CDK6_knockdown_93_GSE27869 Gene Set

Dataset GEO Signatures of Differentially Expressed Genes for Kinase Perturbations
Category transcriptomics
Type kinase perturbation
Description kinase perturbation identified as [kinase gene symbol]_[perturbation]_[perturbation ID]_[GEO accession] (Gene Expression Omnibus)
External Link http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE27869
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Genes

600 genes differentially expressed following the CDK6_knockdown_93_GSE27869 kinase perturbation from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.

increased expression

Symbol Name Standardized Value
NANS N-acetylneuraminic acid synthase 3.00271
ANXA2 annexin A2 2.67156
RPUSD4 RNA pseudouridylate synthase domain containing 4 2.65575
CDK7 cyclin-dependent kinase 7 2.53841
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 2.50994
RPS15A ribosomal protein S15a 2.50226
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2.49859
MRC2 mannose receptor, C type 2 2.47349
SAMD14 sterile alpha motif domain containing 14 2.44022
RDH13 retinol dehydrogenase 13 (all-trans/9-cis) 2.41156
RPL32 ribosomal protein L32 2.40395
INPP4A inositol polyphosphate-4-phosphatase, type I, 107kDa 2.40279
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 2.39228
ZNF721 zinc finger protein 721 2.36987
HAUS2 HAUS augmin-like complex, subunit 2 2.36833
GSS glutathione synthetase 2.34413
PUM1 pumilio RNA-binding family member 1 2.3414
UBE2R2 ubiquitin-conjugating enzyme E2R 2 2.33899
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.33642
DHRSX dehydrogenase/reductase (SDR family) X-linked 2.30451
KIF13B kinesin family member 13B 2.2785
PTRH2 peptidyl-tRNA hydrolase 2 2.26493
ZC2HC1A zinc finger, C2HC-type containing 1A 2.26322
PUF60 poly-U binding splicing factor 60KDa 2.25495
KCTD2 potassium channel tetramerization domain containing 2 2.25482
PITX3 paired-like homeodomain 3 2.25247
SNIP1 Smad nuclear interacting protein 1 2.24254
ARHGAP17 Rho GTPase activating protein 17 2.22528
TUSC1 tumor suppressor candidate 1 2.22408
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 2.22116
SAMM50 SAMM50 sorting and assembly machinery component 2.2169
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26 2.21416
ADK adenosine kinase 2.21284
IP6K2 inositol hexakisphosphate kinase 2 2.20669
NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) 2.20359
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 2.20151
SH3PXD2A SH3 and PX domains 2A 2.19621
TTC1 tetratricopeptide repeat domain 1 2.19099
RAB37 RAB37, member RAS oncogene family 2.18112
PTP4A2 protein tyrosine phosphatase type IVA, member 2 2.17259
PAAF1 proteasomal ATPase-associated factor 1 2.16678
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2.1581
TMCC3 transmembrane and coiled-coil domain family 3 2.15738
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 2.15377
PELO pelota homolog (Drosophila) 2.14657
RBM22 RNA binding motif protein 22 2.14637
EEF1B2 eukaryotic translation elongation factor 1 beta 2 2.139
ILKAP integrin-linked kinase-associated serine/threonine phosphatase 2.13658
RPS24 ribosomal protein S24 2.13393
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 2.12814
EXOSC1 exosome component 1 2.12801
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 2.11452
OXCT1 3-oxoacid CoA transferase 1 2.11025
AKAP17A A kinase (PRKA) anchor protein 17A 2.10876
GSPT1 G1 to S phase transition 1 2.10813
TMCO4 transmembrane and coiled-coil domains 4 2.10346
WIPI1 WD repeat domain, phosphoinositide interacting 1 2.10174
CAMTA2 calmodulin binding transcription activator 2 2.09983
RPL18A ribosomal protein L18a 2.09706
RPL19 ribosomal protein L19 2.09562
TBCK TBC1 domain containing kinase 2.09222
GNB5 guanine nucleotide binding protein (G protein), beta 5 2.09084
TMEM11 transmembrane protein 11 2.08799
