CDK6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cyclin-dependent kinase 6|The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009] (NCBI Entrez Gene Database, 1021)
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Genes

341 genes differentially expressed following the CDK6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.86007
TMEM176B transmembrane protein 176B 2.86007
CFAP157 cilia and flagella associated protein 157 2.86007
SH3TC1 SH3 domain and tetratricopeptide repeats 1 2.86007
ZNF541 zinc finger protein 541 2.86007
CELF3 CUGBP, Elav-like family member 3 2.86007
NRSN1 neurensin 1 2.86007
ERAP2 endoplasmic reticulum aminopeptidase 2 2.86007
NAIF1 nuclear apoptosis inducing factor 1 2.86007
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.86007
DHRS9 dehydrogenase/reductase (SDR family) member 9 2.86007
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 2.86007
GRP gastrin-releasing peptide 2.86007
CTRC chymotrypsin C (caldecrin) 2.86007
PF4V1 platelet factor 4 variant 1 2.86007
RGR retinal G protein coupled receptor 2.86007
PLGLB2 plasminogen-like B2 2.86007
TUBA3D tubulin, alpha 3d 2.86007
TEX101 testis expressed 101 2.86007
CIMAP1D CIMAP1 family member D 2.86007
OR2A25 olfactory receptor, family 2, subfamily A, member 25 2.86007
ACP7 acid phosphatase 7, tartrate resistant (putative) 2.86007
PLCD4 phospholipase C, delta 4 2.86007
FADS6 fatty acid desaturase 6 2.86007
MINDY4B MINDY family member 4B 2.86007
CHADL chondroadherin-like 2.79561
VTN vitronectin 2.79561
FGD2 FYVE, RhoGEF and PH domain containing 2 2.79561
LY86 lymphocyte antigen 86 2.79561
FABP9 fatty acid binding protein 9, testis 2.79561
PRB1 proline-rich protein BstNI subfamily 1 2.79561
FABP2 fatty acid binding protein 2, intestinal 2.79561
GPR4 G protein-coupled receptor 4 2.79561
PLVAP plasmalemma vesicle associated protein 2.79561
SRPX2 sushi-repeat containing protein, X-linked 2 2.79561
TMPRSS11F transmembrane protease, serine 11F 2.79561
TMPRSS11B transmembrane protease, serine 11B 2.79561
IL4I1 interleukin 4 induced 1 2.79561
TREM2 triggering receptor expressed on myeloid cells 2 2.79561
CHRND cholinergic receptor, nicotinic, delta (muscle) 2.79561
GJB1 gap junction protein, beta 1, 32kDa 2.79561
ARHGAP30 Rho GTPase activating protein 30 2.79561
TUBB1 tubulin, beta 1 class VI 2.79561
RDH14 retinol dehydrogenase 14 (all-trans/9-cis/11-cis) 2.79561
NEU4 sialidase 4 2.79561
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 2.79561
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.79561
DEFB106B defensin, beta 106B 2.79561
HAS1 hyaluronan synthase 1 2.79561
NCKAP1L NCK-associated protein 1-like 2.79561
SOX18 SRY (sex determining region Y)-box 18 2.79561
TMEM151A transmembrane protein 151A 2.79561
KNG1 kininogen 1 2.79561
IGFL2 IGF-like family member 2 2.79561
GNLY granulysin 2.79561
HEATR9 HEAT repeat containing 9 2.79561
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 2.79561
TMEM176A transmembrane protein 176A 2.79561
AKR1C2 aldo-keto reductase family 1, member C2 2.79561
MGAM2 maltase-glucoamylase 2 (putative) 2.79561
NDST4 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 2.79561
RAB18 RAB18, member RAS oncogene family 2.79561
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.79561
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 2.79561
ROPN1L rhophilin associated tail protein 1-like 2.79561
AVPR1A arginine vasopressin receptor 1A 2.79561
SOHLH1 spermatogenesis and oogenesis specific basic helix-loop-helix 1 2.79561
CXCL13 chemokine (C-X-C motif) ligand 13 2.79561
C20ORF202 chromosome 20 open reading frame 202 2.79561
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A 2.79561
TMPRSS3 transmembrane protease, serine 3 2.79561
MYPN myopalladin 2.79561
GC group-specific component (vitamin D binding protein) 2.79561
SELL selectin L 2.79561
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 2.79561
H2BC1 H2B clustered histone 1 2.79561
DERPC DERPC proline and glycine rich nuclear protein 2.79561
EPCIP exosomal polycystin 1 interacting protein 2.79561
CIMIP7 ciliary microtubule inner protein 7 2.79561
PRR20G proline rich 20G 2.79561
TBC1D3I TBC1 domain family member 3I 2.79561
LINC02268 long intergenic non-protein coding RNA 2268 2.79561
