CDH1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cadherin 1, type 1, E-cadherin (epithelial)|This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 999)
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Genes

308 genes differentially expressed following the CDH1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
DNASE1L2 deoxyribonuclease I-like 2 2.53441
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.53441
TLX3 T-cell leukemia homeobox 3 2.53441
ASPA aspartoacylase 2.53441
PLXNB3 plexin B3 2.53441
GIMAP4 GTPase, IMAP family member 4 2.53441
SPINT3 serine peptidase inhibitor, Kunitz type, 3 2.53441
MNS1 meiosis-specific nuclear structural 1 2.53441
CXCL8 chemokine (C-X-C motif) ligand 8 2.53441
KATNA1 katanin p60 (ATPase containing) subunit A 1 2.53441
TUBB1 tubulin, beta 1 class VI 2.53441
SIGLEC7 sialic acid binding Ig-like lectin 7 2.53441
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha) 2.53441
PDYN prodynorphin 2.53441
IER2 immediate early response 2 2.53441
MYBPC3 myosin binding protein C, cardiac 2.53441
ZBTB45 zinc finger and BTB domain containing 45 2.53441
C8ORF48 chromosome 8 open reading frame 48 2.53441
MTTP microsomal triglyceride transfer protein 2.53441
DSG3 desmoglein 3 2.53441
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.53441
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.53441
SPP2 secreted phosphoprotein 2, 24kDa 2.53441
SMIM5 small integral membrane protein 5 2.53441
CD69 CD69 molecule 2.53441
PGA5 pepsinogen 5, group I (pepsinogen A) 2.53441
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.53441
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.53441
ANKRD30B ankyrin repeat domain 30B 2.53441
CD226 CD226 molecule 2.53441
DEFB126 defensin, beta 126 2.53441
LPO lactoperoxidase 2.53441
OR4M2 olfactory receptor, family 4, subfamily M, member 2 2.53441
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.53441
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.53441
CFAP54 cilia and flagella associated 54 2.53441
NMUR2 neuromedin U receptor 2 2.53441
TTLL8 tubulin tyrosine ligase-like family member 8 2.53441
ACVRL1 activin A receptor type II-like 1 2.53441
LRRC61 leucine rich repeat containing 61 2.53441
MRPS34 mitochondrial ribosomal protein S34 2.53441
BMP3 bone morphogenetic protein 3 2.53441
BMP5 bone morphogenetic protein 5 2.53441
CPLX1 complexin 1 2.53441
OVCH1 ovochymase 1 2.53441
MPP4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) 2.53441
CKAP2L cytoskeleton associated protein 2-like 2.53441
FGL2 fibrinogen-like 2 2.53441
C3ORF85 chromosome 3 open reading frame 85 2.53441
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.53441
NEURL3 neuralized E3 ubiquitin protein ligase 3 2.53441
MYL10 myosin, light chain 10, regulatory 2.53441
TSPAN9 tetraspanin 9 2.53441
TSPAN8 tetraspanin 8 2.53441
ACE2 angiotensin I converting enzyme 2 2.53441
BARX2 BARX homeobox 2 2.53441
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.53441
GSC goosecoid homeobox 2.53441
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.53441
TYROBP TYRO protein tyrosine kinase binding protein 2.53441
SLC7A13 solute carrier family 7 (anionic amino acid transporter), member 13 2.53441
FAM240A family with sequence similarity 240 member A 2.53441
CPNE8-AS1 CPNE8 antisense RNA 1 2.53441
H2BC8 H2B clustered histone 8 2.53441
GSTT4 glutathione S-transferase theta 4 2.53441
NFILZ NFIL3 like basic leucine zipper 2.53441
PLPPR1 phospholipid phosphatase related 1 2.53441
TCEAL9 transcription elongation factor A like 9 2.53441
SLURP2 secreted LY6/PLAUR domain containing 2 2.53441
H2BC1 H2B clustered histone 1 2.53441
S100G S100 calcium binding protein G 2.53441
TFEC transcription factor EC 2.53441
DNASE2B deoxyribonuclease II beta 2.53441
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 2.53441
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 2.53441