TPT1 tumor protein, translationally-controlled 1 2.08269
LRRC3B leucine rich repeat containing 3B 2.08238
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa 2.08224
CCDC88C coiled-coil domain containing 88C 2.08165
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 2.08131
LGALSL lectin, galactoside-binding-like 2.07841
WDR89 WD repeat domain 89 2.07785
EEF1E1 eukaryotic translation elongation factor 1 epsilon 1 2.07724
RPS14 ribosomal protein S14 2.07647
DNAJB12 DnaJ (Hsp40) homolog, subfamily B, member 12 2.06846
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) 2.06587
FBXL4 F-box and leucine-rich repeat protein 4 2.06246
CXORF56 chromosome X open reading frame 56 2.0585
RPS3A ribosomal protein S3A 2.05314
DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 2.04289
GNPDA2 glucosamine-6-phosphate deaminase 2 2.0413
CD9 CD9 molecule 2.04058
FRMD4A FERM domain containing 4A 2.03819
CTSZ cathepsin Z 2.03523
MED15 mediator complex subunit 15 2.03021
ZBTB46-AS1 ZBTB46 antisense RNA 1 2.02571
ZNF548 zinc finger protein 548 2.0253
EXD2 exonuclease 3'-5' domain containing 2 2.02197
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 2.01612
WBP4 WW domain binding protein 4 2.00478
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.00465
BRAP BRCA1 associated protein 2.00453
RBMX2 RNA binding motif protein, X-linked 2 1.99487
UQCRC1 ubiquinol-cytochrome c reductase core protein I 1.98789
ASNSD1 asparagine synthetase domain containing 1 1.984
ARSK arylsulfatase family, member K 1.97768
LAGE3 L antigen family, member 3 1.97766
KLHL28 kelch-like family member 28 1.97405
HSBP1 heat shock factor binding protein 1 1.97253
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 1.96984
FBXO8 F-box protein 8 1.96903
TMEM263 transmembrane protein 263 1.96874
CD93 CD93 molecule 1.96781
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 1.96352
CCT7 chaperonin containing TCP1, subunit 7 (eta) 1.96148
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 1.95917
GNL1 guanine nucleotide binding protein-like 1 1.95828
IQCE IQ motif containing E 1.95021
TNRC6C trinucleotide repeat containing 6C 1.95012
CORO1B coronin, actin binding protein, 1B 1.94608
WDR83OS WD repeat domain 83 opposite strand 1.94226
TMEM104 transmembrane protein 104 1.94074
HAUS7 HAUS augmin-like complex, subunit 7 1.93794
UQCR10 ubiquinol-cytochrome c reductase, complex III subunit X 1.93764
FAM81A family with sequence similarity 81, member A 1.937
ZDHHC16 zinc finger, DHHC-type containing 16 1.937
C22ORF24 chromosome 22 open reading frame 24 1.93531
AKR1C4 aldo-keto reductase family 1, member C4 1.931
CKLF chemokine-like factor 1.92985
DKK3 dickkopf WNT signaling pathway inhibitor 3 1.92766
KCNA4 potassium channel, voltage gated shaker related subfamily A, member 4 1.92706
ELMO1 engulfment and cell motility 1 1.92603
VIM vimentin 1.92196
TRMT1 tRNA methyltransferase 1 homolog (S. cerevisiae) 1.92069
B3GALT6 UDP-Gal:betaGal beta 1,3-galactosyltransferase polypeptide 6 1.91758
C7ORF26 chromosome 7 open reading frame 26 1.917
CEPT1 choline/ethanolamine phosphotransferase 1 1.91124
KIAA0391 KIAA0391 1.91013
RCC1 regulator of chromosome condensation 1 1.90692
PEX3 peroxisomal biogenesis factor 3 1.90196
PDLIM1 PDZ and LIM domain 1 1.89423
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2 1.89274
FXN frataxin 1.88953
GLUL glutamate-ammonia ligase 1.88912
ZNF2 zinc finger protein 2 1.88712
COG3 component of oligomeric golgi complex 3 1.88557
YLPM1 YLP motif containing 1 1.88396
PPA1 pyrophosphatase (inorganic) 1 1.88325
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit 1.88224
CDK20 cyclin-dependent kinase 20 1.88112
ENOPH1 enolase-phosphatase 1 1.87535
TMSB10 thymosin beta 10 1.87531
WSB2 WD repeat and SOCS box containing 2 1.87367
ZNF502 zinc finger protein 502 1.87203
STX7 syntaxin 7 1.8701
