CDH1 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description cadherin 1, type 1, E-cadherin (epithelial)|This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 999)
External Link https://ncbi.nlm.nih.gov/gene/999
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Genes

498 genes differentially expressed following the CDH1 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
IGFBP5 insulin-like growth factor binding protein 5 0.0164305
MGP matrix Gla protein 0.0164036
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.0143932
PROM1 prominin 1 0.0134353
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 0.0132422
CXCL14 chemokine (C-X-C motif) ligand 14 0.0130552
MT1X metallothionein 1X 0.0124314
ASS1 argininosuccinate synthase 1 0.0123912
MT1H metallothionein 1H 0.0118608
SFRP1 secreted frizzled-related protein 1 0.0115652
MYH11 myosin, heavy chain 11, smooth muscle 0.0114842
HSPB1 heat shock 27kDa protein 1 0.0111741
MT1E metallothionein 1E 0.0111346
CRYAB crystallin, alpha B 0.0111132
CRABP1 cellular retinoic acid binding protein 1 0.0108317
PLK1 polo-like kinase 1 0.0108245
MT1HL1 metallothionein 1H-like 1 0.0108113
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 0.0106796
MT1G metallothionein 1G 0.0106073
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1 0.0105572
MATN2 matrilin 2 0.0103674
OLFM4 olfactomedin 4 0.0103064
SYNM synemin, intermediate filament protein 0.010303
LAMP5 lysosomal-associated membrane protein family, member 5 0.0101411
CALCA calcitonin-related polypeptide alpha 0.00995477
NEFM neurofilament, medium polypeptide 0.00993846
TUBB2B tubulin, beta 2B class IIb 0.00993081
METTL7A methyltransferase like 7A 0.00991236
TFF1 trefoil factor 1 0.00989192
HOXC6 homeobox C6 0.00972358
INSR insulin receptor 0.00971393
CLDN3 claudin 3 0.00924618
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.00921108
CYBA cytochrome b-245, alpha polypeptide 0.0092017
SRPX sushi-repeat containing protein, X-linked 0.00917593
MT1F metallothionein 1F 0.00905947
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 0.00901317
XPO7 exportin 7 0.00900418
THBS4 thrombospondin 4 0.008995
OLFM1 olfactomedin 1 0.00897012
PEBP1 phosphatidylethanolamine binding protein 1 0.00891689
TCTA T-cell leukemia translocation altered 0.00889295
BEX1 brain expressed, X-linked 1 0.008889
ACAA2 acetyl-CoA acyltransferase 2 0.00882694
CXCL12 chemokine (C-X-C motif) ligand 12 0.0087401
PBX3 pre-B-cell leukemia homeobox 3 0.00872716
ASCL1 achaete-scute family bHLH transcription factor 1 0.00866992
CARMIL1 capping protein regulator and myosin 1 linker 1 0.00854751
MAB21L2 mab-21-like 2 (C. elegans) 0.00853104
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.00850192
MT2A metallothionein 2A 0.00842852
RELN reelin 0.00840537
DCLK1 doublecortin-like kinase 1 0.00837166
DES desmin 0.00836631
ZIC1 Zic family member 1 0.00835558
GNAS GNAS complex locus 0.008329
BPIFA1 BPI fold containing family A, member 1 0.00831928
FBP1 fructose-1,6-bisphosphatase 1 0.00819258
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.00818547
STC1 stanniocalcin 1 0.00811859
RET ret proto-oncogene 0.00811398
HOXC10 homeobox C10 0.0080605
MAGEA12 melanoma antigen family A12 0.00804417
RGS5 regulator of G-protein signaling 5 0.00798625
POSTN periostin, osteoblast specific factor 0.00793964
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5 0.00786335
FCGBP Fc fragment of IgG binding protein 0.00781373
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 0.00778829
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 0.00778818
TFF3 trefoil factor 3 (intestinal) 0.00776606
