| Dataset | LINCS L1000 CMAP CRISPR Knockout Consensus Signatures |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | cyclin-dependent kinase 4|The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1019) |
| External Link | https://ncbi.nlm.nih.gov/gene/1019 |
| Similar Terms | |
| Downloads & Tools |
500 genes differentially expressed following the CDK4 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0132601 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0116787 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0114221 |
| LCN2 | lipocalin 2 | 0.00998891 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.00994 |
| BHLHE41 | basic helix-loop-helix family, member e41 | 0.00987567 |
| ISG20 | interferon stimulated exonuclease gene 20kDa | 0.00983936 |
| KRT17 | keratin 17, type I | 0.00980741 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0095277 |
| TNFSF10 | tumor necrosis factor (ligand) superfamily, member 10 | 0.00945539 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.00928301 |
| KRT14 | keratin 14, type I | 0.00918312 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.00911168 |
| XIC | X chromosome inactivation center | 0.00890748 |
| CRYAB | crystallin, alpha B | 0.00889422 |
| SAT1 | spermidine/spermine N1-acetyltransferase 1 | 0.00880638 |
| TUBB2A | tubulin, beta 2A class IIa | 0.00862897 |
| DEFB1 | defensin, beta 1 | 0.00860111 |
| TRIM29 | tripartite motif containing 29 | 0.00855183 |
| HMOX1 | heme oxygenase 1 | 0.00836304 |
| AQP3 | aquaporin 3 (Gill blood group) | 0.00830608 |
| BBOX1 | butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 | 0.00821203 |
| ANXA1 | annexin A1 | 0.00809274 |
| IL1B | interleukin 1, beta | 0.00800998 |
| AREG | amphiregulin | 0.00791254 |
| HIST1H2AC | histone cluster 1, H2ac | 0.00773425 |
| ATF3 | activating transcription factor 3 | 0.0076642 |
| MVP | major vault protein | 0.00757838 |
| POSTN | periostin, osteoblast specific factor | 0.00750544 |
| GPR137B | G protein-coupled receptor 137B | 0.00745779 |
| S100A9 | S100 calcium binding protein A9 | 0.00742879 |
| KRT6A | keratin 6A, type II | 0.00738834 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.00732874 |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) | 0.00727264 |
| IL1RN | interleukin 1 receptor antagonist | 0.00718888 |
| MX2 | MX dynamin-like GTPase 2 | 0.0071855 |
| ECM1 | extracellular matrix protein 1 | 0.00714937 |
| KLK10 | kallikrein-related peptidase 10 | 0.00714312 |
| KLK7 | kallikrein-related peptidase 7 | 0.00713359 |
| KRT5 | keratin 5, type II | 0.00710811 |
| RGS4 | regulator of G-protein signaling 4 | 0.007088 |
| YPEL5 | yippee-like 5 (Drosophila) | 0.0070741 |
| SPRR3 | small proline-rich protein 3 | 0.00698774 |
| HIST1H2BD | histone cluster 1, H2bd | 0.00690872 |
| MT1X | metallothionein 1X | 0.00690539 |
| GADD45A | growth arrest and DNA-damage-inducible, alpha | 0.00683618 |
| SLC18A1 | solute carrier family 18 (vesicular monoamine transporter), member 1 | 0.00679206 |
| CSTA | cystatin A (stefin A) | 0.00676875 |
| KLK11 | kallikrein-related peptidase 11 | 0.00676536 |
| MT1F | metallothionein 1F | 0.00676326 |
| KLK6 | kallikrein-related peptidase 6 | 0.00675142 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.00673744 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.00663503 |
| SIK1 | salt-inducible kinase 1 | 0.0066094 |
| DOK5 | docking protein 5 | 0.00658017 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0065219 |
| BIK | BCL2-interacting killer (apoptosis-inducing) | 0.006486 |
| BAMBI | BMP and activin membrane-bound inhibitor | 0.00647488 |
| FGF1 | fibroblast growth factor 1 (acidic) | 0.00645172 |
