CDK9 Gene Set

Dataset PhosphoSitePlus Substrates of Kinases
Category physical interactions
Type kinase
Description cyclin-dependent kinase 9|The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1025)
External Link http://www.ncbi.nlm.nih.gov/gene/1025
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Genes

12 substrates of the kinase CDK9 from the curated PhosphoSitePlus Substrates of Kinases dataset.

Symbol Name
BORA bora, aurora kinase A activator
CDK9 cyclin-dependent kinase 9
HIST1H1A histone cluster 1, H1a
NCOA2 nuclear receptor coactivator 2
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPARG peroxisome proliferator-activated receptor gamma
RB1 retinoblastoma 1
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
SMAD1 SMAD family member 1
SMAD3 SMAD family member 3
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TP53 tumor protein p53