THBS2 thrombospondin 2 0.00775659
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.00775288
TTC39A tetratricopeptide repeat domain 39A 0.00773956
OPHN1 oligophrenin 1 0.00763363
PCOLCE procollagen C-endopeptidase enhancer 0.0075832
CCN2 cellular communication network factor 2 0.00757172
CHGB chromogranin B 0.00751871
LYZ lysozyme 0.00748382
NR2F2 nuclear receptor subfamily 2, group F, member 2 0.00748024
GSTT1 glutathione S-transferase theta 1 0.00747106
TSPYL5 TSPY-like 5 0.00746943
NES nestin 0.00742648
HSPB8 heat shock 22kDa protein 8 0.00739337
TNNC1 troponin C type 1 (slow) 0.00739202
QPRT quinolinate phosphoribosyltransferase 0.00736933
ACTG2 actin, gamma 2, smooth muscle, enteric 0.00735945
MEN1 multiple endocrine neoplasia I 0.00731642
MX2 MX dynamin-like GTPase 2 0.0073131
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family) 0.00729536
CDC20 cell division cycle 20 0.00727928
CTSE cathepsin E 0.00726233
ATP5F1D ATP synthase F1 subunit delta 0.00722815
CCL21 chemokine (C-C motif) ligand 21 0.00715517
GPC3 glypican 3 0.00714228
ANK2 ankyrin 2, neuronal 0.00712202
APOD apolipoprotein D 0.00711934
MTUS1 microtubule associated tumor suppressor 1 0.00709736
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.00705106
LIPG lipase, endothelial 0.00702144
TPBG trophoblast glycoprotein 0.00700367
CREB3L1 cAMP responsive element binding protein 3-like 1 0.00697585
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 0.00697383
KLF6 Kruppel-like factor 6 0.00695159
NEBL nebulette 0.00694587
SETBP1 SET binding protein 1 0.00692853
PLIN2 perilipin 2 0.00689866
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 0.00687252
ZMYND8 zinc finger, MYND-type containing 8 0.00686194
LEFTY1 left-right determination factor 1 0.00685692
H2AFV H2A histone family, member V 0.00685093
PLN phospholamban 0.00683295
C3ORF14 chromosome 3 open reading frame 14 0.00682094
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.00681835
TENT5A terminal nucleotidyltransferase 5A 0.00681115
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.00680437
GOLGA8A golgin A8 family, member A 0.00680089
ENO2 enolase 2 (gamma, neuronal) 0.00679648
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.00672403
MUC2 mucin 2, oligomeric mucus/gel-forming 0.00671052
MXRA8 matrix-remodelling associated 8 0.00669912
LMO3 LIM domain only 3 (rhombotin-like 2) 0.00669828
IGFBP2 insulin-like growth factor binding protein 2, 36kDa 0.00667533
MFAP4 microfibrillar-associated protein 4 0.00661513
MMP3 matrix metallopeptidase 3 0.00660189
PCP4 Purkinje cell protein 4 0.00659603
STEAP3 STEAP family member 3, metalloreductase 0.00657906
NFIB nuclear factor I/B 0.00656447
FHL1 four and a half LIM domains 1 0.00654139
AEBP1 AE binding protein 1 0.00653516
COL16A1 collagen, type XVI, alpha 1 0.00649333
FXR1 fragile X mental retardation, autosomal homolog 1 0.0064862
DST dystonin 0.00647585
GNA14 guanine nucleotide binding protein (G protein), alpha 14 0.00646456
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.00646037
C14ORF132 chromosome 14 open reading frame 132 0.00641489
SASH1 SAM and SH3 domain containing 1 0.00639802
JUND jun D proto-oncogene 0.00636511
LY6E lymphocyte antigen 6 complex, locus E 0.00636499
IL6 interleukin 6 0.00635083
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 0.00632744
CLTB clathrin, light chain B 0.00632637
COL9A3 collagen, type IX, alpha 3 0.00628885
PRPH peripherin 0.00628201
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G 0.00628123
NUDC nudC nuclear distribution protein 0.00626817
LGALS4 lectin, galactoside-binding, soluble, 4 0.00626366
MAPRE2 microtubule-associated protein, RP/EB family, member 2 0.00620989
