CDK6 Gene Set

Dataset Kinase Library Serine Threonine Kinome Atlas
Category proteomics
Type kinase
Description cyclin-dependent kinase 6|The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009] (NCBI Entrez Gene Database, 1021)
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Genes

100 substrates of the kinase CDK6 from the Kinase Library Serine Threonine Kinome Atlas dataset.

Symbol Name Standardized Value
MICALL1 MICAL-like 1
ZZEF1 zinc finger, ZZ-type with EF-hand domain 1
SRSF1 serine/arginine-rich splicing factor 1
SRSF2 serine/arginine-rich splicing factor 2
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
AAK1 AP2 associated kinase 1
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
E2F4 E2F transcription factor 4, p107/p130-binding
TRIO trio Rho guanine nucleotide exchange factor
RAB42 RAB42, member RAS oncogene family
CRTC1 CREB regulated transcription coactivator 1
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40
ZCCHC7 zinc finger, CCHC domain containing 7
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
BACE1 beta-site APP-cleaving enzyme 1
SON SON DNA binding protein
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
KALRN kalirin, RhoGEF kinase
UCKL1 uridine-cytidine kinase 1-like 1
TOR4A torsin family 4, member A
AKAP12 A kinase (PRKA) anchor protein 12
USP24 ubiquitin specific peptidase 24
SMN2 survival of motor neuron 2, centromeric
MPRIP myosin phosphatase Rho interacting protein
NKX2-4 NK2 homeobox 4
BEST3 bestrophin 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
CNOT10 CCR4-NOT transcription complex, subunit 10
ZMYM3 zinc finger, MYM-type 3
ANO2 anoctamin 2, calcium activated chloride channel
CCDC137 coiled-coil domain containing 137
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
SEC62 SEC62 homolog (S. cerevisiae)
MDC1 mediator of DNA-damage checkpoint 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1
MIS18BP1 MIS18 binding protein 1
CDC6 cell division cycle 6
REXO1 REX1, RNA exonuclease 1 homolog (S. cerevisiae)
ZBTB16 zinc finger and BTB domain containing 16
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RBMX2 RNA binding motif protein, X-linked 2
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4
KIAA1109 KIAA1109
NAV1 neuron navigator 1
PRR12 proline rich 12
RASAL2 RAS protein activator like 2
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
MAP1A microtubule-associated protein 1A
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2
WDR47 WD repeat domain 47
AUTS2 autism susceptibility candidate 2
UHRF1 ubiquitin-like with PHD and ring finger domains 1
RB1 retinoblastoma 1
MAP3K11 mitogen-activated protein kinase kinase kinase 11
ZC3H13 zinc finger CCCH-type containing 13
GAB1 GRB2-associated binding protein 1
AKIRIN2 akirin 2
AKIRIN1 akirin 1
PROSER3 proline and serine rich 3
RAD54L RAD54-like (S. cerevisiae)
WNK3 WNK lysine deficient protein kinase 3
VPRBP Vpr (HIV-1) binding protein
GAS2L1 growth arrest-specific 2 like 1
TBKBP1 TBK1 binding protein 1
ERF Ets2 repressor factor
RPAIN RPA interacting protein
USP6NL USP6 N-terminal like
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTA3 glutathione S-transferase alpha 3
NCKAP5L NCK-associated protein 5-like
SRRM2 serine/arginine repetitive matrix 2
SCAF11 SR-related CTD-associated factor 11
CENPF centromere protein F, 350/400kDa
CENPT centromere protein T
C19ORF57 chromosome 19 open reading frame 57
MAP2K1 mitogen-activated protein kinase kinase 1
SPEN spen family transcriptional repressor
SPEG SPEG complex locus
CRY2 cryptochrome circadian clock 2
KMT2B lysine (K)-specific methyltransferase 2B
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
PERM1 PPARGC1 and ESRR induced regulator, muscle 1
TPR translocated promoter region, nuclear basket protein
KIF1C kinesin family member 1C
PRC1 protein regulator of cytokinesis 1
RREB1 ras responsive element binding protein 1
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2
LMNB2 lamin B2
FRS2 fibroblast growth factor receptor substrate 2
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
FOXO1 forkhead box O1
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
MSL3 male-specific lethal 3 homolog (Drosophila)
MMP14 matrix metallopeptidase 14 (membrane-inserted)
SCNM1 sodium channel modifier 1
SGPP1 sphingosine-1-phosphate phosphatase 1