UBE2D1 ubiquitin-conjugating enzyme E2D 1 1.86904
DBN1 drebrin 1 1.86745
PWP2 PWP2 periodic tryptophan protein homolog (yeast) 1.86601
CDC42 cell division cycle 42 1.8655
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast) 1.86418
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 1.86323
TMEM177 transmembrane protein 177 1.86098
MYO19 myosin XIX 1.86037
NKIRAS2 NFKB inhibitor interacting Ras-like 2 1.85941
ZNF692 zinc finger protein 692 1.85637
BANP BTG3 associated nuclear protein 1.85585
OSTF1 osteoclast stimulating factor 1 1.85439
UCK1 uridine-cytidine kinase 1 1.85311
LAMA1 laminin, alpha 1 1.85275
MRPL51 mitochondrial ribosomal protein L51 1.84972
RRAS2 related RAS viral (r-ras) oncogene homolog 2 1.84955
PDLIM4 PDZ and LIM domain 4 1.84874
NPY4R neuropeptide Y receptor Y4 1.84789
FBXO30 F-box protein 30 1.84684
TONSL tonsoku-like, DNA repair protein 1.84615
COX7B cytochrome c oxidase subunit VIIb 1.84295
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 1.83418
TIMM21 translocase of inner mitochondrial membrane 21 homolog (yeast) 1.83168
ZNF207 zinc finger protein 207 1.83158
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 1.83146
CST5 cystatin D 1.8302
JAM3 junctional adhesion molecule 3 1.82928
NOP58 NOP58 ribonucleoprotein 1.81958
THOC3 THO complex 3 1.8159
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 1.81241
AGO3 argonaute RISC catalytic component 3 1.81167
TESK1 testis-specific kinase 1 1.81071
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3 1.80476
C10ORF2 chromosome 10 open reading frame 2 1.80349
TAPT1 transmembrane anterior posterior transformation 1 1.79935
ZC3H7B zinc finger CCCH-type containing 7B 1.79896
FKBP1A FK506 binding protein 1A, 12kDa 1.79843
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4 1.79722
UBAP1L ubiquitin associated protein 1-like 1.7965
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa 1.79596
MAGED2 melanoma antigen family D2 1.7948
TBCB tubulin folding cofactor B 1.79469
C20ORF195 chromosome 20 open reading frame 195 1.79359
METTL21B methyltransferase like 21B 1.79065
MRPL23 mitochondrial ribosomal protein L23 1.78789
LCMT1 leucine carboxyl methyltransferase 1 1.77433
LCMT1-AS2 LCMT1 antisense RNA 2 1.7734
EPB41 erythrocyte membrane protein band 4.1 1.77332
EXOSC4 exosome component 4 1.77188
ZNF764 zinc finger protein 764 1.7707
UBL3 ubiquitin-like 3 1.76826
APOC4 apolipoprotein C-IV 1.76719
PRR15L proline rich 15-like 1.76712
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1 1.76651
THAP3 THAP domain containing, apoptosis associated protein 3 1.76477
ZNF300 zinc finger protein 300 1.76317
CORO2B coronin, actin binding protein, 2B 1.75819
CAMLG calcium modulating ligand 1.75632
ZDHHC12 zinc finger, DHHC-type containing 12 1.75463
ALPI alkaline phosphatase, intestinal 1.75412
DYNLL1 dynein, light chain, LC8-type 1 1.74916
MOCS3 molybdenum cofactor synthesis 3 1.748
PTPRD protein tyrosine phosphatase, receptor type, D 1.74786
PANX2 pannexin 2 1.74784
STX8 syntaxin 8 1.74737
GNA14 guanine nucleotide binding protein (G protein), alpha 14 1.74517
PRSS22 protease, serine, 22 1.74138
PSTK phosphoseryl-tRNA kinase 1.74051
LOC283788 FSHD region gene 1 pseudogene 1.73857
STARD13 StAR-related lipid transfer (START) domain containing 13 1.73507
TMEM50A transmembrane protein 50A 1.73487
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide 1.7271
UPP1 uridine phosphorylase 1 1.72669
ANKHD1 ankyrin repeat and KH domain containing 1 1.72599
CNOT4 CCR4-NOT transcription complex, subunit 4 1.72442
CENPN centromere protein N 1.72396
SMAD5 SMAD family member 5 1.72055
PARL presenilin associated, rhomboid-like 1.71983
PTPRA protein tyrosine phosphatase, receptor type, A 1.71968
SAT2 spermidine/spermine N1-acetyltransferase family member 2 1.71836
APIP APAF1 interacting protein 1.71649
ADARB1 adenosine deaminase, RNA-specific, B1 1.71549
