CDK1 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description cyclin-dependent kinase 1|The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] (NCBI Entrez Gene Database, 983)
External Link http://www.ncbi.nlm.nih.gov/gene/983
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Genes

255 substrates of the kinase CDK1 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AAK1 AP2 associated kinase 1
ABI1 abl-interactor 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADD1 adducin 1 (alpha)
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
AMPH amphiphysin
ANAPC1 anaphase promoting complex subunit 1
ANAPC4 anaphase promoting complex subunit 4
APLP2 amyloid beta (A4) precursor-like protein 2
APP amyloid beta (A4) precursor protein
AR androgen receptor
BAD BCL2-associated agonist of cell death
BARD1 BRCA1 associated RING domain 1
BCL2 B-cell CLL/lymphoma 2
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BORA bora, aurora kinase A activator
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CANX calnexin
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CCNB1 cyclin B1
CD3EAP CD3e molecule, epsilon associated protein
CDC16 cell division cycle 16
CDC23 cell division cycle 23
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC25C cell division cycle 25C
CDC27 cell division cycle 27
CDC7 cell division cycle 7
CDCA5 cell division cycle associated 5
CDK7 cyclin-dependent kinase 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CKAP2 cytoskeleton associated protein 2
CLASP2 cytoplasmic linker associated protein 2
CREB1 cAMP responsive element binding protein 1
CREM cAMP responsive element modulator
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTTN cortactin
CUEDC2 CUE domain containing 2
CUX1 cut-like homeobox 1
DCTN1 dynactin 1
DCTN6 dynactin 6
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DIAPH1 diaphanous-related formin 1
DLG1 discs, large homolog 1 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1L dynamin 1-like
DNM2 dynamin 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
E2F1 E2F transcription factor 1
ECT2 epithelial cell transforming 2
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EEF2K eukaryotic elongation factor 2 kinase
EFHD2 EF-hand domain family, member D2
EGFR epidermal growth factor receptor
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
EPB41 erythrocyte membrane protein band 4.1
EPN1 epsin 1
ERCC6L excision repair cross-complementation group 6-like
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FANCG Fanconi anemia, complementation group G
FEN1 flap structure-specific endonuclease 1
FLNA filamin A, alpha
FOXK2 forkhead box K2
FOXM1 forkhead box M1
FOXO1 forkhead box O1
GAPVD1 GTPase activating protein and VPS9 domains 1
GATA2 GATA binding protein 2
GIGYF2 GRB10 interacting GYF protein 2
GMPS guanine monphosphate synthase
GSG2 germ cell associated 2 (haspin)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST1H1E histone cluster 1, H1e
HMGA1 high mobility group AT-hook 1
HMGA2 high mobility group AT-hook 2
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGN5 high mobility group nucleosome binding domain 5
HNRNPK heterogeneous nuclear ribonucleoprotein K
IL16 interleukin 16
INCENP inner centromere protein antigens 135/155kDa
ING1 inhibitor of growth family, member 1
IREB2 iron-responsive element binding protein 2
IRS2 insulin receptor substrate 2
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KAT5 K(lysine) acetyltransferase 5
KAT7 K(lysine) acetyltransferase 7
KIF11 kinesin family member 11
KIF20B kinesin family member 20B
KIF22 kinesin family member 22
KIF2C kinesin family member 2C
KMT2E lysine (K)-specific methyltransferase 2E
KRT8 keratin 8, type II
LATS1 large tumor suppressor kinase 1
LBR lamin B receptor
LDHA lactate dehydrogenase A
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
LMNA lamin A/C
LMNB1 lamin B1
MAP2K1 mitogen-activated protein kinase kinase 1
MAP4 microtubule-associated protein 4
MAP7 microtubule-associated protein 7
MAPK6 mitogen-activated protein kinase 6
MAPT microtubule-associated protein tau
MCL1 myeloid cell leukemia 1
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MCTS1 malignant T cell amplified sequence 1
MDM4 MDM4, p53 regulator
MEF2C myocyte enhancer factor 2C
MKI67 marker of proliferation Ki-67
MPLKIP M-phase specific PLK1 interacting protein
MYOD1 myogenic differentiation 1
NAGK N-acetylglucosamine kinase