FGFR1 fibroblast growth factor receptor 1 0.00620535
C7 complement component 7 0.00619754
NR2F6 nuclear receptor subfamily 2, group F, member 6 0.00619312
TP53 tumor protein p53 0.00619119
DKFZP586I1420 uncharacterized protein DKFZp586I1420 0.00617608
TCTN2 tectonic family member 2 0.00614983
DLK1 delta-like 1 homolog (Drosophila) 0.0061379
DMBT1 deleted in malignant brain tumors 1 0.00609772
MX1 MX dynamin-like GTPase 1 0.00609431
WDTC1 WD and tetratricopeptide repeats 1 0.00607155
NNAT neuronatin 0.00605651
OXTR oxytocin receptor 0.00605299
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial 0.00604367
AATF apoptosis antagonizing transcription factor 0.00603284
ELN elastin 0.00602734
SPRY2 sprouty homolog 2 (Drosophila) 0.00602481
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor 0.00602122
KIF3B kinesin family member 3B 0.00600303
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3 0.00599708
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase 0.00598602
DBN1 drebrin 1 0.00596064
FLNC filamin C, gamma 0.00594922
L1CAM L1 cell adhesion molecule 0.00590314
MAT2A methionine adenosyltransferase II, alpha 0.00590263
FAM222B family with sequence similarity 222, member B 0.00587559
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.00586922
SLIT2 slit homolog 2 (Drosophila) 0.00586832
FMO2 flavin containing monooxygenase 2 (non-functional) 0.00586526
ADGRA3 adhesion G protein-coupled receptor A3 0.00585132
ZMAT3 zinc finger, matrin-type 3 0.00584924
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 0.00584775
NUTF2 nuclear transport factor 2 0.00584095
TGFBR3 transforming growth factor, beta receptor III 0.00583019
NCAM1 neural cell adhesion molecule 1 0.00583
RPS4Y1 ribosomal protein S4, Y-linked 1 0.00581772
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 0.00581668
NTRK3 neurotrophic tyrosine kinase, receptor, type 3 0.00581247
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 0.00581084
MYL9 myosin, light chain 9, regulatory 0.00580256
ZMAT4 zinc finger, matrin-type 4 0.00579727
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 0.00579555
PLAAT3 phospholipase A and acyltransferase 3 0.00575507
CLCA1 chloride channel accessory 1 0.00574767
EPCAM epithelial cell adhesion molecule 0.00573339
SSBP2 single-stranded DNA binding protein 2 0.00571927
ABHD2 abhydrolase domain containing 2 0.00571534
SPRED2 sprouty-related, EVH1 domain containing 2 0.00571328
FKBP5 FK506 binding protein 5 0.00571311
HNRNPL heterogeneous nuclear ribonucleoprotein L 0.00571301
SDC2 syndecan 2 0.00571292
TUBB3 tubulin, beta 3 class III 0.00571072
CCNI cyclin I 0.00568601
ARMCX2 armadillo repeat containing, X-linked 2 0.0056768
HOMER1 homer scaffolding protein 1 0.00564746
CPT1A carnitine palmitoyltransferase 1A (liver) 0.00563758
MAOB monoamine oxidase B 0.00562336
TPX2 TPX2, microtubule-associated 0.00561479
ATP2A3 ATPase, Ca++ transporting, ubiquitous 0.00561403
DKK1 dickkopf WNT signaling pathway inhibitor 1 0.00561124
RGS4 regulator of G-protein signaling 4 0.005611
HYOU1 hypoxia up-regulated 1 0.00560461
CAPN6 calpain 6 0.00559518
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 0.00559481
LOC283683 uncharacterized LOC283683 0.0055902
RETREG1 reticulophagy regulator 1 0.0055808
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.00556648
L1TD1 LINE-1 type transposase domain containing 1 0.00556235
KDM5D lysine (K)-specific demethylase 5D 0.00554264
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 0.00552704
DACT1 dishevelled-binding antagonist of beta-catenin 1 0.00549245
IL17RB interleukin 17 receptor B 0.00548763