FOSL2 FOS-like antigen 2 1.71543
SNX27 sorting nexin family member 27 1.71447
TICAM1 toll-like receptor adaptor molecule 1 1.71145
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 1.71112
RETSAT retinol saturase (all-trans-retinol 13,14-reductase) 1.70845
CLK2 CDC-like kinase 2 1.70772
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 1.70763
OSER1 oxidative stress responsive serine-rich 1 1.70749
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa 1.70732
NSMCE4A non-SMC element 4 homolog A (S. cerevisiae) 1.70726
PSMA1 proteasome (prosome, macropain) subunit, alpha type, 1 1.70698
CD276 CD276 molecule 1.70612
TMEM242 transmembrane protein 242 1.70506
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 1.70412
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) 1.70114
BUD31 BUD31 homolog (S. cerevisiae) 1.7007
TMEM194B transmembrane protein 194B 1.70019
TMEM185B transmembrane protein 185B 1.69944
CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 1.69763
MAP3K12 mitogen-activated protein kinase kinase kinase 12 1.69716
KCMF1 potassium channel modulatory factor 1 1.6966
TBRG1 transforming growth factor beta regulator 1 1.69618
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 1.69604
ZNF696 zinc finger protein 696 1.69487
NELFE negative elongation factor complex member E 1.69432
IMPG2 interphotoreceptor matrix proteoglycan 2 1.69306
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 1.69265
PSMD1 proteasome (prosome, macropain) 26S subunit, non-ATPase, 1 1.68884
MIEN1 migration and invasion enhancer 1 1.6886
ITM2B integral membrane protein 2B 1.68797
PSPC1 paraspeckle component 1 1.68733
DMAP1 DNA methyltransferase 1 associated protein 1 1.6871
DTWD1 DTW domain containing 1 1.68529
TMEM164 transmembrane protein 164 1.68512
NTAN1 N-terminal asparagine amidase 1.68477
JADE1 jade family PHD finger 1 1.68385
RWDD3 RWD domain containing 3 1.68378
NDFIP1 Nedd4 family interacting protein 1 1.68342
SDCCAG8 serologically defined colon cancer antigen 8 1.68318
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 1.68215
FAM103A1 family with sequence similarity 103, member A1 1.68026
ACBD5 acyl-CoA binding domain containing 5 1.67896
ZFP36 ZFP36 ring finger protein 1.67636
PHIP pleckstrin homology domain interacting protein 1.67562
LNX2 ligand of numb-protein X 2 1.67404
C1QBP complement component 1, q subcomponent binding protein 1.67374
GAPVD1 GTPase activating protein and VPS9 domains 1 1.67332
TRAPPC10 trafficking protein particle complex 10 1.67332
FLVCR1 feline leukemia virus subgroup C cellular receptor 1 1.67185
ZNF395 zinc finger protein 395 1.67142
SCML1 sex comb on midleg-like 1 (Drosophila) 1.6707
RAD1 RAD1 checkpoint DNA exonuclease 1.66892
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 1.66839
RPARP-AS1 RPARP antisense RNA 1 1.66788
VPS29 vacuolar protein sorting 29 homolog (S. cerevisiae) 1.66753
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.66621
PHC3 polyhomeotic homolog 3 (Drosophila) 1.66589
FOXD1 forkhead box D1 1.66496
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 1.66487
MAP3K7 mitogen-activated protein kinase kinase kinase 7 1.66481
MBIP MAP3K12 binding inhibitory protein 1 1.66477
SNRPA1 small nuclear ribonucleoprotein polypeptide A' 1.6624
ACVR2A activin A receptor, type IIA 1.66211
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 1.6614
TAOK2 TAO kinase 2 1.65643
ASXL1 additional sex combs like transcriptional regulator 1 1.65347
VAX2 ventral anterior homeobox 2 1.65345
SBNO1 strawberry notch homolog 1 (Drosophila) 1.65235
PCDHGA4 protocadherin gamma subfamily A, 4 1.652
AIG1 androgen-induced 1 1.64955
ATG4D autophagy related 4D, cysteine peptidase 1.64609
CAMK2D calcium/calmodulin-dependent protein kinase II delta 1.64557
FBXO17 F-box protein 17 1.6445
PPAP2A phosphatidic acid phosphatase type 2A 1.64396
