CEBPB Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description CCAAT/enhancer binding protein (C/EBP), beta|This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013] (NCBI Entrez Gene Database, 1051)
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Genes

316 genes differentially expressed following the CEBPB gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
CLNK cytokine-dependent hematopoietic cell linker 2.80217
PAX5 paired box 5 2.80217
NIP7 NIP7, nucleolar pre-rRNA processing protein 2.80217
SH2D7 SH2 domain containing 7 2.80217
UMOD uromodulin 2.80217
SIRPB1 signal-regulatory protein beta 1 2.80217
ZNF467 zinc finger protein 467 2.80217
WNT3A wingless-type MMTV integration site family, member 3A 2.80217
PCDHB1 protocadherin beta 1 2.80217
TSGA13 testis specific, 13 2.80217
PGAM4 phosphoglycerate mutase family member 4 2.80217
BTC betacellulin 2.80217
HCRTR1 hypocretin (orexin) receptor 1 2.80217
ANKRD22 ankyrin repeat domain 22 2.80217
OR8A1 olfactory receptor, family 8, subfamily A, member 1 2.80217
IGFL3 IGF-like family member 3 2.80217
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10 2.80217
ADGRE3 adhesion G protein-coupled receptor E3 2.80217
LYVE1 lymphatic vessel endothelial hyaluronan receptor 1 2.80217
XCL1 chemokine (C motif) ligand 1 2.80217
TUBB1 tubulin, beta 1 class VI 2.80217
STOML3 stomatin (EPB72)-like 3 2.80217
CD34 CD34 molecule 2.80217
NRSN1 neurensin 1 2.80217
IL23R interleukin 23 receptor 2.80217
CCDC89 coiled-coil domain containing 89 2.80217
KIAA1755 KIAA1755 2.80217
TMEM132C transmembrane protein 132C 2.80217
RTP1 receptor (chemosensory) transporter protein 1 2.80217
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.80217
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.80217
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 2.80217
CAPS calcyphosine 2.80217
COX15 cytochrome c oxidase assembly homolog 15 (yeast) 2.80217
NOTUM notum pectinacetylesterase homolog (Drosophila) 2.80217
SFXN3 sideroflexin 3 2.80217
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 2.80217
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide 2.80217
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 2.80217
SOX1 SRY (sex determining region Y)-box 1 2.80217
CD5 CD5 molecule 2.80217
LITAFD LITAF domain containing 2.80217
KLHDC7B kelch domain containing 7B 2.80217
STX11 syntaxin 11 2.80217
ELOVL3 ELOVL fatty acid elongase 3 2.80217
ST6GALNAC1 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 2.80217
ALDOB aldolase B, fructose-bisphosphate 2.80217
ARX aristaless related homeobox 2.80217
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.80217
HTD2 hydroxyacyl-thioester dehydratase type 2 2.80217
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.80217
SPACA9 sperm acrosome associated 9 2.80217
BNIP5 BCL2 interacting protein 5 2.80217
ODAPH odontogenesis associated phosphoprotein 2.80217
STPG3 sperm-tail PG-rich repeat containing 3 2.80217
HOATZ HOATZ cilia and flagella associated protein 2.80217
DEFB109B defensin beta 109B 2.80217
CPNE8-AS1 CPNE8 antisense RNA 1 2.80217
TSPAN8 tetraspanin 8 2.80217
TBX10 T-box 10 2.80217
GATA3 GATA binding protein 3 2.80217
CD6 CD6 molecule 2.80217
COL7A1 collagen, type VII, alpha 1 2.80217
PDILT protein disulfide isomerase-like, testis expressed 2.80217
FPR2 formyl peptide receptor 2 2.80217
RLBP1 retinaldehyde binding protein 1 2.80217
LIPK lipase, family member K 2.80217
IRF8 interferon regulatory factor 8 2.80217
C1ORF162 chromosome 1 open reading frame 162 2.80217
S100B S100 calcium binding protein B 2.80217
UTS2 urotensin 2 2.80217
TIMD4 T-cell immunoglobulin and mucin domain containing 4 2.80217
TAS1R1 taste receptor, type 1, member 1 2.80217
PABPC1L2A poly(A) binding protein, cytoplasmic 1-like 2A 2.80217
NPIPB7 nuclear pore complex interacting protein family, member B7 2.80217
