CDX2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description caudal type homeobox 2|This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012] (NCBI Entrez Gene Database, 1045)
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Genes

363 genes differentially expressed following the CDX2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
TDRD9 tudor domain containing 9 2.3723
HIC1 hypermethylated in cancer 1 2.3723
TRIAP1 TP53 regulated inhibitor of apoptosis 1 2.3723
LRRIQ3 leucine-rich repeats and IQ motif containing 3 2.3723
RFPL2 ret finger protein-like 2 2.3723
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 2.3723
MST1R macrophage stimulating 1 receptor 2.3723
ASPG asparaginase 2.3723
WFDC1 WAP four-disulfide core domain 1 2.3723
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1 2.3723
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 2.3723
HPX hemopexin 2.3723
NRG2 neuregulin 2 2.3723
ANPEP alanyl (membrane) aminopeptidase 2.3723
SPDYE17 speedy/RINGO cell cycle regulator family member E17 2.3723
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.3723
SFTPD surfactant protein D 2.3723
SPMIP10 sperm microtubule inner protein 10 2.3723
EBF2 early B-cell factor 2 2.3723
NOTCH2NLB notch 2 N-terminal like B 2.3723
CCDC170 coiled-coil domain containing 170 2.3723
MROH6 maestro heat-like repeat family member 6 2.3723
FOLR1 folate receptor 1 (adult) 2.3723
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.3723
BARX1 BARX homeobox 1 2.3723
SP140L SP140 nuclear body protein-like 2.3723
RASA4B RAS p21 protein activator 4B 2.3723
PRR15 proline rich 15 2.3723
AKR1C2 aldo-keto reductase family 1, member C2 2.29339
SOX11 SRY (sex determining region Y)-box 11 2.29339
SPINK6 serine peptidase inhibitor, Kazal type 6 2.29339
BSND barttin CLCNK-type chloride channel accessory beta subunit 2.29339
THAP4 THAP domain containing 4 2.29339
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.29339
ELF4 E74-like factor 4 (ets domain transcription factor) 2.29339
RTKN2 rhotekin 2 2.29339
SDHAF1 succinate dehydrogenase complex assembly factor 1 2.29339
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 2.29339
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.29339
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.29339
VCX2 variable charge, X-linked 2 2.29339
SCGN secretagogin, EF-hand calcium binding protein 2.29339
CFHR4 complement factor H-related 4 2.29339
ASB12 ankyrin repeat and SOCS box containing 12 2.29339
ELSPBP1 epididymal sperm binding protein 1 2.29339
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 2.29339
CXCL2 chemokine (C-X-C motif) ligand 2 2.29339
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.29339
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 2.29339
F7 coagulation factor VII (serum prothrombin conversion accelerator) 2.29339
TNS4 tensin 4 2.29339
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1 2.29339
LACTBL1 lactamase, beta-like 1 2.29339
MEIKIN meiotic kinetochore factor 2.29339
GIMAP4 GTPase, IMAP family member 4 2.29339
GPR22 G protein-coupled receptor 22 2.29339
ASPA aspartoacylase 2.29339
CCNB3 cyclin B3 2.29339
APLN apelin 2.29339
TMEM191B transmembrane protein 191B 2.29339
OR2AG1 olfactory receptor, family 2, subfamily AG, member 1 (gene/pseudogene) 2.29339
METTL23 methyltransferase like 23 2.29339
TKTL1 transketolase-like 1 2.29339
LRRC56 leucine rich repeat containing 56 2.29339
PAX3 paired box 3 2.29339
DMRTC1B DMRT-like family C1B 2.29339
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 2.29339
