CDK5 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cyclin-dependent kinase 5|This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015] (NCBI Entrez Gene Database, 1020)
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Genes

342 genes differentially expressed following the CDK5 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FAM3D family with sequence similarity 3, member D 2.96296
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 2.96296
PON1 paraoxonase 1 2.96296
UPB1 ureidopropionase, beta 2.96296
SPDYE4 speedy/RINGO cell cycle regulator family member E4 2.96296
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.96296
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 2.96296
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.96296
FOXR1 forkhead box R1 2.96296
OLIG3 oligodendrocyte transcription factor 3 2.96296
SCNN1G sodium channel, non voltage gated 1 gamma subunit 2.96296
DNASE1L2 deoxyribonuclease I-like 2 2.96296
AKR1C2 aldo-keto reductase family 1, member C2 2.96296
LRRTM1 leucine rich repeat transmembrane neuronal 1 2.96296
SYCP2 synaptonemal complex protein 2 2.96296
GPR6 G protein-coupled receptor 6 2.96296
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 2.96296
CD5 CD5 molecule 2.96296
INHBB inhibin, beta B 2.96296
MYBPHL myosin binding protein H-like 2.96296
NOTO notochord homeobox 2.96296
LRRD1 leucine-rich repeats and death domain containing 1 2.96296
ZNF492 zinc finger protein 492 2.96296
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 2.96296
GRIA2 glutamate receptor, ionotropic, AMPA 2 2.96296
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.96296
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.96296
TBATA thymus, brain and testes associated 2.96296
FAM216B family with sequence similarity 216, member B 2.96296
PRDM12 PR domain containing 12 2.96296
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.96296
TMC8 transmembrane channel-like 8 2.96296
OR56A5 olfactory receptor, family 56, subfamily A, member 5 2.96296
NR4A3 nuclear receptor subfamily 4, group A, member 3 2.96296
CLCF1 cardiotrophin-like cytokine factor 1 2.96296
PCDHGA11 protocadherin gamma subfamily A, 11 2.96296
TPRX1 tetra-peptide repeat homeobox 1 2.96296
WNT8B wingless-type MMTV integration site family, member 8B 2.96296
FOXJ1 forkhead box J1 2.96296
TMEM121 transmembrane protein 121 2.96296
GPR21 G protein-coupled receptor 21 2.96296
GPR20 G protein-coupled receptor 20 2.96296
ADAD2 adenosine deaminase domain containing 2 2.96296
MS4A18 membrane-spanning 4-domains, subfamily A, member 18 2.96296
TMEM72 transmembrane protein 72 2.96296
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.96296
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 2.96296
TTLL2 tubulin tyrosine ligase-like family member 2 2.96296
MAGED4 melanoma antigen family D4 2.96296
PLK5 polo-like kinase 5 2.96296
BTBD16 BTB (POZ) domain containing 16 2.96296
LOC124906892 uncharacterized LOC124906892 2.96296
DMAC2 distal membrane arm assembly component 2 2.96296
CCDC9B coiled-coil domain containing 9B 2.96296
UNC93A unc-93 homolog A (C. elegans) 2.96296
ROPN1L rhophilin associated tail protein 1-like 2.96296
CAPN6 calpain 6 2.96296
SIM1 single-minded family bHLH transcription factor 1 2.96296
RHCG Rh family, C glycoprotein 2.96296
OR2T8 olfactory receptor, family 2, subfamily T, member 8 2.96296
OTOR otoraplin 2.96296
FMO3 flavin containing monooxygenase 3 2.96296
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) 2.96296
RNF227 ring finger protein 227 2.96296
VXN vexin 2.96296
OR2I1 olfactory receptor family 2 subfamily I member 1 (gene/pseudogene) 2.96296
TEX53 testis expressed 53 2.96296
AGA-DT AGA divergent transcript 2.96296
PRRT1B proline rich transmembrane protein 1B 2.96296
C17ORF113 chromosome 17 open reading frame 113 2.96296
CLEC20A C-type lectin domain containing 20A 2.96296
H2BW2 H2B.W histone 2 2.96296
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 2.96296
GARIN4 golgi associated RAB2 interactor family member 4 2.96296
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.96296
TMPRSS4 transmembrane protease, serine 4 2.96296
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 2.96296
SYT15 synaptotagmin XV 2.96296
ZIC4 Zic family member 4 2.96296