PRG4 proteoglycan 4 2.80217
RNF183 ring finger protein 183 2.80217
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.80217
WASL-DT WASL divergent transcript 2.80217
TNNI1 troponin I type 1 (skeletal, slow) 2.80217
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3 2.80217
KIF6 kinesin family member 6 2.80217
PRTN3 proteinase 3 2.80217
OR4D5 olfactory receptor, family 4, subfamily D, member 5 2.80217
CPZ carboxypeptidase Z 2.80217
KRT17 keratin 17, type I 2.80217
CALML5 calmodulin-like 5 2.80217
RGS8 regulator of G-protein signaling 8 2.80217
FZD1 frizzled class receptor 1 2.80217
SHOX short stature homeobox 2.80217
TRIM7 tripartite motif containing 7 2.80217
WDFY4 WDFY family member 4 2.80217
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 2.80217
EPX eosinophil peroxidase 2.80217
EPO erythropoietin 2.80217
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.80217
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 2.80217
OR56A4 olfactory receptor, family 56, subfamily A, member 4 2.80217
CLEC18C C-type lectin domain family 18, member C 2.80217
RANBP3L RAN binding protein 3-like 2.80217
RELN reelin 2.80217
CALHM3 calcium homeostasis modulator 3 2.80217
LRRC15 leucine rich repeat containing 15 2.80217
SLC32A1 solute carrier family 32 (GABA vesicular transporter), member 1 2.80217
CYSLTR1 cysteinyl leukotriene receptor 1 2.80217
CLRN2 clarin 2 2.80217
DPRX divergent-paired related homeobox 2.80217
TESPA1 thymocyte expressed, positive selection associated 1 2.80217
DNLZ DNL-type zinc finger 2.80217
TDP2 tyrosyl-DNA phosphodiesterase 2 2.80217
SIGLEC11 sialic acid binding Ig-like lectin 11 2.80217
EDN3 endothelin 3 2.80217
OR2C1 olfactory receptor, family 2, subfamily C, member 1 2.80217
ANGPTL6 angiopoietin-like 6 2.80217
TMPRSS15 transmembrane protease, serine 15 2.80217
TEX38 testis expressed 38 2.80217
GOLGA8R golgin A8 family, member R 2.80217
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.80217
SLITRK1 SLIT and NTRK-like family, member 1 2.80217
PADI6 peptidyl arginine deiminase, type VI 2.80217
TGM1 transglutaminase 1 2.80217
EVI2A ecotropic viral integration site 2A 2.80217
SDSL serine dehydratase-like 2.80217
OR10G7 olfactory receptor, family 10, subfamily G, member 7 2.80217
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.80217
SFTA2 surfactant associated 2 2.80217
MEIS1 Meis homeobox 1 2.80217
LAMB3 laminin, beta 3 2.80217
OTP orthopedia homeobox 2.80217
SNTN sentan, cilia apical structure protein 2.80217
ARHGAP40 Rho GTPase activating protein 40 2.80217
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.80217
GP1BB glycoprotein Ib (platelet), beta polypeptide 2.80217
PXT1 peroxisomal, testis specific 1 2.80217
GSG1 germ cell associated 1 2.79068
CCNJL cyclin J-like 2.72633
GEMIN5 gem (nuclear organelle) associated protein 5 2.72633
TMEM131L transmembrane 131 like 2.72633
ZNF765 zinc finger protein 765 2.72633
ANG angiogenin, ribonuclease, RNase A family, 5 2.72633
RAB3A RAB3A, member RAS oncogene family 2.72633
RPS16 ribosomal protein S16 2.72633
TEAD3 TEA domain family member 3 2.72633
POLR1D polymerase (RNA) I polypeptide D, 16kDa 2.68555
PHGDH phosphoglycerate dehydrogenase 2.65149
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 2.64733
ZNF506 zinc finger protein 506 2.61314
PRDX2 peroxiredoxin 2 2.61076
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.60803
EMC9 ER membrane protein complex subunit 9 2.59043
H4C13 H4 clustered histone 13 2.57804
HESX1 HESX homeobox 1 2.56035
NELFE negative elongation factor complex member E 2.56035
RCN3 reticulocalbin 3, EF-hand calcium binding domain 2.51531
CHERP calcium homeostasis endoplasmic reticulum protein 2.49832
ABT1 activator of basal transcription 1 2.49832
ZNF37A zinc finger protein 37A 2.49832
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa 2.48686