KIF2B kinesin family member 2B 2.29339
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.29339
SELE selectin E 2.29339
CES4A carboxylesterase 4A 2.29339
HAO2 hydroxyacid oxidase 2 (long chain) 2.29339
LINGO1 leucine rich repeat and Ig domain containing 1 2.29339
FKBP6 FK506 binding protein 6, 36kDa 2.29339
RHCG Rh family, C glycoprotein 2.29339
SPRR2F small proline-rich protein 2F 2.29339
CEACAM8 carcinoembryonic antigen-related cell adhesion molecule 8 2.29339
TBC1D3L TBC1 domain family, member 3L 2.29339
ANO3 anoctamin 3 2.29339
LY6K lymphocyte antigen 6 complex, locus K 2.29339
BHLHE41 basic helix-loop-helix family, member e41 2.29339
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 2.29339
CYRIA CYFIP related Rac1 interactor A 2.29339
DUSP13B dual specificity phosphatase 13B 2.29339
SAXO4 stabilizer of axonemal microtubules 4 2.29339
CIMAP1B ciliary microtubule associated protein 1B 2.29339
TMA7B translation machinery associated 7 homolog B 2.29339
C20ORF204 chromosome 20 open reading frame 204 2.29339
FYB2 FYN binding protein 2 2.29339
NDUFAF8 NADH:ubiquinone oxidoreductase complex assembly factor 8 2.29339
DUSP29 dual specificity phosphatase 29 2.29339
CFAP141 cilia and flagella associated protein 141 2.29339
CLXN calaxin 2.29339
ILRUN inflammation and lipid regulator with UBA-like and NBR1-like domains 2.29339
H3-5 H3.5 histone 2.29339
OSTN osteocrin 2.29339
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 2.29339
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.29339
CD48 CD48 molecule 2.29339
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.29339
AKR1D1 aldo-keto reductase family 1, member D1 2.29339
FOSL2 FOS-like antigen 2 2.29339
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 2.29339
SERTAD3 SERTA domain containing 3 2.29339
IRF7 interferon regulatory factor 7 2.29339
CCDC17 coiled-coil domain containing 17 2.29339
RPS12 ribosomal protein S12 2.29339
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.29339
PRB1 proline-rich protein BstNI subfamily 1 2.29339
NPNT nephronectin 2.29339
DNASE2B deoxyribonuclease II beta 2.29339
HNF1A HNF1 homeobox A 2.29339
PCDHGC3 protocadherin gamma subfamily C, 3 2.29339
GPR85 G protein-coupled receptor 85 2.29339
PNPLA4 patatin-like phospholipase domain containing 4 2.29339
MPPED1 metallophosphoesterase domain containing 1 2.29339
VCX3B variable charge, X-linked 3B 2.29339
PGA5 pepsinogen 5, group I (pepsinogen A) 2.29339
CAPN8 calpain 8 2.29339
TLR2 toll-like receptor 2 2.29339
NHLRC4 NHL repeat containing 4 2.29339
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 2.29339
DMBX1 diencephalon/mesencephalon homeobox 1 2.29339
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.29339
PDCL2 phosducin-like 2 2.29339
FOXE3 forkhead box E3 2.29339
ISL2 ISL LIM homeobox 2 2.29339
COL17A1 collagen, type XVII, alpha 1 2.29339
ZNF84 zinc finger protein 84 2.29339
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 2.29339
PATE4 prostate and testis expressed 4 2.29339
KLK7 kallikrein-related peptidase 7 2.29339
CFAP47 cilia and flagella associated protein 47 2.29339
LRRC19 leucine rich repeat containing 19 2.29339
SAMD7 sterile alpha motif domain containing 7 2.29339
BAHCC1 BAH domain and coiled-coil containing 1 2.29339
PCDHGA3 protocadherin gamma subfamily A, 3 2.29339
C2CD4B C2 calcium-dependent domain containing 4B 2.29339
KCNK4 potassium channel, two pore domain subfamily K, member 4 2.29339
DPRX divergent-paired related homeobox 2.29339
S100Z S100 calcium binding protein Z 2.29339