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.00548482
GOLGA8H golgin A8 family, member H 0.00547371
SF3A2 splicing factor 3a, subunit 2, 66kDa 0.00546811
FABP1 fatty acid binding protein 1, liver 0.0054617
PLEKHJ1 pleckstrin homology domain containing, family J member 1 0.00545926
CIRBP cold inducible RNA binding protein 0.00545302
TCF7 transcription factor 7 (T-cell specific, HMG-box) 0.00544654
OBSL1 obscurin-like 1 0.00543747
GSE1 Gse1 coiled-coil protein 0.00543518
ZBTB18 zinc finger and BTB domain containing 18 0.00543458
RASA4 RAS p21 protein activator 4 0.00543391
FAXDC2 fatty acid hydroxylase domain containing 2 0.00543029
ACTC1 actin, alpha, cardiac muscle 1 0.00542454
PFKL phosphofructokinase, liver 0.00540849
RBM34 RNA binding motif protein 34 0.00539623
PDLIM3 PDZ and LIM domain 3 0.00539548
EGR1 early growth response 1 0.00538938
PIMREG PICALM interacting mitotic regulator 0.0053485
OXA1L oxidase (cytochrome c) assembly 1-like 0.00534312
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa 0.00533493
ESRP2 epithelial splicing regulatory protein 2 0.00532228
SOBP sine oculis binding protein homolog (Drosophila) 0.00531887
FAM189A2 family with sequence similarity 189, member A2 0.00530977
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase 0.00530908
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2 0.00529698
ACAT1 acetyl-CoA acetyltransferase 1 0.00529117
ARMCX1 armadillo repeat containing, X-linked 1 0.00528907
LRP4 low density lipoprotein receptor-related protein 4 0.00527781
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.00527664
EIF5B eukaryotic translation initiation factor 5B 0.00527324
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0052674
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 0.00526273

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.016162
GJA1 gap junction protein, alpha 1, 43kDa -0.0148732
MAP7 microtubule-associated protein 7 -0.0146948
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 -0.0143026
RGCC regulator of cell cycle -0.0138074
CSTA cystatin A (stefin A) -0.0134667
CXCL10 chemokine (C-X-C motif) ligand 10 -0.0133125
TFEC transcription factor EC -0.0131536
CXCL11 chemokine (C-X-C motif) ligand 11 -0.0125431
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0124165
ANXA1 annexin A1 -0.0122557
BASP1 brain abundant, membrane attached signal protein 1 -0.0120728
S100A8 S100 calcium binding protein A8 -0.0118692
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) -0.0115605
TACSTD2 tumor-associated calcium signal transducer 2 -0.0113745
HOPX HOP homeobox -0.0111925
EREG epiregulin -0.0111354
CD69 CD69 molecule -0.0110761
GRB7 growth factor receptor-bound protein 7 -0.0110623
S100A9 S100 calcium binding protein A9 -0.0108141
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) -0.0108106
CAV2 caveolin 2 -0.0107081
KRT14 keratin 14, type I -0.0105923
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -0.010573
CPA3 carboxypeptidase A3 (mast cell) -0.0104794
CHN1 chimerin 1 -0.010075
VCAM1 vascular cell adhesion molecule 1 -0.0100387
S100A2 S100 calcium binding protein A2 -0.0100317
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -0.00995959
GBP1 guanylate binding protein 1, interferon-inducible -0.00989517
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 -0.0098798
FXYD3 FXYD domain containing ion transport regulator 3 -0.00978149
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -0.00972335
TPSAB1 tryptase alpha/beta 1 -0.00949284
ADO 2-aminoethanethiol (cysteamine) dioxygenase -0.00943428
CXCL13 chemokine (C-X-C motif) ligand 13 -0.00942476
