CDKN1A Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description cyclin-dependent kinase inhibitor 1A (p21, Cip1)|This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010] (NCBI Entrez Gene Database, 1026)
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Genes

344 genes differentially expressed following the CDKN1A gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
LAMB3 laminin, beta 3 2.56889
CRIP1 cysteine-rich protein 1 (intestinal) 2.56889
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.56889
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.56889
APOBEC4 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative) 2.56889
TMEM217 transmembrane protein 217 2.56889
KIF19 kinesin family member 19 2.56889
CD8A CD8a molecule 2.56889
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.56889
LIX1 Lix1 homolog (chicken) 2.56889
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.56889
APLN apelin 2.56889
GPR162 G protein-coupled receptor 162 2.56889
PNLDC1 poly(A)-specific ribonuclease (PARN)-like domain containing 1 2.56889
LIF leukemia inhibitory factor 2.56889
TAS2R5 taste receptor, type 2, member 5 2.56889
MYO1G myosin IG 2.56889
DDX43 DEAD (Asp-Glu-Ala-Asp) box polypeptide 43 2.56889
CARNS1 carnosine synthase 1 2.56889
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 2.56889
VEGFD vascular endothelial growth factor D 2.56889
RGS8 regulator of G-protein signaling 8 2.56889
NUTM2G NUT family member 2G 2.55283
PCDHB8 protocadherin beta 8 2.49067
HDC histidine decarboxylase 2.49067
ZNF668 zinc finger protein 668 2.49067
VPS18 vacuolar protein sorting 18 homolog (S. cerevisiae) 2.49067
TMEM244 transmembrane protein 244 2.49067
PGAM4 phosphoglycerate mutase family member 4 2.49067
SCGB3A1 secretoglobin, family 3A, member 1 2.49067
FOLR1 folate receptor 1 (adult) 2.49067
NANOS2 nanos homolog 2 (Drosophila) 2.49067
SLC46A3 solute carrier family 46, member 3 2.49067
TSSK4 testis-specific serine kinase 4 2.49067
UCN urocortin 2.49067
SCG2 secretogranin II 2.49067
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 2.49067
ZNF346 zinc finger protein 346 2.49067
LRRC63 leucine rich repeat containing 63 2.49067
ATOH7 atonal homolog 7 (Drosophila) 2.49067
LGALS2 lectin, galactoside-binding, soluble, 2 2.49067
LGALS9 lectin, galactoside-binding, soluble, 9 2.49067
MYO1A myosin IA 2.49067
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.49067
CLEC14A C-type lectin domain family 14, member A 2.49067
VCP valosin containing protein 2.49067
FAM229A family with sequence similarity 229, member A 2.49067
LCN10 lipocalin 10 2.49067
GUCY2F guanylate cyclase 2F, retinal 2.49067
OR10A2 olfactory receptor, family 10, subfamily A, member 2 2.49067
SLC25A41 solute carrier family 25, member 41 2.49067
SH2D7 SH2 domain containing 7 2.49067
SH2D6 SH2 domain containing 6 2.49067
MSC musculin 2.49067
ASB12 ankyrin repeat and SOCS box containing 12 2.49067
GPR21 G protein-coupled receptor 21 2.49067
ADAMTSL5 ADAMTS-like 5 2.49067
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 2.49067
SP6 Sp6 transcription factor 2.49067
ACKR5 atypical chemokine receptor 5 2.49067
CAPN9 calpain 9 2.49067
ACER1 alkaline ceramidase 1 2.49067
SPI1 Spi-1 proto-oncogene 2.49067
FRG2C FSHD region gene 2 family, member C 2.49067
STX11 syntaxin 11 2.49067
FMOD fibromodulin 2.49067
C9ORF43 chromosome 9 open reading frame 43 2.49067
PKD2L1 polycystic kidney disease 2-like 1 2.49067
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 2.49067
RSPH4A radial spoke head 4 homolog A (Chlamydomonas) 2.49067
HPSE heparanase 2.49067
PTH1R parathyroid hormone 1 receptor 2.49067
PHF24 PHD finger protein 24 2.49067
TBC1D3I TBC1 domain family member 3I 2.49067
FAM237A family with sequence similarity 237 member A 2.49067
CPNE8-AS1 CPNE8 antisense RNA 1 2.49067
IRF2-DT IRF2 divergent transcript 2.49067
LOC122526780 uncharacterized LOC122526780 2.49067
SEPTIN12 septin 12 2.49067
MEIOSIN meiosis initiator 2.49067
GSTT4 glutathione S-transferase theta 4 2.49067
MTRES1 mitochondrial transcription rescue factor 1 2.49067
H1-6 H1.6 linker histone, cluster member 2.49067
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.49067