| ANXA2P2 | annexin A2 pseudogene 2 | 0.00643397 |
| LAMC2 | laminin, gamma 2 | 0.00640814 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.00636763 |
| MX1 | MX dynamin-like GTPase 1 | 0.00628066 |
| KRT6B | keratin 6B, type II | 0.00627412 |
| DSP | desmoplakin | 0.00625567 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 0.00622919 |
| SPRR1B | small proline-rich protein 1B | 0.00621368 |
| SLPI | secretory leukocyte peptidase inhibitor | 0.00617773 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.00616755 |
| PLAT | plasminogen activator, tissue | 0.0061514 |
| S100A11 | S100 calcium binding protein A11 | 0.00612746 |
| CLIC5 | chloride intracellular channel 5 | 0.00609831 |
| SP100 | SP100 nuclear antigen | 0.00606529 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.00605229 |
| S100A8 | S100 calcium binding protein A8 | 0.00602955 |
| LYPD1 | LY6/PLAUR domain containing 1 | 0.00602034 |
| MAFB | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B | 0.00601179 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 0.00599096 |
| HSPB8 | heat shock 22kDa protein 8 | 0.00595257 |
| CX3CR1 | chemokine (C-X3-C motif) receptor 1 | 0.00592739 |
| S100P | S100 calcium binding protein P | 0.00592014 |
| SPRR2B | small proline-rich protein 2B | 0.00590565 |
| ST6GALNAC2 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 | 0.00590172 |
| HTRA1 | HtrA serine peptidase 1 | 0.00587496 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 0.0058677 |
| BCL3 | B-cell CLL/lymphoma 3 | 0.00586269 |
| VCAN | versican | 0.00585488 |
| THBS2 | thrombospondin 2 | 0.00582523 |
| PLK2 | polo-like kinase 2 | 0.00581859 |
| LBH | limb bud and heart development | 0.00580573 |
| HSPA1A | heat shock 70kDa protein 1A | 0.00579991 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0057884 |
| CLDN10 | claudin 10 | 0.0057812 |
| MT1E | metallothionein 1E | 0.00578013 |
| CAST | calpastatin | 0.00577849 |
| SPRR1A | small proline-rich protein 1A | 0.0057722 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.00576908 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.0057391 |
| MT1G | metallothionein 1G | 0.00573175 |
| EGFL6 | EGF-like-domain, multiple 6 | 0.00572101 |
| TRIP6 | thyroid hormone receptor interactor 6 | 0.0056981 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.00569144 |
| SPON1 | spondin 1, extracellular matrix protein | 0.00566366 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.00565552 |
| OPTN | optineurin | 0.00565136 |
| PTHLH | parathyroid hormone-like hormone | 0.00564756 |
| NMRK1 | nicotinamide riboside kinase 1 | 0.00563836 |
| CFB | complement factor B | 0.00562819 |
| MUC16 | mucin 16, cell surface associated | 0.00562684 |
| TSC22D1 | TSC22 domain family, member 1 | 0.00562565 |
| NEBL | nebulette | 0.00562493 |
| ZMAT3 | zinc finger, matrin-type 3 | 0.00558538 |
| COL4A5 | collagen, type IV, alpha 5 | 0.00557314 |
| AKR1B10 | aldo-keto reductase family 1, member B10 (aldose reductase) | 0.00554172 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.00552968 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.00549699 |
| IRF7 | interferon regulatory factor 7 | 0.00549574 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.00546303 |
| SQSTM1 | sequestosome 1 | 0.0054597 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.0054521 |
| STC2 | stanniocalcin 2 | 0.00544911 |
| ABHD4 | abhydrolase domain containing 4 | 0.0054475 |
| CTSD | cathepsin D | 0.00543733 |
| GRB7 | growth factor receptor-bound protein 7 | 0.00543594 |
| KYNU | kynureninase | 0.00542547 |
| HMGA1 | high mobility group AT-hook 1 | 0.00542371 |