CAMKV CaM kinase-like vesicle-associated 2.53441
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.53441
MYBPHL myosin binding protein H-like 2.53441
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.53441
ZBTB5 zinc finger and BTB domain containing 5 2.53441
ZNF503 zinc finger protein 503 2.53441
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.53441
MS4A6E membrane-spanning 4-domains, subfamily A, member 6E 2.53441
KLHL35 kelch-like family member 35 2.53441
CES1 carboxylesterase 1 2.53441
CXCL16 chemokine (C-X-C motif) ligand 16 2.53441
OR2AT4 olfactory receptor, family 2, subfamily AT, member 4 2.53441
C10ORF67 chromosome 10 open reading frame 67 2.53441
HPR haptoglobin-related protein 2.53441
GHSR growth hormone secretagogue receptor 2.53441
CLEC3A C-type lectin domain family 3, member A 2.53441
IL12RB1 interleukin 12 receptor, beta 1 2.53441
PTTG2 pituitary tumor-transforming 2 2.53441
FRMD7 FERM domain containing 7 2.53441
SPINK4 serine peptidase inhibitor, Kazal type 4 2.53441
PSG6 pregnancy specific beta-1-glycoprotein 6 2.53441
OR8J1 olfactory receptor, family 8, subfamily J, member 1 2.53441
GLT1D1 glycosyltransferase 1 domain containing 1 2.53441
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.53441
ERICH6B glutamate-rich 6B 2.53441
AQP3 aquaporin 3 (Gill blood group) 2.53441
ADGRA1 adhesion G protein-coupled receptor A1 2.53441
EDN2 endothelin 2 2.53441
SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 2.53441
PALMD palmdelphin 2.53441
PCDHGB1 protocadherin gamma subfamily B, 1 2.53441
PCDHGB4 protocadherin gamma subfamily B, 4 2.53441
MORC1 MORC family CW-type zinc finger 1 2.53441
BMX BMX non-receptor tyrosine kinase 2.53441
HS3ST6 heparan sulfate (glucosamine) 3-O-sulfotransferase 6 2.53441
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.53441
HSF4 heat shock transcription factor 4 2.53441
IL12A interleukin 12A 2.53441
SERINC4 serine incorporator 4 2.53441
TCP11X1 t-complex 11 family, X-linked 1 2.53441
APOC4 apolipoprotein C-IV 2.53441
OR52N5 olfactory receptor, family 52, subfamily N, member 5 2.53441
SOSTDC1 sclerostin domain containing 1 2.53441
CD27 CD27 molecule 2.53441
TMPPE transmembrane protein with metallophosphoesterase domain 2.53441
PRH2 proline-rich protein HaeIII subfamily 2 2.53441
PRSS38 protease, serine, 38 2.53441
SPHKAP SPHK1 interactor, AKAP domain containing 2.53441
SIGLEC16 sialic acid binding Ig-like lectin 16 (gene/pseudogene) 2.53441
TF transferrin 2.53441
MNDA myeloid cell nuclear differentiation antigen 2.53441
OR13G1 olfactory receptor, family 13, subfamily G, member 1 2.53441
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 2.53441
NKX6-2 NK6 homeobox 2 2.53441
HRCT1 histidine rich carboxyl terminus 1 2.53441
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.53441
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 2.53441
FAIM2 Fas apoptotic inhibitory molecule 2 2.53441
ACLY ATP citrate lyase 2.53441
GOLGA8K golgin A8 family, member K 2.53441
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) 2.53441
CD80 CD80 molecule 2.53441
REN renin 2.53441
MSLN mesothelin 2.53441
LRRC31 leucine rich repeat containing 31 2.53441
SPRYD7 SPRY domain containing 7 2.53441
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.53441
SLC36A2 solute carrier family 36 (proton/amino acid symporter), member 2 2.53441
TMPRSS13 transmembrane protease, serine 13 2.53441
TEX38 testis expressed 38 2.53441
CLCNKB chloride channel, voltage-sensitive Kb 2.53441
IFNK interferon, kappa 2.53441
FRMPD1 FERM and PDZ domain containing 1 2.53441
TGM3 transglutaminase 3 2.53441
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) 2.53441
PF4V1 platelet factor 4 variant 1 2.53441
BTG4 B-cell translocation gene 4 2.53441
LGALS9C lectin, galactoside-binding, soluble, 9C 2.53441
EPX eosinophil peroxidase 2.53441
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) 2.53441