ACSL5 acyl-CoA synthetase long-chain family member 5 2.49067
EID3 EP300 interacting inhibitor of differentiation 3 2.49067
MIP major intrinsic protein of lens fiber 2.49067
LOC124909439 uncharacterized LOC124909439 2.49067
GZMM granzyme M (lymphocyte met-ase 1) 2.49067
HOXC5 homeobox C5 2.49067
AMHR2 anti-Mullerian hormone receptor, type II 2.49067
GSC goosecoid homeobox 2.49067
PCDHB11 protocadherin beta 11 2.49067
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.49067
RHOXF2 Rhox homeobox family, member 2 2.49067
C1QL2 complement component 1, q subcomponent-like 2 2.49067
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.49067
EXOC3L1 exocyst complex component 3-like 1 2.49067
NBPF10 neuroblastoma breakpoint family, member 10 2.49067
LY6K lymphocyte antigen 6 complex, locus K 2.49067
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.49067
SYT15 synaptotagmin XV 2.49067
MOV10L1 Mov10 RISC complex RNA helicase like 1 2.49067
HAL histidine ammonia-lyase 2.49067
OR2D2 olfactory receptor, family 2, subfamily D, member 2 2.49067
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 2.49067
CCR8 chemokine (C-C motif) receptor 8 2.49067
CCR3 chemokine (C-C motif) receptor 3 2.49067
ACOT4 acyl-CoA thioesterase 4 2.49067
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) 2.49067
ZNF541 zinc finger protein 541 2.49067
THTPA thiamine triphosphatase 2.49067
TSLP thymic stromal lymphopoietin 2.49067
GCOM1 GRINL1A complex locus 1 2.49067
ADAMDEC1 ADAM-like, decysin 1 2.49067
GOLGA6B golgin A6 family, member B 2.49067
APOC2 apolipoprotein C-II 2.49067
TRIM55 tripartite motif containing 55 2.49067
DRD5 dopamine receptor D5 2.49067
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.49067
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.49067
FNDC9 fibronectin type III domain containing 9 2.49067
POTEA POTE ankyrin domain family, member A 2.49067
TRIM29 tripartite motif containing 29 2.49067
DEFB112 defensin, beta 112 2.49067
ANKRD62 ankyrin repeat domain 62 2.49067
MAGEA11 melanoma antigen family A11 2.49067
DES desmin 2.49067
C17ORF107 chromosome 17 open reading frame 107 2.49067
CABP5 calcium binding protein 5 2.49067
APOH apolipoprotein H (beta-2-glycoprotein I) 2.49067
P2RY13 purinergic receptor P2Y, G-protein coupled, 13 2.49067
ALOXE3 arachidonate lipoxygenase 3 2.49067
DMRT2 doublesex and mab-3 related transcription factor 2 2.49067
CD28 CD28 molecule 2.49067
LOXHD1 lipoxygenase homology domains 1 2.49067
FAIM2 Fas apoptotic inhibitory molecule 2 2.49067
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.49067
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.49067
FKBP1C FK506 binding protein 1C 2.49067
DRC7 dynein regulatory complex subunit 7 2.49067
OR52N2 olfactory receptor, family 52, subfamily N, member 2 2.49067
TG thyroglobulin 2.49067
LY96 lymphocyte antigen 96 2.49067
CTXN2 cortexin 2 2.49067
VWA7 von Willebrand factor A domain containing 7 2.49067
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 2.49067
COL6A5 collagen, type VI, alpha 5 2.49067
PRDM9 PR domain containing 9 2.49067
EGR3 early growth response 3 2.49067
ZFP92 ZFP92 zinc finger protein 2.49067
SVOP SV2 related protein homolog (rat) 2.49067
SAMD5 sterile alpha motif domain containing 5 2.49067
TBX1 T-box 1 2.49067
PHACTR3 phosphatase and actin regulator 3 2.49067
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.49067
HMX1 H6 family homeobox 1 2.49067
ZNF407 zinc finger protein 407 2.49067
CASR calcium-sensing receptor 2.49067
CD226 CD226 molecule 2.49067
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.49067
PADI6 peptidyl arginine deiminase, type VI 2.49067
TGM2 transglutaminase 2 2.49067
TTC36 tetratricopeptide repeat domain 36 2.49067
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1 2.49067
ASCL2 achaete-scute family bHLH transcription factor 2 2.49067
ADRA1D adrenoceptor alpha 1D 2.49067
HIC1 hypermethylated in cancer 1 2.49067
EVPL envoplakin 2.49067
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.49067
SPAG6 sperm associated antigen 6 2.49067
CENPF centromere protein F, 350/400kDa 2.49067
LEP leptin 2.49067
HRG histidine-rich glycoprotein 2.49067