| KLK8 | kallikrein-related peptidase 8 | 0.00542368 |
| SCGB2A1 | secretoglobin, family 2A, member 1 | 0.00540169 |
| FXYD3 | FXYD domain containing ion transport regulator 3 | 0.00537858 |
| KRT13 | keratin 13, type I | 0.00536703 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | 0.00536254 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00534296 |
| FOLR1 | folate receptor 1 (adult) | 0.00532693 |
| SLC2A6 | solute carrier family 2 (facilitated glucose transporter), member 6 | 0.0053239 |
| FOSL2 | FOS-like antigen 2 | 0.00531558 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.00529051 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.00528925 |
| MSMB | microseminoprotein, beta- | 0.00528075 |
| PLEKHB1 | pleckstrin homology domain containing, family B (evectins) member 1 | 0.00524833 |
| HOMER3 | homer scaffolding protein 3 | 0.00523969 |
| WIPI1 | WD repeat domain, phosphoinositide interacting 1 | 0.00523741 |
| KRT7 | keratin 7, type II | 0.00523068 |
| RIPK2 | receptor-interacting serine-threonine kinase 2 | 0.00522244 |
| MYOF | myoferlin | 0.00521219 |
| COL6A3 | collagen, type VI, alpha 3 | 0.00519844 |
| KLHL24 | kelch-like family member 24 | 0.00518906 |
| IFI44L | interferon-induced protein 44-like | 0.00518473 |
| FN1 | fibronectin 1 | 0.00516863 |
| RGCC | regulator of cell cycle | 0.00516825 |
| APOL2 | apolipoprotein L, 2 | 0.00515548 |
| CD9 | CD9 molecule | 0.00515079 |
| TSPAN1 | tetraspanin 1 | 0.00514095 |
| GPER1 | G protein-coupled estrogen receptor 1 | 0.00513797 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.00512502 |
| APOL1 | apolipoprotein L, 1 | 0.00511743 |
| MIR22HG | MIR22 host gene | 0.00510314 |
| C8ORF4 | chromosome 8 open reading frame 4 | 0.00510116 |
| RNASET2 | ribonuclease T2 | 0.00508751 |
| KRT23 | keratin 23, type I | 0.00505688 |
| LOXL2 | lysyl oxidase-like 2 | 0.00503496 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.00503171 |
| ADAMTS1 | ADAM metallopeptidase with thrombospondin type 1 motif, 1 | 0.00501161 |
| LPAR1 | lysophosphatidic acid receptor 1 | 0.00501066 |
| TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | 0.00501065 |
| CXCL10 | chemokine (C-X-C motif) ligand 10 | 0.00500325 |
| ZNF185 | zinc finger protein 185 (LIM domain) | 0.00498558 |
| MT1HL1 | metallothionein 1H-like 1 | 0.00498533 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.00497377 |
| DDX58 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 | 0.00496858 |
| MSLN | mesothelin | 0.00496538 |
| PFKFB3 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 | 0.00496354 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.00495696 |
| COQ10B | coenzyme Q10 homolog B (S. cerevisiae) | 0.00495678 |
| AQP1 | aquaporin 1 (Colton blood group) | 0.00492836 |
| MAFF | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F | 0.00491933 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.00491817 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 0.0049167 |
| S100A12 | S100 calcium binding protein A12 | 0.00490984 |
| DDX10 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 | 0.00490472 |
| UBE2L6 | ubiquitin-conjugating enzyme E2L 6 | 0.00489367 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | 0.00487844 |
| IL32 | interleukin 32 | 0.00487759 |
| CRABP2 | cellular retinoic acid binding protein 2 | 0.00484739 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.00482996 |
| PIP | prolactin-induced protein | 0.00482945 |
| C9ORF16 | chromosome 9 open reading frame 16 | 0.00482645 |
| AHNAK | AHNAK nucleoprotein | 0.00482629 |
| PDZK1IP1 | PDZK1 interacting protein 1 | 0.0048239 |
| PRAME | preferentially expressed antigen in melanoma | 0.00481824 |