OVOL3 ovo-like zinc finger 3 2.47416
MSX1 msh homeobox 1 2.47416
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 2.46283
RAB31 RAB31, member RAS oncogene family 2.46073
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.43213
KLB klotho beta 2.42836
MYOZ1 myozenin 1 2.42308
PRDM6 PR domain containing 6 2.34692
PDCL3 phosducin-like 3 2.34428
FABP5 fatty acid binding protein 5 (psoriasis-associated) 2.34199
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.33983
RSL1D1 ribosomal L1 domain containing 1 2.33287
MRPL20 mitochondrial ribosomal protein L20 2.33197
NPIPB8 nuclear pore complex interacting protein family, member B8 2.31655
TP63 tumor protein p63 2.31655
RTL4 retrotransposon Gag like 4 2.3054
GMNN geminin, DNA replication inhibitor 2.28047
PITPNA phosphatidylinositol transfer protein, alpha 2.27907
CFL2 cofilin 2 (muscle) 2.27336
RPL15 ribosomal protein L15 2.27178
PHF8 PHD finger protein 8 2.25166
GEMIN8 gem (nuclear organelle) associated protein 8 2.24849
SYNPR synaptoporin 2.24138
CCDC91 coiled-coil domain containing 91 2.23124
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 2.22697
DDR1 discoidin domain receptor tyrosine kinase 1 2.22644
MAST3 microtubule associated serine/threonine kinase 3 2.21206
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2.21206
TMED3 transmembrane emp24 protein transport domain containing 3 2.21206
MPPE1 metallophosphoesterase 1 2.20795
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 2.20528
NCOA1 nuclear receptor coactivator 1 2.20286
MRPL47 mitochondrial ribosomal protein L47 2.20286
INO80E INO80 complex subunit E 2.19782
DERL3 derlin 3 2.19037
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 2.15194
A2M alpha-2-macroglobulin 2.14074
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 2.13995
REEP6 receptor accessory protein 6 2.11542
KDM4B lysine (K)-specific demethylase 4B 2.10167
H1-0 H1.0 linker histone 2.10017
CAPN1 calpain 1, (mu/I) large subunit 2.09136
VDAC2 voltage-dependent anion channel 2 2.09052
EPOR erythropoietin receptor 2.09036
ETFRF1 electron transfer flavoprotein regulatory factor 1 2.08396
ABHD14B abhydrolase domain containing 14B 2.08193
LNPEP leucyl/cystinyl aminopeptidase 2.06165
TOMM6 translocase of outer mitochondrial membrane 6 homolog (yeast) 2.0582
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 2.03291
BTBD18 BTB (POZ) domain containing 18 2.01787
CEP350 centrosomal protein 350kDa 2.00901
PURB purine-rich element binding protein B 2.00857
SENP6 SUMO1/sentrin specific peptidase 6 2.0051

decreased expression

Symbol Name Standardized Value
CFAP54 cilia and flagella associated 54 -2.80217
MNS1 meiosis-specific nuclear structural 1 -2.80217
CCDC184 coiled-coil domain containing 184 -2.80217
SRRM5 serine/arginine repetitive matrix 5 -2.80217
PROM2 prominin 2 -2.80217
MCU mitochondrial calcium uniporter -2.80217
PGF placental growth factor -2.80217
SLC10A1 solute carrier family 10 (sodium/bile acid cotransporter), member 1 -2.80217
SPTLC3 serine palmitoyltransferase, long chain base subunit 3 -2.80217
HSH2D hematopoietic SH2 domain containing -2.80217
CLDN18 claudin 18 -2.80217
IRX4 iroquois homeobox 4 -2.72633
THSD1 thrombospondin, type I, domain containing 1 -2.72633
AHSG alpha-2-HS-glycoprotein -2.72633
RAMP3 receptor (G protein-coupled) activity modifying protein 3 -2.72633
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family) -2.72633
NLRP7 NLR family, pyrin domain containing 7 -2.72633
OTX1 orthodenticle homeobox 1 -2.72633
CYGB cytoglobin -2.72633
GHRH growth hormone releasing hormone -2.72633
MED4 mediator complex subunit 4 -2.72633
SHISA7 shisa family member 7 -2.72633
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 -2.72633
RAG2 recombination activating gene 2 -2.72633
CAPN9 calpain 9 -2.72633
SLC22A1 solute carrier family 22 (organic cation transporter), member 1 -2.72633
