CDK8 Gene Set

Dataset KEA Substrates of Kinases
Category physical interactions
Type kinase
Description cyclin-dependent kinase 8|The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1024)
External Link http://www.ncbi.nlm.nih.gov/gene/1024
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Genes

4 substrates of the kinase CDK8 from the curated KEA Substrates of Kinases dataset.

Symbol Name
CCNH cyclin H
E2F1 E2F transcription factor 1
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3