| FMO1 | flavin containing monooxygenase 1 | 0.00481569 |
| KRT16 | keratin 16, type I | 0.00481426 |
| CA12 | carbonic anhydrase XII | 0.00481015 |
| POLDIP2 | polymerase (DNA-directed), delta interacting protein 2 | 0.00480987 |
| DYNC1I2 | dynein, cytoplasmic 1, intermediate chain 2 | 0.00480213 |
| CYB5R1 | cytochrome b5 reductase 1 | 0.00479504 |
| ZYX | zyxin | 0.00479296 |
| UPK1B | uroplakin 1B | 0.00479012 |
| JAG1 | jagged 1 | 0.00476252 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.00475446 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.00473751 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.00473451 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | 0.00472661 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.00472413 |
| MEIS1 | Meis homeobox 1 | 0.00471148 |
| IER3 | immediate early response 3 | 0.00471138 |
| NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.00471064 |
| DNAJB9 | DnaJ (Hsp40) homolog, subfamily B, member 9 | 0.00470617 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.00470237 |
| FADS3 | fatty acid desaturase 3 | 0.0047006 |
| CYP4B1 | cytochrome P450, family 4, subfamily B, polypeptide 1 | 0.00469948 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | 0.00468997 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.00467358 |
| PITX3 | paired-like homeodomain 3 | 0.00465968 |
| DDA1 | DET1 and DDB1 associated 1 | 0.00465531 |
| STX12 | syntaxin 12 | 0.00464765 |
| FAM107A | family with sequence similarity 107, member A | 0.00464369 |
| MDK | midkine (neurite growth-promoting factor 2) | 0.00462128 |
| MT1H | metallothionein 1H | 0.00459984 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.00457996 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.00457728 |
| RFTN1 | raftlin, lipid raft linker 1 | 0.00457648 |
| SRPX2 | sushi-repeat containing protein, X-linked 2 | 0.004561 |
| MYO1C | myosin IC | 0.00456039 |
| PLK3 | polo-like kinase 3 | 0.00454549 |
| TCN1 | transcobalamin I (vitamin B12 binding protein, R binder family) | 0.00454306 |
| ALOX5 | arachidonate 5-lipoxygenase | 0.00454057 |
| ZBED2 | zinc finger, BED-type containing 2 | 0.00453963 |
| LY96 | lymphocyte antigen 96 | 0.00453045 |
| FSCN1 | fascin actin-bundling protein 1 | 0.00452397 |
| JUNB | jun B proto-oncogene | 0.0045173 |
| RND3 | Rho family GTPase 3 | 0.00451441 |
| LAMB3 | laminin, beta 3 | 0.00451293 |
| SUGCT | succinyl-CoA:glutarate-CoA transferase | 0.00449431 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0044829 |
| TRIM22 | tripartite motif containing 22 | 0.00448028 |
| PON2 | paraoxonase 2 | 0.00447274 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 0.00446528 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.00445783 |
| GRAMD2B | GRAM domain containing 2B | 0.00444985 |
| KLK5 | kallikrein-related peptidase 5 | 0.00444859 |
| IQCG | IQ motif containing G | 0.0044475 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.00444578 |
| SP110 | SP110 nuclear body protein | 0.00444297 |
| SERPINB8 | serpin peptidase inhibitor, clade B (ovalbumin), member 8 | 0.00443233 |
| ZC3H12A | zinc finger CCCH-type containing 12A | 0.00441523 |
| MMP7 | matrix metallopeptidase 7 | 0.00441387 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.00441106 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | 0.00441009 |
| BCL2A1 | BCL2-related protein A1 | 0.00440703 |
| TRIM16 | tripartite motif containing 16 | 0.00440649 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CDK4 | cyclin-dependent kinase 4 | -0.0118373 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.0118008 |
| USP7 | ubiquitin specific peptidase 7 (herpes virus-associated) | -0.0106554 |