NCAPG non-SMC condensin I complex, subunit G
NCOA3 nuclear receptor coactivator 3
NDEL1 nudE neurodevelopment protein 1-like 1
NEDD1 neural precursor cell expressed, developmentally down-regulated 1
NIFK nucleolar protein interacting with the FHA domain of MKI67
NINL ninein-like
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME2 NME/NM23 nucleoside diphosphate kinase 2
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NSFL1C NSFL1 (p97) cofactor (p47)
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUCLEOLIN nucleolin multifunctional protein
NUMA1 nuclear mitotic apparatus protein 1
NUP50 nucleoporin 50kDa
NUP98 nucleoporin 98kDa
NUSAP1 nucleolar and spindle associated protein 1
ODF2 outer dense fiber of sperm tails 2
OGFR opioid growth factor receptor
ORC6 origin recognition complex, subunit 6
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PALLD palladin, cytoskeletal associated protein
PBK PDZ binding kinase
PDIA3 protein disulfide isomerase family A, member 3
PDS5B PDS5 cohesin associated factor B
PHF8 PHD finger protein 8
PI4KB phosphatidylinositol 4-kinase, catalytic, beta
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PKN2 protein kinase N2
PML promyelocytic leukemia
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PRC1 protein regulator of cytokinesis 1
PRDX1 peroxiredoxin 1
PTPN1 protein tyrosine phosphatase, non-receptor type 1
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTTG2 pituitary tumor-transforming 2
PYCR2 pyrroline-5-carboxylate reductase family, member 2
RAB11FIP3 RAB11 family interacting protein 3 (class II)
RAB4A RAB4A, member RAS oncogene family
RAB5B RAB5B, member RAS oncogene family
RAD9A RAD9 homolog A (S. pombe)
RANBP2 RAN binding protein 2
RANGAP1 Ran GTPase activating protein 1
RARA retinoic acid receptor, alpha
RB1 retinoblastoma 1
RCC1 regulator of chromosome condensation 1
REPS2 RALBP1 associated Eps domain containing 2
RFC1 replication factor C (activator 1) 1, 145kDa
RGCC regulator of cell cycle
RGPD3 RANBP2-like and GRIP domain containing 3
RGPD4 RANBP2-like and GRIP domain containing 4
RGPD6 RANBP2-like and GRIP domain containing 6
RGPD8 RANBP2-like and GRIP domain containing 8
RPA2 replication protein A2, 32kDa
RPS3 ribosomal protein S3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RPTOR regulatory associated protein of MTOR, complex 1
RRM2 ribonucleotide reductase M2
RUNX1 runt-related transcription factor 1
RUNX2 runt-related transcription factor 2
SAMHD1 SAM domain and HD domain 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SETD8 SET domain containing (lysine methyltransferase) 8
SGOL1 shugoshin-like 1 (S. pombe)
SIRT1 sirtuin 1
SIRT2 sirtuin 2
SLBP stem-loop binding protein
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOD2 superoxide dismutase 2, mitochondrial
SP1 Sp1 transcription factor
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
SRRM2 serine/arginine repetitive matrix 2
SSR1 signal sequence receptor, alpha
STIM1 stromal interaction molecule 1
STIP1 stress-induced phosphoprotein 1
STMN1 stathmin 1
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SYN3 synapsin III
TCOF1 Treacher Collins-Franceschetti syndrome 1
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TEX14 testis expressed 14
TFPT TCF3 (E2A) fusion partner (in childhood Leukemia)
TK1 thymidine kinase 1, soluble
TMPO thymopoietin
TOP1 topoisomerase (DNA) I
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP73 tumor protein p73
TPP1 tripeptidyl peptidase I
TPR translocated promoter region, nuclear basket protein
TPX2 TPX2, microtubule-associated
TSC1 tuberous sclerosis 1
TUBB tubulin, beta class I
U2AF2 U2 small nuclear RNA auxiliary factor 2
UBA1 ubiquitin-like modifier activating enzyme 1
UBAP2L ubiquitin associated protein 2-like
UBE2A ubiquitin-conjugating enzyme E2A
UBE2I ubiquitin-conjugating enzyme E2I
UBXN2B UBX domain protein 2B
UGDH UDP-glucose 6-dehydrogenase
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UIMC1 ubiquitin interaction motif containing 1
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
USP16 ubiquitin specific peptidase 16
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1
VIM vimentin
WEE1 WEE1 G2 checkpoint kinase
WWC1 WW and C2 domain containing 1
XPO1 exportin 1
YAP1 Yes-associated protein 1
ZC3H11A zinc finger CCCH-type containing 11A
ZC3HC1 zinc finger, C3HC-type containing 1
ZMYM3 zinc finger, MYM-type 3