| Dataset | CM4AI KOLF21J CRISPRi Gene Perturbation Atlas |
| Category | transcriptomics |
| Type | gene perturbation |
| Description | centromere protein A|Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 1058) |
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195 genes differentially expressed following the CENPA gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.
| Symbol | Name | Standardized Value |
|---|---|---|
| PTER | phosphotriesterase related | 2.28511 |
| PM20D2 | peptidase M20 domain containing 2 | 2.28511 |
| PIGM | phosphatidylinositol glycan anchor biosynthesis, class M | 2.28511 |
| TMSB4X | thymosin beta 4, X-linked | 2.28511 |
| ANPEP | alanyl (membrane) aminopeptidase | 2.18717 |
| RAP1GAP | RAP1 GTPase activating protein | 2.18717 |
| FTCD | formimidoyltransferase cyclodeaminase | 2.18717 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 2.18717 |
| RNF19B | ring finger protein 19B | 2.18717 |
| TNK1 | tyrosine kinase, non-receptor, 1 | 2.18717 |
| ATRIP | ATR interacting protein | 2.18717 |
| KIF26A | kinesin family member 26A | 2.18717 |
| HSPA1A | heat shock 70kDa protein 1A | 2.18717 |
| EPHA7 | EPH receptor A7 | 2.18717 |
| EAF2 | ELL associated factor 2 | 2.18717 |
| CHGA | chromogranin A | 2.18717 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | 2.18717 |
| ATP7B | ATPase, Cu++ transporting, beta polypeptide | 2.18717 |
| SLC7A14 | solute carrier family 7, member 14 | 2.18717 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | 2.18392 |
| ATP13A2 | ATPase type 13A2 | 2.12943 |
| PAAF1 | proteasomal ATPase-associated factor 1 | 2.12943 |
| ZNF597 | zinc finger protein 597 | 2.12943 |
| MS4A4A | membrane-spanning 4-domains, subfamily A, member 4A | 2.12943 |
| FLT3 | fms-related tyrosine kinase 3 | 2.12943 |
| EPS8L1 | EPS8-like 1 | 2.12943 |
| ZNF780A | zinc finger protein 780A | 2.12943 |
| ADCK5 | aarF domain containing kinase 5 | 2.12943 |
| ZNF14 | zinc finger protein 14 | 2.12943 |
| BTN3A2 | butyrophilin, subfamily 3, member A2 | 2.12943 |
| C14ORF132 | chromosome 14 open reading frame 132 | 2.12943 |
| ZBTB9 | zinc finger and BTB domain containing 9 | 2.12943 |
| SOX8 | SRY (sex determining region Y)-box 8 | 2.12943 |
| RPS14 | ribosomal protein S14 | 2.12943 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 2.12943 |
| FAM13C | family with sequence similarity 13, member C | 2.12943 |
| ARC | activity-regulated cytoskeleton-associated protein | 2.12943 |
| TRMO | tRNA methyltransferase O | 2.12943 |
| FAAP100 | FA core complex associated protein 100 | 2.12943 |
| EEF1AKMT4 | EEF1A lysine methyltransferase 4 | 2.12943 |
| INKA1 | inka box actin regulator 1 | 2.12943 |
| GARIN5A | golgi associated RAB2 interactor 5A | 2.12943 |
| WASHC1 | WASH complex subunit 1 | 2.12943 |
| RNF144B | ring finger protein 144B | 2.12943 |
| CLDN19 | claudin 19 | 2.12943 |
| PHKA1 | phosphorylase kinase, alpha 1 (muscle) | 2.12943 |
| PDE1A | phosphodiesterase 1A, calmodulin-dependent | 2.12943 |
| ZNF687 | zinc finger protein 687 | 2.12943 |
| SPATA21 | spermatogenesis associated 21 | 2.12943 |
| HIP1R | huntingtin interacting protein 1 related | 2.12943 |
| MNMIP1 | manchette microtubule inner protein 1 | 2.12943 |
| OTUD1 | OTU deubiquitinase 1 | 2.12943 |
| RSU1 | Ras suppressor protein 1 | 2.12943 |
| MAP2K5-DT | MAP2K5 divergent transcript | 2.12943 |
| CDC50B | cell division cycle 50 P4-ATPase accessory subunit B | 2.12943 |
| FOXO6 | forkhead box O6 | 2.12943 |
| RPS6KL1 | ribosomal protein S6 kinase-like 1 | 2.12943 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 2.12943 |
| DNAJC27 | DnaJ (Hsp40) homolog, subfamily C, member 27 | 2.12943 |
| CD177 | CD177 molecule | 2.12943 |
| CTF1 | cardiotrophin 1 | 2.12943 |
| ATAT1 | alpha tubulin acetyltransferase 1 | 2.12943 |