| HMGB2 | high mobility group box 2 | -0.0105354 |
| KIF20A | kinesin family member 20A | -0.0104232 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.00966902 |
| DLGAP5 | discs, large (Drosophila) homolog-associated protein 5 | -0.00880179 |
| TMEM106C | transmembrane protein 106C | -0.00875833 |
| TYMS | thymidylate synthetase | -0.00861001 |
| NDC80 | NDC80 kinetochore complex component | -0.00847717 |
| PRC1 | protein regulator of cytokinesis 1 | -0.00821862 |
| CCNA2 | cyclin A2 | -0.00819268 |
| POLE2 | polymerase (DNA directed), epsilon 2, accessory subunit | -0.00812848 |
| KIF14 | kinesin family member 14 | -0.00811826 |
| TNFSF13B | tumor necrosis factor (ligand) superfamily, member 13b | -0.00799788 |
| PRIM1 | primase, DNA, polypeptide 1 (49kDa) | -0.00797418 |
| HOXC6 | homeobox C6 | -0.0078138 |
| FOXM1 | forkhead box M1 | -0.00779252 |
| KIF11 | kinesin family member 11 | -0.00778365 |
| BIRC5 | baculoviral IAP repeat containing 5 | -0.0077519 |
| FBXO5 | F-box protein 5 | -0.00772843 |
| GNA11 | guanine nucleotide binding protein (G protein), alpha 11 (Gq class) | -0.00763748 |
| CDKN2C | cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) | -0.00763279 |
| CCNB2 | cyclin B2 | -0.00755595 |
| TMSB15A | thymosin beta 15a | -0.00750659 |
| SKP2 | S-phase kinase-associated protein 2, E3 ubiquitin protein ligase | -0.00747034 |
| ENPP2 | ectonucleotide pyrophosphatase/phosphodiesterase 2 | -0.00746772 |
| NEMP1 | nuclear envelope integral membrane protein 1 | -0.00743297 |
| CENPF | centromere protein F, 350/400kDa | -0.00739412 |
| OIP5 | Opa interacting protein 5 | -0.00738579 |
| NUSAP1 | nucleolar and spindle associated protein 1 | -0.00737205 |
| LMNB1 | lamin B1 | -0.00728332 |
| NEK2 | NIMA-related kinase 2 | -0.00724995 |
| TMPO | thymopoietin | -0.00723464 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.00719117 |
| CDC20 | cell division cycle 20 | -0.00717913 |
| GINS2 | GINS complex subunit 2 (Psf2 homolog) | -0.0070852 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -0.00707506 |
| HELLS | helicase, lymphoid-specific | -0.00700304 |
| CDK1 | cyclin-dependent kinase 1 | -0.00696937 |
| YEATS4 | YEATS domain containing 4 | -0.00693411 |
| RACGAP1 | Rac GTPase activating protein 1 | -0.00692685 |
| CCNF | cyclin F | -0.00690363 |
| PTTG1 | pituitary tumor-transforming 1 | -0.00684231 |
| PCNA | proliferating cell nuclear antigen | -0.00683421 |
| RRM2 | ribonucleotide reductase M2 | -0.00679749 |
| UBE2C | ubiquitin-conjugating enzyme E2C | -0.0067756 |
| SPC25 | SPC25, NDC80 kinetochore complex component | -0.00676415 |
| HMGB1 | high mobility group box 1 | -0.0067428 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.00673019 |
| TSFM | Ts translation elongation factor, mitochondrial | -0.00671978 |
| AURKB | aurora kinase B | -0.00671057 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | -0.00670642 |
| USP1 | ubiquitin specific peptidase 1 | -0.00669438 |
| KIF15 | kinesin family member 15 | -0.00664713 |
| TIMELESS | timeless circadian clock | -0.00660765 |
| ATP8A1 | ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1 | -0.00658903 |
| STMN1 | stathmin 1 | -0.00657085 |
| GTSE1 | G-2 and S-phase expressed 1 | -0.00656141 |
| NUP107 | nucleoporin 107kDa | -0.00655728 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | -0.0065172 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.00651185 |
| LBR | lamin B receptor | -0.00650093 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | -0.00645784 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0064453 |
| ZWINT | ZW10 interacting kinetochore protein | -0.00643384 |
