CDK6 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cyclin-dependent kinase 6|The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Expression of this gene is up-regulated in some types of cancer. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009] (NCBI Entrez Gene Database, 1021)
External Link http://www.ncbi.nlm.nih.gov/gene/1021
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151 interacting proteins for CDK6 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABI1 abl-interactor 1
ABI2 abl-interactor 2
ACLY ATP citrate lyase
ACTB actin, beta
ACTG1 actin gamma 1
ACTN4 actinin, alpha 4
AMY2A amylase, alpha 2A (pancreatic)
ANKRD12 ankyrin repeat domain 12
AR androgen receptor
ATF6B activating transcription factor 6 beta
ATXN1 ataxin 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CASC3 cancer susceptibility candidate 3
CBY1 chibby homolog 1 (Drosophila)
CCNA2 cyclin A2
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CCNH cyclin H
CDC37 cell division cycle 37
CDC6 cell division cycle 6
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK7 cyclin-dependent kinase 7
CDKL3 cyclin-dependent kinase-like 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CELF1 CUGBP, Elav-like family member 1
CLASRP CLK4-associating serine/arginine rich protein
CNOT7 CCR4-NOT transcription complex, subunit 7
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DDIT3 DNA-damage-inducible transcript 3
DEDD2 death effector domain containing 2
DMBT1 deleted in malignant brain tumors 1
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
EBF4 early B-cell factor 4
EEF2 eukaryotic translation elongation factor 2
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1
ELAVL1 ELAV like RNA binding protein 1
ELK1 ELK1, member of ETS oncogene family
EPHA3 EPH receptor A3
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBXO7 F-box protein 7
FOXM1 forkhead box M1
FOXO3 forkhead box O3
GAPDH glyceraldehyde-3-phosphate dehydrogenase
HDAC1 histone deacetylase 1
HIST1H1A histone cluster 1, H1a
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HSF1 heat shock transcription factor 1
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
ISL1 ISL LIM homeobox 1
KIF26B kinesin family member 26B
KLF10 Kruppel-like factor 10
LPIN1 lipin 1
MAX MYC associated factor X
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM6 minichromosome maintenance complex component 6
MEF2D myocyte enhancer factor 2D
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
MMRN1 multimerin 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MSL3 male-specific lethal 3 homolog (Drosophila)
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MZF1 myeloid zinc finger 1
N4BP1 NEDD4 binding protein 1
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NIPBL Nipped-B homolog (Drosophila)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NUMA1 nuclear mitotic apparatus protein 1
PCNA proliferating cell nuclear antigen
PDCD6 programmed cell death 6
PIGR polymeric immunoglobulin receptor
PML promyelocytic leukemia
POGZ pogo transposable element with ZNF domain
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPHLN1 periphilin 1
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PRX periaxin
RB1 retinoblastoma 1
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RBM23 RNA binding motif protein 23
RIN2 Ras and Rab interactor 2
RUNX1 runt-related transcription factor 1
RUVBL2 RuvB-like AAA ATPase 2
SENP3 SUMO1/sentrin/SMT3 specific peptidase 3
SIRT1 sirtuin 1
SLBP stem-loop binding protein
SNIP1 Smad nuclear interacting protein 1
SNRPA small nuclear ribonucleoprotein polypeptide A
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORBS1 sorbin and SH3 domain containing 1
SOX10 SRY (sex determining region Y)-box 10
SOX5 SRY (sex determining region Y)-box 5
SRSF1 serine/arginine-rich splicing factor 1
SRSF11 serine/arginine-rich splicing factor 11
SRSF12 serine/arginine-rich splicing factor 12
SRSF2 serine/arginine-rich splicing factor 2
SRSF7 serine/arginine-rich splicing factor 7
SSBP2 single-stranded DNA binding protein 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNPO2 synaptopodin 2
TCEB3B transcription elongation factor B polypeptide 3B (elongin A2)
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TGFBR1 transforming growth factor, beta receptor 1
TJP2 tight junction protein 2
TPX2 TPX2, microtubule-associated
TRA2A transformer 2 alpha homolog (Drosophila)
TRA2B transformer 2 beta homolog (Drosophila)
TRAK1 trafficking protein, kinesin binding 1
TRAP1 TNF receptor-associated protein 1
TUBA1A tubulin, alpha 1a
TUBA1C tubulin, alpha 1c
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
UBC ubiquitin C
UBE4B ubiquitination factor E4B
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
USP26 ubiquitin specific peptidase 26
VGLL4 vestigial-like family member 4
WDR33 WD repeat domain 33
ZEB1 zinc finger E-box binding homeobox 1
ZFP36 ZFP36 ring finger protein
ZMYM3 zinc finger, MYM-type 3
ZNF101 zinc finger protein 101
ZNF174 zinc finger protein 174
ZNF335 zinc finger protein 335
ZNF823 zinc finger protein 823
ZSCAN1 zinc finger and SCAN domain containing 1