H2BK1 H2B.K variant histone 1 2.79561
SERTM2 serine rich and transmembrane domain containing 2 2.79561
IHO1 interactor of HORMAD1 1 2.79561
GARIN6 golgi associated RAB2 interactor family member 6 2.79561
SPATA46 spermatogenesis associated 46 2.79561
CLEC6A C-type lectin domain family 6, member A 2.79561
HNF1A HNF1 homeobox A 2.79561
LTA lymphotoxin alpha 2.79561
MEOX1 mesenchyme homeobox 1 2.79561
ANXA13 annexin A13 2.79561
ANXA10 annexin A10 2.79561
DAO D-amino-acid oxidase 2.79561
AMBP alpha-1-microglobulin/bikunin precursor 2.79561
CHRD chordin 2.79561
NXPE4 neurexophilin and PC-esterase domain family, member 4 2.79561
CFAP97D1 CFAP97 domain containing 1 2.79561
TMEM229A transmembrane protein 229A 2.79561
OR2A1 olfactory receptor, family 2, subfamily A, member 1 2.79561
CBLN3 cerebellin 3 precursor 2.79561
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.79561
OVOL3 ovo-like zinc finger 3 2.79561
DLK2 delta-like 2 homolog (Drosophila) 2.79561
GDF9 growth differentiation factor 9 2.79561
PABPC1L2B poly(A) binding protein, cytoplasmic 1-like 2B 2.79561
FGFBP2 fibroblast growth factor binding protein 2 2.79561
C7 complement component 7 2.79561
SAA1 serum amyloid A1 2.79561
C7ORF57 chromosome 7 open reading frame 57 2.79561
GSC goosecoid homeobox 2.79561
NPFF neuropeptide FF-amide peptide precursor 2.79561
BHLHA9 basic helix-loop-helix family, member a9 2.79561
CLTA clathrin, light chain A 2.79561
LCN15 lipocalin 15 2.79561
VTCN1 V-set domain containing T cell activation inhibitor 1 2.79561
NIM1K NIM1 serine/threonine protein kinase 2.79561
EDN2 endothelin 2 2.79561
SUPT20HL1 suppressor of Ty 20 homolog (S. cerevisiae)-like 1 2.79561
EHF ets homologous factor 2.79561
ADGRA1 adhesion G protein-coupled receptor A1 2.79561
GRK1 G protein-coupled receptor kinase 1 2.79561
BTNL2 butyrophilin-like 2 2.79561
NOX1 NADPH oxidase 1 2.79561
WFDC6 WAP four-disulfide core domain 6 2.79561
CABP7 calcium binding protein 7 2.79561
C10ORF120 chromosome 10 open reading frame 120 2.79561
LST1 leukocyte specific transcript 1 2.79561
CARNS1 carnosine synthase 1 2.79561
C5AR2 complement component 5a receptor 2 2.79561
STMND1 stathmin domain containing 1 2.79561
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.79561
MCTP2 multiple C2 domains, transmembrane 2 2.79561
TSPAN32 tetraspanin 32 2.79561
SMIM22 small integral membrane protein 22 2.79561
CLEC7A C-type lectin domain family 7, member A 2.79561
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.79561
TRADD TNFRSF1A-associated via death domain 2.79561
GLRB glycine receptor, beta 2.79561
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 2.79561
SIGLEC11 sialic acid binding Ig-like lectin 11 2.79561
SIGLEC15 sialic acid binding Ig-like lectin 15 2.79561
LY9 lymphocyte antigen 9 2.79561
TRIM7 tripartite motif containing 7 2.79561
KCNA7 potassium channel, voltage gated shaker related subfamily A, member 7 2.79561
NPY2R neuropeptide Y receptor Y2 2.79561
GOLGA8J golgin A8 family, member J 2.79561
ACKR2 atypical chemokine receptor 2 2.79561
SIRPG signal-regulatory protein gamma 2.79561
AMHR2 anti-Mullerian hormone receptor, type II 2.79561
MAB21L2 mab-21-like 2 (C. elegans) 2.79561
TRIM50 tripartite motif containing 50 2.79561
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 2.79561
WNT7A wingless-type MMTV integration site family, member 7A 2.79561
VWA3B von Willebrand factor A domain containing 3B 2.79561
SLC22A24 solute carrier family 22, member 24 2.79561
PROK1 prokineticin 1 2.79561
C20ORF144 chromosome 20 open reading frame 144 2.79561
GOLGA8T golgin A8 family, member T 2.79561
LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 2.79561
TEX36 testis expressed 36 2.79561
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.79561
TTC36 tetratricopeptide repeat domain 36 2.79561
PPP1R3G protein phosphatase 1, regulatory subunit 3G 2.79561
SSX3 synovial sarcoma, X breakpoint 3 2.79561
LHX1 LIM homeobox 1 2.79561
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.79561
FGF5 fibroblast growth factor 5 2.79561
ANGPTL3 angiopoietin-like 3 2.79561
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.79561
GCSAML germinal center-associated, signaling and motility-like 2.79561