| SUB1 | SUB1 homolog (S. cerevisiae) | -0.00643328 |
| PBX1 | pre-B-cell leukemia homeobox 1 | -0.00638187 |
| SLC37A4 | solute carrier family 37 (glucose-6-phosphate transporter), member 4 | -0.00636788 |
| CEP55 | centrosomal protein 55kDa | -0.00634288 |
| CEBPA | CCAAT/enhancer binding protein (C/EBP), alpha | -0.00629465 |
| NELL2 | NEL-like 2 (chicken) | -0.00622973 |
| DHFR | dihydrofolate reductase | -0.0062255 |
| TXNIP | thioredoxin interacting protein | -0.00621945 |
| DEK | DEK proto-oncogene | -0.00621362 |
| RAD51AP1 | RAD51 associated protein 1 | -0.00620665 |
| TRMT5 | tRNA methyltransferase 5 | -0.00615117 |
| MCM2 | minichromosome maintenance complex component 2 | -0.00614175 |
| KNTC1 | kinetochore associated 1 | -0.00613501 |
| KIF18B | kinesin family member 18B | -0.00613011 |
| LMNB2 | lamin B2 | -0.00608834 |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | -0.0060807 |
| NTS | neurotensin | -0.00607932 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | -0.0060584 |
| DBF4 | DBF4 zinc finger | -0.0060416 |
| MPHOSPH9 | M-phase phosphoprotein 9 | -0.00603838 |
| NCAPH | non-SMC condensin I complex, subunit H | -0.0060367 |
| TTK | TTK protein kinase | -0.00603047 |
| SDC2 | syndecan 2 | -0.00601301 |
| MCM5 | minichromosome maintenance complex component 5 | -0.00600269 |
| FANCI | Fanconi anemia, complementation group I | -0.00598237 |
| DEPDC1 | DEP domain containing 1 | -0.00590875 |
| PRKCB | protein kinase C, beta | -0.00590543 |
| CIT | citron rho-interacting serine/threonine kinase | -0.00586404 |
| MAD2L1 | MAD2 mitotic arrest deficient-like 1 (yeast) | -0.00584945 |
| NCAPD3 | non-SMC condensin II complex, subunit D3 | -0.00584682 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.00584369 |
| ESPL1 | extra spindle pole bodies homolog 1 (S. cerevisiae) | -0.00583682 |
| H2AX | H2A.X variant histone | -0.00581389 |
| FEN1 | flap structure-specific endonuclease 1 | -0.00581145 |
| SRSF7 | serine/arginine-rich splicing factor 7 | -0.00578132 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.00577291 |
| NETO2 | neuropilin (NRP) and tolloid (TLL)-like 2 | -0.00576643 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.00576496 |
| CENPU | centromere protein U | -0.00576093 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.00575009 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -0.00570395 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.00570369 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | -0.00565292 |
| PAXIP1 | PAX interacting (with transcription-activation domain) protein 1 | -0.0056311 |
| BCHE | butyrylcholinesterase | -0.00562719 |
| UNG | uracil-DNA glycosylase | -0.00561692 |
| ASF1B | anti-silencing function 1B histone chaperone | -0.00558024 |
| IMPA2 | inositol(myo)-1(or 4)-monophosphatase 2 | -0.00556483 |
| H2AZ1 | H2A.Z variant histone 1 | -0.00553579 |
| CCNE2 | cyclin E2 | -0.00553243 |
| RNASEH2A | ribonuclease H2, subunit A | -0.00553076 |
| TK1 | thymidine kinase 1, soluble | -0.0055282 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.00552665 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | -0.00552147 |
| OXCT1 | 3-oxoacid CoA transferase 1 | -0.00551629 |
| PIMREG | PICALM interacting mitotic regulator | -0.00551322 |
| PCSK1 | proprotein convertase subtilisin/kexin type 1 | -0.00550417 |
| EIF1AY | eukaryotic translation initiation factor 1A, Y-linked | -0.0055004 |
| MPPED2 | metallophosphoesterase domain containing 2 | -0.00549789 |
| OLFM1 | olfactomedin 1 | -0.0054844 |
| BUB1 | BUB1 mitotic checkpoint serine/threonine kinase | -0.00544871 |
| MKI67 | marker of proliferation Ki-67 | -0.00544762 |