FDX1 ferredoxin 1 1.64312

decreased expression

Symbol Name Standardized Value
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -3.64173
ATP6V1E1 ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1 -3.34988
CHMP4B charged multivesicular body protein 4B -2.98219
TMEM199 transmembrane protein 199 -2.90494
RNF166 ring finger protein 166 -2.77188
ARF1 ADP-ribosylation factor 1 -2.69261
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -2.66254
PCID2 PCI domain containing 2 -2.6438
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.62882
RMDN3 regulator of microtubule dynamics 3 -2.61505
ERP29 endoplasmic reticulum protein 29 -2.60807
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -2.56248
ICMT isoprenylcysteine carboxyl methyltransferase -2.55053
RFC1 replication factor C (activator 1) 1, 145kDa -2.52824
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.46635
PDAP1 PDGFA associated protein 1 -2.41551
PARVG parvin, gamma -2.4149
KIAA0195 KIAA0195 -2.37428
SCAF11 SR-related CTD-associated factor 11 -2.35915
TGOLN2 trans-golgi network protein 2 -2.35048
NEK6 NIMA-related kinase 6 -2.34665
BMP2K BMP2 inducible kinase -2.33725
GRASP GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein -2.33393
PRELID2 PRELI domain containing 2 -2.3012
LARS2 leucyl-tRNA synthetase 2, mitochondrial -2.29181
INTS3 integrator complex subunit 3 -2.28619
FBXW11 F-box and WD repeat domain containing 11 -2.28069
GTF3A general transcription factor IIIA -2.27773
EMD emerin -2.27554
GSR glutathione reductase -2.26835
MPZL1 myelin protein zero-like 1 -2.26135
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.26087
HADH hydroxyacyl-CoA dehydrogenase -2.25912
DARS aspartyl-tRNA synthetase -2.25609
C5ORF28 chromosome 5 open reading frame 28 -2.25557
CAMK2G calcium/calmodulin-dependent protein kinase II gamma -2.23598
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31 -2.22444
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta -2.21466
LSM1 LSM1, U6 small nuclear RNA associated -2.21011
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.20723
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.20332
ADGRL4 adhesion G protein-coupled receptor L4 -2.20033
TGS1 trimethylguanosine synthase 1 -2.17948
TMEM209 transmembrane protein 209 -2.17334
PPAPDC1B phosphatidic acid phosphatase type 2 domain containing 1B -2.1724
SP1 Sp1 transcription factor -2.17161
ZMPSTE24 zinc metallopeptidase STE24 -2.14223
PSMB1 proteasome (prosome, macropain) subunit, beta type, 1 -2.13407
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 -2.13246
MAPRE3 microtubule-associated protein, RP/EB family, member 3 -2.13124
RPIA ribose 5-phosphate isomerase A -2.13035
FBXO22 F-box protein 22 -2.13034
DCAF13 DDB1 and CUL4 associated factor 13 -2.11678
TBC1D20 TBC1 domain family, member 20 -2.11614
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.11313
KDM4A lysine (K)-specific demethylase 4A -2.11143
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3 -2.10922
PPA2 pyrophosphatase (inorganic) 2 -2.10265
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 -2.09576
PEBP1 phosphatidylethanolamine binding protein 1 -2.09121
FOXN3 forkhead box N3 -2.08992
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -2.08876
GNAS GNAS complex locus -2.08273
ACVR1B activin A receptor, type IB -2.0775
WWC2 WW and C2 domain containing 2 -2.06827
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing -2.06528
ATCAY ataxia, cerebellar, Cayman type -2.06137
IFT46 intraflagellar transport 46 -2.05603
UIMC1 ubiquitin interaction motif containing 1 -2.05079
STAU2 staufen double-stranded RNA binding protein 2 -2.04277
EIF4B eukaryotic translation initiation factor 4B -2.03904
PLEKHO2 pleckstrin homology domain containing, family O member 2 -2.03731
NNMT nicotinamide N-methyltransferase -2.03157
ASF1B anti-silencing function 1B histone chaperone -2.02625
