CDKN1A Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description cyclin-dependent kinase inhibitor 1A (p21, Cip1)|This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010] (NCBI Entrez Gene Database, 1026)
External Link http://www.ncbi.nlm.nih.gov/gene/1026
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363 interacting proteins for CDKN1A from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
A1BG alpha-1-B glycoprotein
A2M alpha-2-macroglobulin
ABR active BCR-related
ACTB actin, beta
ACTL6B actin-like 6B
ADAMTS10 ADAM metallopeptidase with thrombospondin type 1 motif, 10
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALAS1 5'-aminolevulinate synthase 1
AMOT angiomotin
ANAPC1 anaphase promoting complex subunit 1
ANAPC10 anaphase promoting complex subunit 10
ANAPC11 anaphase promoting complex subunit 11
ANAPC2 anaphase promoting complex subunit 2
ANAPC4 anaphase promoting complex subunit 4
ANAPC5 anaphase promoting complex subunit 5
ANAPC7 anaphase promoting complex subunit 7
ANGPT2 angiopoietin 2
ANKRD17 ankyrin repeat domain 17
APLP1 amyloid beta (A4) precursor-like protein 1
APP amyloid beta (A4) precursor protein
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATXN3 ataxin 3
BAD BCL2-associated agonist of cell death
BAG6 BCL2-associated athanogene 6
BCCIP BRCA2 and CDKN1A interacting protein
BRAP BRCA1 associated protein
C1ORF123 chromosome 1 open reading frame 123
C2CD5 C2 calcium-dependent domain containing 5
CABLES1 Cdk5 and Abl enzyme substrate 1
CABLES2 Cdk5 and Abl enzyme substrate 2
CAMK1 calcium/calmodulin-dependent protein kinase I
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCDC85B coiled-coil domain containing 85B
CCNA1 cyclin A1
CCNA2 cyclin A2
CCNB1 cyclin B1
CCNB2 cyclin B2
CCND1 cyclin D1
CCND2 cyclin D2
CCND3 cyclin D3
CCNE1 cyclin E1
CCNE2 cyclin E2
CCNH cyclin H
CCNJ cyclin J
CCNO cyclin O
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT3 chaperonin containing TCP1, subunit 3 (gamma)
CCT4 chaperonin containing TCP1, subunit 4 (delta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CDC16 cell division cycle 16
CDC20 cell division cycle 20
CDC23 cell division cycle 23
CDC26 cell division cycle 26
CDC27 cell division cycle 27
CDC42 cell division cycle 42
CDC45 cell division cycle 45
CDC5L cell division cycle 5-like
CDC6 cell division cycle 6
CDC7 cell division cycle 7
CDK1 cyclin-dependent kinase 1
CDK13 cyclin-dependent kinase 13
CDK14 cyclin-dependent kinase 14
CDK18 cyclin-dependent kinase 18
CDK2 cyclin-dependent kinase 2
CDK3 cyclin-dependent kinase 3
CDK4 cyclin-dependent kinase 4
CDK5 cyclin-dependent kinase 5
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDK6 cyclin-dependent kinase 6
CDK7 cyclin-dependent kinase 7
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CDT1 chromatin licensing and DNA replication factor 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELF3 CUGBP, Elav-like family member 3
CENPB centromere protein B, 80kDa
CEP290 centrosomal protein 290kDa
CHEK1 checkpoint kinase 1
CHGB chromogranin B
CIZ1 CDKN1A interacting zinc finger protein 1
CKS1B CDC28 protein kinase regulatory subunit 1B
CKS2 CDC28 protein kinase regulatory subunit 2
CLEC3B C-type lectin domain family 3, member B
CLINT1 clathrin interactor 1
COL4A5 collagen, type IV, alpha 5
COPS6 COP9 signalosome subunit 6
CPNE2 copine II
CPNE6 copine VI (neuronal)
CPVL carboxypeptidase, vitellogenic-like
CREBBP CREB binding protein
CRELD2 cysteine-rich with EGF-like domains 2
CRTC2 CREB regulated transcription coactivator 2
CSAD cysteine sulfinic acid decarboxylase
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CSNK2B casein kinase 2, beta polypeptide
CTSB cathepsin B
CUL1 cullin 1
CUL4A cullin 4A
CXCL13 chemokine (C-X-C motif) ligand 13
DAPK3 death-associated protein kinase 3
DCLK3 doublecortin-like kinase 3
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDB1 damage-specific DNA binding protein 1, 127kDa
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5