| KIF4A | kinesin family member 4A | -0.00544118 |
| COQ8A | coenzyme Q8A | -0.0053781 |
| MCM3 | minichromosome maintenance complex component 3 | -0.00537215 |
| FANCL | Fanconi anemia, complementation group L | -0.00537155 |
| PBK | PDZ binding kinase | -0.00536815 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | -0.00535732 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.00535421 |
| CTDSP2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 | -0.0053495 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | -0.00533996 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | -0.0053385 |
| MCM6 | minichromosome maintenance complex component 6 | -0.00532311 |
| SNRPA | small nuclear ribonucleoprotein polypeptide A | -0.00530325 |
| KIF23 | kinesin family member 23 | -0.00530055 |
| PXMP2 | peroxisomal membrane protein 2, 22kDa | -0.00529414 |
| CDCA3 | cell division cycle associated 3 | -0.00527733 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.00526726 |
| DUT | deoxyuridine triphosphatase | -0.00525126 |
| C7 | complement component 7 | -0.00524108 |
| CCL19 | chemokine (C-C motif) ligand 19 | -0.00522773 |
| MARS1 | methionyl-tRNA synthetase 1 | -0.00522528 |
| LGALS13 | lectin, galactoside-binding, soluble, 13 | -0.0052033 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.00518853 |
| POLE | polymerase (DNA directed), epsilon, catalytic subunit | -0.00518472 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.00518363 |
| PLK1 | polo-like kinase 1 | -0.00518226 |
| METTL7A | methyltransferase like 7A | -0.00517369 |
| CDC25B | cell division cycle 25B | -0.00516055 |
| CDC7 | cell division cycle 7 | -0.00515665 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | -0.005153 |
| SRSF1 | serine/arginine-rich splicing factor 1 | -0.00514328 |
| SHCBP1 | SHC SH2-domain binding protein 1 | -0.00513721 |
| DNMT1 | DNA (cytosine-5-)-methyltransferase 1 | -0.00512036 |
| NCAPG | non-SMC condensin I complex, subunit G | -0.00511126 |
| CBX5 | chromobox homolog 5 | -0.0050956 |
| RFC4 | replication factor C (activator 1) 4, 37kDa | -0.00509453 |
| MTHFD1 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase | -0.00508912 |
| AURKA | aurora kinase A | -0.00506515 |
| GET1 | guided entry of tail-anchored proteins factor 1 | -0.005029 |
| FUS | FUS RNA binding protein | -0.00502831 |
| RAD21 | RAD21 homolog (S. pombe) | -0.00502659 |
| HAUS4 | HAUS augmin-like complex, subunit 4 | -0.00502542 |
| RPS6KA5 | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | -0.00502344 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | -0.00500475 |
| UBE2S | ubiquitin-conjugating enzyme E2S | -0.0049942 |
| SUV39H1 | suppressor of variegation 3-9 homolog 1 (Drosophila) | -0.00499335 |
| TIA1 | TIA1 cytotoxic granule-associated RNA binding protein | -0.00499214 |
| ZDHHC6 | zinc finger, DHHC-type containing 6 | -0.00498429 |
| PAN2 | PAN2 poly(A) specific ribonuclease subunit | -0.00497729 |
| KDM5D | lysine (K)-specific demethylase 5D | -0.00496321 |
| ADCY1 | adenylate cyclase 1 (brain) | -0.00496243 |
| TBC1D16 | TBC1 domain family, member 16 | -0.00495976 |
| MDFIC | MyoD family inhibitor domain containing | -0.00495813 |
| PTCH1 | patched 1 | -0.00495303 |
| DPYD | dihydropyrimidine dehydrogenase | -0.00494734 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | -0.0049426 |
| CENPM | centromere protein M | -0.00493033 |
| LIG1 | ligase I, DNA, ATP-dependent | -0.00491556 |
| REEP1 | receptor accessory protein 1 | -0.00491011 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | -0.00490443 |
| TMEM109 | transmembrane protein 109 | -0.00489407 |
| CCNB1 | cyclin B1 | -0.00488387 |