INTS7 integrator complex subunit 7 -2.02554
CBWD5 COBW domain containing 5 -2.01835
ENDOG endonuclease G -2.01453
SUMO3 small ubiquitin-like modifier 3 -2.01249
CDK6 cyclin-dependent kinase 6 -2.00897
PHKG1 phosphorylase kinase, gamma 1 (muscle) -2.00787
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -2.00273
MAGT1 magnesium transporter 1 -2.00265
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase -2.00039
CALU calumenin -1.99469
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 -1.99379
ICK intestinal cell (MAK-like) kinase -1.98723
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 -1.9868
LCMT2 leucine carboxyl methyltransferase 2 -1.98367
PHACTR4 phosphatase and actin regulator 4 -1.98353
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -1.98237
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -1.98053
DDOST dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic) -1.97454
CHKA choline kinase alpha -1.97171
HIST1H3H histone cluster 1, H3h -1.96549
BDH2 3-hydroxybutyrate dehydrogenase, type 2 -1.961
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) -1.96049
ATP2A1 ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 -1.95883
BCL6 B-cell CLL/lymphoma 6 -1.95628
PLA2G12A phospholipase A2, group XIIA -1.95422
ECI1 enoyl-CoA delta isomerase 1 -1.94852
S100A2 S100 calcium binding protein A2 -1.94806
TCTEX1D2 Tctex1 domain containing 2 -1.9441
RHBDD1 rhomboid domain containing 1 -1.94318
C18ORF8 chromosome 18 open reading frame 8 -1.94307
PEX14 peroxisomal biogenesis factor 14 -1.94003
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 -1.93939
EPOR erythropoietin receptor -1.93372
C1ORF109 chromosome 1 open reading frame 109 -1.93324
RFWD3 ring finger and WD repeat domain 3 -1.92864
ANKRD49 ankyrin repeat domain 49 -1.92657
PDIA5 protein disulfide isomerase family A, member 5 -1.92652
SDF2L1 stromal cell-derived factor 2-like 1 -1.92195
PMEPA1 prostate transmembrane protein, androgen induced 1 -1.91695
ITGB1BP1 integrin beta 1 binding protein 1 -1.91486
STIM1 stromal interaction molecule 1 -1.91371
TWIST2 twist family bHLH transcription factor 2 -1.91095
NCOA3 nuclear receptor coactivator 3 -1.90972
ARMCX2 armadillo repeat containing, X-linked 2 -1.90709
FUBP3 far upstream element (FUSE) binding protein 3 -1.90562
STAT5B signal transducer and activator of transcription 5B -1.90549
PGR progesterone receptor -1.90148
ERLIN2 ER lipid raft associated 2 -1.90092
GPANK1 G patch domain and ankyrin repeats 1 -1.8953
AKAP4 A kinase (PRKA) anchor protein 4 -1.893
SETD6 SET domain containing 6 -1.89035
PKN3 protein kinase N3 -1.88977
ACAD9 acyl-CoA dehydrogenase family, member 9 -1.88961
SLC46A3 solute carrier family 46, member 3 -1.87928
ZNF606 zinc finger protein 606 -1.87559
TMED1 transmembrane emp24 protein transport domain containing 1 -1.87476
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) -1.87274
ADAMTS8 ADAM metallopeptidase with thrombospondin type 1 motif, 8 -1.87178
METTL13 methyltransferase like 13 -1.86697
ZMAT2 zinc finger, matrin-type 2 -1.86271
PHF10 PHD finger protein 10 -1.86215
HSPA8 heat shock 70kDa protein 8 -1.85558
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -1.85286
SIRT3 sirtuin 3 -1.85094
RUVBL1 RuvB-like AAA ATPase 1 -1.84793
GDE1 glycerophosphodiester phosphodiesterase 1 -1.84165
ALDH4A1 aldehyde dehydrogenase 4 family, member A1 -1.8403
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide -1.83593
CEP85 centrosomal protein 85kDa -1.83067
MESDC2 mesoderm development candidate 2 -1.82912
CCDC107 coiled-coil domain containing 107 -1.82685
THADA thyroid adenoma associated -1.82561
KCTD11 potassium channel tetramerization domain containing 11 -1.82423
CDC73 cell division cycle 73 -1.82238
LRTOMT leucine rich transmembrane and O-methyltransferase domain containing -1.82164
HACD1 3-hydroxyacyl-CoA dehydratase 1 -1.82048
