CDK2 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description cyclin-dependent kinase 2|This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] (NCBI Entrez Gene Database, 1017)
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Genes

100 substrates of the kinase CDK2 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
SSH3 slingshot protein phosphatase 3
IRAK1 interleukin-1 receptor-associated kinase 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
UCKL1 uridine-cytidine kinase 1-like 1
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1
PLAGL1 pleiomorphic adenoma gene-like 1
CHAMP1 chromosome alignment maintaining phosphoprotein 1
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis)
HTT huntingtin
AKAP12 A kinase (PRKA) anchor protein 12
USP24 ubiquitin specific peptidase 24
BLK BLK proto-oncogene, Src family tyrosine kinase
PDZD8 PDZ domain containing 8
THRAP3 thyroid hormone receptor associated protein 3
FNDC3A fibronectin type III domain containing 3A
ATG4C autophagy related 4C, cysteine peptidase
NOP9 NOP9 nucleolar protein
SPEN spen family transcriptional repressor
PARP14 poly (ADP-ribose) polymerase family, member 14
TNS3 tensin 3
MKI67 marker of proliferation Ki-67
ANKRD17 ankyrin repeat domain 17
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
DOPEY2 dopey family member 2
HMGXB4 HMG box domain containing 4
CTNNBL1 catenin, beta like 1
MSH6 mutS homolog 6
HJURP Holliday junction recognition protein
PRR14L proline rich 14-like
STMN2 stathmin 2
SEC62 SEC62 homolog (S. cerevisiae)
PHIP pleckstrin homology domain interacting protein
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
HAO2 hydroxyacid oxidase 2 (long chain)
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HEBP2 heme binding protein 2
GAREM GRB2 associated, regulator of MAPK1
NINL ninein-like
ZCCHC8 zinc finger, CCHC domain containing 8
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PTTG1 pituitary tumor-transforming 1
PTTG2 pituitary tumor-transforming 2
ZZZ3 zinc finger, ZZ-type containing 3
TRIO trio Rho guanine nucleotide exchange factor
CDC6 cell division cycle 6
RAB11FIP4 RAB11 family interacting protein 4 (class II)
SH3PXD2A SH3 and PX domains 2A
FAM178A family with sequence similarity 178, member A
NFIC nuclear factor I/C (CCAAT-binding transcription factor)
PHACTR3 phosphatase and actin regulator 3
GSTA2 glutathione S-transferase alpha 2
GSTA3 glutathione S-transferase alpha 3
SRSF12 serine/arginine-rich splicing factor 12
FAM111A family with sequence similarity 111, member A
FAM135A family with sequence similarity 135, member A
KIAA1217 KIAA1217
C8ORF88 chromosome 8 open reading frame 88
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24
CDKN2AIP CDKN2A interacting protein
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
GSTA1 glutathione S-transferase alpha 1
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
CTSC cathepsin C
MPHOSPH8 M-phase phosphoprotein 8
MGA MGA, MAX dimerization protein
GAS2L3 growth arrest-specific 2 like 3
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
NCOA2 nuclear receptor coactivator 2
NCOA3 nuclear receptor coactivator 3
DAPL1 death associated protein-like 1
KRI1 KRI1 homolog (S. cerevisiae)
LIMCH1 LIM and calponin homology domains 1
REV1 REV1, polymerase (DNA directed)
NOS1 nitric oxide synthase 1 (neuronal)
NCKAP5 NCK-associated protein 5
INPP5F inositol polyphosphate-5-phosphatase F
FLNC filamin C, gamma
SGMS1 sphingomyelin synthase 1
KIF1A kinesin family member 1A
KIF1B kinesin family member 1B
KIF1C kinesin family member 1C
METTL15 methyltransferase like 15
UHRF1BP1 UHRF1 binding protein 1
SCLY selenocysteine lyase
LIG3 ligase III, DNA, ATP-dependent
NIPBL Nipped-B homolog (Drosophila)
SLAIN2 SLAIN motif family, member 2
SCML2 sex comb on midleg-like 2 (Drosophila)
RB1 retinoblastoma 1
FLNA filamin A, alpha
ZC3H13 zinc finger CCCH-type containing 13
SCAF11 SR-related CTD-associated factor 11
MSL2 male-specific lethal 2 homolog (Drosophila)
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2
SIPA1L3 signal-induced proliferation-associated 1 like 3
FAM161B family with sequence similarity 161, member B