GOLGA7B golgin A7 family, member B 2.96296
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 2.96296
C3ORF80 chromosome 3 open reading frame 80 2.96296
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.96296
WNT11 wingless-type MMTV integration site family, member 11 2.96296
VSX2 visual system homeobox 2 2.96296
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.96296
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 2.96296
PCDHA7 protocadherin alpha 7 2.96296
NPNT nephronectin 2.96296
DMBX1 diencephalon/mesencephalon homeobox 1 2.96296
ADGRG1 adhesion G protein-coupled receptor G1 2.96296
RNF186 ring finger protein 186 2.96296
LTB lymphotoxin beta (TNF superfamily, member 3) 2.96296
S100G S100 calcium binding protein G 2.96296
S100P S100 calcium binding protein P 2.96296
CCR3 chemokine (C-C motif) receptor 3 2.96296
EXOC3L4 exocyst complex component 3-like 4 2.96296
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.96296
C1QTNF9 C1q and tumor necrosis factor related protein 9 2.96296
C1QL2 complement component 1, q subcomponent-like 2 2.96296
RNF113B ring finger protein 113B 2.96296
FPR1 formyl peptide receptor 1 2.96296
PODN podocan 2.96296
CPO carboxypeptidase O 2.96296
FAM177B family with sequence similarity 177, member B 2.96296
TRADD TNFRSF1A-associated via death domain 2.96296
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 2.96296
TRIM55 tripartite motif containing 55 2.96296
CGB2 chorionic gonadotropin, beta polypeptide 2 2.96296
FOXE3 forkhead box E3 2.96296
ALOXE3 arachidonate lipoxygenase 3 2.96296
VWA7 von Willebrand factor A domain containing 7 2.96296
CDK20 cyclin-dependent kinase 20 2.96296
PCDH12 protocadherin 12 2.96296
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 2.96296
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.96296
KLF1 Kruppel-like factor 1 (erythroid) 2.96296
GAL3ST2 galactose-3-O-sulfotransferase 2 2.96296
NOG noggin 2.96296
ACCSL 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like 2.96296
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.96296
S100A14 S100 calcium binding protein A14 2.96296
FAM50A family with sequence similarity 50, member A 2.96296
CXCR5 chemokine (C-X-C motif) receptor 5 2.96296
TBC1D17 TBC1 domain family, member 17 2.96296
F11 coagulation factor XI 2.96296
C2ORF66 chromosome 2 open reading frame 66 2.96296
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 2.96296
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.96296
CLUL1 clusterin-like 1 (retinal) 2.96296
TSPAN19 tetraspanin 19 2.96296
GPR150 G protein-coupled receptor 150 2.96296
ESPNL espin-like 2.96296
IL25 interleukin 25 2.96296
MEPE matrix extracellular phosphoglycoprotein 2.96296
SFTA2 surfactant associated 2 2.96296
ADRA2A adrenoceptor alpha 2A 2.96296
ZNF835 zinc finger protein 835 2.96296
VMO1 vitelline membrane outer layer 1 homolog (chicken) 2.96296
MSMP microseminoprotein, prostate associated 2.96296
KCTD18 potassium channel tetramerization domain containing 18 2.96296
PFN4 profilin family, member 4 2.96296
PROK1 prokineticin 1 2.96296
UBQLNL ubiquilin-like 2.96296
SVOP SV2 related protein homolog (rat) 2.96296
PRR35 proline rich 35 2.96296
KCNV1 potassium channel, voltage gated modifier subfamily V, member 1 2.96296
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 2.96296
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.96296
GPR62 G protein-coupled receptor 62 2.96296
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.96296
RGS8 regulator of G-protein signaling 8 2.96296
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.96296
PLA2G4E phospholipase A2, group IVE 2.96296
CALML5 calmodulin-like 5 2.96296
ABRA actin binding Rho activating protein 2.96296
ZC2HC1B zinc finger, C2HC-type containing 1B 2.96296
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 2.96296
FZD1 frizzled class receptor 1 2.96296
CD86 CD86 molecule 2.96296
CARD6 caspase recruitment domain family, member 6 2.96296
MAEL maelstrom spermatogenic transposon silencer 2.96296
TRPM5 transient receptor potential cation channel, subfamily M, member 5 2.96296
R3HDML R3H domain containing-like 2.96296
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.96296
POTEE POTE ankyrin domain family, member E 2.96296
POTEI POTE ankyrin domain family, member I 2.96296