PRSS54 protease, serine, 54 2.53441
FZD1 frizzled class receptor 1 2.53441
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 2.53441
TBC1D28 TBC1 domain family, member 28 2.53441
POTEI POTE ankyrin domain family, member I 2.53441
SLITRK1 SLIT and NTRK-like family, member 1 2.53441
FGFR4 fibroblast growth factor receptor 4 2.4962
WNT3 wingless-type MMTV integration site family, member 3 2.47127
LRP2BP LRP2 binding protein 2.44835
H2AC14 H2A clustered histone 14 2.4446
S100Z S100 calcium binding protein Z 2.4446
VPS39 vacuolar protein sorting 39 homolog (S. cerevisiae) 2.4446
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) 2.4446
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16 2.43991
TRAPPC2L trafficking protein particle complex 2-like 2.43991
H4C11 H4 clustered histone 11 2.37933
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 2.37085
ADAP1 ArfGAP with dual PH domains 1 2.36561
POLE4 polymerase (DNA-directed), epsilon 4, accessory subunit 2.36382
ANKS3 ankyrin repeat and sterile alpha motif domain containing 3 2.35768
CD83 CD83 molecule 2.35768
MEX3D mex-3 RNA binding family member D 2.34816
ZSCAN31 zinc finger and SCAN domain containing 31 2.33519
ARG2 arginase 2 2.33515
FRK fyn-related Src family tyrosine kinase 2.33503
SLCO1C1 solute carrier organic anion transporter family, member 1C1 2.3162
UTP18 UTP18 small subunit (SSU) processome component homolog (yeast) 2.28022
KDM4D lysine (K)-specific demethylase 4D 2.27979
VSIG10L V-set and immunoglobulin domain containing 10 like 2.25702
GFPT2 glutamine-fructose-6-phosphate transaminase 2 2.25701
DUS4L dihydrouridine synthase 4-like (S. cerevisiae) 2.19375
ACTB actin, beta 2.19361
CCDC22 coiled-coil domain containing 22 2.1747
NTMT2 N-terminal Xaa-Pro-Lys N-methyltransferase 2 2.16319
TMEM37 transmembrane protein 37 2.1592
WDR1 WD repeat domain 1 2.1592
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like 2.15711
PLCD1 phospholipase C, delta 1 2.13702
TST thiosulfate sulfurtransferase (rhodanese) 2.13227
TSPAN10 tetraspanin 10 2.11523
ZBTB38 zinc finger and BTB domain containing 38 2.09984
TARS1 threonyl-tRNA synthetase 1 2.09177
AHSP alpha hemoglobin stabilizing protein 2.08372
NBPF1 neuroblastoma breakpoint family, member 1 2.07469
DCTN4 dynactin 4 (p62) 2.07453
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 2.06818
BUD13 BUD13 homolog (S. cerevisiae) 2.05
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa 2.0204
ETF1 eukaryotic translation termination factor 1 2.01215
EIF4A1 eukaryotic translation initiation factor 4A1 2.00893
FBN3 fibrillin 3 2.00606
GLS glutaminase 2.00585
KDM1B lysine (K)-specific demethylase 1B 2.00585
MRPL17 mitochondrial ribosomal protein L17 2.0025
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa 2.00141
TRIM13 tripartite motif containing 13 2.00111
SRSF10 serine/arginine-rich splicing factor 10 2.00111

decreased expression

Symbol Name Standardized Value
ANKRD42-DT ANKRD42 divergent transcript -2.53441
HBZ hemoglobin, zeta -2.53441
IL2RB interleukin 2 receptor, beta -2.53441
PLA2G10 phospholipase A2, group X -2.53441
RAB36 RAB36, member RAS oncogene family -2.53441
EYA4 EYA transcriptional coactivator and phosphatase 4 -2.53441
NLRP3 NLR family, pyrin domain containing 3 -2.53441
MMP16 matrix metallopeptidase 16 (membrane-inserted) -2.53441
PGM5 phosphoglucomutase 5 -2.53441
MSH4 mutS homolog 4 -2.53441
MUSK muscle, skeletal, receptor tyrosine kinase -2.53441
FSTL1 follistatin-like 1 -2.53441
C5AR1 complement component 5a receptor 1 -2.53441
LCN10 lipocalin 10 -2.53441
GIP gastric inhibitory polypeptide -2.53441
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -2.53441
ACP7 acid phosphatase 7, tartrate resistant (putative) -2.53441
PLPP4 phospholipid phosphatase 4 -2.53441
EPOP elongin BC and polycomb repressive complex 2 associated protein -2.53441
GPR34 G protein-coupled receptor 34 -2.53441