| KLHL9 | kelch-like family member 9 | 2.12943 |
| NRK | Nik related kinase | 2.12943 |
| ERMAP | erythroblast membrane-associated protein (Scianna blood group) | 2.12943 |
| SNX33 | sorting nexin 33 | 2.12943 |
| MUC19 | mucin 19, oligomeric | 2.12943 |
| TYSND1 | trypsin domain containing 1 | 2.12943 |
| LIN7B | lin-7 homolog B (C. elegans) | 2.12943 |
| BMPER | BMP binding endothelial regulator | 2.12943 |
| SLC22A2 | solute carrier family 22 (organic cation transporter), member 2 | 2.12943 |
| ZNF829 | zinc finger protein 829 | 2.12943 |
| ZFYVE19 | zinc finger, FYVE domain containing 19 | 2.12943 |
| TBX19 | T-box 19 | 2.12943 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 2.12943 |
| KAT5 | K(lysine) acetyltransferase 5 | 2.12943 |
| SPN | sialophorin | 2.12943 |
| TRAF3IP2 | TRAF3 interacting protein 2 | 2.12943 |
| HIC2 | hypermethylated in cancer 2 | 2.12943 |
| RYR2 | ryanodine receptor 2 (cardiac) | 2.12943 |
| ORAI3 | ORAI calcium release-activated calcium modulator 3 | 2.12943 |
| SLC25A40 | solute carrier family 25, member 40 | 2.12943 |
| DSTYK | dual serine/threonine and tyrosine protein kinase | 2.12943 |
| ZNF395 | zinc finger protein 395 | 2.12943 |
| MAST1 | microtubule associated serine/threonine kinase 1 | 2.12943 |
| EFS | embryonal Fyn-associated substrate | 2.12404 |
| ZNF747 | zinc finger protein 747 | 2.12198 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 2.12198 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 2.12198 |
| ELN | elastin | 2.12198 |
| CSNK1G2 | casein kinase 1, gamma 2 | 2.11746 |
| FHIT | fragile histidine triad | 2.11123 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 2.09787 |
| TAFA2 | TAFA chemokine like family member 2 | 2.09704 |
| LRMDA | leucine rich melanocyte differentiation associated | 2.07987 |
| ZFYVE28 | zinc finger, FYVE domain containing 28 | 2.07987 |
| AGFG1 | ArfGAP with FG repeats 1 | 2.07917 |
| CKS1B | CDC28 protein kinase regulatory subunit 1B | 2.07191 |
| TRIB2 | tribbles pseudokinase 2 | 2.07191 |
| TMEM47 | transmembrane protein 47 | 2.04576 |
| H2AZ2 | H2A.Z variant histone 2 | 2.01152 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TOP3A | topoisomerase (DNA) III alpha | -2.28511 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -2.28511 |
| KATNIP | katanin interacting protein | -2.28511 |
| ACAD9 | acyl-CoA dehydrogenase family, member 9 | -2.28511 |
| ZNF724 | zinc finger protein 724 | -2.28511 |
| KCTD10 | potassium channel tetramerization domain containing 10 | -2.28511 |
| KDM5C | lysine (K)-specific demethylase 5C | -2.28511 |
| NUDT22 | nudix (nucleoside diphosphate linked moiety X)-type motif 22 | -2.28511 |
| HSCB | HscB mitochondrial iron-sulfur cluster co-chaperone | -2.26052 |
| ZNF680 | zinc finger protein 680 | -2.18717 |
| NMRAL1 | NmrA-like family domain containing 1 | -2.18717 |
| ZNF20 | zinc finger protein 20 | -2.18717 |
| ATXN10 | ataxin 10 | -2.18717 |
| CD200 | CD200 molecule | -2.18717 |
| SRF | serum response factor (c-fos serum response element-binding transcription factor) | -2.12943 |
| LRFN5 | leucine rich repeat and fibronectin type III domain containing 5 | -2.12943 |
| HDX | highly divergent homeobox | -2.12943 |
| ZDHHC11 | zinc finger, DHHC-type containing 11 | -2.12943 |
| NCSTN | nicastrin | -2.12943 |
| ZCCHC2 | zinc finger, CCHC domain containing 2 | -2.12943 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -2.12943 |
| NUDT4 | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | -2.12943 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -2.12943 |
| ZNF462 | zinc finger protein 462 | -2.12943 |
| SLC35G2 | solute carrier family 35, member G2 | -2.12943 |
| THAP5 | THAP domain containing 5 | -2.12943 |
| NXPH2 | neurexophilin 2 | -2.12943 |
| MERTK | MER proto-oncogene, tyrosine kinase | -2.12943 |