GDF6 growth differentiation factor 6 -2.72633
LGALS7B lectin, galactoside-binding, soluble, 7B -2.72633
CIROZ ciliated left-right organizer protein containing ZP-N domains -2.72633
SPDYE6 speedy/RINGO cell cycle regulator family member E6 -2.72633
MYBPHL myosin binding protein H-like -2.72633
CARD14 caspase recruitment domain family, member 14 -2.72633
GLYR1 glyoxylate reductase 1 homolog (Arabidopsis) -2.72633
IL5RA interleukin 5 receptor, alpha -2.72633
TMEM100 transmembrane protein 100 -2.72633
LMO1 LIM domain only 1 (rhombotin 1) -2.72633
NECTIN4 nectin cell adhesion molecule 4 -2.72633
PLGLB1 plasminogen-like B1 -2.72633
ERICH6B glutamate-rich 6B -2.72633
CAMK2A calcium/calmodulin-dependent protein kinase II alpha -2.72633
LHX2 LIM homeobox 2 -2.72633
ZDHHC11B zinc finger, DHHC-type containing 11B -2.72633
CCNA1 cyclin A1 -2.72633
CFAP126 cilia and flagella associated protein 126 -2.72633
CLEC18A C-type lectin domain family 18, member A -2.72633
IGFBP7 insulin-like growth factor binding protein 7 -2.72633
C11ORF16 chromosome 11 open reading frame 16 -2.72633
CLCNKB chloride channel, voltage-sensitive Kb -2.72633
DND1 DND microRNA-mediated repression inhibitor 1 -2.72633
KLK6 kallikrein-related peptidase 6 -2.72633
GOLGA8H golgin A8 family, member H -2.72633
NACA2 nascent polypeptide-associated complex alpha subunit 2 -2.72633
LAMP5 lysosomal-associated membrane protein family, member 5 -2.72633
DEPDC7 DEP domain containing 7 -2.72579
PELI1 pellino E3 ubiquitin protein ligase 1 -2.72579
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.71538
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -2.71538
LIPE lipase, hormone-sensitive -2.68552
TAGLN2 transgelin 2 -2.68291
TRIM33 tripartite motif containing 33 -2.67844
NRXN3 neurexin 3 -2.67844
CKAP5 cytoskeleton associated protein 5 -2.65149
MCL1 myeloid cell leukemia 1 -2.61076
FLT3LG fms-related tyrosine kinase 3 ligand -2.60365
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 -2.60365
NCOA2 nuclear receptor coactivator 2 -2.55323
MEOX2 mesenchyme homeobox 2 -2.55323
TXNL4B thioredoxin-like 4B -2.54024
LYG1 lysozyme G-like 1 -2.50125
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.48686
CEP128 centrosomal protein 128kDa -2.48117
ANO6 anoctamin 6 -2.46639
PNMA6A paraneoplastic Ma antigen family member 6A -2.46639
TAS2R30 taste receptor, type 2, member 30 -2.46639
SORD sorbitol dehydrogenase -2.46327
TMEM209 transmembrane protein 209 -2.44275
ZNF318 zinc finger protein 318 -2.43213
TUBGCP2 tubulin, gamma complex associated protein 2 -2.42936
ANK2 ankyrin 2, neuronal -2.4204
RNF31 ring finger protein 31 -2.4204
WDR33 WD repeat domain 33 -2.36859
PRPF31 pre-mRNA processing factor 31 -2.3342
SHISA9 shisa family member 9 -2.31655
INO80D INO80 complex subunit D -2.28134
CDADC1 cytidine and dCMP deaminase domain containing 1 -2.27336
HIP1 huntingtin interacting protein 1 -2.23112
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain -2.21719
PTPRK protein tyrosine phosphatase, receptor type, K -2.21436
WASF3 WAS protein family, member 3 -2.17371
STC2 stanniocalcin 2 -2.14541
TASP1 taspase, threonine aspartase, 1 -2.1395
AIF1 allograft inflammatory factor 1 -2.13829
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G -2.13334
C1ORF167 chromosome 1 open reading frame 167 -2.13334
FGF22 fibroblast growth factor 22 -2.13334
RIPOR1 RHO family interacting cell polarization regulator 1 -2.12358
CCDC63 coiled-coil domain containing 63 -2.12358
MTMR11 myotubularin related protein 11 -2.11542
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -2.11542
KRIT1 KRIT1, ankyrin repeat containing -2.10471
ARRDC4 arrestin domain containing 4 -2.1025
NID1 nidogen 1 -2.1025
ADAM22 ADAM metallopeptidase domain 22 -2.06165
THAP6 THAP domain containing 6 -2.00553
ZNF189 zinc finger protein 189 -2.0051