SNAI2 snail family zinc finger 2 -0.00934632
KRT17 keratin 17, type I -0.00934238
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) -0.00932444
PTP4A1 protein tyrosine phosphatase type IVA, member 1 -0.00924013
DYNLT1 dynein, light chain, Tctex-type 1 -0.00923141
GPR65 G protein-coupled receptor 65 -0.00904898
PEA15 phosphoprotein enriched in astrocytes 15 -0.00902011
SOD2 superoxide dismutase 2, mitochondrial -0.00892983
KLK8 kallikrein-related peptidase 8 -0.00886846
TRAM1 translocation associated membrane protein 1 -0.00885298
HPGDS hematopoietic prostaglandin D synthase -0.00885201
MNDA myeloid cell nuclear differentiation antigen -0.00882262
CD86 CD86 molecule -0.00878996
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.00872934
RNF167 ring finger protein 167 -0.00869661
PERP PERP, TP53 apoptosis effector -0.00863184
EVI2A ecotropic viral integration site 2A -0.00861962
GLIPR1 GLI pathogenesis-related 1 -0.00858646
LY96 lymphocyte antigen 96 -0.00856401
SRGN serglycin -0.00855754
CLDND1 claudin domain containing 1 -0.00853107
KRT6A keratin 6A, type II -0.00852825
ELOVL5 ELOVL fatty acid elongase 5 -0.00844595
FRMD4B FERM domain containing 4B -0.00843878
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide -0.00841955
CAV1 caveolin 1, caveolae protein, 22kDa -0.00841438
RGS1 regulator of G-protein signaling 1 -0.00840175
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -0.00835724
WT1 Wilms tumor 1 -0.00833441
CD34 CD34 molecule -0.00832063
PLAU plasminogen activator, urokinase -0.00829684
KRT5 keratin 5, type II -0.00829183
CD59 CD59 molecule, complement regulatory protein -0.00821511
SGK1 serum/glucocorticoid regulated kinase 1 -0.00814723
IQCG IQ motif containing G -0.0080848
ADIRF adipogenesis regulatory factor -0.0080816
COL4A5 collagen, type IV, alpha 5 -0.00803979
CXCL9 chemokine (C-X-C motif) ligand 9 -0.00802147
CD48 CD48 molecule -0.00794797
CA2 carbonic anhydrase II -0.00793361
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 -0.00792644
SAR1B secretion associated, Ras related GTPase 1B -0.00792033
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 -0.00790867
RIN2 Ras and Rab interactor 2 -0.00787274
EFNB2 ephrin-B2 -0.00787163
HBB hemoglobin, beta -0.00782811
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 -0.00772738
PTGER4 prostaglandin E receptor 4 (subtype EP4) -0.0076618
CLEC2B C-type lectin domain family 2, member B -0.0076612
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase) -0.00763601
GSAP gamma-secretase activating protein -0.00759135
TMEM106B transmembrane protein 106B -0.00757883
OPN3 opsin 3 -0.00754927
HCRT hypocretin (orexin) neuropeptide precursor -0.00752296
TSC22D1 TSC22 domain family, member 1 -0.00750826
BLVRB biliverdin reductase B -0.00749632
GPX1 glutathione peroxidase 1 -0.00747954
MET MET proto-oncogene, receptor tyrosine kinase -0.00747696
GZMK granzyme K (granzyme 3; tryptase II) -0.00745831
CLEC2D C-type lectin domain family 2, member D -0.00744854
SAMSN1 SAM domain, SH3 domain and nuclear localization signals 1 -0.00741996
CYB5R4 cytochrome b5 reductase 4 -0.00741986
KRT13 keratin 13, type I -0.00741556
GIMAP4 GTPase, IMAP family member 4 -0.0074054
WBP5 WW domain binding protein 5 -0.0074052
HPSE heparanase -0.00737201
S100A12 S100 calcium binding protein A12 -0.00736957
CLC Charcot-Leyden crystal galectin -0.00734776
BET1 Bet1 golgi vesicular membrane trafficking protein -0.0073437
CD46 CD46 molecule, complement regulatory protein -0.00734027
CD40 CD40 molecule, TNF receptor superfamily member 5 -0.00730596
TLE4 transducin-like enhancer of split 4 -0.00730205
SIK1 salt-inducible kinase 1 -0.00729125