| PCLAF | PCNA clamp associated factor | -0.00487002 |
| ARG2 | arginase 2 | -0.00486447 |
| RPA3 | replication protein A3, 14kDa | -0.00486169 |
| ANGEL2 | angel homolog 2 (Drosophila) | -0.00485791 |
| NUP37 | nucleoporin 37kDa | -0.00485598 |
| PARPBP | PARP1 binding protein | -0.0048535 |
| LMO3 | LIM domain only 3 (rhombotin-like 2) | -0.0048507 |
| SPAG5 | sperm associated antigen 5 | -0.00484204 |
| GPSM2 | G-protein signaling modulator 2 | -0.00478538 |
| IGFBP1 | insulin-like growth factor binding protein 1 | -0.00477371 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | -0.00476452 |
| DNAJC9 | DnaJ (Hsp40) homolog, subfamily C, member 9 | -0.00474555 |
| TACC3 | transforming, acidic coiled-coil containing protein 3 | -0.00474226 |
| ATF1 | activating transcription factor 1 | -0.00473989 |
| SNRPF | small nuclear ribonucleoprotein polypeptide F | -0.00471151 |
| TPX2 | TPX2, microtubule-associated | -0.00471072 |
| TROAP | trophinin associated protein | -0.00470824 |
| PCF11 | PCF11 cleavage and polyadenylation factor subunit | -0.00469711 |
| ZNF586 | zinc finger protein 586 | -0.00468263 |
| CD1E | CD1e molecule | -0.0046788 |
| USP13 | ubiquitin specific peptidase 13 (isopeptidase T-3) | -0.00463662 |
| IARS2 | isoleucyl-tRNA synthetase 2, mitochondrial | -0.00462426 |
| INPP5A | inositol polyphosphate-5-phosphatase, 40kDa | -0.00462271 |
| GRB14 | growth factor receptor-bound protein 14 | -0.00462223 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | -0.00462122 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.00459826 |
| YKT6 | YKT6 v-SNARE homolog (S. cerevisiae) | -0.00459238 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | -0.00459042 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | -0.00457211 |
| SMC1A | structural maintenance of chromosomes 1A | -0.00457157 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | -0.004571 |
| RANBP1 | RAN binding protein 1 | -0.00456466 |
| PER3 | period circadian clock 3 | -0.00453577 |
| RBBP7 | retinoblastoma binding protein 7 | -0.00453353 |
| METTL21B | methyltransferase like 21B | -0.0045123 |
| BARD1 | BRCA1 associated RING domain 1 | -0.00450647 |
| FUBP1 | far upstream element (FUSE) binding protein 1 | -0.00449062 |
| IPO9 | importin 9 | -0.00449014 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | -0.00448517 |
| CDCA4 | cell division cycle associated 4 | -0.00448086 |
| SPDL1 | spindle apparatus coiled-coil protein 1 | -0.00446453 |
| ELP1 | elongator acetyltransferase complex subunit 1 | -0.00446423 |
| METTL1 | methyltransferase like 1 | -0.00445314 |
| MYBL2 | v-myb avian myeloblastosis viral oncogene homolog-like 2 | -0.00443339 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.00442422 |
| CDC25C | cell division cycle 25C | -0.00442251 |
| NFYB | nuclear transcription factor Y, beta | -0.0044168 |
| RMI1 | RecQ mediated genome instability 1 | -0.00441003 |
| TARDBP | TAR DNA binding protein | -0.00440571 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.00439606 |
| BCL2 | B-cell CLL/lymphoma 2 | -0.00439498 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 | -0.00438921 |
| FAM3C | family with sequence similarity 3, member C | -0.00438896 |
| INSM1 | insulinoma-associated 1 | -0.00437231 |
| GRIA2 | glutamate receptor, ionotropic, AMPA 2 | -0.00436339 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.00435261 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.00433665 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | -0.00433643 |
| SETBP1 | SET binding protein 1 | -0.00431541 |
| PLK4 | polo-like kinase 4 | -0.00429597 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.00429355 |