C5ORF46 chromosome 5 open reading frame 46 2.79561
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.79561
FGF7 fibroblast growth factor 7 2.79561
IL23R interleukin 23 receptor 2.79561
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.79561
CLEC14A C-type lectin domain family 14, member A 2.79561
IL2RA interleukin 2 receptor, alpha 2.79561
UBA7 ubiquitin-like modifier activating enzyme 7 2.79561
MOGAT2 monoacylglycerol O-acyltransferase 2 2.79561
TRIM42 tripartite motif containing 42 2.79561
ANKRD30B ankyrin repeat domain 30B 2.79561
PNOC prepronociceptin 2.79561
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.79561
GRIFIN galectin-related inter-fiber protein 2.79561
OR5V1 olfactory receptor, family 5, subfamily V, member 1 2.79561
NPIPA8 nuclear pore complex interacting protein family, member A8 2.79561
RFX6 regulatory factor X, 6 2.79561
KLHDC10 kelch domain containing 10 2.73075
PSPN persephin 2.71986
WNT5A wingless-type MMTV integration site family, member 5A 2.69141
PIK3C2G phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma 2.69141
VWF von Willebrand factor 2.69141
CLPSL1 colipase-like 1 2.69141
SCT secretin 2.69141
MKKS McKusick-Kaufman syndrome 2.65489
TCOF1 Treacher Collins-Franceschetti syndrome 1 2.64776
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.61477
PRPF39 pre-mRNA processing factor 39 2.6002
CCDC144A coiled-coil domain containing 144A 2.58981
FMN2 formin 2 2.58591
STARD5 StAR-related lipid transfer (START) domain containing 5 2.50965
ATP13A2 ATPase type 13A2 2.49224
TRIP6 thyroid hormone receptor interactor 6 2.48387
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2 2.46673
FNTB farnesyltransferase, CAAX box, beta 2.46003
EXOSC10 exosome component 10 2.45661
CDK6 cyclin-dependent kinase 6 2.42611
TMPRSS6 transmembrane protease, serine 6 2.40501
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 2.39491
CCDC102A coiled-coil domain containing 102A 2.38826
PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2.38826
SGPP2 sphingosine-1-phosphate phosphatase 2 2.35296
TBC1D15 TBC1 domain family, member 15 2.34133
NBEA neurobeachin 2.33687
ZNF432 zinc finger protein 432 2.33416
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.33416
NMT2 N-myristoyltransferase 2 2.32899
SCN8A sodium channel, voltage gated, type VIII alpha subunit 2.31969
IRF2BPL interferon regulatory factor 2 binding protein-like 2.31804
ALKBH3 alkB, alkylation repair homolog 3 (E. coli) 2.31804
TSPAN10 tetraspanin 10 2.29802
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 2.2771
FAM161B family with sequence similarity 161, member B 2.2771
LRGUK leucine-rich repeats and guanylate kinase domain containing 2.27135
CATSPER2 cation channel, sperm associated 2 2.26574
PLEKHH1 pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 2.26284
ANKMY1 ankyrin repeat and MYND domain containing 1 2.26284
MED28 mediator complex subunit 28 2.26284
REPS2 RALBP1 associated Eps domain containing 2 2.26004
CYB561A3 cytochrome b561 family, member A3 2.23934
SLTM SAFB-like, transcription modulator 2.23683
KARS1 lysyl-tRNA synthetase 1 2.22413
IP6K3 inositol hexakisphosphate kinase 3 2.22357
ACAD10 acyl-CoA dehydrogenase family, member 10 2.16485
SMAD7 SMAD family member 7 2.12268
ARL3 ADP-ribosylation factor-like 3 2.12268
ACP5 acid phosphatase 5, tartrate resistant 2.10874
STEEP1 STING1 ER exit protein 1 2.10793
ATP5MG ATP synthase membrane subunit g 2.10102
SARAF store-operated calcium entry-associated regulatory factor 2.0956
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 2.0853
DPY19L1 dpy-19-like 1 (C. elegans) 2.08407
SF3B2 splicing factor 3b, subunit 2, 145kDa 2.07113
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.05039
KANK4 KN motif and ankyrin repeat domains 4 2.02672
SYNJ2 synaptojanin 2 2.02507
CD9 CD9 molecule 2.01655
ADCY2 adenylate cyclase 2 (brain) 2.00968
EEF1AKMT1 EEF1A lysine methyltransferase 1 2.00407
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 2.00359

decreased expression

Symbol Name Standardized Value
COL11A2 collagen, type XI, alpha 2 -2.86007
ADAM11 ADAM metallopeptidase domain 11 -2.86007
NALCN sodium leak channel, non selective -2.86007
CISH cytokine inducible SH2-containing protein -2.79561
