 71, member E2
FBXO6 F-box protein 6
FGA fibrinogen alpha chain
FN1 fibronectin 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GBAS glioblastoma amplified sequence
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GFAP glial fibrillary acidic protein
GINS4 GINS complex subunit 4 (Sld5 homolog)
GJC2 gap junction protein, gamma 2, 47kDa
GLG1 golgi glycoprotein 1
GPC4 glypican 4
GRAP2 GRB2-related adaptor protein 2
GSN gelsolin
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
HACD3 3-hydroxyacyl-CoA dehydratase 3
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HIST1H3B histone cluster 1, H3b
HLA-H major histocompatibility complex, class I, H (pseudogene)
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HP haptoglobin
HPX hemopexin
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker)
IGKC immunoglobulin kappa constant
INA internexin neuronal intermediate filament protein, alpha
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGB5 integrin, beta 5
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1
JARID2 jumonji, AT rich interactive domain 2
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KEAP1 kelch-like ECH-associated protein 1
KIAA0232 KIAA0232
KIAA1551 KIAA1551
KLK3 kallikrein-related peptidase 3
KRT1 keratin 1, type II
KRT10 keratin 10, type I
KRT13 keratin 13, type I
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT4 keratin 4, type II
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KRT73 keratin 73, type II
KRT9 keratin 9, type I
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LAGE3 L antigen family, member 3
LAT linker for activation of T cells
LDB3 LIM domain binding 3
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MARK2 MAP/microtubule affinity-regulating kinase 2
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MICU1 mitochondrial calcium uptake 1
MICU2 mitochondrial calcium uptake 2
MRPL38 mitochondrial ribosomal protein L38
MRPS9 mitochondrial ribosomal protein S9
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLK3 myosin light chain kinase 3
NBR1 neighbor of BRCA1 gene 1
NCOA3 nuclear receptor coactivator 3
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)
NEDD8 neural precursor cell expressed, developmentally down-regulated 8
NEFM neurofilament, medium polypeptide
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NLRC4 NLR family, CARD domain containing 4
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NSUN4 NOP2/Sun domain family, member 4
OBSL1 obscurin-like 1
OR2T6 olfactory receptor, family 2, subfamily T, member 6
OR3A2 olfactory receptor, family 3, subfamily A, member 2
OR8D2 olfactory receptor, family 8, subfamily D, member 2 (gene/pseudogene)
ORC1 origin recognition complex, subunit 1
ORC2 origin recognition complex, subunit 2
ORC3 origin recognition complex, subunit 3
ORC5 origin recognition complex, subunit 5
ORC6 origin recognition complex, subunit 6
OSBPL8 oxysterol binding protein-like 8
PALB2 partner and localizer of BRCA2
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative)
PCDH1 protocadherin 1
PCED1B PC-esterase domain containing 1B
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PDS5B PDS5 cohesin associated factor B
PDZRN4 PDZ domain containing ring finger 4
PEG3 paternally expressed 3
PF4V1 platelet factor 4 variant 1
PHC3 polyhomeotic homolog 3 (Drosophila)
PLA2G4F phospholipase A2, group IVF
PLAG1 pleiomorphic adenoma gene 1
PLEC plectin
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLD1 polymerase (DNA directed), delta 1, catalytic subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)
PPP4C protein phosphatase 4, catalytic subunit
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PRKCI protein kinase C, iota
PRSS3 protease, serine, 3
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RAD21 RAD21 homolog (S. pombe)
RAD54L2 RAD54-like 2 (S. cerevisiae)
RANBP2 RAN binding protein 2
RANBP3 RAN binding protein 3
RLF rearranged L-myc fusion
RPA2 replication protein A2, 32kDa
RYR2 ryanodine receptor 2 (cardiac)
SACS sacsin molecular chaperone
SARS2 seryl-tRNA synthetase 2, mitochondrial
SAV1 salvador family WW domain containing protein 1
SCAF1 SR-related CTD-associated factor 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SETX senataxin
SGOL2 shugoshin-like 2 (S. pombe)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLA2 Src-like-adaptor 2
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMC3 structural maintenance of chromosomes 3
SORBS3 sorbin and SH3 domain containing 3
SPAST spastin
SPATA31A7 SPATA31 subfamily A, member 7
SQSTM1 sequestosome 1
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STK3 serine/threonine kinase 3
STK4 serine/threonine kinase 4
TCEAL2 transcription elongation factor A (SII)-like 2
THRAP3 thyroid hormone receptor associated protein 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TLN2 talin 2
TMEM160 transmembrane protein 160
TMLHE trimethyllysine hydroxylase, epsilon
TMX1 thioredoxin-related transmembrane protein 1
TOPBP1 topoisomerase (DNA) II binding protein 1
TRAPPC11 trafficking protein particle complex 11
TRAPPC3 trafficking protein particle complex 3
TRMT61B tRNA methyltransferase 61B
TSC22D1 TSC22 domain family, member 1
TTN titin
TTPAL tocopherol (alpha) transfer protein-like
TTR transthyretin
UBC ubiquitin C
VIM vimentin
YME1L1 YME1-like 1 ATPase
ZNF232 zinc finger protein 232
ZNF292 zinc finger protein 292