TOPAZ1 testis and ovary specific PAZ domain containing 1 2.96296
LST1 leukocyte specific transcript 1 2.96296
CLEC2A C-type lectin domain family 2, member A 2.96296
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.96296
KCNK15 potassium channel, two pore domain subfamily K, member 15 2.96296
MMEL1 membrane metallo-endopeptidase-like 1 2.96296
CHIA chitinase, acidic 2.96296
SDSL serine dehydratase-like 2.96296
MAGEB17 melanoma antigen family B17 2.96296
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.96296
TGM5 transglutaminase 5 2.96296
TEX38 testis expressed 38 2.96296
NBPF14 neuroblastoma breakpoint family, member 14 2.94872
CCDC88B coiled-coil domain containing 88B 2.89528
ANKMY1 ankyrin repeat and MYND domain containing 1 2.86371
MAVS mitochondrial antiviral signaling protein 2.86047
LHX8 LIM homeobox 8 2.83619
NUP35 nucleoporin 35kDa 2.76474
ZBTB40 zinc finger and BTB domain containing 40 2.76148
ZNF789 zinc finger protein 789 2.69387
FADS2 fatty acid desaturase 2 2.603
NFRKB nuclear factor related to kappaB binding protein 2.60174
PFDN1 prefoldin subunit 1 2.59579
GLS2 glutaminase 2 (liver, mitochondrial) 2.5579
DDTL D-dopachrome tautomerase-like 2.52673
DCDC2B doublecortin domain containing 2B 2.52673
C6ORF120 chromosome 6 open reading frame 120 2.52101
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2.50613
PKD1L1 polycystic kidney disease 1 like 1 2.475
TMF1 TATA element modulatory factor 1 2.46535
CDK7 cyclin-dependent kinase 7 2.43075
SEMG1 semenogelin I 2.40046
CYSRT1 cysteine-rich tail protein 1 2.40046
PGM1 phosphoglucomutase 1 2.35116
C2CD4D C2 calcium-dependent domain containing 4D 2.32432
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 2.32432
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.32432
ORAI2 ORAI calcium release-activated calcium modulator 2 2.31793
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 2.30842
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.29437
CHURC1 churchill domain containing 1 2.28494
ZNF7 zinc finger protein 7 2.26513
PLXNB1 plexin B1 2.26361
PVALB parvalbumin 2.23138
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 2.20901
BSG basigin (Ok blood group) 2.20684
FBXL19 F-box and leucine-rich repeat protein 19 2.18783
ZNF460 zinc finger protein 460 2.13684
BTD biotinidase 2.13191
RANBP6 RAN binding protein 6 2.10676
KCTD15 potassium channel tetramerization domain containing 15 2.10558
NIPAL3 NIPA-like domain containing 3 2.09797
TMEM187 transmembrane protein 187 2.07813
TRMT10A tRNA methyltransferase 10 homolog A (S. cerevisiae) 2.07454
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 2.07273
TRAPPC8 trafficking protein particle complex 8 2.05607
EPPK1 epiplakin 1 2.04396
NCAN neurocan 2.04329
ARL16 ADP-ribosylation factor-like 16 2.04329
ING3 inhibitor of growth family, member 3 2.04329
PACRGL PARK2 co-regulated-like 2.02121
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 2.01926
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2 2.01159

decreased expression

Symbol Name Standardized Value
ADH6 alcohol dehydrogenase 6 (class V) -2.96296
LRG1 leucine-rich alpha-2-glycoprotein 1 -2.96296
SP100 SP100 nuclear antigen -2.96296
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit -2.96296
DRICH1 aspartate-rich 1 -2.96296
MRPL53 mitochondrial ribosomal protein L53 -2.96296
GP1BB glycoprotein Ib (platelet), beta polypeptide -2.96296
ZNF467 zinc finger protein 467 -2.96296
GFRA3 GDNF family receptor alpha 3 -2.96296
RORC RAR-related orphan receptor C -2.96296
RAD21L1 RAD21-like 1 (S. pombe) -2.96296
C19ORF38 chromosome 19 open reading frame 38 -2.96296
LAMP3 lysosomal-associated membrane protein 3 -2.96296
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 -2.96296
LONRF2 LON peptidase N-terminal domain and ring finger 2 -2.96296
PPP4R2 protein phosphatase 4, regulatory subunit 2 -2.96296
IRX5 iroquois homeobox 5 -2.96296
WNT5A wingless-type MMTV integration site family, member 5A -2.96296
AZU1 azurocidin 1 -2.96296
TRAF3IP3 TRAF3 interacting protein 3 -2.96296
OXCT2 3-oxoacid CoA transferase 2 -2.96296
BAAT bile acid CoA:amino acid N-acyltransferase -2.96296
TRPM2 transient receptor potential cation channel, subfamily M, member 2 -2.96296
TUBA8 tubulin, alpha 8 -2.96296
SLC22A14 solute carrier family 22, member 14 -2.96296