ANKRD63 ankyrin repeat domain 63 2.29339
HOGA1 4-hydroxy-2-oxoglutarate aldolase 1 2.29339
DGCR6 DiGeorge syndrome critical region gene 6 2.29339
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.29339
KLF9 Kruppel-like factor 9 2.29339
ADAM8 ADAM metallopeptidase domain 8 2.29339
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.29339
ITGB7 integrin, beta 7 2.29339
KRT222 keratin 222, type II 2.29339
EPHA5 EPH receptor A5 2.29339
ERVV-2 endogenous retrovirus group V, member 2 2.29339
KLHDC1 kelch domain containing 1 2.29339
MEIS2 Meis homeobox 2 2.29339
LMX1A LIM homeobox transcription factor 1, alpha 2.29339
TTC29 tetratricopeptide repeat domain 29 2.29339
SYT4 synaptotagmin IV 2.29339
EVI2B ecotropic viral integration site 2B 2.29339
EVI2A ecotropic viral integration site 2A 2.29339
GSDMA gasdermin A 2.29339
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) 2.29339
GFY golgi-associated, olfactory signaling regulator 2.29339
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.29339
LOXHD1 lipoxygenase homology domains 1 2.29339
TPPP3 tubulin polymerization-promoting protein family member 3 2.29339
RETN resistin 2.29339
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 2.29339
LYN LYN proto-oncogene, Src family tyrosine kinase 2.29339
NT5C1B 5'-nucleotidase, cytosolic IB 2.29339
SOSTDC1 sclerostin domain containing 1 2.29339
UBXN11 UBX domain protein 11 2.29339
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) 2.29339
RAB27B RAB27B, member RAS oncogene family 2.29339
CLEC1A C-type lectin domain family 1, member A 2.29339
ART3 ADP-ribosyltransferase 3 2.29339
BMX BMX non-receptor tyrosine kinase 2.29339
TECTA tectorin alpha 2.29339
LOC105378220 macrophage receptor MARCO-like 2.29339
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.29339
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 2.29339
PRSS22 protease, serine, 22 2.29339
NRSN1 neurensin 1 2.29339
RHOJ ras homolog family member J 2.29339
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.29339
CHAD chondroadherin 2.29339
BCAS1 breast carcinoma amplified sequence 1 2.29339
AGBL4 ATP/GTP binding protein-like 4 2.29339
TEX38 testis expressed 38 2.29339
PITX2 paired-like homeodomain 2 2.29339
TGM1 transglutaminase 1 2.29339
TGM6 transglutaminase 6 2.29339
TRAF3IP3 TRAF3 interacting protein 3 2.29339
WRN Werner syndrome, RecQ helicase-like 2.29339
GPR17 G protein-coupled receptor 17 2.29339
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 2.29339
OIT3 oncoprotein induced transcript 3 2.29339
TMEM150B transmembrane protein 150B 2.29339
ERMN ermin, ERM-like protein 2.29339
GNRHR gonadotropin-releasing hormone receptor 2.29339
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.29339
IL13RA1 interleukin 13 receptor, alpha 1 2.29339
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.29339
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.29339
LGI1 leucine-rich, glioma inactivated 1 2.29339
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.29339
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.29339
ETV7 ets variant 7 2.29339
SLC39A12 solute carrier family 39 (zinc transporter), member 12 2.29339
ACKR2 atypical chemokine receptor 2 2.29339
ALOX15B arachidonate 15-lipoxygenase, type B 2.29339
SYMPK symplekin 2.29339
CHD2 chromodomain helicase DNA binding protein 2 2.29339
TREML2 triggering receptor expressed on myeloid cells-like 2 2.29339
MISP mitotic spindle positioning 2.29339
BZW2 basic leucine zipper and W2 domains 2 2.29218
SCO1 SCO1 cytochrome c oxidase assembly protein 2.29072