CD22 CD22 molecule 2.49067
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 2.49067
PSMA8 proteasome (prosome, macropain) subunit, alpha type, 8 2.49067
PARP15 poly (ADP-ribose) polymerase family, member 15 2.49067
PPY pancreatic polypeptide 2.49067
ITPKA inositol-trisphosphate 3-kinase A 2.49067
UQCRQ ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5kDa 2.49067
ZBED6 zinc finger, BED-type containing 6 2.49067
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 2.49067
RNF222 ring finger protein 222 2.49067
SAP25 Sin3A-associated protein, 25kDa 2.48825
ZNF469 zinc finger protein 469 2.48825
DGKH diacylglycerol kinase, eta 2.47756
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila) 2.47554
ATE1 arginyltransferase 1 2.4731
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 2.4731
SYCE3 synaptonemal complex central element protein 3 2.4731
EPRS1 glutamyl-prolyl-tRNA synthetase 1 2.4334
SAFB scaffold attachment factor B 2.411
RCC2 regulator of chromosome condensation 2 2.39271
CRABP1 cellular retinoic acid binding protein 1 2.37062
SPEF1 sperm flagellar 1 2.35448
MFAP4 microfibrillar-associated protein 4 2.35448
OSBPL7 oxysterol binding protein-like 7 2.35448
BICD2 bicaudal D homolog 2 (Drosophila) 2.3381
RAMAC RNA guanine-7 methyltransferase activating subunit 2.32034
QTMAN queuosine-tRNA mannosyltransferase 2.28788
DEFB131B defensin beta 131B 2.28553
LMF1 lipase maturation factor 1 2.28013
MRS2 MRS2 magnesium transporter 2.26915
ZNF506 zinc finger protein 506 2.26915
ACOXL acyl-CoA oxidase-like 2.26915
GOLGA2 golgin A2 2.25478
XPO4 exportin 4 2.24398
MID1 midline 1 2.23591
LRP1B low density lipoprotein receptor-related protein 1B 2.23014
CEP170B centrosomal protein 170B 2.22628
COL6A2 collagen, type VI, alpha 2 2.21844
PHC1 polyhomeotic homolog 1 (Drosophila) 2.20146
MRPS14 mitochondrial ribosomal protein S14 2.18899
CCDC82 coiled-coil domain containing 82 2.17047
RBP5 retinol binding protein 5, cellular 2.16454
RAD51C RAD51 paralog C 2.15825
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 2.1104
ACVR2A activin A receptor, type IIA 2.10875
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 2.10121
EXOSC9 exosome component 9 2.09792
KLHL20 kelch-like family member 20 2.08817
PILRB paired immunoglobin-like type 2 receptor beta 2.06177
MBTD1 mbt domain containing 1 2.05789
RIC8A RIC8 guanine nucleotide exchange factor A 2.04295
MYBPC1 myosin binding protein C, slow type 2.03457
RHNO1 RAD9-HUS1-RAD1 interacting nuclear orphan 1 2.03457
TMEM267 transmembrane protein 267 2.03457
SANBR SANT and BTB domain regulator of CSR 2.033
ZNF32 zinc finger protein 32 2.00886
SETD3 SET domain containing 3 2.00886

decreased expression

Symbol Name Standardized Value
GPHA2 glycoprotein hormone alpha 2 -2.56889
DKKL1 dickkopf-like 1 -2.56889
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -2.56889
TTLL9 tubulin tyrosine ligase-like family member 9 -2.56889
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 -2.56889
ZNF554 zinc finger protein 554 -2.56889
TRIM34 tripartite motif containing 34 -2.56889
TLCD2 TLC domain containing 2 -2.56889
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.56889
BCAS1 breast carcinoma amplified sequence 1 -2.56889
TRIM38 tripartite motif containing 38 -2.51128
HDX highly divergent homeobox -2.49067
MRO maestro -2.49067
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -2.49067
CHD8 chromodomain helicase DNA binding protein 8 -2.49067
FAM110D family with sequence similarity 110, member D -2.49067
TXNDC11 thioredoxin domain containing 11 -2.49067
FAM161B family with sequence similarity 161, member B -2.49067
ANXA9 annexin A9 -2.49067
TGM1 transglutaminase 1 -2.49067
THEM6 thioesterase superfamily member 6 -2.49067
CD8B CD8b molecule -2.49067
CPLX1 complexin 1 -2.49067
TRPV2 transient receptor potential cation channel, subfamily V, member 2 -2.49067
GCKR glucokinase (hexokinase 4) regulator -2.49067
CXORF65 chromosome X open reading frame 65 -2.49067
FIMP1 fertilization-influencing membrane protein 1 -2.49067
PIERCE2 piercer of microtubule wall 2 -2.49067
MCMDC2 minichromosome maintenance domain containing 2 -2.49067