VSTM1 V-set and transmembrane domain containing 1 -2.96296
ACSBG2 acyl-CoA synthetase bubblegum family member 2 -2.96296
KLC4 kinesin light chain 4 -2.96296
LGALS14 lectin, galactoside-binding, soluble, 14 -2.96296
RGS22 regulator of G-protein signaling 22 -2.96296
NPIPB7 nuclear pore complex interacting protein family, member B7 -2.96296
SMTNL1 smoothelin-like 1 -2.96296
CPHXL2 cytoplasmic polyadenylated homeobox like 2 -2.96296
DEUP1 deuterosome assembly protein 1 -2.96296
RAD9B RAD9 homolog B (S. pombe) -2.96296
SPDYE17 speedy/RINGO cell cycle regulator family member E17 -2.96296
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7 -2.96296
CER1 cerberus 1, DAN family BMP antagonist -2.96296
DPF3 D4, zinc and double PHD fingers, family 3 -2.96296
TIGD3 tigger transposable element derived 3 -2.96296
IZUMO1 izumo sperm-egg fusion 1 -2.96296
PCDHB14 protocadherin beta 14 -2.96296
PRB3 proline-rich protein BstNI subfamily 3 -2.96296
THPO thrombopoietin -2.96296
RAB11FIP4 RAB11 family interacting protein 4 (class II) -2.96296
CALCA calcitonin-related polypeptide alpha -2.96296
ACP4 acid phosphatase 4 -2.96296
ZFYVE19 zinc finger, FYVE domain containing 19 -2.94181
MVP major vault protein -2.94181
ZNF765 zinc finger protein 765 -2.90321
PYGO1 pygopus family PHD finger 1 -2.79578
PBX1 pre-B-cell leukemia homeobox 1 -2.79426
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -2.76474
ADIPOR2 adiponectin receptor 2 -2.69194
PLEKHO2 pleckstrin homology domain containing, family O member 2 -2.65946
ZIC5 Zic family member 5 -2.65436
ZNF860 zinc finger protein 860 -2.6378
RAB5C RAB5C, member RAS oncogene family -2.6348
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -2.60025
NLRP10 NLR family, pyrin domain containing 10 -2.58222
HRH3 histamine receptor H3 -2.58005
LSM10 LSM10, U7 small nuclear RNA associated -2.5579
ZNF430 zinc finger protein 430 -2.51452
C17ORF75 chromosome 17 open reading frame 75 -2.50894
PF4 platelet factor 4 -2.475
ZFYVE1 zinc finger, FYVE domain containing 1 -2.475
COX6B2 cytochrome c oxidase subunit VIb polypeptide 2 (testis) -2.46535
SPDYE18 speedy/RINGO cell cycle regulator family member E18 -2.44369
SYPL2 synaptophysin-like 2 -2.42677
WTIP Wilms tumor 1 interacting protein -2.41929
COMMD10 COMM domain containing 10 -2.40626
RANBP2 RAN binding protein 2 -2.40587
ZEB1 zinc finger E-box binding homeobox 1 -2.39435
ADAMTSL4 ADAMTS-like 4 -2.39435
SDK1 sidekick cell adhesion molecule 1 -2.35136
PRICKLE2 prickle homolog 2 (Drosophila) -2.35136
MAST4 microtubule associated serine/threonine kinase family member 4 -2.34761
ZBTB14 zinc finger and BTB domain containing 14 -2.34024
BCHE butyrylcholinesterase -2.34024
MRPL48 mitochondrial ribosomal protein L48 -2.32432
H1-3 H1.3 linker histone, cluster member -2.32171
SAAL1 serum amyloid A-like 1 -2.32171
PNMA8A PNMA family member 8A -2.31793
NSUN7 NOP2/Sun domain family, member 7 -2.29437
NAV2 neuron navigator 2 -2.26411
GHR growth hormone receptor -2.25674
XAB2 XPA binding protein 2 -2.23217
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4 -2.22819
THADA thyroid adenoma associated -2.22076
SULT4A1 sulfotransferase family 4A, member 1 -2.20897
DDHD2 DDHD domain containing 2 -2.20684
EMG1 EMG1 N1-specific pseudouridine methyltransferase -2.19621
ZNF256 zinc finger protein 256 -2.18131
SBK2 SH3 domain binding kinase family, member 2 -2.17874
ZC3H11A zinc finger CCCH-type containing 11A -2.17874
AMY2B amylase, alpha 2B (pancreatic) -2.17874
NCMAP noncompact myelin associated protein -2.15808
C17ORF49 chromosome 17 open reading frame 49 -2.12381
SPRED1 sprouty-related, EVH1 domain containing 1 -2.11938
HPSE heparanase -2.10656
MROH9 maestro heat-like repeat family member 9 -2.10656
ZNF576 zinc finger protein 576 -2.0947
BBS1 Bardet-Biedl syndrome 1 -2.07156
LIMCH1 LIM and calponin homology domains 1 -2.05479
LRRC26 leucine rich repeat containing 26 -2.03217
BSPRY B-box and SPRY domain containing -2.02581
FAAP24 FA core complex associated protein 24 -2.01926
THNSL2 threonine synthase-like 2 (S. cerevisiae) -2.01926
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 -2.01068
MRPS28 mitochondrial ribosomal protein S28 -2.00887
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -2.00787
RTN1 reticulon 1 -2.00787