CDK8 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cyclin-dependent kinase 8|The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1024)
External Link http://www.ncbi.nlm.nih.gov/gene/1024
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210 interacting proteins for CDK8 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACIN1 apoptotic chromatin condensation inducer 1
AFF1 AF4/FMR2 family, member 1
AFF4 AF4/FMR2 family, member 4
AHCTF1 AT hook containing transcription factor 1
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ANAPC1 anaphase promoting complex subunit 1
ANAPC2 anaphase promoting complex subunit 2
ANAPC5 anaphase promoting complex subunit 5
BAG2 BCL2-associated athanogene 2
BCL6 B-cell CLL/lymphoma 6
BRCA1 breast cancer 1, early onset
BRD2 bromodomain containing 2
BRD4 bromodomain containing 4
CCAR1 cell division cycle and apoptosis regulator 1
CCNC cyclin C
CCNH cyclin H
CCNT1 cyclin T1
CCNT2 cyclin T2
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CDC23 cell division cycle 23
CDK11B cyclin-dependent kinase 11B
CDK19 cyclin-dependent kinase 19
CDK9 cyclin-dependent kinase 9
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHD9 chromodomain helicase DNA binding protein 9
CMSS1 cms1 ribosomal small subunit homolog (yeast)
CREBBP CREB binding protein
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
DCD dermcidin
DDB1 damage-specific DNA binding protein 1, 127kDa
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DDX52 DEAD (Asp-Glu-Ala-Asp) box polypeptide 52
DICER1 dicer 1, ribonuclease type III
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNALI1 dynein, axonemal, light intermediate chain 1
DNM2 dynamin 2
E2F1 E2F transcription factor 1
EAF1 ELL associated factor 1
EAF2 ELL associated factor 2
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EHMT2 euchromatic histone-lysine N-methyltransferase 2
EIF4A1 eukaryotic translation initiation factor 4A1
ELL elongation factor RNA polymerase II
ELL2 elongation factor, RNA polymerase II, 2
ELL3 elongation factor RNA polymerase II-like 3
EP300 E1A binding protein p300
ERCC3 excision repair cross-complementation group 3
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
EXOC4 exocyst complex component 4
FBL fibrillarin
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GPN3 GPN-loop GTPase 3
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa
HAUS7 HAUS augmin-like complex, subunit 7
HCFC1 host cell factor C1
HDAC6 histone deacetylase 6
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIST2H3A histone cluster 2, H3a
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPF heterogeneous nuclear ribonucleoprotein F
HNRNPM heterogeneous nuclear ribonucleoprotein M
HSPA1L heat shock 70kDa protein 1-like
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IPO4 importin 4
KANSL3 KAT8 regulatory NSL complex subunit 3
KAT2A K(lysine) acetyltransferase 2A
KAT2B K(lysine) acetyltransferase 2B
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNA4 karyopherin alpha 4 (importin alpha 3)
LMNA lamin A/C
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAML1 mastermind-like 1 (Drosophila)
MBP myelin basic protein
MED1 mediator complex subunit 1
MED10 mediator complex subunit 10
MED11 mediator complex subunit 11
MED12 mediator complex subunit 12
MED13 mediator complex subunit 13
MED13L mediator complex subunit 13-like
MED14 mediator complex subunit 14
MED15 mediator complex subunit 15
MED16 mediator complex subunit 16
MED17 mediator complex subunit 17
MED18 mediator complex subunit 18
MED19 mediator complex subunit 19
MED20 mediator complex subunit 20
MED21 mediator complex subunit 21
MED22 mediator complex subunit 22
MED23 mediator complex subunit 23
MED24 mediator complex subunit 24
MED25 mediator complex subunit 25
MED26 mediator complex subunit 26
MED27 mediator complex subunit 27
MED28 mediator complex subunit 28
MED29 mediator complex subunit 29
MED30 mediator complex subunit 30
MED31 mediator complex subunit 31
MED4 mediator complex subunit 4
MED6 mediator complex subunit 6
MED7 mediator complex subunit 7
MED8 mediator complex subunit 8
MED9 mediator complex subunit 9
MSH6 mutS homolog 6
MYBBP1A MYB binding protein (P160) 1a
MYC v-myc avian myelocytomatosis viral oncogene homolog
NIPBL Nipped-B homolog (Drosophila)
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae)
NOL8 nucleolar protein 8
NOLC1 nucleolar and coiled-body phosphoprotein 1
NONO non-POU domain containing, octamer-binding
NOP56 NOP56 ribonucleoprotein
NOP58 NOP58 ribonucleoprotein
NOTCH1 notch 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NRIP1 nuclear receptor interacting protein 1
NUMA1 nuclear mitotic apparatus protein 1
P3H1 prolyl 3-hydroxylase 1
P4HB prolyl 4-hydroxylase, beta polypeptide
PARP1 poly (ADP-ribose) polymerase 1
PNN pinin, desmosome associated protein
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
POLR2C polymerase (RNA) II (DNA directed) polypeptide C, 33kDa
POLR2D polymerase (RNA) II (DNA directed) polypeptide D
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2F polymerase (RNA) II (DNA directed) polypeptide F
POLR2G polymerase (RNA) II (DNA directed) polypeptide G
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
POLR2J polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRPF19 pre-mRNA processing factor 19
PRPF4B pre-mRNA processing factor 4B
PTBP1 polypyrimidine tract binding protein 1
RANGAP1 Ran GTPase activating protein 1
RBM39 RNA binding motif protein 39
RECQL5 RecQ protein-like 5
RNPS1 RNA binding protein S1, serine-rich domain
RPAP2 RNA polymerase II associated protein 2
RSL1D1 ribosomal L1 domain containing 1
RUVBL1 RuvB-like AAA ATPase 1
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD5 SMAD family member 5
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1
SMC1A structural maintenance of chromosomes 1A
SMC3 structural maintenance of chromosomes 3
SMC4 structural maintenance of chromosomes 4
SMN2 survival of motor neuron 2, centromeric
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
SRSF3 serine/arginine-rich splicing factor 3
SUZ12 SUZ12 polycomb repressive complex 2 subunit
TADA2A transcriptional adaptor 2A
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAF2 TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
TAF4B TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa
TAF8 TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDa
TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
TARDBP TAR DNA binding protein
TBP TATA box binding protein
TCEA1 transcription elongation factor A (SII), 1
TCOF1 Treacher Collins-Franceschetti syndrome 1
THRA thyroid hormone receptor, alpha
THRAP3 thyroid hormone receptor associated protein 3
TMLHE trimethyllysine hydroxylase, epsilon
TMPO thymopoietin
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae)
TRRAP transformation/transcription domain-associated protein
TTN titin
U2SURP U2 snRNP-associated SURP domain containing
UBB ubiquitin B
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UBTF upstream binding transcription factor, RNA polymerase I
ZBTB9 zinc finger and BTB domain containing 9
ZCCHC10 zinc finger, CCHC domain containing 10
ZNF281 zinc finger protein 281