DHX35 DEAH (Asp-Glu-Ala-His) box polypeptide 35 -1.81965
FAM214B family with sequence similarity 214, member B -1.81724
TMEM54 transmembrane protein 54 -1.8172
COMMD3 COMM domain containing 3 -1.81602
TSPAN3 tetraspanin 3 -1.81264
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog -1.81255
TNPO2 transportin 2 -1.8113
KANSL1L KAT8 regulatory NSL complex subunit 1-like -1.81054
AP4M1 adaptor-related protein complex 4, mu 1 subunit -1.80939
LRRK1 leucine-rich repeat kinase 1 -1.80883
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -1.80855
UBE2F ubiquitin-conjugating enzyme E2F (putative) -1.80649
NEK9 NIMA-related kinase 9 -1.79391
NUDCD1 NudC domain containing 1 -1.78986
NT5C2 5'-nucleotidase, cytosolic II -1.7896
NOTCH1 notch 1 -1.78842
ZCRB1 zinc finger CCHC-type and RNA binding motif 1 -1.78704
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 -1.78659
ATG2A autophagy related 2A -1.78556
TMEM47 transmembrane protein 47 -1.78467
BFAR bifunctional apoptosis regulator -1.78444
WDR73 WD repeat domain 73 -1.78067
RAB14 RAB14, member RAS oncogene family -1.77955
KDM2B lysine (K)-specific demethylase 2B -1.77822
CHMP5 charged multivesicular body protein 5 -1.7778
KSR1 kinase suppressor of ras 1 -1.77758
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 -1.77652
SMYD2 SET and MYND domain containing 2 -1.77642
HMBS hydroxymethylbilane synthase -1.77574
PTK7 protein tyrosine kinase 7 (inactive) -1.77569
REXO2 RNA exonuclease 2 -1.77332
TMEM204 transmembrane protein 204 -1.76669
OTULIN OTU deubiquitinase with linear linkage specificity -1.76572
HLA-DQB2 major histocompatibility complex, class II, DQ beta 2 -1.76437
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 -1.7572
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific -1.75715
MUM1 melanoma associated antigen (mutated) 1 -1.75678
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -1.75421
FAM63B family with sequence similarity 63, member B -1.75234
AGGF1 angiogenic factor with G patch and FHA domains 1 -1.75066
SEPW1 selenoprotein W, 1 -1.75028
RNGTT RNA guanylyltransferase and 5'-phosphatase -1.75024
CTTNBP2NL CTTNBP2 N-terminal like -1.74987
NOL6 nucleolar protein 6 (RNA-associated) -1.74935
IPO4 importin 4 -1.74736
CNPY3 canopy FGF signaling regulator 3 -1.74318
LMCD1 LIM and cysteine-rich domains 1 -1.74003
GCDH glutaryl-CoA dehydrogenase -1.73993
SRBD1 S1 RNA binding domain 1 -1.7388
ARV1 ARV1 homolog (S. cerevisiae) -1.73585
EMC6 ER membrane protein complex subunit 6 -1.7326
CDH23 cadherin-related 23 -1.72957
TRAM2 translocation associated membrane protein 2 -1.72956
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -1.72878
MLEC malectin -1.7284
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase) -1.72831
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -1.72778
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase -1.72759
E2F5 E2F transcription factor 5, p130-binding -1.72617
PJA1 praja ring finger 1, E3 ubiquitin protein ligase -1.72592
BUD13 BUD13 homolog (S. cerevisiae) -1.72192
SGSM3 small G protein signaling modulator 3 -1.72173
TMEM170A transmembrane protein 170A -1.72055
PRKDC protein kinase, DNA-activated, catalytic polypeptide -1.72018
FADD Fas (TNFRSF6)-associated via death domain -1.71915
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3) -1.71847
ZFYVE9 zinc finger, FYVE domain containing 9 -1.71665
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 -1.71597
PCGF6 polycomb group ring finger 6 -1.71529
TMEM143 transmembrane protein 143 -1.71514
PSMD4 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -1.71505
DARS2 aspartyl-tRNA synthetase 2, mitochondrial -1.71102
WWP2 WW domain containing E3 ubiquitin protein ligase 2 -1.70996
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -1.70867
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -1.70776
