CDK5 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description cyclin-dependent kinase 5|This gene encodes a proline-directed serine/threonine kinase that is a member of the cyclin-dependent kinase family of proteins. Unlike other members of the family, the protein encoded by this gene does not directly control cell cycle regulation. Instead the protein, which is predominantly expressed at high levels in mammalian postmitotic central nervous system neurons, functions in diverse processes such as synaptic plasticity and neuronal migration through phosphorylation of proteins required for cytoskeletal organization, endocytosis and exocytosis, and apoptosis. In humans, an allelic variant of the gene that results in undetectable levels of the protein has been associated with lethal autosomal recessive lissencephaly-7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2015] (NCBI Entrez Gene Database, 1020)
External Link http://www.ncbi.nlm.nih.gov/gene/1020
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Genes

96 substrates of the kinase CDK5 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
ADD2 adducin 2 (beta)
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
AMPH amphiphysin
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AR androgen receptor
ATM ATM serine/threonine kinase
AXIN1 axin 1
BCL2 B-cell CLL/lymphoma 2
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CDK16 cyclin-dependent kinase 16
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLOCK clock circadian regulator
CORO1A coronin, actin binding protein, 1A
CRMP1 collapsin response mediator protein 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND2 catenin (cadherin-associated protein), delta 2
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila)
DBN1 drebrin 1
DCX doublecortin
DIXDC1 DIX domain containing 1
DNM1 dynamin 1
DNM1L dynamin 1-like
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DRD2 dopamine receptor D2
ELAVL1 ELAV like RNA binding protein 1
EPRS glutamyl-prolyl-tRNA synthetase
ESYT1 extended synaptotagmin-like protein 1
EZR ezrin
FOXO1 forkhead box O1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
HDAC5 histone deacetylase 5
HTRA2 HtrA serine peptidase 2
HTT huntingtin
KALRN kalirin, RhoGEF kinase
LMTK1 lemur tail kinase 1
LMTK2 lemur tyrosine kinase 2
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPT microtubule-associated protein tau
MEF2A myocyte enhancer factor 2A
MEF2D myocyte enhancer factor 2D
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDEL1 nudE neurodevelopment protein 1-like 1
NEFL neurofilament, light polypeptide
NES nestin
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NFE2L2 nuclear factor, erythroid 2-like 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PARK2 parkin RBR E3 ubiquitin protein ligase
PHACTR3 phosphatase and actin regulator 3
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLD2 phospholipase D2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARG peroxisome proliferator-activated receptor gamma
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R1B protein phosphatase 1, regulatory (inhibitor) subunit 1B
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PRDX2 peroxiredoxin 2
PRNP prion protein
PSEN1 presenilin 1
PTK2 protein tyrosine kinase 2
PXN paxillin
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2
RB1 retinoblastoma 1
RHOQ ras homolog family member Q
SEPT5 septin 5
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIPA1L1 signal-induced proliferation-associated 1 like 1
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STK24 serine/threonine kinase 24
STMN1 stathmin 1
STMN3 stathmin-like 3
SUDS3 suppressor of defective silencing 3 homolog (S. cerevisiae)
SYN3 synapsin III
TH tyrosine hydroxylase
TLN1 talin 1
TP53 tumor protein p53
TPPP tubulin polymerization promoting protein
TRPV1 transient receptor potential cation channel, subfamily V, member 1
VIM vimentin
WASF2 WAS protein family, member 2
XDH xanthine dehydrogenase