CDK2 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description cyclin-dependent kinase 2|This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014] (NCBI Entrez Gene Database, 1017)
External Link http://www.ncbi.nlm.nih.gov/gene/1017
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Genes

270 substrates of the kinase CDK2 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AARS2 alanyl-tRNA synthetase 2, mitochondrial
ADD1 adducin 1 (alpha)
ADD3 adducin 3 (gamma)
ADRBK1 adrenergic, beta, receptor kinase 1
AKIRIN2 akirin 2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AMOT angiomotin
ANKLE2 ankyrin repeat and LEM domain containing 2
ANKRD17 ankyrin repeat domain 17
APC adenomatous polyposis coli
ARHGAP19 Rho GTPase activating protein 19
ARID1A AT rich interactive domain 1A (SWI-like)
ARID4A AT rich interactive domain 4A (RBP1-like)
ATF2 activating transcription factor 2
ATRIP ATR interacting protein
BARD1 BRCA1 associated RING domain 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BOD1L1 biorientation of chromosomes in cell division 1-like 1
BRCA1 breast cancer 1, early onset
BTG1 B-cell translocation gene 1, anti-proliferative
C17ORF49 chromosome 17 open reading frame 49
C1ORF198 chromosome 1 open reading frame 198
C2ORF49 chromosome 2 open reading frame 49
C6ORF106 chromosome 6 open reading frame 106
C9ORF40 chromosome 9 open reading frame 40
CALD1 caldesmon 1
CAMSAP1 calmodulin regulated spectrin-associated protein 1
CC2D1A coiled-coil and C2 domain containing 1A
CCDC6 coiled-coil domain containing 6
CCNA2 cyclin A2
CCNE1 cyclin E1
CDC25C cell division cycle 25C
CDC5L cell division cycle 5-like
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK16 cyclin-dependent kinase 16
CDK2 cyclin-dependent kinase 2
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CDT1 chromatin licensing and DNA replication factor 1
CDX2 caudal type homeobox 2
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPF centromere protein F, 350/400kDa
CHD4 chromodomain helicase DNA binding protein 4
CHD7 chromodomain helicase DNA binding protein 7
CHEK1 checkpoint kinase 1
CIC capicua transcriptional repressor
CRMP1 collapsin response mediator protein 1
CROCC ciliary rootlet coiled-coil, rootletin
CRTC2 CREB regulated transcription coactivator 2
CTTN cortactin
CTTNBP2NL CTTNBP2 N-terminal like
DBNL drebrin-like
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38
DIAPH3 diaphanous-related formin 3
DLG1 discs, large homolog 1 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DMAP1 DNA methyltransferase 1 associated protein 1
DNM1L dynamin 1-like
DNM2 dynamin 2
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPF2 D4, zinc and double PHD fingers family 2
DPYSL3 dihydropyrimidinase-like 3
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
E2F5 E2F transcription factor 5, p130-binding
EEF2 eukaryotic translation elongation factor 2
EFHD2 EF-hand domain family, member D2
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EIF4A3 eukaryotic translation initiation factor 4A3
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ELAVL1 ELAV like RNA binding protein 1
ELF4 E74-like factor 4 (ets domain transcription factor)
EML3 echinoderm microtubule associated protein like 3
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ERAL1 Era-like 12S mitochondrial rRNA chaperone 1
ESR1 estrogen receptor 1
EYA3 EYA transcriptional coactivator and phosphatase 3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FAM122A family with sequence similarity 122A
FAM168B family with sequence similarity 168, member B
FOXC1 forkhead box C1
FOXK2 forkhead box K2
FOXM1 forkhead box M1
FOXO1 forkhead box O1
FOXP3 forkhead box P3
GATA3 GATA binding protein 3
GATAD2A GATA zinc finger domain containing 2A
GIGYF2 GRB10 interacting GYF protein 2
GMPS guanine monphosphate synthase
GORASP2 golgi reassembly stacking protein 2, 55kDa
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
GTF2I general transcription factor IIi
HIRA histone cell cycle regulator
HIST1H1A histone cluster 1, H1a
HIST1H1E histone cluster 1, H1e
HMGA1 high mobility group AT-hook 1
HMGN5 high mobility group nucleosome binding domain 5
HN1L hematological and neurological expressed 1-like
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2 (H')
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
ILF3 interleukin enhancer binding factor 3, 90kDa
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1
ING5 inhibitor of growth family, member 5
INO80E INO80 complex subunit E
IREB2 iron-responsive element binding protein 2
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KAT7 K(lysine) acetyltransferase 7
KDM2A lysine (K)-specific demethylase 2A
KIF22 kinesin family member 22
KMT2D lysine (K)-specific methyltransferase 2D
LARP1 La ribonucleoprotein domain family, member 1
LIG1 ligase I, DNA, ATP-dependent
LIG3 ligase III, DNA, ATP-dependent
LMNB2 lamin B2
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3
LRWD1 leucine-rich repeats and WD repeat domain containing 1
MACF1 microtubule-actin crosslinking factor 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCL1 myeloid cell leukemia 1
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM3AP minichromosome maintenance complex component 3 associated protein