CNTN1 contactin 1 2.29072
APELA apelin receptor early endogenous ligand 2.29072
RPL5 ribosomal protein L5 2.29072
ARL13B ADP-ribosylation factor-like 13B 2.29072
CRYGD crystallin, gamma D 2.28768
XPO6 exportin 6 2.2861
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 2.26908
NSD1 nuclear receptor binding SET domain protein 1 2.26908
MED6 mediator complex subunit 6 2.22118
ZNF253 zinc finger protein 253 2.18945
FGF11 fibroblast growth factor 11 2.18945
EGR1 early growth response 1 2.18945
CBX1 chromobox homolog 1 2.18945
USF1 upstream transcription factor 1 2.15434
HEBP2 heme binding protein 2 2.14763
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 2.14702
UQCC6 ubiquinol-cytochrome c reductase complex assembly factor 6 2.13793
MKRN2 makorin ring finger protein 2 2.13793
SET SET nuclear proto-oncogene 2.1272
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 2.12546
DHRS7B dehydrogenase/reductase (SDR family) member 7B 2.11865
SGO2 shugoshin 2 2.11714
IFRD2 interferon-related developmental regulator 2 2.10857
ATL2 atlastin GTPase 2 2.10607
IMMP1L IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae) 2.10607
CCDC137 coiled-coil domain containing 137 2.08914
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.08777
MIGA1 mitoguardin 1 2.08719
KIF2A kinesin heavy chain member 2A 2.07008
LRRC20 leucine rich repeat containing 20 2.05297
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 2.03824
CKAP2 cytoskeleton associated protein 2 2.03824
TRIM27 tripartite motif containing 27 2.0375
UCK1 uridine-cytidine kinase 1 2.01264

decreased expression

Symbol Name Standardized Value
TPH2 tryptophan hydroxylase 2 -2.3723
BCL6B B-cell CLL/lymphoma 6, member B -2.3723
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) -2.3723
ANKRD13C ankyrin repeat domain 13C -2.3723
PTPN23 protein tyrosine phosphatase, non-receptor type 23 -2.3723
INTS6L integrator complex subunit 6 like -2.29583
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2) -2.29583
PRIMA1 proline rich membrane anchor 1 -2.29583
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 -2.29583
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 -2.29583
CA10 carbonic anhydrase X -2.29583
AHSP alpha hemoglobin stabilizing protein -2.29583
DYNLT2 dynein light chain Tctex-type 2 -2.29583
DNAH5 dynein, axonemal, heavy chain 5 -2.29583
EIF3H eukaryotic translation initiation factor 3, subunit H -2.29339
TSC2 tuberous sclerosis 2 -2.29339
RPL13A ribosomal protein L13a -2.29339
SYNGR1 synaptogyrin 1 -2.29339
ANXA7 annexin A7 -2.29339
FMO4 flavin containing monooxygenase 4 -2.29339
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2 -2.29339
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) -2.29339
AGBL2 ATP/GTP binding protein-like 2 -2.29339
LSMEM2 leucine-rich single-pass membrane protein 2 -2.29339
SETD7 SET domain containing (lysine methyltransferase) 7 -2.29339
EFHC2 EF-hand domain (C-terminal) containing 2 -2.29339
GUCY2C guanylate cyclase 2C -2.29339
RNF126 ring finger protein 126 -2.29339
TSPYL4 TSPY-like 4 -2.29339
NPTXR neuronal pentraxin receptor -2.29339
PLEKHG4 pleckstrin homology domain containing, family G (with RhoGef domain) member 4 -2.29339
RELL2 RELT-like 2 -2.29339
TLE2 transducin-like enhancer of split 2 -2.29339
USH1C Usher syndrome 1C (autosomal recessive, severe) -2.29339
MEX3B mex-3 RNA binding family member B -2.29339
TEK TEK tyrosine kinase, endothelial -2.29339
MBLAC2 metallo-beta-lactamase domain containing 2 -2.29339
DCDC2 doublecortin domain containing 2 -2.29339
