CDK4 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description cyclin-dependent kinase 4|The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1019)
External Link http://www.ncbi.nlm.nih.gov/gene/1019
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Genes

18 substrates of the kinase CDK4 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
BRCA1 breast cancer 1, early onset
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELF1 CUGBP, Elav-like family member 1
FOXM1 forkhead box M1
FOXO1 forkhead box O1
GATA4 GATA binding protein 4
MEF2D myocyte enhancer factor 2D
PELP1 proline, glutamate and leucine rich protein 1
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RUNX3 runt-related transcription factor 3
SMAD3 SMAD family member 3
SOD2 superoxide dismutase 2, mitochondrial
TCF3 transcription factor 3
UBTF upstream binding transcription factor, RNA polymerase I
WDR77 WD repeat domain 77