MCM4 minichromosome maintenance complex component 4
MCM7 minichromosome maintenance complex component 7
MDC1 mediator of DNA-damage checkpoint 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED1 mediator complex subunit 1
MICALL1 MICAL-like 1
MKI67 marker of proliferation Ki-67
MKL1 megakaryoblastic leukemia (translocation) 1
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MRPS18B mitochondrial ribosomal protein S18B
MTA1 metastasis associated 1
MTA2 metastasis associated 1 family, member 2
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYOD1 myogenic differentiation 1
NBN nibrin
NCAPH non-SMC condensin I complex, subunit H
NCL nucleolin
NDE1 nudE neurodevelopment protein 1
NELFA negative elongation factor complex member A
NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)
NOSIP nitric oxide synthase interacting protein
NPAT nuclear protein, ataxia-telangiectasia locus
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR1I2 nuclear receptor subfamily 1, group I, member 2
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUDC nudC nuclear distribution protein
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2
NUMA1 nuclear mitotic apparatus protein 1
NUP107 nucleoporin 107kDa
NUP133 nucleoporin 133kDa
NUP153 nucleoporin 153kDa
NUP98 nucleoporin 98kDa
ORC1 origin recognition complex, subunit 1
ORC2 origin recognition complex, subunit 2
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP10 poly (ADP-ribose) polymerase family, member 10
PBRM1 polybromo 1
PDS5B PDS5 cohesin associated factor B
PELP1 proline, glutamate and leucine rich protein 1
PGR progesterone receptor
PHF6 PHD finger protein 6
PML promyelocytic leukemia
POLL polymerase (DNA directed), lambda
POLM polymerase (DNA directed), mu
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POU2F1 POU class 2 homeobox 1
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R12C protein phosphatase 1, regulatory subunit 12C
PPP1R35 protein phosphatase 1, regulatory subunit 35
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PRPF3 pre-mRNA processing factor 3
PRPF31 pre-mRNA processing factor 31
PRRC2A proline-rich coiled-coil 2A
PTHLH parathyroid hormone-like hormone
PTPN2 protein tyrosine phosphatase, non-receptor type 2
PTPN6 protein tyrosine phosphatase, non-receptor type 6
PYCR1 pyrroline-5-carboxylate reductase 1
PYCR2 pyrroline-5-carboxylate reductase family, member 2
QTRT1 queuine tRNA-ribosyltransferase 1
RAD18 RAD18 E3 ubiquitin protein ligase
RAD9A RAD9 homolog A (S. pombe)
RALY RALY heterogeneous nuclear ribonucleoprotein
RANGAP1 Ran GTPase activating protein 1
RB1 retinoblastoma 1
RBBP8 retinoblastoma binding protein 8
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RBM27 RNA binding motif protein 27
RPL11 ribosomal protein L11
RPL12 ribosomal protein L12
RPS27 ribosomal protein S27
RPS27L ribosomal protein S27-like
RPS3 ribosomal protein S3
RRM2 ribonucleotide reductase M2
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae)
RUNX1 runt-related transcription factor 1
SAMHD1 SAM domain and HD domain 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SETDB1 SET domain, bifurcated 1
SF3B1 splicing factor 3b, subunit 1, 155kDa
SIRT2 sirtuin 2
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLAIN2 SLAIN motif family, member 2
SMAD3 SMAD family member 3
SNAPIN SNAP-associated protein
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SNW1 SNW domain containing 1
SORBS3 sorbin and SH3 domain containing 3
SPAG9 sperm associated antigen 9
SPDL1 spindle apparatus coiled-coil protein 1
SRRM1 serine/arginine repetitive matrix 1
SRSF11 serine/arginine-rich splicing factor 11
SRSF9 serine/arginine-rich splicing factor 9
STMN1 stathmin 1
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1
TBCE tubulin folding cofactor E
TCF3 transcription factor 3
TCOF1 Treacher Collins-Franceschetti syndrome 1
TERF2 telomeric repeat binding factor 2
TERF2IP telomeric repeat binding factor 2, interacting protein
TFAM transcription factor A, mitochondrial
TFCP2 transcription factor CP2
THRAP3 thyroid hormone receptor associated protein 3
TICRR TOPBP1-interacting checkpoint and replication regulator
TK1 thymidine kinase 1, soluble
TNKS1BP1 tankyrase 1 binding protein 1, 182kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TOR1AIP1 torsin A interacting protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TPR translocated promoter region, nuclear basket protein
TPX2 TPX2, microtubule-associated
TSPYL2 TSPY-like 2
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TUBG1 tubulin, gamma 1
UBE2A ubiquitin-conjugating enzyme E2A
UBE2O ubiquitin-conjugating enzyme E2O
UBTF upstream binding transcription factor, RNA polymerase I
UBXN1 UBX domain protein 1
UHRF1 ubiquitin-like with PHD and ring finger domains 1
UNG uracil-DNA glycosylase
USP37 ubiquitin specific peptidase 37
VIM vimentin
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBTB16 zinc finger and BTB domain containing 16
ZC3H11A zinc finger CCCH-type containing 11A
ZC3H18 zinc finger CCCH-type containing 18
ZC3HC1 zinc finger, C3HC-type containing 1
ZHX1 zinc fingers and homeoboxes 1
ZMYM3 zinc finger, MYM-type 3
ZNF609 zinc finger protein 609
ZYX zyxin