CDK4 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description cyclin-dependent kinase 4|The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1019)
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100 substrates of the kinase CDK4 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
MKI67 marker of proliferation Ki-67
KALRN kalirin, RhoGEF kinase
HTT huntingtin
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
FGD4 FYVE, RhoGEF and PH domain containing 4
ZCCHC7 zinc finger, CCHC domain containing 7
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
CRTC1 CREB regulated transcription coactivator 1
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1
DNM3 dynamin 3
BOP1 block of proliferation 1
SON SON DNA binding protein
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
ATXN2 ataxin 2
CRY2 cryptochrome circadian clock 2
LBR lamin B receptor
KMT2B lysine (K)-specific methyltransferase 2B
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
SLBP stem-loop binding protein
C19ORF26 chromosome 19 open reading frame 26
PERM1 PPARGC1 and ESRR induced regulator, muscle 1
PROB1 proline-rich basic protein 1
THRAP3 thyroid hormone receptor associated protein 3
SGPP1 sphingosine-1-phosphate phosphatase 1
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
PLEKHA6 pleckstrin homology domain containing, family A member 6
BAZ2A bromodomain adjacent to zinc finger domain, 2A
ORC1 origin recognition complex, subunit 1
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
BEST3 bestrophin 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
CCDC137 coiled-coil domain containing 137
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
RAB11FIP2 RAB11 family interacting protein 2 (class I)
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
E2F4 E2F transcription factor 4, p107/p130-binding
TRIO trio Rho guanine nucleotide exchange factor
RAB4A RAB4A, member RAS oncogene family
MPRIP myosin phosphatase Rho interacting protein
NKX2-4 NK2 homeobox 4
CDC6 cell division cycle 6
MDC1 mediator of DNA-damage checkpoint 1
MAP1A microtubule-associated protein 1A
UHRF1 ubiquitin-like with PHD and ring finger domains 1
RB1 retinoblastoma 1
MAP3K11 mitogen-activated protein kinase kinase kinase 11
ZC3H13 zinc finger CCCH-type containing 13
APC adenomatous polyposis coli
GAB1 GRB2-associated binding protein 1
AKIRIN2 akirin 2
AKIRIN1 akirin 1
SRRM2 serine/arginine repetitive matrix 2
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
AUTS2 autism susceptibility candidate 2
WDR47 WD repeat domain 47
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
GAS2L1 growth arrest-specific 2 like 1
TBKBP1 TBK1 binding protein 1
ERF Ets2 repressor factor
RPAIN RPA interacting protein
WNK3 WNK lysine deficient protein kinase 3
SCNN1A sodium channel, non voltage gated 1 alpha subunit
EFHD2 EF-hand domain family, member D2
LMOD2 leiomodin 2 (cardiac)
PROSER3 proline and serine rich 3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SCAF11 SR-related CTD-associated factor 11
NPAT nuclear protein, ataxia-telangiectasia locus
KIF1C kinesin family member 1C
MED9 mediator complex subunit 9
TPR translocated promoter region, nuclear basket protein
CENPT centromere protein T
C19ORF57 chromosome 19 open reading frame 57
MAP2K1 mitogen-activated protein kinase kinase 1
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3
SPEN spen family transcriptional repressor
SPEG SPEG complex locus
CIT citron rho-interacting serine/threonine kinase
PRC1 protein regulator of cytokinesis 1
SCNM1 sodium channel modifier 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
PRPF4B pre-mRNA processing factor 4B
FRS2 fibroblast growth factor receptor substrate 2
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
LSR lipolysis stimulated lipoprotein receptor
FOXO1 forkhead box O1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
MSL3 male-specific lethal 3 homolog (Drosophila)
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
RBM8A RNA binding motif protein 8A
TNS3 tensin 3