PPIL6 peptidylprolyl isomerase (cyclophilin)-like 6 -2.29339
TMEM117 transmembrane protein 117 -2.29339
MYL7 myosin, light chain 7, regulatory -2.29072
FER1L6 fer-1-like family member 6 -2.29072
RNF26 ring finger protein 26 -2.29072
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.29072
PLK5 polo-like kinase 5 -2.29072
RNF17 ring finger protein 17 -2.29072
FAM43B family with sequence similarity 43, member B -2.29072
UCN urocortin -2.29072
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) -2.29072
MYH13 myosin, heavy chain 13, skeletal muscle -2.29072
FBP2 fructose-1,6-bisphosphatase 2 -2.29072
RARB retinoic acid receptor, beta -2.29072
TRIM54 tripartite motif containing 54 -2.29072
IHO1 interactor of HORMAD1 1 -2.29072
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.29072
RUMY3 RUMY family member 3 -2.29072
CDK20 cyclin-dependent kinase 20 -2.29072
EMILIN3 elastin microfibril interfacer 3 -2.29072
PTH2R parathyroid hormone 2 receptor -2.29072
VSTM5 V-set and transmembrane domain containing 5 -2.29072
ADAP2 ArfGAP with dual PH domains 2 -2.29072
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 -2.29072
TMEM121B transmembrane protein 121B -2.29072
PCDHGB7 protocadherin gamma subfamily B, 7 -2.29072
CYGB cytoglobin -2.29072
PP2D1 protein phosphatase 2C-like domain containing 1 -2.29072
KYNU kynureninase -2.29072
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 -2.29072
TMEM190 transmembrane protein 190 -2.29072
WDR64 WD repeat domain 64 -2.29072
SF1 splicing factor 1 -2.29072
AGBL1 ATP/GTP binding protein-like 1 -2.29072
EPOP elongin BC and polycomb repressive complex 2 associated protein -2.29072
YEATS2 YEATS domain containing 2 -2.28473
DNMBP dynamin binding protein -2.26908
USP24 ubiquitin specific peptidase 24 -2.26544
CUZD1 CUB and zona pellucida-like domains 1 -2.26544
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2 -2.25824
RAB5A RAB5A, member RAS oncogene family -2.22448
KIAA1143 KIAA1143 -2.20969
ZNF25 zinc finger protein 25 -2.20566
DNAH7 dynein, axonemal, heavy chain 7 -2.20566
TNNI3 troponin I type 3 (cardiac) -2.20282
DDR2 discoidin domain receptor tyrosine kinase 2 -2.19954
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11 -2.18913
POR P450 (cytochrome) oxidoreductase -2.18495
CCDC88A coiled-coil domain containing 88A -2.17808
RACGAP1 Rac GTPase activating protein 1 -2.1779
MIER3 mesoderm induction early response 1, family member 3 -2.17689
GAS2 growth arrest-specific 2 -2.15978
PCDHGA6 protocadherin gamma subfamily A, 6 -2.15018
IL27RA interleukin 27 receptor, alpha -2.14763
OTUD3 OTU deubiquitinase 3 -2.13793
TMSB15C thymosin beta 15C -2.1272
PIGH phosphatidylinositol glycan anchor biosynthesis, class H -2.1272
ZDHHC3 zinc finger, DHHC-type containing 3 -2.12182
LRRC69 leucine rich repeat containing 69 -2.11826
LRRC37B leucine rich repeat containing 37B -2.11543
H2AC6 H2A clustered histone 6 -2.11543
TFRC transferrin receptor -2.11342
HPSE heparanase -2.10607
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.10607
SH2D2A SH2 domain containing 2A -2.10607
BCKDK branched chain ketoacid dehydrogenase kinase -2.10607
APOL2 apolipoprotein L, 2 -2.10607
SAP25 Sin3A-associated protein, 25kDa -2.10607
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 -2.08719
TRMT6 tRNA methyltransferase 6 -2.08081
NUP93 nucleoporin 93kDa -2.05482
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 -2.05085
INSC inscuteable homolog (Drosophila) -2.03824
UNC119B unc-119 homolog B (C. elegans) -2.0375
ARRB1 arrestin, beta 1 -2.03372