DEAF1 DEAF1 transcription factor
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9
DOCK7 dedicator of cytokinesis 7
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
E2F4 E2F transcription factor 4, p107/p130-binding
E2F5 E2F transcription factor 5, p130-binding
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EEF1A2 eukaryotic translation elongation factor 1 alpha 2
EFTUD2 elongation factor Tu GTP binding domain containing 2
EIF4EBP3 eukaryotic translation initiation factor 4E binding protein 3
EP300 E1A binding protein p300
EPPK1 epiplakin 1
ESR1 estrogen receptor 1
EXT2 exostosin glycosyltransferase 2
F13A1 coagulation factor XIII, A1 polypeptide
FAF1 Fas (TNFRSF6) associated factor 1
FBN3 fibrillin 3
FBXO21 F-box protein 21
FBXO32 F-box protein 32
FGB fibrinogen beta chain
FIBP fibroblast growth factor (acidic) intracellular binding protein
FKBPL FK506 binding protein like
FLAD1 flavin adenine dinucleotide synthetase 1
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GADD45G growth arrest and DNA-damage-inducible, gamma
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GCKR glucokinase (hexokinase 4) regulator
GDF9 growth differentiation factor 9
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae)
GIGYF2 GRB10 interacting GYF protein 2
GLUD1 glutamate dehydrogenase 1
GMNN geminin, DNA replication inhibitor
GNB2 guanine nucleotide binding protein (G protein), beta polypeptide 2
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GNB5 guanine nucleotide binding protein (G protein), beta 5
GOLGA2 golgin A2
GSK3B glycogen synthase kinase 3 beta
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HDAC1 histone deacetylase 1
HDAC11 histone deacetylase 11
HDAC2 histone deacetylase 2
HDAC4 histone deacetylase 4
HDAC6 histone deacetylase 6
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST1H1B histone cluster 1, H1b
HIST1H4F histone cluster 1, H4f
HMGXB3 HMG box domain containing 3
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HNRNPK heterogeneous nuclear ribonucleoprotein K
HOXD8 homeobox D8
HPD 4-hydroxyphenylpyruvate dioxygenase
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1B heat shock 70kDa protein 1B
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA8 heat shock 70kDa protein 8
HSPA9 heat shock 70kDa protein 9 (mortalin)
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ING5 inhibitor of growth family, member 5
INPP5K inositol polyphosphate-5-phosphatase K
IRS4 insulin receptor substrate 4
JUN jun proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KAT5 K(lysine) acetyltransferase 5
KIAA0195 KIAA0195
KLHL23 kelch-like family member 23
KMT2B lysine (K)-specific methyltransferase 2B
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRPPRC leucine-rich pentatricopeptide repeat containing
MAP3K5 mitogen-activated protein kinase kinase kinase 5
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK15 mitogen-activated protein kinase 15
MAPK8 mitogen-activated protein kinase 8
MARK2 MAP/microtubule affinity-regulating kinase 2
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MCM8 minichromosome maintenance complex component 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MED31 mediator complex subunit 31
MGMT O-6-methylguanine-DNA methyltransferase
MKRN1 makorin ring finger protein 1
MNAT1 MNAT CDK-activating kinase assembly factor 1
MOGS mannosyl-oligosaccharide glucosidase
MSH2 mutS homolog 2
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NABP2 nucleic acid binding protein 2
NCOR1 nuclear receptor corepressor 1
NCOR2 nuclear receptor corepressor 2
NFE2L2 nuclear factor, erythroid 2-like 2
NGFR nerve growth factor receptor
NKD2 naked cuticle homolog 2 (Drosophila)
NMRK2 nicotinamide riboside kinase 2
NOV nephroblastoma overexpressed
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRBP1 nuclear receptor binding protein 1
NTN4 netrin 4
NUCLEOLIN nucleolin multifunctional protein
OPTN optineurin
ORC1 origin recognition complex, subunit 1
ORC2 origin recognition complex, subunit 2