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 -2.79561
PSD3 pleckstrin and Sec7 domain containing 3 -2.79561
TAL2 T-cell acute lymphocytic leukemia 2 -2.79561
GCKR glucokinase (hexokinase 4) regulator -2.79561
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -2.79561
FNBP1L formin binding protein 1-like -2.79561
FNDC1 fibronectin type III domain containing 1 -2.79561
DCST2 DC-STAMP domain containing 2 -2.79561
TRAF3IP3 TRAF3 interacting protein 3 -2.79561
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.79561
CD8A CD8a molecule -2.79561
MUC1 mucin 1, cell surface associated -2.79561
LHFPL7 LHFPL tetraspan subfamily member 7 -2.79561
CFAP299 cilia and flagella associated protein 299 -2.79561
DEPP1 DEPP autophagy regulator 1 -2.79561
RBIS ribosomal biogenesis factor -2.79561
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial -2.79561
GPR37L1 G protein-coupled receptor 37 like 1 -2.79561
ADCY4 adenylate cyclase 4 -2.79561
PTGDR prostaglandin D2 receptor (DP) -2.79561
SHC4 SHC (Src homology 2 domain containing) family, member 4 -2.79561
HLA-G major histocompatibility complex, class I, G -2.79561
PRR4 proline rich 4 (lacrimal) -2.79561
FBXO2 F-box protein 2 -2.79561
NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa -2.79561
C1QTNF7 C1q and tumor necrosis factor related protein 7 -2.79561
MYH10 myosin, heavy chain 10, non-muscle -2.79561
ARHGAP8 Rho GTPase activating protein 8 -2.76265
RPL7 ribosomal protein L7 -2.76265
DCAKD dephospho-CoA kinase domain containing -2.74167
PKD1L1 polycystic kidney disease 1 like 1 -2.64139
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.64139
TMC7 transmembrane channel-like 7 -2.63939
PLLP plasmolipin -2.38964
ABHD12 abhydrolase domain containing 12 -2.35296
UBE2Z ubiquitin-conjugating enzyme E2Z -2.33687
SKA1 spindle and kinetochore associated complex subunit 1 -2.33666
TMEM87A transmembrane protein 87A -2.32899
TASP1 taspase, threonine aspartase, 1 -2.31804
THBS4 thrombospondin 4 -2.30774
CKAP4 cytoskeleton-associated protein 4 -2.3034
PDE10A phosphodiesterase 10A -2.29017
RNF208 ring finger protein 208 -2.28347
RGPD5 RANBP2-like and GRIP domain containing 5 -2.27135
EXD1 exonuclease 3'-5' domain containing 1 -2.27135
NUTM2G NUT family member 2G -2.26693
ZNF524 zinc finger protein 524 -2.26693
OTOA otoancorin -2.26693
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -2.26033
PLXNB2 plexin B2 -2.26004
BECN1 beclin 1, autophagy related -2.249
DNAH12 dynein, axonemal, heavy chain 12 -2.21996
RARS1 arginyl-tRNA synthetase 1 -2.21996
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -2.20742
CEP104 centrosomal protein 104kDa -2.1736
LOC728743 zinc finger protein pseudogene -2.1736
MDK midkine (neurite growth-promoting factor 2) -2.1669
TEKT3 tektin 3 -2.16485
RNF7 ring finger protein 7 -2.15917
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -2.15917
EPAS1 endothelial PAS domain protein 1 -2.13552
KLHL17 kelch-like family member 17 -2.10874
CIART circadian associated repressor of transcription -2.10874
RICTOR RPTOR independent companion of MTOR, complex 2 -2.10602
GPHN gephyrin -2.09608
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.08883
LGALS7B lectin, galactoside-binding, soluble, 7B -2.0649
L1CAM L1 cell adhesion molecule -2.0556
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3 -2.05312
STOML2 stomatin (EPB72)-like 2 -2.05039
UBTD2 ubiquitin domain containing 2 -2.05039
ICOSLG inducible T-cell co-stimulator ligand -2.04926
CDCA4 cell division cycle associated 4 -2.03389
IFT81 intraflagellar transport 81 -2.0301
SHCBP1 SHC SH2-domain binding protein 1 -2.02827
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa -2.02507
KIF1B kinesin family member 1B -2.02507
CASTOR2 cytosolic arginine sensor for mTORC1 subunit 2 -2.02386
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent) -2.01655
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -2.0115
PDCD11 programmed cell death 11 -2.0115
ERGIC3 ERGIC and golgi 3 -2.00968
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -2.00786
DGCR2 DiGeorge syndrome critical region gene 2 -2.00395
DCLK2 doublecortin-like kinase 2 -2.00359
PPP1R3F protein phosphatase 1, regulatory subunit 3F -2.00024