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A -2.49067
MRPL30 mitochondrial ribosomal protein L30 -2.49067
OAT ornithine aminotransferase -2.49067
GDF15 growth differentiation factor 15 -2.49067
GGACT gamma-glutamylamine cyclotransferase -2.49067
PPP4C protein phosphatase 4, catalytic subunit -2.49067
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic -2.49067
SLC67A1 solute carrier family 67 member 1 -2.49067
MMS22L MMS22-like, DNA repair protein -2.49067
NOTO notochord homeobox -2.49067
COLEC10 collectin sub-family member 10 (C-type lectin) -2.49067
SPINK6 serine peptidase inhibitor, Kazal type 6 -2.49067
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like -2.49067
GPR34 G protein-coupled receptor 34 -2.49067
CCT7 chaperonin containing TCP1, subunit 7 (eta) -2.49067
SNX31 sorting nexin 31 -2.49067
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -2.49067
ZP3 zona pellucida glycoprotein 3 (sperm receptor) -2.49067
COL28A1 collagen, type XXVIII, alpha 1 -2.49067
ZNF365 zinc finger protein 365 -2.49067
CDH10 cadherin 10, type 2 (T2-cadherin) -2.49067
RAD21L1 RAD21-like 1 (S. pombe) -2.49067
RAP1GAP RAP1 GTPase activating protein -2.49067
NPFFR1 neuropeptide FF receptor 1 -2.49067
PHF8 PHD finger protein 8 -2.49067
PTGES3 prostaglandin E synthase 3 (cytosolic) -2.49067
RANBP3L RAN binding protein 3-like -2.49067
GTF2A1L general transcription factor IIA, 1-like -2.49067
ERICH6 glutamate-rich 6 -2.49067
HLA-G major histocompatibility complex, class I, G -2.49067
PTGDR prostaglandin D2 receptor (DP) -2.49067
CDH22 cadherin 22, type 2 -2.49067
ZFP42 ZFP42 zinc finger protein -2.49067
CTAGE9 CTAGE family, member 9 -2.49067
IER5L immediate early response 5-like -2.49067
SPHKAP SPHK1 interactor, AKAP domain containing -2.49067
SNRPC small nuclear ribonucleoprotein polypeptide C -2.48436
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 -2.47486
NICN1 nicolin 1 -2.47486
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.47486
SAMM50 SAMM50 sorting and assembly machinery component -2.4731
GVQW3 GVQW motif containing 3 -2.4731
DPY19L4 dpy-19-like 4 (C. elegans) -2.44125
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 -2.41489
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -2.37713
CATSPERG catsper channel auxiliary subunit gamma -2.37298
CABP1 calcium binding protein 1 -2.35607
RBP1 retinol binding protein 1, cellular -2.35448
SFT2D2 SFT2 domain containing 2 -2.34721
GMPPA GDP-mannose pyrophosphorylase A -2.33904
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -2.33904
ZUP1 zinc finger containing ubiquitin peptidase 1 -2.33655
ADAMTS15 ADAM metallopeptidase with thrombospondin type 1 motif, 15 -2.30711
BCHE butyrylcholinesterase -2.28337
NDUFAF6 NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 -2.27664
RPL9 ribosomal protein L9 -2.25292
ZNF836 zinc finger protein 836 -2.25292
TMEM45A transmembrane protein 45A -2.24344
OR4D1 olfactory receptor, family 4, subfamily D, member 1 -2.23449
FBXO4 F-box protein 4 -2.23449
GIGYF1 GRB10 interacting GYF protein 1 -2.21202
SLIRP SRA stem-loop interacting RNA binding protein -2.18044
BAG3 BCL2-associated athanogene 3 -2.1661
PPA1 pyrophosphatase (inorganic) 1 -2.15402
CLK3 CDC-like kinase 3 -2.15073
UBAC1 UBA domain containing 1 -2.13922
RAB1A RAB1A, member RAS oncogene family -2.13922
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) -2.13922
CFAP20 cilia and flagella associated protein 20 -2.13358
NR2E3 nuclear receptor subfamily 2, group E, member 3 -2.13357
GXYLT2 glucoside xylosyltransferase 2 -2.13319
ZNF404 zinc finger protein 404 -2.12081
MCUR1 mitochondrial calcium uniporter regulator 1 -2.11599
GLRA1 glycine receptor, alpha 1 -2.10121
FOXJ2 forkhead box J2 -2.10121
COPS3 COP9 signalosome subunit 3 -2.07982
THYN1 thymocyte nuclear protein 1 -2.07532
CST6 cystatin E/M -2.06724
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 -2.06222
PA2G4 proliferation-associated 2G4, 38kDa -2.04295
CREBZF CREB/ATF bZIP transcription factor -2.04295
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -2.01962
TSPAN33 tetraspanin 33 -2.01782
SLCO5A1 solute carrier organic anion transporter family, member 5A1 -2.01658