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7 -0.00727322
NCOA4 nuclear receptor coactivator 4 -0.00725514
NLRP2 NLR family, pyrin domain containing 2 -0.00721112
RIT1 Ras-like without CAAX 1 -0.00713225
LAPTM4B lysosomal protein transmembrane 4 beta -0.00709346
CLGN calmegin -0.00708479
SLPI secretory leukocyte peptidase inhibitor -0.0070702
KLK7 kallikrein-related peptidase 7 -0.00704486
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.00704256
BIRC3 baculoviral IAP repeat containing 3 -0.00703308
DAPK1 death-associated protein kinase 1 -0.00702188
RAD23B RAD23 homolog B (S. cerevisiae) -0.00701775
SFN stratifin -0.00698591
CD9 CD9 molecule -0.00697512
IFI27 interferon, alpha-inducible protein 27 -0.00696981
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.00693251
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -0.00691448
XIC X chromosome inactivation center -0.00691418
CASP8 caspase 8, apoptosis-related cysteine peptidase -0.00690293
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A -0.00689586
IFT27 intraflagellar transport 27 -0.00689045
IGSF6 immunoglobulin superfamily, member 6 -0.00685069
CST7 cystatin F (leukocystatin) -0.00682461
ATF3 activating transcription factor 3 -0.0068128
DOCK4 dedicator of cytokinesis 4 -0.00678118
NOC3L nucleolar complex associated 3 homolog (S. cerevisiae) -0.00676988
SCEL sciellin -0.00675286
CLEC5A C-type lectin domain family 5, member A -0.00675079
JCHAIN joining chain of multimeric IgA and IgM -0.00673909
TMEM165 transmembrane protein 165 -0.0067365
IL18 interleukin 18 -0.00669909
DCK deoxycytidine kinase -0.00664596
COG5 component of oligomeric golgi complex 5 -0.00663244
KLK10 kallikrein-related peptidase 10 -0.0066106
TLR1 toll-like receptor 1 -0.00660449
SGMS1 sphingomyelin synthase 1 -0.00660342
IL15 interleukin 15 -0.0065999
CD58 CD58 molecule -0.00658902
TARP TCR gamma alternate reading frame protein -0.00657649
VAMP7 vesicle-associated membrane protein 7 -0.00656082
MARCHF1 membrane associated ring-CH-type finger 1 -0.00654887
TM4SF1 transmembrane 4 L six family member 1 -0.00654429
CTNND1 catenin (cadherin-associated protein), delta 1 -0.00653787
WASHC4 WASH complex subunit 4 -0.00652381
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) -0.0065146
KLK5 kallikrein-related peptidase 5 -0.00651428
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.00648175
IL2RB interleukin 2 receptor, beta -0.00647853
BTN3A3 butyrophilin, subfamily 3, member A3 -0.00645209
ADAM10 ADAM metallopeptidase domain 10 -0.00644217
GUCY1A3 guanylate cyclase 1, soluble, alpha 3 -0.00643881
GIMAP6 GTPase, IMAP family member 6 -0.00641324
SLC38A6 solute carrier family 38, member 6 -0.00641107
HHEX hematopoietically expressed homeobox -0.00640285
CLDN1 claudin 1 -0.00640122
YPEL5 yippee-like 5 (Drosophila) -0.00639299
SNX13 sorting nexin 13 -0.00637001
NCF2 neutrophil cytosolic factor 2 -0.0063315
IRF1 interferon regulatory factor 1 -0.00632583
GNG10 guanine nucleotide binding protein (G protein), gamma 10 -0.00631974
PLAGL1 pleiomorphic adenoma gene-like 1 -0.00630745
MYO1D myosin ID -0.00629682
BPGM 2,3-bisphosphoglycerate mutase -0.00628728
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) -0.00627235
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 -0.00626799
FBXO11 F-box protein 11 -0.00626237
PDE4B phosphodiesterase 4B, cAMP-specific -0.00626199
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) -0.00624966
DSE dermatan sulfate epimerase -0.00622919
CLCA2 chloride channel accessory 2 -0.00621858
HIST1H2BK histone cluster 1, H2bk -0.00621659
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.00620672