| RBBP8 | retinoblastoma binding protein 8 | -2.12943 |
| GSPT2 | G1 to S phase transition 2 | -2.12943 |
| DMAC2L | distal membrane arm assembly component 2 like | -2.12943 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -2.12943 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.12943 |
| APH1B | APH1B gamma secretase subunit | -2.12943 |
| DARS2 | aspartyl-tRNA synthetase 2, mitochondrial | -2.12943 |
| MOSPD1 | motile sperm domain containing 1 | -2.12943 |
| RMP24 | ribonuclease MRP subunit p24 | -2.12943 |
| TAPBP | TAP binding protein (tapasin) | -2.12943 |
| HSPA12A | heat shock 70kDa protein 12A | -2.12943 |
| ANAPC16 | anaphase promoting complex subunit 16 | -2.12943 |
| AIM2 | absent in melanoma 2 | -2.12943 |
| TIMM10 | translocase of inner mitochondrial membrane 10 homolog (yeast) | -2.12943 |
| ADAL | adenosine deaminase-like | -2.12943 |
| PI4K2B | phosphatidylinositol 4-kinase type 2 beta | -2.12943 |
| CCDC91 | coiled-coil domain containing 91 | -2.12943 |
| RNF40 | ring finger protein 40, E3 ubiquitin protein ligase | -2.12943 |
| SLC35D2 | solute carrier family 35 (UDP-GlcNAc/UDP-glucose transporter), member D2 | -2.12943 |
| H2AC14 | H2A clustered histone 14 | -2.12943 |
| FKBP15 | FK506 binding protein 15, 133kDa | -2.12943 |
| ZNF786 | zinc finger protein 786 | -2.12943 |
| ZNF532 | zinc finger protein 532 | -2.12943 |
| EXOSC2 | exosome component 2 | -2.12943 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -2.12943 |
| JMJD6 | jumonji domain containing 6 | -2.12943 |
| HAGHL | hydroxyacylglutathione hydrolase-like | -2.12943 |
| FAM20B | family with sequence similarity 20, member B | -2.12943 |
| SPATA2 | spermatogenesis associated 2 | -2.12943 |
| TRAPPC6B | trafficking protein particle complex 6B | -2.12943 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -2.12943 |
| DCPS | decapping enzyme, scavenger | -2.12943 |
| EDC4 | enhancer of mRNA decapping 4 | -2.12943 |
| ZNF418 | zinc finger protein 418 | -2.12943 |
| DYNC1I1 | dynein, cytoplasmic 1, intermediate chain 1 | -2.12943 |
| UPF3A | UPF3 regulator of nonsense transcripts homolog A (yeast) | -2.12943 |
| RPE | ribulose-5-phosphate-3-epimerase | -2.12943 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -2.12943 |
| ZNF44 | zinc finger protein 44 | -2.12943 |
| TFCP2 | transcription factor CP2 | -2.12943 |
| PDE8B | phosphodiesterase 8B | -2.12943 |
| FN1 | fibronectin 1 | -2.12943 |
| C6ORF89 | chromosome 6 open reading frame 89 | -2.12943 |
| SHF | Src homology 2 domain containing F | -2.12943 |
| CA11 | carbonic anhydrase XI | -2.12943 |
| ADAMTS20 | ADAM metallopeptidase with thrombospondin type 1 motif, 20 | -2.12943 |
| GTF2I | general transcription factor IIi | -2.12198 |
| IRAK1BP1 | interleukin-1 receptor-associated kinase 1 binding protein 1 | -2.12198 |
| GOSR2 | golgi SNAP receptor complex member 2 | -2.12198 |
| ATAD2 | ATPase family, AAA domain containing 2 | -2.09787 |
| WWC2 | WW and C2 domain containing 2 | -2.09704 |
| ALKBH1 | alkB, alkylation repair homolog 1 (E. coli) | -2.09278 |
| PCOLCE | procollagen C-endopeptidase enhancer | -2.07987 |
| CAVIN3 | caveolae associated protein 3 | -2.07987 |
| PRSS16 | protease, serine, 16 (thymus) | -2.07987 |
| SPTBN2 | spectrin, beta, non-erythrocytic 2 | -2.07987 |
| LRRC40 | leucine rich repeat containing 40 | -2.07987 |
| NFU1 | NFU1 iron-sulfur cluster scaffold | -2.07191 |
| CLCC1 | chloride channel CLIC-like 1 | -2.07191 |
| NUP54 | nucleoporin 54kDa | -2.07191 |
| BCAS3 | breast carcinoma amplified sequence 3 | -2.05639 |
| BCL2L1 | BCL2-like 1 | -2.05639 |
| DCAF16 | DDB1 and CUL4 associated factor 16 | -2.05639 |
| RAP1GDS1 | RAP1, GTP-GDP dissociation stimulator 1 | -2.02398 |
| HEATR5A | HEAT repeat containing 5A | -2.0119 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | -2.00534 |