B3GAT3 beta-1,3-glucuronyltransferase 3 -1.70643
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -1.70252
SNRPF small nuclear ribonucleoprotein polypeptide F -1.69956
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -1.6991
NAA38 N(alpha)-acetyltransferase 38, NatC auxiliary subunit -1.69864
STK38 serine/threonine kinase 38 -1.69386
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 -1.69037
TTPAL tocopherol (alpha) transfer protein-like -1.68849
SHROOM3 shroom family member 3 -1.68784
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 -1.68779
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -1.68378
CEP89 centrosomal protein 89kDa -1.68375
TMEM248 transmembrane protein 248 -1.68115
PNMA1 paraneoplastic Ma antigen 1 -1.6811
COPZ1 coatomer protein complex, subunit zeta 1 -1.67888
ABHD4 abhydrolase domain containing 4 -1.67849
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -1.67785
CUL2 cullin 2 -1.67742
EIF4H eukaryotic translation initiation factor 4H -1.67701
KDM1B lysine (K)-specific demethylase 1B -1.67657
HIST1H2BF histone cluster 1, H2bf -1.6762
CLASP1 cytoplasmic linker associated protein 1 -1.67546
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1 -1.67522
DIEXF digestive organ expansion factor homolog (zebrafish) -1.67394
TMEM230 transmembrane protein 230 -1.66891
PEG10 paternally expressed 10 -1.66591
HCG18 HLA complex group 18 (non-protein coding) -1.66473
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -1.66434
THRIL TNF and HNRNPL related immunoregulatory long non-coding RNA -1.66032
RSF1 remodeling and spacing factor 1 -1.66023
FASTKD3 FAST kinase domains 3 -1.65984
AMDHD2 amidohydrolase domain containing 2 -1.65869
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2 -1.65736
HINT3 histidine triad nucleotide binding protein 3 -1.65735
NOL12 nucleolar protein 12 -1.65393
S100A6 S100 calcium binding protein A6 -1.64925
CEP57 centrosomal protein 57kDa -1.64863
SERBP1 SERPINE1 mRNA binding protein 1 -1.64685
PTEN phosphatase and tensin homolog -1.64417
BRWD1 bromodomain and WD repeat domain containing 1 -1.64376
DYNLT1 dynein, light chain, Tctex-type 1 -1.64283
STX6 syntaxin 6 -1.64235
FRMD5 FERM domain containing 5 -1.64221
RNF167 ring finger protein 167 -1.64202
VPREB1 pre-B lymphocyte 1 -1.63996
SLC8A3 solute carrier family 8 (sodium/calcium exchanger), member 3 -1.63994
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane) -1.63427
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 -1.63423
PAPD4 PAP associated domain containing 4 -1.63375
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -1.63288
HDAC4 histone deacetylase 4 -1.63007
H2AFZ H2A histone family, member Z -1.62864
ECHDC1 ethylmalonyl-CoA decarboxylase 1 -1.62719
EEF2 eukaryotic translation elongation factor 2 -1.62673
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like -1.62553
ADCY3 adenylate cyclase 3 -1.62149
KIF1B kinesin family member 1B -1.62093
FGD3 FYVE, RhoGEF and PH domain containing 3 -1.62033
PCGF5 polycomb group ring finger 5 -1.61994
CD2AP CD2-associated protein -1.61992
RCL1 RNA terminal phosphate cyclase-like 1 -1.61827
RNF135 ring finger protein 135 -1.61766
HAT1 histone acetyltransferase 1 -1.61652
CHRND cholinergic receptor, nicotinic, delta (muscle) -1.61607
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -1.61471
DHODH dihydroorotate dehydrogenase (quinone) -1.61434
TXNRD1 thioredoxin reductase 1 -1.61382
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -1.6125
PI4K2A phosphatidylinositol 4-kinase type 2 alpha -1.61248
NEDD8 neural precursor cell expressed, developmentally down-regulated 8 -1.61037
ERO1LB ERO1-like beta (S. cerevisiae) -1.61034
FLNC filamin C, gamma -1.60992
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -1.60755
FBXO31 F-box protein 31 -1.60431
UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 -1.60401
Funding