MSR1 macrophage scavenger receptor 1 -0.00620427
CHMP5 charged multivesicular body protein 5 -0.00620163
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2 -0.00619033
ACP3 acid phosphatase 3 -0.00616678
MSLN mesothelin -0.00615209
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) -0.0061489
NELL1 NEL-like 1 (chicken) -0.00613954
KLK6 kallikrein-related peptidase 6 -0.00613566
ZEB1 zinc finger E-box binding homeobox 1 -0.00612961
TPST2 tyrosylprotein sulfotransferase 2 -0.0061249
FOSL2 FOS-like antigen 2 -0.0061201
CCR2 chemokine (C-C motif) receptor 2 -0.00611127
HTRA1 HtrA serine peptidase 1 -0.00610896
CRISP3 cysteine-rich secretory protein 3 -0.00610697
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) -0.00610084
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase) -0.00607466
WASF1 WAS protein family, member 1 -0.00603596
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) -0.00603467
LYPD1 LY6/PLAUR domain containing 1 -0.00601485
LGALS2 lectin, galactoside-binding, soluble, 2 -0.00601209
MSMO1 methylsterol monooxygenase 1 -0.00600956
GNG11 guanine nucleotide binding protein (G protein), gamma 11 -0.00599983
MAPK1 mitogen-activated protein kinase 1 -0.00599113
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.00596969
GCLC glutamate-cysteine ligase, catalytic subunit -0.00596725
AKR1C3 aldo-keto reductase family 1, member C3 -0.00596642
SLC25A46 solute carrier family 25, member 46 -0.0059618
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -0.00595636
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.00595538
FABP5 fatty acid binding protein 5 (psoriasis-associated) -0.00594735
ARF4 ADP-ribosylation factor 4 -0.00592593
RNF146 ring finger protein 146 -0.00592328
SLAMF7 SLAM family member 7 -0.00591194
ACSM3 acyl-CoA synthetase medium-chain family member 3 -0.00590025
BCL2A1 BCL2-related protein A1 -0.00589559
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha -0.00589148
IL18RAP interleukin 18 receptor accessory protein -0.00588539
F13A1 coagulation factor XIII, A1 polypeptide -0.00588446
MOSPD1 motile sperm domain containing 1 -0.00586459
PEX3 peroxisomal biogenesis factor 3 -0.00585846
MARCHF7 membrane associated ring-CH-type finger 7 -0.00583942
HAVCR1 hepatitis A virus cellular receptor 1 -0.00582316
PHACTR2 phosphatase and actin regulator 2 -0.00581343
ZNF267 zinc finger protein 267 -0.00581055
CRTAM cytotoxic and regulatory T cell molecule -0.00580404
ZDHHC11 zinc finger, DHHC-type containing 11 -0.0058028
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 -0.00578907
WNT5A wingless-type MMTV integration site family, member 5A -0.00578151
KRT6B keratin 6B, type II -0.00575705
CASP1 caspase 1, apoptosis-related cysteine peptidase -0.00574593
MUC16 mucin 16, cell surface associated -0.005734
GPR88 G protein-coupled receptor 88 -0.00573189
G6PD glucose-6-phosphate dehydrogenase -0.00571432
ANXA3 annexin A3 -0.00571011
EGR2 early growth response 2 -0.00569647
ZCCHC10 zinc finger, CCHC domain containing 10 -0.00568289
FAM149B1 family with sequence similarity 149, member B1 -0.00567669
XCL1 chemokine (C motif) ligand 1 -0.00567501
CTSS cathepsin S -0.00567364
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1 -0.00567019
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) -0.00566787
SCGB1D2 secretoglobin, family 1D, member 2 -0.00566268
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0056578
SLC38A2 solute carrier family 38, member 2 -0.00565543
NCF4 neutrophil cytosolic factor 4, 40kDa -0.00565367
RGS20 regulator of G-protein signaling 20 -0.00564843
UXT ubiquitously-expressed, prefoldin-like chaperone -0.00563945