CDC6 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cell division cycle 6|The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 990)
External Link http://www.ncbi.nlm.nih.gov/gene/990
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Genes

59 interacting proteins for CDC6 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKAP8L A kinase (PRKA) anchor protein 8-like
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
ATRIP ATR interacting protein
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
BCLAF1 BCL2-associated transcription factor 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
CCL2 chemokine (C-C motif) ligand 2
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNE1 cyclin E1
CDC14A cell division cycle 14A
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDT1 chromatin licensing and DNA replication factor 1
E2F1 E2F transcription factor 1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HNF4A hepatocyte nuclear factor 4, alpha
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
JMY junction mediating and regulatory protein, p53 cofactor
KAT7 K(lysine) acetyltransferase 7
MAX MYC associated factor X
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MCM8 minichromosome maintenance complex component 8
MYC v-myc avian myelocytomatosis viral oncogene homolog
ORC1 origin recognition complex, subunit 1
ORC2 origin recognition complex, subunit 2
ORC3 origin recognition complex, subunit 3
ORC5 origin recognition complex, subunit 5
ORC6 origin recognition complex, subunit 6
PCNA proliferating cell nuclear antigen
PLK1 polo-like kinase 1
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit
POLA2 polymerase (DNA directed), alpha 2, accessory subunit
POLE polymerase (DNA directed), epsilon, catalytic subunit
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRIM1 primase, DNA, polypeptide 1 (49kDa)
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PSKH1 protein serine kinase H1
RB1 retinoblastoma 1
RPS27A ribosomal protein S27a
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
UBB ubiquitin B
UBC ubiquitin C
UBE2K ubiquitin-conjugating enzyme E2K