ACSL5 acyl-CoA synthetase long-chain family member 5 -2.53441
S100B S100 calcium binding protein B -2.53441
CAPN14 calpain 14 -2.53441
ZNF98 zinc finger protein 98 -2.53441
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma -2.53441
SMOC1 SPARC related modular calcium binding 1 -2.53441
CDH1 cadherin 1, type 1, E-cadherin (epithelial) -2.53441
ZNF492 zinc finger protein 492 -2.53441
RPA4 replication protein A4, 30kDa -2.53441
INSC inscuteable homolog (Drosophila) -2.53441
SHOX2 short stature homeobox 2 -2.53441
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -2.53441
PLD1 phospholipase D1, phosphatidylcholine-specific -2.53441
CYS1 cystin 1 -2.53441
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 -2.53441
GPRC6A G protein-coupled receptor, class C, group 6, member A -2.53441
NOTCH4 notch 4 -2.53441
TBC1D10C TBC1 domain family, member 10C -2.53441
SEZ6L seizure related 6 homolog (mouse)-like -2.53441
UPK1A uroplakin 1A -2.53441
CTSL cathepsin L -2.46665
CD70 CD70 molecule -2.45222
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 -2.45222
FAM209B family with sequence similarity 209, member B -2.45222
PEX1 peroxisomal biogenesis factor 1 -2.4446
ZBTB7C zinc finger and BTB domain containing 7C -2.44359
KRABD4 KRAB domain containing 4 -2.44275
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 -2.43476
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit -2.41229
PARP14 poly (ADP-ribose) polymerase family, member 14 -2.37738
TLN1 talin 1 -2.36108
TRIM58 tripartite motif containing 58 -2.36108
ZNF608 zinc finger protein 608 -2.34816
SFSWAP splicing factor, suppressor of white-apricot family -2.33519
SOS1 son of sevenless homolog 1 (Drosophila) -2.3162
LY75 lymphocyte antigen 75 -2.3162
KCTD2 potassium channel tetramerization domain containing 2 -2.28022
TOGARAM2 TOG array regulator of axonemal microtubules 2 -2.26341
PLEKHN1 pleckstrin homology domain containing, family N member 1 -2.25996
ADM5 adrenomedullin 5 (putative) -2.25996
RNF227 ring finger protein 227 -2.25996
TERF1 telomeric repeat binding factor (NIMA-interacting) 1 -2.23827
CYFIP1 cytoplasmic FMR1 interacting protein 1 -2.21738
MAPK6 mitogen-activated protein kinase 6 -2.21231
SALL2 spalt-like transcription factor 2 -2.17609
PDE7A phosphodiesterase 7A -2.1747
PBX4 pre-B-cell leukemia homeobox 4 -2.16845
DCAKD dephospho-CoA kinase domain containing -2.16193
TMEM19 transmembrane protein 19 -2.1592
RFTN1 raftlin, lipid raft linker 1 -2.13702
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 -2.13573
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 -2.11721
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia) -2.113
TMEM170A transmembrane protein 170A -2.11277
PCDHGA7 protocadherin gamma subfamily A, 7 -2.11204
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) -2.09411
ZNF589 zinc finger protein 589 -2.08935
TMEM61 transmembrane protein 61 -2.08488
EGFL8 EGF-like-domain, multiple 8 -2.07469
SGMS2 sphingomyelin synthase 2 -2.0729
ZC3H12C zinc finger CCCH-type containing 12C -2.07142
ANKRD16 ankyrin repeat domain 16 -2.06956
PABPC1 poly(A) binding protein, cytoplasmic 1 -2.06818
CAMKMT calmodulin-lysine N-methyltransferase -2.06204
ZNF470 zinc finger protein 470 -2.05137
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -2.02417
COBLL1 cordon-bleu WH2 repeat protein-like 1 -2.02243
KDM5A lysine (K)-specific demethylase 5A -2.01176
CCDC196 coiled-coil domain containing 196 -2.00606
RAB9B RAB9B, member RAS oncogene family -2.00606
MTURN maturin, neural progenitor differentiation regulator homolog (Xenopus) -2.00606
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 -2.00606
LDB3 LIM domain binding 3 -2.00606
ZSWIM1 zinc finger, SWIM-type containing 1 -2.00606
KCNG2 potassium channel, voltage gated modifier subfamily G, member 2 -2.00606
MARK1 MAP/microtubule affinity-regulating kinase 1 -2.00399