ORC3 origin recognition complex, subunit 3
ORC4 origin recognition complex, subunit 4
ORC5 origin recognition complex, subunit 5
ORC6 origin recognition complex, subunit 6
OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1
PARP1 poly (ADP-ribose) polymerase 1
PCNA proliferating cell nuclear antigen
PDE4DIP phosphodiesterase 4D interacting protein
PDHB pyruvate dehydrogenase (lipoamide) beta
PDHX pyruvate dehydrogenase complex, component X
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIAS2 protein inhibitor of activated STAT, 2
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PKM pyruvate kinase, muscle
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
POLD2 polymerase (DNA directed), delta 2, accessory subunit
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRKCA protein kinase C, alpha
PRKCH protein kinase C, eta
PRPF8 pre-mRNA processing factor 8
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
PUF60 poly-U binding splicing factor 60KDa
PUM1 pumilio RNA-binding family member 1
QARS glutaminyl-tRNA synthetase
RAB1A RAB1A, member RAS oncogene family
RAI1 retinoic acid induced 1
RAVER1 ribonucleoprotein, PTB-binding 1
RB1 retinoblastoma 1
RBBP4 retinoblastoma binding protein 4
RBL1 retinoblastoma-like 1
RBL2 retinoblastoma-like 2
RBM14 RNA binding motif protein 14
RBM48 RNA binding motif protein 48
RNF126 ring finger protein 126
RNF144B ring finger protein 144B
RPA1 replication protein A1, 70kDa
RPL18 ribosomal protein L18
RPL35 ribosomal protein L35
RPS16 ribosomal protein S16
RPS2 ribosomal protein S2
RPS25 ribosomal protein S25
RPS27A ribosomal protein S27a
RPS4X ribosomal protein S4, X-linked
RPS9 ribosomal protein S9
S100A8 S100 calcium binding protein A8
SBF1 SET binding factor 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SDF4 stromal cell derived factor 4
SET SET nuclear proto-oncogene
SETDB1 SET domain, bifurcated 1
SIPA1 signal-induced proliferation-associated 1
SKP1 S-phase kinase-associated protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SMAD4 SMAD family member 4
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SP110 SP110 nuclear body protein
SPRED1 sprouty-related, EVH1 domain containing 1
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIP1 stress-induced phosphoprotein 1
SUMO3 small ubiquitin-like modifier 3
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TBC1D4 TBC1 domain family, member 4
TCOF1 Treacher Collins-Franceschetti syndrome 1
TCP1 t-complex 1
TEX11 testis expressed 11
TFDP1 transcription factor Dp-1
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2)
TK1 thymidine kinase 1, soluble
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMSB4X thymosin beta 4, X-linked
TNIP1 TNFAIP3 interacting protein 1
TNIP2 TNFAIP3 interacting protein 2
TOP1 topoisomerase (DNA) I
TP53 tumor protein p53
TRAP1 TNF receptor-associated protein 1
TRIM39 tripartite motif containing 39
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae)
TRRAP transformation/transcription domain-associated protein
TSG101 tumor susceptibility 101
TTLL5 tubulin tyrosine ligase-like family member 5
TUBA1A tubulin, alpha 1a
TUBB tubulin, beta class I
TUBB2B tubulin, beta 2B class IIb
TUBB3 tubulin, beta 3 class III
TXN thioredoxin
TXNDC11 thioredoxin domain containing 11
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1
UBB ubiquitin B
UBC ubiquitin C
UBE2C ubiquitin-conjugating enzyme E2C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UNC119 unc-119 homolog (C. elegans)
USP11 ubiquitin specific peptidase 11
USP4 ubiquitin specific peptidase 4 (proto-oncogene)
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VIM vimentin
VPS51 vacuolar protein sorting 51 homolog (S. cerevisiae)
WDR73 WD repeat domain 73
WIZ widely interspaced zinc finger motifs
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ZBTB16 zinc finger and BTB domain containing 16
ZBTB48 zinc finger and BTB domain containing 48
ZNF135 zinc finger protein 135
ZNF431 zinc finger protein 431