CDK7 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description cyclin-dependent kinase 7|The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1022)
External Link http://www.ncbi.nlm.nih.gov/gene/1022
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Genes

18 substrates of the kinase CDK7 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
AR androgen receptor
CDK1 cyclin-dependent kinase 1
CDK11B cyclin-dependent kinase 11B
CDK12 cyclin-dependent kinase 12
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
E2F1 E2F transcription factor 1
ESR1 estrogen receptor 1
ICK intestinal cell (MAK-like) kinase
MCM2 minichromosome maintenance complex component 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
PCGF6 polycomb group ring finger 6
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
RARA retinoic acid receptor, alpha
RARG retinoic acid receptor, gamma
SMAD1 SMAD family member 1
TP53 tumor protein p53